P26232 (CTNA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catenin alpha-2

Alternative name(s):
Alpha N-catenin
Alpha-catenin-related protein

Gene names

Name:	CTNNA2
Synonyms:	CAPR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	953 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation By similarity.
Subunit structure	Interacts with ZNF639. Ref.8
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton By similarity. Cell junction › adherens junction By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell projection › axon By similarity. Note: Recruited to the nucleus upon ZNF639 overexpression. Ref.8
Sequence similarities	Belongs to the vinculin/alpha-catenin family.

Ontologies

Keywords
Biological process	Cell adhesion Differentiation
Cellular component	Cell junction Cell membrane Cell projection Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing
Molecular function	Developmental protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	axonogenesis Inferred from sequence or structural similarity. Source: UniProtKB brain morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB dendrite morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB muscle cell differentiation Traceable author statement. Source: Reactome positive regulation of muscle cell differentiation Traceable author statement. Source: Reactome prepulse inhibition Inferred from sequence or structural similarity. Source: UniProtKB radial glia guided migration of Purkinje cell Inferred from sequence or structural similarity. Source: UniProtKB regulation of synapse structural plasticity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	actin cytoskeleton Inferred from electronic annotation. Source: InterPro axon Inferred from sequence or structural similarity. Source: UniProtKB cytosol Traceable author statement. Source: Reactome
Molecular function	cadherin binding Inferred from electronic annotation. Source: InterPro structural constituent of cytoskeleton Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P26232-1)

Also known as: AlphaN-catenin II;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P26232-2)

Also known as: AlphaN-catenin I;

The sequence of this isoform differs from the canonical sequence as follows:
     811-858: Missing.

Isoform 3 (identifier: P26232-3)

The sequence of this isoform differs from the canonical sequence as follows:
     766-858: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: P26232-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-368: Missing.
     811-858: Missing.

Isoform 5 (identifier: P26232-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSGLICLQYGLWHGQKIDFGGPRRLLQRNRGEGSM
     811-858: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: P26232-6)

Also known as: AlphaN-catenin III;

