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Protein

Ferric enterobactin transport protein FepE

Gene

fepE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ferric enterobactin transport system.

GO - Molecular functioni

  • ferric-enterobactin transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • ferric-enterobactin transport Source: EcoCyc
  • iron ion homeostasis Source: UniProtKB-KW
  • lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:EG10297-MONOMER.
ECOL316407:JW0579-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric enterobactin transport protein FepE
Gene namesi
Name:fepE
Ordered Locus Names:b0587, JW0579
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10297. fepE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141CytoplasmicSequence analysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Topological domaini63 – 338276PeriplasmicSequence analysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence analysisAdd
BLAST
Topological domaini360 – 37718CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Ferric enterobactin transport protein FepEPRO_0000087225Add
BLAST

Proteomic databases

PaxDbiP26266.

Expressioni

Inductioni

Repressed by H-NS, induced by LeuO. A monocistronic operon.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259898. 146 interactions.
DIPiDIP-9596N.
IntActiP26266. 9 interactions.
STRINGi511145.b0587.

Structurei

3D structure databases

ProteinModelPortaliP26266.
SMRiP26266. Positions 64-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the WzzB/Cld/Rol family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108QY5. Bacteria.
COG3765. LUCA.
HOGENOMiHOG000117856.
InParanoidiP26266.
OMAiDRASVFN.
OrthoDBiEOG6H4K52.
PhylomeDBiP26266.

Family and domain databases

InterProiIPR003856. LipoPS_biosynth.
[Graphical view]
PfamiPF02706. Wzz. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLNIKQGS DAHFPDYPLA SPSNNEIDLL NLISVLWRAK KTVMAVVFAF
60 70 80 90 100
ACAGLLISFI LPQKWTSAAV VTPPEPVQWQ ELEKSFTKLR VLDLDIKIDR
110 120 130 140 150
TEAFNLFIKK FQSVSLLEEY LRSSPYVMDQ LKEAKIDELD LHRAIVALSE
160 170 180 190 200
KMKAVDDNAS KKKDEPSLYT SWTLSFTAPT SEEAQTVLSG YIDYISTLVV
210 220 230 240 250
KESLENVRNK LEIKTQFEKE KLAQDRIKTK NQLDANIQRL NYSLDIANAA
260 270 280 290 300
GIKKPVYSNG QAVKDDPDFS ISLGADGIER KLEIEKAVTD VAELNGELRN
310 320 330 340 350
RQYLVEQLTK AHVNDVNFTP FKYQLSPSLP VKKDGPGKAI IVILSALIGG
360 370
MVACGGVLLR YAMASRKQDA MMADHLV
Length:377
Mass (Da):42,100
Last modified:October 1, 1993 - v2
Checksum:i1C81D51BBFC3A499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74129 Genomic DNA. Translation: CAA52226.1.
U82598 Genomic DNA. Translation: AAB40786.1.
U00096 Genomic DNA. Translation: AAC73688.1.
AP009048 Genomic DNA. Translation: BAE76342.1.
M60177 Genomic DNA. No translation available.
PIRiS34703.
RefSeqiNP_415119.1. NC_000913.3.
WP_000096692.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73688; AAC73688; b0587.
BAE76342; BAE76342; BAE76342.
GeneIDi945180.
KEGGiecj:JW0579.
eco:b0587.
PATRICi32116350. VBIEscCol129921_0615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74129 Genomic DNA. Translation: CAA52226.1.
U82598 Genomic DNA. Translation: AAB40786.1.
U00096 Genomic DNA. Translation: AAC73688.1.
AP009048 Genomic DNA. Translation: BAE76342.1.
M60177 Genomic DNA. No translation available.
PIRiS34703.
RefSeqiNP_415119.1. NC_000913.3.
WP_000096692.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP26266.
SMRiP26266. Positions 64-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259898. 146 interactions.
DIPiDIP-9596N.
IntActiP26266. 9 interactions.
STRINGi511145.b0587.

Proteomic databases

PaxDbiP26266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73688; AAC73688; b0587.
BAE76342; BAE76342; BAE76342.
GeneIDi945180.
KEGGiecj:JW0579.
eco:b0587.
PATRICi32116350. VBIEscCol129921_0615.

Organism-specific databases

EchoBASEiEB0293.
EcoGeneiEG10297. fepE.

Phylogenomic databases

eggNOGiENOG4108QY5. Bacteria.
COG3765. LUCA.
HOGENOMiHOG000117856.
InParanoidiP26266.
OMAiDRASVFN.
OrthoDBiEOG6H4K52.
PhylomeDBiP26266.

Enzyme and pathway databases

BioCyciEcoCyc:EG10297-MONOMER.
ECOL316407:JW0579-MONOMER.

Miscellaneous databases

PROiP26266.

Family and domain databases

InterProiIPR003856. LipoPS_biosynth.
[Graphical view]
PfamiPF02706. Wzz. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Shea Cleavinger C.M., Ozenberger B., McIntosh M.
    Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine."
    Rusnak F., Sakaitani M., Drueckhammer D., Reichert J., Walsh C.T.
    Biochemistry 30:2916-2927(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-89.
    Strain: K12.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.
  7. "Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux."
    Shimada T., Yamamoto K., Ishihama A.
    J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: OPERON STRUCTURE, INDUCTION.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiFEPE_ECOLI
AccessioniPrimary (citable) accession number: P26266
Secondary accession number(s): Q2MBL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: October 1, 1993
Last modified: January 20, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.