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Protein

Beta-3 adrenergic receptor

Gene

Adrb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141Agonist or antagonistBy similarity
Binding sitei119 – 1191Agonist or antagonistBy similarity

GO - Molecular functioni

  • beta3-adrenergic receptor activity Source: HGNC
  • beta-adrenergic receptor activity Source: HGNC
  • epinephrine binding Source: RGD
  • norepinephrine binding Source: RGD
  • protein homodimerization activity Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390696. Adrenoceptors.
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-3 adrenergic receptor
Alternative name(s):
Beta-3 adrenoreceptor
Short name:
Beta-3 adrenoceptor
Gene namesi
Name:Adrb3
Synonyms:Adrb3r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi2061. Adrb3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularBy similarityAdd
BLAST
Transmembranei37 – 6024Helical; Name=1By similarityAdd
BLAST
Topological domaini61 – 699CytoplasmicBy similarity
Transmembranei70 – 8819Helical; Name=2By similarityAdd
BLAST
Topological domaini89 – 10820ExtracellularBy similarityAdd
BLAST
Transmembranei109 – 13022Helical; Name=3By similarityAdd
BLAST
Topological domaini131 – 15222CytoplasmicBy similarityAdd
BLAST
Transmembranei153 – 17523Helical; Name=4By similarityAdd
BLAST
Topological domaini176 – 20025ExtracellularBy similarityAdd
BLAST
Transmembranei201 – 22222Helical; Name=5By similarityAdd
BLAST
Topological domaini223 – 28967CytoplasmicBy similarityAdd
BLAST
Transmembranei290 – 31122Helical; Name=6By similarityAdd
BLAST
Topological domaini312 – 32312ExtracellularBy similarityAdd
BLAST
Transmembranei324 – 34421Helical; Name=7By similarityAdd
BLAST
Topological domaini345 – 40056CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • nucleus Source: RGD
  • receptor complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2095166.
GuidetoPHARMACOLOGYi30.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Beta-3 adrenergic receptorPRO_0000069148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis
Disulfide bondi107 ↔ 193PROSITE-ProRule annotation
Disulfide bondi186 ↔ 192PROSITE-ProRule annotation
Lipidationi358 – 3581S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP26255.
PRIDEiP26255.

PTM databases

iPTMnetiP26255.

Expressioni

Tissue specificityi

White and brown adipose tissues, and digestive tract.

Gene expression databases

GenevisibleiP26255. RN.

Interactioni

Subunit structurei

Interacts with ARRDC3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016907.

Chemistry

BindingDBiP26255.

Structurei

3D structure databases

ProteinModelPortaliP26255.
SMRiP26255. Positions 44-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni195 – 20915Agonist and antagonist bindingBy similarityAdd
BLAST
Regioni302 – 3098Agonist and antagonist bindingBy similarity
Regioni329 – 3335Agonist and antagonist bindingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP26255.
KOiK04143.
OMAiAPIMSKW.
OrthoDBiEOG7BS4BS.
PhylomeDBiP26255.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000681. ADRB3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00563. ADRENRGCB3AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPWPHKNGS LAFWSDAPTL DPSAANTSGL PGVPWAAALA GALLALATVG
60 70 80 90 100
GNLLVITAIA RTPRLQTITN VFVTSLATAD LVVGLLVMPP GATLALTGHW
110 120 130 140 150
PLGATGCELW TSVDVLCVTA SIETLCALAV DRYLAVTNPL RYGTLVTKRR
160 170 180 190 200
ARAAVVLVWI VSATVSFAPI MSQWWRVGAD AEAQECHSNP RCCSFASNMP
210 220 230 240 250
YALLSSSVSF YLPLLVMLFV YARVFVVAKR QRRLLRRELG RFPPEESPRS
260 270 280 290 300
PSRSPSPATV GTPTASDGVP SCGRRPARLL PLGEHRALRT LGLIMGIFSL
310 320 330 340 350
CWLPFFLANV LRALVGPSLV PSGVFIALNW LGYANSAFNP LIYCRSPDFR
360 370 380 390 400
DAFRRLLCSY GGRGPEEPRV VTFPASPVAS RQNSPLNRFD GYEGERPFPT
Length:400
Mass (Da):43,146
Last modified:June 1, 1994 - v2
Checksum:iD588540C4B2CE813
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti234 – 2352LL → FV in AAA74470 (PubMed:1721063).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74716 mRNA. Translation: AAA74470.1.
S73473 mRNA. Translation: AAB20702.1.
S56481 mRNA. Translation: AAB25520.1.
S56152 Genomic DNA. Translation: AAB25521.1.
PIRiA41679.
A53281.
RefSeqiNP_037240.2. NM_013108.2.
UniGeneiRn.10100.

Genome annotation databases

EnsembliENSRNOT00000016907; ENSRNOP00000016907; ENSRNOG00000012674.
GeneIDi25645.
KEGGirno:25645.
UCSCiRGD:2061. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74716 mRNA. Translation: AAA74470.1.
S73473 mRNA. Translation: AAB20702.1.
S56481 mRNA. Translation: AAB25520.1.
S56152 Genomic DNA. Translation: AAB25521.1.
PIRiA41679.
A53281.
RefSeqiNP_037240.2. NM_013108.2.
UniGeneiRn.10100.

3D structure databases

ProteinModelPortaliP26255.
SMRiP26255. Positions 44-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016907.

Chemistry

BindingDBiP26255.
ChEMBLiCHEMBL2095166.
GuidetoPHARMACOLOGYi30.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP26255.

Proteomic databases

PaxDbiP26255.
PRIDEiP26255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016907; ENSRNOP00000016907; ENSRNOG00000012674.
GeneIDi25645.
KEGGirno:25645.
UCSCiRGD:2061. rat.

Organism-specific databases

CTDi155.
RGDi2061. Adrb3.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP26255.
KOiK04143.
OMAiAPIMSKW.
OrthoDBiEOG7BS4BS.
PhylomeDBiP26255.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiR-RNO-390696. Adrenoceptors.
R-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP26255.

Gene expression databases

GenevisibleiP26255. RN.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000681. ADRB3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00563. ADRENRGCB3AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity."
    Muzzin P., Revelli J.-P., Kuhne F., Gocayne J.D., McCombie W.R., Venter J.C., Giacobino J.-P., Fraser C.M.
    J. Biol. Chem. 266:24053-24058(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and expression of the rat beta 3-adrenergic receptor."
    Granneman J.G., Lahners K.N., Chaudhry A.
    Mol. Pharmacol. 40:895-899(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The rat beta 3-adrenergic receptor gene contains an intron."
    Bensaid M., Kaghad M., Rodriguez M., le Fur G., Caput D.
    FEBS Lett. 318:223-226(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiADRB3_RAT
AccessioniPrimary (citable) accession number: P26255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 1, 1994
Last modified: July 6, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.