The sequence of this isoform differs from the canonical sequence as follows:
     1-351: Missing.
     352-352: N → MDGWRRPLQSVGKVCEKNMKTSEMHTMSGAQ
     811-858: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 953	952	Catenin alpha-2		PRO_0000064263
Amino acid modifications
	Modified residue	2	1	N-acetylthreonine By similarity
	Modified residue	5	1	Phosphothreonine By similarity
	Modified residue	6	1	Phosphoserine By similarity
	Modified residue	151	1	Phosphoserine Ref.10
	Modified residue	261	1	Phosphothreonine By similarity
	Modified residue	262	1	Phosphoserine By similarity
	Modified residue	640	1	Phosphoserine By similarity
	Modified residue	653	1	Phosphothreonine By similarity
	Modified residue	654	1	Phosphoserine By similarity
	Modified residue	657	1	Phosphothreonine By similarity
	Modified residue	889	1	N6-acetyllysine Ref.11
	Modified residue	901	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 368	368	Missing in isoform 4.		VSP_038008
	Alternative sequence	1 – 351	351	Missing in isoform 6.		VSP_038005
	Alternative sequence	1	1	M → MSGLICLQYGLWHGQKIDFG GPRRLLQRNRGEGSM in isoform 5.		VSP_038007
	Alternative sequence	352	1	N → MDGWRRPLQSVGKVCEKNMK TSEMHTMSGAQ in isoform 6.		VSP_038006
	Alternative sequence	766 – 858	93	Missing in isoform 3.		VSP_038009
	Alternative sequence	811 – 858	48	Missing in isoform 2, isoform 4, isoform 5 and isoform 6.		VSP_020337
Experimental info
	Sequence conflict	122	1	T → A in BAH12003. Ref.3
	Sequence conflict	182	1	E → K in AAA58407. Ref.1
	Sequence conflict	309	1	S → SS in AAY15008. Ref.5
	Sequence conflict	651 – 652	2	SR → RG in AAA58407. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (AlphaN-catenin II) [UniParc]. Last modified January 23, 2007. Version 5. Checksum: 5FC88907B37E8A6C	FASTA	953	105,313
	10 20 30 40 50 60 MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK KGRSKKAHVL 70 80 90 100 110 120 AASVEQATQN FLEKGEQIAK ESQDLKEELV AAVEDVRKQG ETMRIASSEF ADDPCSSVKR 130 140 150 160 170 180 GTMVRAARAL LSAVTRLLIL ADMADVMRLL SHLKIVEEAL EAVKNATNEQ DLANRFKEFG 190 200 210 220 230 240 KEMVKLNYVA ARRQQELKDP HCRDEMAAAR GALKKNATML YTASQAFLRH PDVAATRANR 250 260 270 280 290 300 DYVFKQVQEA IAGISNAAQA TSPTDEAKGH TGIGELAAAL NEFDNKIILD PMTFSEARFR 310 320 330 340 350 360 PSLEERLESI ISGAALMADS SCTRDDRRER IVAECNAVRQ ALQDLLSEYM NNTGRKEKGD 370 380 390 400 410 420 PLNIAIDKMT KKTRDLRRQL RKAVMDHISD SFLETNVPLL VLIEAAKSGN EKEVKEYAQV 430 440 450 460 470 480 FREHANKLVE VANLACSISN NEEGVKLVRM AATQIDSLCP QVINAALTLA ARPQSKVAQD 490 500 510 520 530 540 NMDVFKDQWE KQVRVLTEAV DDITSVDDFL SVSENHILED VNKCVIALQE GDVDTLDRTA 550 560 570 580 590 600 GAIRGRAARV IHIINAEMEN YEAGVYTEKV LEATKLLSET VMPRFAEQVE VAIEALSANV 610 620 630 640 650 660 PQPFEENEFI DASRLVYDGV RDIRKAVLMI RTPEELEDDS DFEQEDYDVR SRTSVQTEDD 670 680 690 700 710 720 QLIAGQSARA IMAQLPQEEK AKIAEQVEIF HQEKSKLDAE VAKWDDSGND IIVLAKQMCM 730 740 750 760 770 780 IMMEMTDFTR GKGPLKNTSD VINAAKKIAE AGSRMDKLAR AVADQCPDSA CKQDLLAYLQ 790 800 810 820 830 840 RIALYCHQLN ICSKVKAEVQ NLGGELIVSG TGVQSTFTTF YEVDCDVIDG GRASQLSTHL 850 860 870 880 890 900 PTCAEGAPIG SGSSDSSMLD SATSLIQAAK NLMNAVVLTV KASYVASTKY QKVYGTAAVN 910 920 930 940 950 SPVVSWKMKA PEKKPLVKRE KPEEFQTRVR RGSQKKHISP VQALSEFKAM DSF
	Isoform 2 (AlphaN-catenin I) [UniParc]. Checksum: ECDB5DA119B443CF	FASTA	905	100,447
	10 20 30 40 50 60 MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK KGRSKKAHVL 70 80 90 100 110 120 AASVEQATQN FLEKGEQIAK ESQDLKEELV AAVEDVRKQG ETMRIASSEF ADDPCSSVKR 130 140 150 160 170 180 GTMVRAARAL LSAVTRLLIL ADMADVMRLL SHLKIVEEAL EAVKNATNEQ DLANRFKEFG 190 200 210 220 230 240 KEMVKLNYVA ARRQQELKDP HCRDEMAAAR GALKKNATML YTASQAFLRH PDVAATRANR 250 260 270 280 290 300 DYVFKQVQEA IAGISNAAQA TSPTDEAKGH TGIGELAAAL NEFDNKIILD PMTFSEARFR 310 320 330 340 350 360 PSLEERLESI ISGAALMADS SCTRDDRRER IVAECNAVRQ ALQDLLSEYM NNTGRKEKGD 370 380 390 400 410 420 PLNIAIDKMT KKTRDLRRQL RKAVMDHISD SFLETNVPLL VLIEAAKSGN EKEVKEYAQV 430 440 450 460 470 480 FREHANKLVE VANLACSISN NEEGVKLVRM AATQIDSLCP QVINAALTLA ARPQSKVAQD 490 500 510 520 530 540 NMDVFKDQWE KQVRVLTEAV DDITSVDDFL SVSENHILED VNKCVIALQE GDVDTLDRTA 550 560 570 580 590 600 GAIRGRAARV IHIINAEMEN YEAGVYTEKV LEATKLLSET VMPRFAEQVE VAIEALSANV 610 620 630 640 650 660 PQPFEENEFI DASRLVYDGV RDIRKAVLMI RTPEELEDDS DFEQEDYDVR SRTSVQTEDD 670 680 690 700 710 720 QLIAGQSARA IMAQLPQEEK AKIAEQVEIF HQEKSKLDAE VAKWDDSGND IIVLAKQMCM 730 740 750 760 770 780 IMMEMTDFTR GKGPLKNTSD VINAAKKIAE AGSRMDKLAR AVADQCPDSA CKQDLLAYLQ 790 800 810 820 830 840 RIALYCHQLN ICSKVKAEVQ NLGGELIVSG LDSATSLIQA AKNLMNAVVL TVKASYVAST 850 860 870 880 890 900 KYQKVYGTAA VNSPVVSWKM KAPEKKPLVK REKPEEFQTR VRRGSQKKHI SPVQALSEFK AMDSF
	Isoform 3 [UniParc]. Checksum: 33963B324E2787FE	FASTA	860	95,558
	10 20 30 40 50 60 MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK KGRSKKAHVL 70 80 90 100 110 120 AASVEQATQN FLEKGEQIAK ESQDLKEELV AAVEDVRKQG ETMRIASSEF ADDPCSSVKR 130 140 150 160 170 180 GTMVRAARAL LSAVTRLLIL ADMADVMRLL SHLKIVEEAL EAVKNATNEQ DLANRFKEFG 190 200 210 220 230 240 KEMVKLNYVA ARRQQELKDP HCRDEMAAAR GALKKNATML YTASQAFLRH PDVAATRANR 250 260 270 280 290 300 DYVFKQVQEA IAGISNAAQA TSPTDEAKGH TGIGELAAAL NEFDNKIILD PMTFSEARFR 310 320 330 340 350 360 PSLEERLESI ISGAALMADS SCTRDDRRER IVAECNAVRQ ALQDLLSEYM NNTGRKEKGD 370 380 390 400 410 420 PLNIAIDKMT KKTRDLRRQL RKAVMDHISD SFLETNVPLL VLIEAAKSGN EKEVKEYAQV 430 440 450 460 470 480 FREHANKLVE VANLACSISN NEEGVKLVRM AATQIDSLCP QVINAALTLA ARPQSKVAQD 490 500 510 520 530 540 NMDVFKDQWE KQVRVLTEAV DDITSVDDFL SVSENHILED VNKCVIALQE GDVDTLDRTA 550 560 570 580 590 600 GAIRGRAARV IHIINAEMEN YEAGVYTEKV LEATKLLSET VMPRFAEQVE VAIEALSANV 610 620 630 640 650 660 PQPFEENEFI DASRLVYDGV RDIRKAVLMI RTPEELEDDS DFEQEDYDVR SRTSVQTEDD 670 680 690 700 710 720 QLIAGQSARA IMAQLPQEEK AKIAEQVEIF HQEKSKLDAE VAKWDDSGND IIVLAKQMCM 730 740 750 760 770 780 IMMEMTDFTR GKGPLKNTSD VINAAKKIAE AGSRMDKLAR AVADQLDSAT SLIQAAKNLM 790 800 810 820 830 840 NAVVLTVKAS YVASTKYQKV YGTAAVNSPV VSWKMKAPEK KPLVKREKPE EFQTRVRRGS 850 860 QKKHISPVQA LSEFKAMDSF
	Isoform 4 [UniParc]. Checksum: 71B24F41F0B4D6FB	FASTA	537	59,868
	10 20 30 40 50 60 MTKKTRDLRR QLRKAVMDHI SDSFLETNVP LLVLIEAAKS GNEKEVKEYA QVFREHANKL 70 80 90 100 110 120 VEVANLACSI SNNEEGVKLV RMAATQIDSL CPQVINAALT LAARPQSKVA QDNMDVFKDQ 130 140 150 160 170 180 WEKQVRVLTE AVDDITSVDD FLSVSENHIL EDVNKCVIAL QEGDVDTLDR TAGAIRGRAA 190 200 210 220 230 240 RVIHIINAEM ENYEAGVYTE KVLEATKLLS ETVMPRFAEQ VEVAIEALSA NVPQPFEENE 250 260 270 280 290 300 FIDASRLVYD GVRDIRKAVL MIRTPEELED DSDFEQEDYD VRSRTSVQTE DDQLIAGQSA 310 320 330 340 350 360 RAIMAQLPQE EKAKIAEQVE IFHQEKSKLD AEVAKWDDSG NDIIVLAKQM CMIMMEMTDF 370 380 390 400 410 420 TRGKGPLKNT SDVINAAKKI AEAGSRMDKL ARAVADQCPD SACKQDLLAY LQRIALYCHQ 430 440 450 460 470 480 LNICSKVKAE VQNLGGELIV SGLDSATSLI QAAKNLMNAV VLTVKASYVA STKYQKVYGT 490 500 510 520 530 AAVNSPVVSW KMKAPEKKPL VKREKPEEFQ TRVRRGSQKK HISPVQALSE FKAMDSF
