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Protein

Annexin-B12

Gene

ANXB12

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin-B12
Alternative name(s):
Annexin XII
Annexin-12
Gene namesi
Name:ANXB12
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidolinaAnthoathecataAplanulataHydridaeHydra

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675191 – 316Annexin-B12Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6Phosphothreonine; by PKCSequence analysis1

Post-translational modificationi

Phosphorylated in vitro on serine(s) and threonine(s) by PKC.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homohexamer.

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 26Combined sources12
Beta strandi27 – 30Combined sources4
Helixi33 – 42Combined sources10
Helixi45 – 59Combined sources15
Helixi63 – 70Combined sources8
Helixi73 – 83Combined sources11
Helixi86 – 99Combined sources14
Beta strandi100 – 102Combined sources3
Helixi105 – 112Combined sources8
Helixi117 – 131Combined sources15
Helixi135 – 142Combined sources8
Helixi145 – 155Combined sources11
Helixi167 – 180Combined sources14
Turni181 – 183Combined sources3
Beta strandi184 – 186Combined sources3
Helixi189 – 198Combined sources10
Helixi201 – 214Combined sources14
Beta strandi215 – 217Combined sources3
Helixi219 – 226Combined sources8
Helixi229 – 257Combined sources29
Beta strandi259 – 261Combined sources3
Helixi264 – 274Combined sources11
Turni275 – 278Combined sources4
Helixi279 – 290Combined sources12
Helixi294 – 301Combined sources8
Helixi304 – 314Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AEIX-ray2.80A/B/C/D/E/F2-316[»]
1DM5X-ray1.93A/B/C/D/E/F2-316[»]
ProteinModelPortaliP26256.
SMRiP26256.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26256.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 82Annexin 1Add BLAST61
Repeati94 – 154Annexin 2Add BLAST61
Repeati178 – 238Annexin 3Add BLAST61
Repeati253 – 313Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

KOiK17095.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVQGTVKPH ASFNSREDAE TLRKAMKGIG TDEKSITHIL ATRSNAQRQQ
60 70 80 90 100
IKTDYTTLFG KHLEDELKSE LSGNYEAAAL ALLRKPDEFL AEQLHAAMKG
110 120 130 140 150
LGTDENALID ILCTQSNAQI HAIKAAFKLL YKEDLEKEII SETSGNFQRL
160 170 180 190 200
LVSMLQGGRK EDEPVNAAHA AEDAAAIYQA GEGQIGTDES RFNAVLATRS
210 220 230 240 250
YPQLHQIFHE YSKISNKTIL QAIENEFSGD IKNGLLAIVK SVENRFAYFA
260 270 280 290 300
ERLHHAMKGL GTSDKTLIRI LVSRSEIDLA NIKETFQAMY GKSLYEFIAD
310
DCSGDYKDLL LQITGH
Length:316
Mass (Da):35,109
Last modified:May 1, 1992 - v1
Checksum:i10599869CBA853EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83736 mRNA. Translation: AAA29206.1.
PIRiA42660. LUJF12.
RefSeqiNP_001296699.1. NM_001309770.1.
XP_002155286.3. XM_002155250.3.
UniGeneiHma.11394.

Genome annotation databases

GeneIDi100203975.
KEGGihmg:100203975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83736 mRNA. Translation: AAA29206.1.
PIRiA42660. LUJF12.
RefSeqiNP_001296699.1. NM_001309770.1.
XP_002155286.3. XM_002155250.3.
UniGeneiHma.11394.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AEIX-ray2.80A/B/C/D/E/F2-316[»]
1DM5X-ray1.93A/B/C/D/E/F2-316[»]
ProteinModelPortaliP26256.
SMRiP26256.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100203975.
KEGGihmg:100203975.

Phylogenomic databases

KOiK17095.

Miscellaneous databases

EvolutionaryTraceiP26256.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANX12_HYDVU
AccessioniPrimary (citable) accession number: P26256
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.