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P26233

- CTNB_XENLA

UniProt

P26233 - CTNB_XENLA

Protein

Catenin beta

Gene

ctnnb1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Key downstream component of the canonical Wnt signaling pathway. In the presence of Wnt ligand, accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes By similarity.By similarity
    Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Essential component of the vertebrate Wnt-signaling pathway and is required for formation of the embryonic axis.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cardiac muscle tissue development Source: BHF-UCL
    2. cartilage condensation Source: AgBase
    3. chondrocyte differentiation Source: AgBase
    4. embryonic camera-type eye development Source: BHF-UCL
    5. negative regulation of cartilage development Source: AgBase
    6. negative regulation of cell migration Source: AgBase
    7. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    8. positive regulation of protein ubiquitination Source: AgBase
    9. positive regulation of transcription, DNA-templated Source: AgBase
    10. transcription, DNA-templated Source: UniProtKB-KW
    11. Wnt signaling pathway Source: UniProtKB-KW
    12. wound healing Source: AgBase

    Keywords - Biological processi

    Cell adhesion, Transcription, Transcription regulation, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Catenin beta
    Alternative name(s):
    Beta-catenin
    Gene namesi
    Name:ctnnb1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6254184. ctnnb1.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. basal part of cell Source: BHF-UCL
    2. cell-cell junction Source: UniProtKB
    3. cytoplasm Source: UniProtKB-SubCell
    4. cytoskeleton Source: UniProtKB-SubCell
    5. membrane Source: UniProtKB
    6. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 781781Catenin betaPRO_0000064276Add
    BLAST

    Proteomic databases

    PRIDEiP26233.

    Interactioni

    Subunit structurei

    Interacts with EP-Cadherin/CDH3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Sox17Q614733EBI-7373758,EBI-9106822From a different organism.
    TCF4P158842EBI-7373758,EBI-533224From a different organism.
    tshz3A0SNQ73EBI-7373758,EBI-7373787

    Protein-protein interaction databases

    DIPiDIP-44044N.
    IntActiP26233. 5 interactions.
    MINTiMINT-138497.

    Structurei

    3D structure databases

    ProteinModelPortaliP26233.
    SMRiP26233. Positions 19-44, 118-682.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati141 – 18040ARM 1Add
    BLAST
    Repeati225 – 26440ARM 2Add
    BLAST
    Repeati267 – 30640ARM 3Add
    BLAST
    Repeati351 – 39040ARM 4Add
    BLAST
    Repeati391 – 42939ARM 5Add
    BLAST
    Repeati432 – 47342ARM 6Add
    BLAST
    Repeati479 – 51941ARM 7Add
    BLAST
    Repeati521 – 56242ARM 8Add
    BLAST
    Repeati584 – 62340ARM 9Add
    BLAST
    Repeati625 – 66440ARM 10Add
    BLAST

    Sequence similaritiesi

    Belongs to the beta-catenin family.Curated
    Contains 10 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG000919.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view]
    PfamiPF00514. Arm. 4 hits.
    [Graphical view]
    PRINTSiPR01869. BCATNINFAMLY.
    SMARTiSM00185. ARM. 12 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26233-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG    50
    NPEDEDVDTN QVLYEWEQGF SQSFTQDQVA DIDGQYAMTR AQRVRAAMFP 100
    ETLDEGMQIP STQFDSAHPT NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT 150
    RAIPELTKLL NDEDQVVVNK AAVMVHQLSK KEASRHAIMR SPQMVSAIVR 200
    TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL VKMLGSPVDS 250
    VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 300
    LQILAYGNQE SKLIILASGG PQALVNIMRT YSYEKLLWTT SRVLKVLSVC 350
    SSNKPAIVEA GGMQALGLHL TDSSQRLVQN CLWTLRNLSD AATKQEGMEG 400
    LLGTLVQLLG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT 450
    VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP 500
    PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR 550
    TSIGGTQQQF VEGVRMEEIV EGCTGALHIL ARDIHNRIVI RGLNTIPLFV 600
    QLLYSPIENI QRVAAGVLCD VAQDKEAAEA IEAEGATAPL TELLHSRNEG 650
    VATYAAAVLF RMSEDKPQDY KKRLSVELTS SLFRTEPMPW NEAADLGLDI 700
    GAQGEPLGYR QDDSSYRSFH AAGYGQDAMG MDSMMDHDMG GHHPGADYPV 750
    DGLPDLSHAQ DLMDGLPPGD SNQLAWFDTD L 781
    Length:781
    Mass (Da):85,449
    Last modified:May 1, 1992 - v1
    Checksum:i3ECD27232239F799
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77013 mRNA. Translation: AAA49670.1.
    PIRiS35099.
    UniGeneiXl.23136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77013 mRNA. Translation: AAA49670.1 .
    PIRi S35099.
    UniGenei Xl.23136.

    3D structure databases

    ProteinModelPortali P26233.
    SMRi P26233. Positions 19-44, 118-682.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-44044N.
    IntActi P26233. 5 interactions.
    MINTi MINT-138497.

    Proteomic databases

    PRIDEi P26233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Xenbasei XB-GENE-6254184. ctnnb1.

    Phylogenomic databases

    HOVERGENi HBG000919.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view ]
    Pfami PF00514. Arm. 4 hits.
    [Graphical view ]
    PRINTSi PR01869. BCATNINFAMLY.
    SMARTi SM00185. ARM. 12 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin."
      McCrea P.D., Turck C.W., Gumbiner B.M.
      Science 254:1359-1361(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Brain.
    2. "Crystal structure of a beta-catenin/BCL9/Tcf4 complex."
      Sampietro J., Dahlberg C.L., Cho U.S., Hinds T.R., Kimelman D., Xu W.
      Mol. Cell 24:293-300(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDH3.

    Entry informationi

    Entry nameiCTNB_XENLA
    AccessioniPrimary (citable) accession number: P26233
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3