	Isoform 5 [UniParc]. Checksum: 4B4AF75F8A539C5B	FASTA	939	104,273
	10 20 30 40 50 60 MSGLICLQYG LWHGQKIDFG GPRRLLQRNR GEGSMTSATS PIILKWDPKS LEIRTLTVER 70 80 90 100 110 120 LLEPLVTQVT TLVNTSNKGP SGKKKGRSKK AHVLAASVEQ ATQNFLEKGE QIAKESQDLK 130 140 150 160 170 180 EELVAAVEDV RKQGETMRIA SSEFADDPCS SVKRGTMVRA ARALLSAVTR LLILADMADV 190 200 210 220 230 240 MRLLSHLKIV EEALEAVKNA TNEQDLANRF KEFGKEMVKL NYVAARRQQE LKDPHCRDEM 250 260 270 280 290 300 AAARGALKKN ATMLYTASQA FLRHPDVAAT RANRDYVFKQ VQEAIAGISN AAQATSPTDE 310 320 330 340 350 360 AKGHTGIGEL AAALNEFDNK IILDPMTFSE ARFRPSLEER LESIISGAAL MADSSCTRDD 370 380 390 400 410 420 RRERIVAECN AVRQALQDLL SEYMNNTGRK EKGDPLNIAI DKMTKKTRDL RRQLRKAVMD 430 440 450 460 470 480 HISDSFLETN VPLLVLIEAA KSGNEKEVKE YAQVFREHAN KLVEVANLAC SISNNEEGVK 490 500 510 520 530 540 LVRMAATQID SLCPQVINAA LTLAARPQSK VAQDNMDVFK DQWEKQVRVL TEAVDDITSV 550 560 570 580 590 600 DDFLSVSENH ILEDVNKCVI ALQEGDVDTL DRTAGAIRGR AARVIHIINA EMENYEAGVY 610 620 630 640 650 660 TEKVLEATKL LSETVMPRFA EQVEVAIEAL SANVPQPFEE NEFIDASRLV YDGVRDIRKA 670 680 690 700 710 720 VLMIRTPEEL EDDSDFEQED YDVRSRTSVQ TEDDQLIAGQ SARAIMAQLP QEEKAKIAEQ 730 740 750 760 770 780 VEIFHQEKSK LDAEVAKWDD SGNDIIVLAK QMCMIMMEMT DFTRGKGPLK NTSDVINAAK 790 800 810 820 830 840 KIAEAGSRMD KLARAVADQC PDSACKQDLL AYLQRIALYC HQLNICSKVK AEVQNLGGEL 850 860 870 880 890 900 IVSGLDSATS LIQAAKNLMN AVVLTVKASY VASTKYQKVY GTAAVNSPVV SWKMKAPEKK 910 920 930 PLVKREKPEE FQTRVRRGSQ KKHISPVQAL SEFKAMDSF
	Isoform 6 (AlphaN-catenin III) [UniParc]. Checksum: A3A1391C89740337	FASTA	584	65,111
	10 20 30 40 50 60 MDGWRRPLQS VGKVCEKNMK TSEMHTMSGA QTGRKEKGDP LNIAIDKMTK KTRDLRRQLR 70 80 90 100 110 120 KAVMDHISDS FLETNVPLLV LIEAAKSGNE KEVKEYAQVF REHANKLVEV ANLACSISNN 130 140 150 160 170 180 EEGVKLVRMA ATQIDSLCPQ VINAALTLAA RPQSKVAQDN MDVFKDQWEK QVRVLTEAVD 190 200 210 220 230 240 DITSVDDFLS VSENHILEDV NKCVIALQEG DVDTLDRTAG AIRGRAARVI HIINAEMENY 250 260 270 280 290 300 EAGVYTEKVL EATKLLSETV MPRFAEQVEV AIEALSANVP QPFEENEFID ASRLVYDGVR 310 320 330 340 350 360 DIRKAVLMIR TPEELEDDSD FEQEDYDVRS RTSVQTEDDQ LIAGQSARAI MAQLPQEEKA 370 380 390 400 410 420 KIAEQVEIFH QEKSKLDAEV AKWDDSGNDI IVLAKQMCMI MMEMTDFTRG KGPLKNTSDV 430 440 450 460 470 480 INAAKKIAEA GSRMDKLARA VADQCPDSAC KQDLLAYLQR IALYCHQLNI CSKVKAEVQN 490 500 510 520 530 540 LGGELIVSGL DSATSLIQAA KNLMNAVVLT VKASYVASTK YQKVYGTAAV NSPVVSWKMK 550 560 570 580 APEKKPLVKR EKPEEFQTRV RRGSQKKHIS PVQALSEFKA MDSF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein (alpha-catenin)." Claverie J.-M., Hardelin J.-P., Legouis R., Levilliers J., Bougueleret L., Mattei M.-G., Petit C. Genomics 15:13-20(1993) [PubMed: 8432524] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	Hardelin J.-P. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO C-TERMINUS.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5). Tissue: Brain, Hippocampus and Testis.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Hippocampus.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: PNS.
[8]	"Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1." Bogaerts S., Vanlandschoot A., van Hengel J., van Roy F. Exp. Cell Res. 311:1-13(2005) [PubMed: 16182284] [Abstract] Cited for: INTERACTION WITH ZNF639, SUBCELLULAR LOCATION.
