P26233 (CTNB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catenin beta

Alternative name(s):
Beta-catenin

Gene names

Name:

ctnnb1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	781 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Key downstream component of the canonical Wnt signaling pathway. In the presence of Wnt ligand, accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes By similarity. Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Essential component of the vertebrate Wnt-signaling pathway and is required for formation of the embryonic axis.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the beta-catenin family. Contains 10 ARM repeats.

Ontologies

Keywords
Biological process	Cell adhesion Transcription Transcription regulation Wnt signaling pathway
Cellular component	Cytoplasm Cytoskeleton Nucleus
Domain	Repeat
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW cardiac muscle tissue development Inferred from mutant phenotype PubMed 18804460. Source: BHF-UCL cartilage condensation Inferred from mutant phenotype PubMed 17202865. Source: AgBase chondrocyte differentiation Inferred from mutant phenotype PubMed 17202865. Source: AgBase embryonic camera-type eye development Inferred from mutant phenotype PubMed 18804460. Source: BHF-UCL negative regulation of cartilage development Inferred from mutant phenotype PubMed 19492414. Source: AgBase negative regulation of cell migration Inferred from mutant phenotype PubMed 19492414. Source: AgBase negative regulation of sequence-specific DNA binding transcription factor activity Inferred from mutant phenotype PubMed 18804460. Source: BHF-UCL positive regulation of protein ubiquitination Inferred from mutant phenotype PubMed 17202865. Source: AgBase positive regulation of transcription, DNA-dependent Inferred from mutant phenotype PubMed 9596583. Source: AgBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW wound healing Inferred from mutant phenotype PubMed 19492414. Source: AgBase
Cellular_component	basal part of cell Inferred from direct assay PubMed 18981481. Source: BHF-UCL cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from direct assay PubMed 15163629. Source: UniProtKB nucleus Inferred from direct assay PubMed 15163629. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 781	781	Catenin beta		PRO_0000064276
Regions
	Repeat	141 – 180	40	ARM 1
	Repeat	225 – 264	40	ARM 2
	Repeat	267 – 306	40	ARM 3
	Repeat	351 – 390	40	ARM 4
	Repeat	391 – 429	39	ARM 5
	Repeat	432 – 473	42	ARM 6
	Repeat	479 – 519	41	ARM 7
	Repeat	521 – 562	42	ARM 8
	Repeat	584 – 623	40	ARM 9
	Repeat	625 – 664	40	ARM 10

Sequences

	Sequence		Length	Mass (Da)
	P26233 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: 3ECD27232239F799	FASTA	781	85,449
	10 20 30 40 50 60 MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEDEDVDTN 70 80 90 100 110 120 QVLYEWEQGF SQSFTQDQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDSAHPT 130 140 150 160 170 180 NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 190 200 210 220 230 240 KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 250 260 270 280 290 300 VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 310 320 330 340 350 360 LQILAYGNQE SKLIILASGG PQALVNIMRT YSYEKLLWTT SRVLKVLSVC SSNKPAIVEA 370 380 390 400 410 420 GGMQALGLHL TDSSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 430 440 450 460 470 480 AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 490 500 510 520 530 540 AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 550 560 570 580 590 600 VRAHQDTQRR TSIGGTQQQF VEGVRMEEIV EGCTGALHIL ARDIHNRIVI RGLNTIPLFV 610 620 630 640 650 660 QLLYSPIENI QRVAAGVLCD VAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 670 680 690 700 710 720 RMSEDKPQDY KKRLSVELTS SLFRTEPMPW NEAADLGLDI GAQGEPLGYR QDDSSYRSFH 730 740 750 760 770 780 AAGYGQDAMG MDSMMDHDMG GHHPGADYPV DGLPDLSHAQ DLMDGLPPGD SNQLAWFDTD L

References

[1]	"A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin." McCrea P.D., Turck C.W., Gumbiner B.M. Science 254:1359-1361(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M77013 mRNA. Translation: AAA49670.1.
PIR	S35099.
UniGene	Xl.23136.
3D structure databases
ProteinModelPortal	P26233.
SMR	P26233. Positions 19-44, 118-682.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-44044N.
MINT	MINT-138497.
Proteomic databases
PRIDE	P26233.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Xenbase	XB-GENE-6254184. ctnnb1.
Phylogenomic databases
HOVERGEN	HBG000919.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. IPR013284. Beta-catenin. [Graphical view]
Pfam	PF00514. Arm. 4 hits. [Graphical view]
PRINTS	PR01869. BCATNINFAMLY.
SMART	SM00185. ARM. 12 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. 9 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTNB_XENLA

Accession

Primary (citable) accession number: P26233

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program