Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Annexin-B12

Gene

ANXB12

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin-B12
Alternative name(s):
Annexin XII
Annexin-12
Gene namesi
Name:ANXB12
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidolinaAnthoathecataAplanulataHydridaeHydra

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Annexin-B12PRO_0000067519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61Phosphothreonine; by PKCSequence analysis

Post-translational modificationi

Phosphorylated in vitro on serine(s) and threonine(s) by PKC.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homohexamer.

Structurei

Secondary structure

1
316
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 2612Combined sources
Beta strandi27 – 304Combined sources
Helixi33 – 4210Combined sources
Helixi45 – 5915Combined sources
Helixi63 – 708Combined sources
Helixi73 – 8311Combined sources
Helixi86 – 9914Combined sources
Beta strandi100 – 1023Combined sources
Helixi105 – 1128Combined sources
Helixi117 – 13115Combined sources
Helixi135 – 1428Combined sources
Helixi145 – 15511Combined sources
Helixi167 – 18014Combined sources
Turni181 – 1833Combined sources
Beta strandi184 – 1863Combined sources
Helixi189 – 19810Combined sources
Helixi201 – 21414Combined sources
Beta strandi215 – 2173Combined sources
Helixi219 – 2268Combined sources
Helixi229 – 25729Combined sources
Beta strandi259 – 2613Combined sources
Helixi264 – 27411Combined sources
Turni275 – 2784Combined sources
Helixi279 – 29012Combined sources
Helixi294 – 3018Combined sources
Helixi304 – 31411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AEIX-ray2.80A/B/C/D/E/F2-316[»]
1DM5X-ray1.93A/B/C/D/E/F2-316[»]
ProteinModelPortaliP26256.
SMRiP26256. Positions 2-316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26256.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati22 – 8261Annexin 1Add
BLAST
Repeati94 – 15461Annexin 2Add
BLAST
Repeati178 – 23861Annexin 3Add
BLAST
Repeati253 – 31361Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVQGTVKPH ASFNSREDAE TLRKAMKGIG TDEKSITHIL ATRSNAQRQQ
60 70 80 90 100
IKTDYTTLFG KHLEDELKSE LSGNYEAAAL ALLRKPDEFL AEQLHAAMKG
110 120 130 140 150
LGTDENALID ILCTQSNAQI HAIKAAFKLL YKEDLEKEII SETSGNFQRL
160 170 180 190 200
LVSMLQGGRK EDEPVNAAHA AEDAAAIYQA GEGQIGTDES RFNAVLATRS
210 220 230 240 250
YPQLHQIFHE YSKISNKTIL QAIENEFSGD IKNGLLAIVK SVENRFAYFA
260 270 280 290 300
ERLHHAMKGL GTSDKTLIRI LVSRSEIDLA NIKETFQAMY GKSLYEFIAD
310
DCSGDYKDLL LQITGH
Length:316
Mass (Da):35,109
Last modified:May 1, 1992 - v1
Checksum:i10599869CBA853EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83736 mRNA. Translation: AAA29206.1.
PIRiA42660. LUJF12.
RefSeqiNP_001296699.1. NM_001309770.1.
XP_002155286.3. XM_002155250.3.
UniGeneiHma.11394.

Genome annotation databases

GeneIDi100203975.
KEGGihmg:100203975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83736 mRNA. Translation: AAA29206.1.
PIRiA42660. LUJF12.
RefSeqiNP_001296699.1. NM_001309770.1.
XP_002155286.3. XM_002155250.3.
UniGeneiHma.11394.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AEIX-ray2.80A/B/C/D/E/F2-316[»]
1DM5X-ray1.93A/B/C/D/E/F2-316[»]
ProteinModelPortaliP26256.
SMRiP26256. Positions 2-316.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100203975.
KEGGihmg:100203975.

Miscellaneous databases

EvolutionaryTraceiP26256.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANX12_HYDVU
AccessioniPrimary (citable) accession number: P26256
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: January 20, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.