[9]	"Regulation of a novel alphaN-catenin splice variant in schizophrenic smokers." Mexal S., Berger R., Pearce L., Barton A., Logel J., Adams C.E., Ross R.G., Freedman R., Leonard S. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147:759-768(2008) [PubMed: 18163523] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 6).
[10]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-889, MASS SPECTROMETRY.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M94151 mRNA. Translation: AAA58407.2. AK127226 mRNA. Translation: BAG54457.1. AK295181 mRNA. Translation: BAH12003.1. AK295493 mRNA. Translation: BAH12088.1. AK303035 mRNA. Translation: BAH13884.1. BX537769 mRNA. Translation: CAD97832.1. AC008067 Genomic DNA. Translation: AAY15073.1. AC010975 Genomic DNA. No translation available. AC011741 Genomic DNA. Translation: AAX93241.1. AC011746 Genomic DNA. Translation: AAY15008.1. AC016670 Genomic DNA. No translation available. AC016716 Genomic DNA. No translation available. AC093322 Genomic DNA. No translation available. AC096573 Genomic DNA. Translation: AAY14758.1. AC096753 Genomic DNA. Translation: AAY14763.1. AC104780 Genomic DNA. Translation: AAX88946.1. FJ695201 Genomic DNA. No translation available. CH471053 Genomic DNA. Translation: EAW99564.1. CH471053 Genomic DNA. Translation: EAW99565.1. BC052996 mRNA. Translation: AAH52996.1.
IPI	IPI00385055. IPI00514038. IPI00743859. IPI00916487. IPI00944536. IPI00944563.
PIR	A45011.
RefSeq	NP_001158355.1. NM_001164883.1. NP_004380.2. NM_004389.3.
UniGene	Hs.167368.
3D structure databases
ProteinModelPortal	P26232.
SMR	P26232. Positions 56-260, 375-629.
ModBase	Search...
Protein-protein interaction databases
IntAct	P26232. 1 interaction.
STRING	P26232.
PTM databases
PhosphoSite	P26232.
Polymorphism databases
DMDM	114152793.
Proteomic databases
PRIDE	P26232.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361291; ENSP00000355398; ENSG00000066032. ENST00000402739; ENSP00000384638; ENSG00000066032. ENST00000466387; ENSP00000418191; ENSG00000066032. ENST00000496558; ENSP00000419295; ENSG00000066032.
GeneID	1496.
KEGG	hsa:1496.
UCSC	uc002sog.1. human. uc002soi.1. human.
Organism-specific databases
CTD	1496.
GeneCards	GC02P079412.
HGNC	HGNC:2510. CTNNA2.
HPA	HPA019162.
MIM	114025. gene.
neXtProt	NX_P26232.
PharmGKB	PA27013.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10001.
GeneTree	ENSGT00550000074411.
HOVERGEN	HBG000069.
InParanoid	P26232.
OMA	DIIFLAK.
OrthoDB	EOG49W2G4.
PhylomeDB	P26232.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	P26232.
Bgee	P26232.
CleanEx	HS_CTNNA2.
Genevestigator	P26232.
GermOnline	ENSG00000066032. Homo sapiens.
Family and domain databases
InterPro	IPR001033. Alpha_catenin. IPR006077. Vinculin/catenin. IPR000633. Vinculin_CS. [Graphical view]
KO	K05691.
Pfam	PF01044. Vinculin. 2 hits. [Graphical view]
PRINTS	PR00805. ALPHACATENIN.
SUPFAM	SSF47220. Vinculin/catenin. 4 hits.
PROSITE	PS00663. VINCULIN_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	6149.
SOURCE	Search...

Entry information

Entry name

CTNA2_HUMAN

Accession

Primary (citable) accession number: P26232
Secondary accession number(s): B3KXE5 , B7Z2W7, B7Z352, B7Z898, Q4ZFW1, Q53R26, Q53R33, Q53T67, Q53T71, Q53TM8, Q7Z3L1, Q7Z3Y0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 114 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.