Skip Header

Contribute Send feedback
Read comments (?) or add your own

P26270 (PSD7_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
26S proteasome non-ATPase regulatory subunit 7
Alternative name(s):
26S proteasome regulatory subunit RPN8
26S proteasome regulatory subunit S12
Proteasome subunit p39B
Proteasome subunit p40
Protein Mov34
Gene names
Name:Mov34
ORF Names:CG3416
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Ref.5

Sequence similarities

Belongs to the peptidase M67A family.

Contains 1 MPN (JAB/Mov34) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Rpn9Q7KMP83EBI-253612,EBI-151692

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 33833726S proteasome non-ATPase regulatory subunit 7
PRO_0000213945

Regions

Domain6 – 121116MPN
Compositional bias289 – 33850Glu/Lys-rich

Experimental info

Sequence conflict561S → T in AAA28695. Ref.1
Sequence conflict631E → V in AAA28695. Ref.1
Sequence conflict121 – 14626NSVLV…ISVEE → TPCWSSSTPSPRIWACPQRR TYRWRK in AAA28695. Ref.1
Sequence conflict1671A → P in AAA28695. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P26270 [UniParc].

Last modified January 23, 2007. Version 6.
Checksum: 1074BBB94268B2D6

FASTA33838,089
        10         20         30         40         50         60 
MPSQEVSVNK VIVHPLVLLS VVDHFNRMGK IGNQKRVVGV LLGCWRSKGV LDVSNSFAVP 

        70         80         90        100        110        120 
FDEDDKDKSV WFLDHDYLEN MYGMFKKVNA RERVVGWYHT GPKLHQNDIA INELVRRYCP 

       130        140        150        160        170        180 
NSVLVIIDAK PKDLGLPTEA YISVEEVHDD GSPTSKTFEH VPSEIGAEEA EEVGVEHLLR 

       190        200        210        220        230        240 
DIKDTTVGSL SQKITNQLMG LKGLNAQLRD IKQYLQRVGD SKMPINHQIV YQLQDIFNLL 

       250        260        270        280        290        300 
PDITNDQFTG TMYVKTNDQM LVVYLASMVR SIIALHNLIN NKLANRDAEE GKSDSKEAKE 

       310        320        330 
KNKDSKDKDN KETKDKDGKK AEEKADKGKD EGGKGSRK

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila."
Gridley T., Gray D.A., Orr-Weaver T., Soriano P., Barton D.E., Francke U., Jaenisch R.
Development 109:235-242(1990) [PubMed: 2209467] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Head.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Testis.
[5]"The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme."
Hoelzl H., Kapelari B., Kellermann J., Seemueller E., Suemegi M., Udvardy A., Medalia O., Sperling J., Mueller S.A., Engel A., Baumeister W.
J. Cell Biol. 150:119-130(2000) [PubMed: 10893261] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-10, FUNCTION.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M64643 mRNA. Translation: AAA28695.1.
AE013599 Genomic DNA. Translation: AAF47199.1.
AY089283 mRNA. Translation: AAL90021.1.
RefSeqNP_523845.2. NM_079121.2.
UniGeneDm.770.

3D structure databases

ProteinModelPortalP26270.
SMRP26270. Positions 5-184.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-22847N.
IntActP26270. 5 interactions.
MINTMINT-819762.
STRINGP26270.

Protein family/group databases

MEROPSM67.973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0072290; FBpp0072197; FBgn0002787.
GeneID37894.
KEGGdme:Dmel_CG3416.
NMPDRfig|7227.3.peg.7302.
UCSCCG3416-RA. d. melanogaster.

Organism-specific databases

CTD37894.
FlyBaseFBgn0002787. Mov34.

Phylogenomic databases

eggNOGinNOG04155.
GeneTreeEMGT00050000010889.
InParanoidP26270.
OMARSIIALH.
OrthoDBEOG4BG7BS.
PhylomeDBP26270.

Enzyme and pathway databases

BRENDA3.4.25.1. 1994.

Gene expression databases

ArrayExpressP26270.
BgeeP26270.
GermOnlineCG3416. Drosophila melanogaster.

Family and domain databases

InterProIPR000555. Mov34_MPN_PAD1.
[Graphical view]
KOK03038.
PfamPF01398. Mov34. 1 hit.
[Graphical view]
SMARTSM00232. JAB_MPN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio805917.

Entry information

Entry namePSD7_DROME
AccessionPrimary (citable) accession number: P26270
Secondary accession number(s): Q9W178
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 95 of the entry and version 6 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents