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Protein

26S proteasome non-ATPase regulatory subunit 7

Gene

Rpn8

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.1 Publication

GO - Biological processi

  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase

Enzyme and pathway databases

BRENDAi3.4.25.1 1994
ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209406 Degradation of NF-kappa-B inhibitor, CACT
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-216167 Nuclear CI is degraded
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-432395 Degradation of TIM
R-DME-432524 Degradation of PER
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-538848 Degradation of CLK
R-DME-538864 Degradation of CRY
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-6798695 Neutrophil degranulation
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiM67.973

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 7
Alternative name(s):
26S proteasome regulatory subunit RPN8
26S proteasome regulatory subunit S12
Proteasome subunit p39B
Proteasome subunit p40
Protein Mov34
Gene namesi
Name:Rpn8
Synonyms:Mov34
ORF Names:CG3416
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi

Organism-specific databases

FlyBaseiFBgn0002787 Rpn8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002139452 – 33826S proteasome non-ATPase regulatory subunit 7Add BLAST337

Proteomic databases

PaxDbiP26270
PRIDEiP26270

Expressioni

Gene expression databases

BgeeiFBgn0002787
ExpressionAtlasiP26270 baseline and differential
GenevisibleiP26270 DM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Rpn9Q7KMP83EBI-253612,EBI-151692

Protein-protein interaction databases

BioGridi63468, 28 interactors
DIPiDIP-22847N
IntActiP26270, 17 interactors
STRINGi7227.FBpp0303270

Structurei

3D structure databases

ProteinModelPortaliP26270
SMRiP26270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 147MPNPROSITE-ProRule annotationAdd BLAST137

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi289 – 338Glu/Lys-richAdd BLAST50

Sequence similaritiesi

Belongs to the peptidase M67A family.Curated

Phylogenomic databases

eggNOGiKOG1556 Eukaryota
COG1310 LUCA
GeneTreeiENSGT00530000063075
InParanoidiP26270
KOiK03038
OMAiDAYFAVE
OrthoDBiEOG091G0DX6
PhylomeDBiP26270

Family and domain databases

CDDicd08062 MPN_RPN7_8, 1 hit
InterProiView protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR033858 MPN_RPN7_8
IPR024969 Rpn11/EIF3F_C
PANTHERiPTHR10540:SF7 PTHR10540:SF7, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF13012 MitMem_reg, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQEVSVNK VIVHPLVLLS VVDHFNRMGK IGNQKRVVGV LLGCWRSKGV
60 70 80 90 100
LDVSNSFAVP FDEDDKDKSV WFLDHDYLEN MYGMFKKVNA RERVVGWYHT
110 120 130 140 150
GPKLHQNDIA INELVRRYCP NSVLVIIDAK PKDLGLPTEA YISVEEVHDD
160 170 180 190 200
GSPTSKTFEH VPSEIGAEEA EEVGVEHLLR DIKDTTVGSL SQKITNQLMG
210 220 230 240 250
LKGLNAQLRD IKQYLQRVGD SKMPINHQIV YQLQDIFNLL PDITNDQFTG
260 270 280 290 300
TMYVKTNDQM LVVYLASMVR SIIALHNLIN NKLANRDAEE GKSDSKEAKE
310 320 330
KNKDSKDKDN KETKDKDGKK AEEKADKGKD EGGKGSRK
Length:338
Mass (Da):38,089
Last modified:January 23, 2007 - v6
Checksum:i1074BBB94268B2D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56S → T in AAA28695 (PubMed:2209467).Curated1
Sequence conflicti63E → V in AAA28695 (PubMed:2209467).Curated1
Sequence conflicti121 – 146NSVLV…ISVEE → TPCWSSSTPSPRIWACPQRR TYRWRK in AAA28695 (PubMed:2209467).CuratedAdd BLAST26
Sequence conflicti167A → P in AAA28695 (PubMed:2209467).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64643 mRNA Translation: AAA28695.1
AE013599 Genomic DNA Translation: AAF47199.1
AY089283 mRNA Translation: AAL90021.1
RefSeqiNP_001261168.1, NM_001274239.1
NP_523845.2, NM_079121.3
UniGeneiDm.38517
Dm.770

Genome annotation databases

EnsemblMetazoaiFBtr0072290; FBpp0072197; FBgn0002787
FBtr0332921; FBpp0305141; FBgn0002787
GeneIDi37894
KEGGidme:Dmel_CG3416
UCSCiCG3416-RA d. melanogaster

Entry informationi

Entry nameiPSMD7_DROME
AccessioniPrimary (citable) accession number: P26270
Secondary accession number(s): Q9W178
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 155 of the entry and version 6 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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