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P26233 (CTNB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Catenin beta
Alternative name(s):
Beta-catenin
Gene names
Name:ctnnb1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length781 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Key downstream component of the canonical Wnt signaling pathway. In the presence of Wnt ligand, accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes By similarity.

Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Essential component of the vertebrate Wnt-signaling pathway and is required for formation of the embryonic axis.

Subunit structure

Interacts with EP-Cadherin/CDH3. Ref.2

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the beta-catenin family.

Contains 10 ARM repeats.

Ontologies

Keywords
   Biological processCell adhesion
Transcription
Transcription regulation
Wnt signaling pathway
   Cellular componentCytoplasm
Cytoskeleton
Nucleus
   DomainRepeat
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

cardiac muscle tissue development

Inferred from mutant phenotype PubMed 18804460. Source: BHF-UCL

cartilage condensation

Inferred from mutant phenotype PubMed 17202865. Source: AgBase

chondrocyte differentiation

Inferred from mutant phenotype PubMed 17202865. Source: AgBase

embryonic camera-type eye development

Inferred from mutant phenotype PubMed 18804460. Source: BHF-UCL

negative regulation of cartilage development

Inferred from mutant phenotype PubMed 19492414. Source: AgBase

negative regulation of cell migration

Inferred from mutant phenotype PubMed 19492414. Source: AgBase

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from mutant phenotype PubMed 18804460. Source: BHF-UCL

positive regulation of protein ubiquitination

Inferred from mutant phenotype PubMed 17202865. Source: AgBase

positive regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 9596583. Source: AgBase

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

wound healing

Inferred from mutant phenotype PubMed 19492414. Source: AgBase

   Cellular_componentbasal part of cell

Inferred from direct assay PubMed 18981481. Source: BHF-UCL

cell-cell junction

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from direct assay PubMed 15163629. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 15163629. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 20708585. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sox17Q614733EBI-7373758,EBI-9106822From a different organism.
TCF4P158842EBI-7373758,EBI-533224From a different organism.
tshz3A0SNQ73EBI-7373758,EBI-7373787

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 781781Catenin beta
PRO_0000064276

Regions

Repeat141 – 18040ARM 1
Repeat225 – 26440ARM 2
Repeat267 – 30640ARM 3
Repeat351 – 39040ARM 4
Repeat391 – 42939ARM 5
Repeat432 – 47342ARM 6
Repeat479 – 51941ARM 7
Repeat521 – 56242ARM 8
Repeat584 – 62340ARM 9
Repeat625 – 66440ARM 10

Sequences

Sequence LengthMass (Da)Tools
P26233 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 3ECD27232239F799

FASTA78185,449
        10         20         30         40         50         60 
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEDEDVDTN 

        70         80         90        100        110        120 
QVLYEWEQGF SQSFTQDQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDSAHPT 

       130        140        150        160        170        180 
NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 

       190        200        210        220        230        240 
KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 

       250        260        270        280        290        300 
VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 

       310        320        330        340        350        360 
LQILAYGNQE SKLIILASGG PQALVNIMRT YSYEKLLWTT SRVLKVLSVC SSNKPAIVEA 

       370        380        390        400        410        420 
GGMQALGLHL TDSSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 

       430        440        450        460        470        480 
AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 

       490        500        510        520        530        540 
AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 

       550        560        570        580        590        600 
VRAHQDTQRR TSIGGTQQQF VEGVRMEEIV EGCTGALHIL ARDIHNRIVI RGLNTIPLFV 

       610        620        630        640        650        660 
QLLYSPIENI QRVAAGVLCD VAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 

       670        680        690        700        710        720 
RMSEDKPQDY KKRLSVELTS SLFRTEPMPW NEAADLGLDI GAQGEPLGYR QDDSSYRSFH 

       730        740        750        760        770        780 
AAGYGQDAMG MDSMMDHDMG GHHPGADYPV DGLPDLSHAQ DLMDGLPPGD SNQLAWFDTD 


L 

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References

[1]"A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin."
McCrea P.D., Turck C.W., Gumbiner B.M.
Science 254:1359-1361(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Brain.
[2]"Crystal structure of a beta-catenin/BCL9/Tcf4 complex."
Sampietro J., Dahlberg C.L., Cho U.S., Hinds T.R., Kimelman D., Xu W.
Mol. Cell 24:293-300(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CDH3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M77013 mRNA. Translation: AAA49670.1.
PIRS35099.
UniGeneXl.23136.

3D structure databases

ProteinModelPortalP26233.
SMRP26233. Positions 19-44, 118-682.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-44044N.
IntActP26233. 5 interactions.
MINTMINT-138497.

Proteomic databases

PRIDEP26233.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-6254184. ctnnb1.

Phylogenomic databases

HOVERGENHBG000919.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamPF00514. Arm. 4 hits.
[Graphical view]
PRINTSPR01869. BCATNINFAMLY.
SMARTSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTNB_XENLA
AccessionPrimary (citable) accession number: P26233
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families