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Protein

Syndecan-1

Gene

Sdc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Molecular functioni

  • extracellular matrix binding Source: RGD
  • identical protein binding Source: RGD
  • protein C-terminus binding Source: RGD

GO - Biological processi

  • canonical Wnt signaling pathway Source: RGD
  • cell adhesion Source: RGD
  • cell-cell signaling Source: RGD
  • cell migration Source: GO_Central
  • inflammatory response Source: RGD
  • myoblast development Source: RGD
  • odontogenesis Source: RGD
  • positive regulation of exosomal secretion Source: RGD
  • positive regulation of extracellular exosome assembly Source: RGD
  • response to calcium ion Source: RGD
  • response to cAMP Source: RGD
  • response to glucocorticoid Source: RGD
  • response to hydrogen peroxide Source: RGD
  • response to organic substance Source: RGD
  • response to toxic substance Source: RGD
  • Sertoli cell development Source: RGD
  • striated muscle cell development Source: RGD
  • ureteric bud development Source: RGD
  • wound healing Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-RNO-2022928 HS-GAG biosynthesis
R-RNO-2024096 HS-GAG degradation
R-RNO-202733 Cell surface interactions at the vascular wall
R-RNO-3000170 Syndecan interactions
R-RNO-449836 Other interleukin signaling
R-RNO-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-1
Short name:
SYND1
Alternative name(s):
CD_antigen: CD138
Gene namesi
Name:Sdc1
Synonyms:Synd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3648 Sdc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 257ExtracellularSequence analysisAdd BLAST235
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 313CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003350223 – 313Syndecan-1Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45O-linked (Xyl...) (heparan sulfate) serineBy similarity1
Glycosylationi47O-linked (Xyl...) (heparan sulfate) serineBy similarity1
Glycosylationi209O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi219O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Modified residuei288PhosphoserineBy similarity1

Post-translational modificationi

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei253 – 254Cleavage of ectodomainSequence analysis2

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP26260
PRIDEiP26260

PTM databases

iPTMnetiP26260
PhosphoSitePlusiP26260

Expressioni

Gene expression databases

BgeeiENSRNOG00000059947
GenevisibleiP26260 RN

Interactioni

Subunit structurei

Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP26260, 1 interactor
STRINGi10116.ENSRNOP00000008582

Structurei

3D structure databases

SMRiP26260
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYWX Eukaryota
ENOG410Y2QY LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000133092
HOVERGENiHBG017783
InParanoidiP26260
KOiK06257
OMAiPTKQEEF
OrthoDBiEOG091G0EYV
PhylomeDBiP26260
TreeFamiTF320463

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031190 Syndecan-1
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF5 PTHR10915:SF5, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAALWLWL CALALRLQPA LPQIVTANVP PEDQDGSGDD SDNFSGSGTG
60 70 80 90 100
ALPDMTLSRQ TPSTWKDVWL LTATPTAPEP TSRDTEATLT SILPAGEKPE
110 120 130 140 150
EGEPVAHVEA EPDFTARDKE KEATTRPRET TQLPVTQQAS TAARATTAQA
160 170 180 190 200
SVTSHPHGDV QPGLHETLAP TAPGQPDHQP PSVEDGGTSV IKEVVEDETT
210 220 230 240 250
NQLPAGEGSG EQDFTFETSG ENTAVAGVEP DLRNQSPVDE GATGASQGLL
260 270 280 290 300
DRKEVLGGVI AGGLVGLIFA VCLVAFMLYR MKKKDEGSYS LEEPKQANGG
310
AYQKPTKQEE FYA
Length:313
Mass (Da):33,214
Last modified:February 1, 1994 - v2
Checksum:iC6EC50E8798A5218
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15L → V (PubMed:1639809).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60651 mRNA Translation: CAA43058.1
M81785 mRNA Translation: AAA42198.1
S61865 mRNA Translation: AAB26726.1
BC061834 mRNA Translation: AAH61834.1
PIRiA42853
RefSeqiNP_037158.1, NM_013026.2
UniGeneiRn.11176

Genome annotation databases

EnsembliENSRNOT00000086633; ENSRNOP00000072283; ENSRNOG00000059947
GeneIDi25216
KEGGirno:25216

Similar proteinsi

Entry informationi

Entry nameiSDC1_RAT
AccessioniPrimary (citable) accession number: P26260
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1994
Last modified: April 25, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health