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Protein

Endoglucanase E-4

Gene

celD

Organism
Thermobifida fusca (Thermomonospora fusca)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei427By similarity1
Active sitei461By similarity1
Active sitei470By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BRENDAi3.2.1.4 6298
UniPathwayiUPA00696

Protein family/group databases

CAZyiCBM2 Carbohydrate-Binding Module Family 2
CBM3 Carbohydrate-Binding Module Family 3
GH9 Glycoside Hydrolase Family 9

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase E-4 (EC:3.2.1.4)
Alternative name(s):
Cellulase E-4
Cellulase E4
Endo-1,4-beta-glucanase E-4
Gene namesi
Name:celD
OrganismiThermobifida fusca (Thermomonospora fusca)
Taxonomic identifieri2021 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida

Pathology & Biotechi

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 461 PublicationAdd BLAST46
ChainiPRO_000000795947 – 880Endoglucanase E-4Add BLAST834

Proteomic databases

PRIDEiP26221

Structurei

Secondary structure

1880
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi52 – 65Combined sources14
Turni85 – 88Combined sources4
Helixi89 – 91Combined sources3
Beta strandi102 – 104Combined sources3
Helixi109 – 125Combined sources17
Helixi127 – 132Combined sources6
Helixi136 – 152Combined sources17
Beta strandi159 – 165Combined sources7
Helixi167 – 172Combined sources6
Helixi177 – 179Combined sources3
Beta strandi186 – 190Combined sources5
Helixi196 – 213Combined sources18
Turni214 – 216Combined sources3
Helixi218 – 237Combined sources20
Helixi242 – 244Combined sources3
Helixi249 – 252Combined sources4
Helixi259 – 273Combined sources15
Helixi276 – 285Combined sources10
Helixi286 – 288Combined sources3
Beta strandi295 – 298Combined sources4
Beta strandi305 – 307Combined sources3
Helixi310 – 321Combined sources12
Helixi324 – 336Combined sources13
Turni337 – 339Combined sources3
Beta strandi358 – 360Combined sources3
Helixi361 – 378Combined sources18
Helixi382 – 400Combined sources19
Beta strandi413 – 416Combined sources4
Helixi424 – 427Combined sources4
Beta strandi430 – 432Combined sources3
Beta strandi436 – 439Combined sources4
Turni466 – 469Combined sources4
Helixi473 – 476Combined sources4
Helixi477 – 490Combined sources14
Beta strandi508 – 517Combined sources10
Beta strandi520 – 531Combined sources12
Beta strandi542 – 550Combined sources9
Helixi557 – 559Combined sources3
Beta strandi561 – 563Combined sources3
Beta strandi565 – 569Combined sources5
Beta strandi576 – 579Combined sources4
Beta strandi582 – 588Combined sources7
Beta strandi596 – 598Combined sources3
Turni599 – 602Combined sources4
Beta strandi603 – 611Combined sources9
Helixi618 – 620Combined sources3
Helixi622 – 624Combined sources3
Beta strandi637 – 641Combined sources5
Beta strandi644 – 648Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JS4X-ray2.00A/B47-651[»]
1TF4X-ray1.90A/B47-651[»]
3TF4X-ray2.20A/B47-651[»]
4TF4X-ray2.00A/B47-651[»]
ProteinModelPortaliP26221
SMRiP26221
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26221

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini504 – 652CBM3PROSITE-ProRule annotationAdd BLAST149
Domaini678 – 770Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST93
Domaini771 – 880CBM2PROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105CYP Bacteria
ENOG410XPC9 LUCA

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di1.50.10.10, 1 hit
2.60.40.10, 1 hit
2.60.40.290, 1 hit
2.60.40.710, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR001919 CBD2
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR012291 CBM2_carb-bd_dom_sf
IPR018366 CBM2_CS
IPR001956 CBM3
IPR036966 CBM3_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR018221 Glyco_hydro_9_His_AS
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00553 CBM_2, 1 hit
PF00942 CBM_3, 1 hit
PF00041 fn3, 1 hit
PF00759 Glyco_hydro_9, 1 hit
SMARTiView protein in SMART
SM00637 CBD_II, 1 hit
SM01067 CBM_3, 1 hit
SM00060 FN3, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF49265 SSF49265, 1 hit
SSF49384 SSF49384, 2 hits
PROSITEiView protein in PROSITE
PS51173 CBM2, 1 hit
PS00561 CBM2_A, 1 hit
PS51172 CBM3, 1 hit
PS50853 FN3, 1 hit
PS00592 GLYCOSYL_HYDROL_F9_1, 1 hit
PS00698 GLYCOSYL_HYDROL_F9_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTEPPPRR RGRHSRARRF LTSLGATAAL TAGMLGVPLA TGTAHAEPAF
60 70 80 90 100
NYAEALQKSM FFYEAQRSGK LPENNRVSWR GDSGLNDGAD VGLDLTGGWY
110 120 130 140 150
DAGDHVKFGF PMAFTATMLA WGAIESPEGY IRSGQMPYLK DNLRWVNDYF
160 170 180 190 200
IKAHPSPNVL YVQVGDGDAD HKWWGPAEVM PMERPSFKVD PSCPGSDVAA
210 220 230 240 250
ETAAAMAASS IVFADDDPAY AATLVQHAKQ LYTFADTYRG VYSDCVPAGA
260 270 280 290 300
FYNSWSGYQD ELVWGAYWLY KATGDDSYLA KAEYEYDFLS TEQQTDLRSY
310 320 330 340 350
RWTIAWDDKS YGTYVLLAKE TGKQKYIDDA NRWLDYWTVG VNGQRVPYSP
360 370 380 390 400
GGMAVLDTWG ALRYAANTAF VALVYAKVID DPVRKQRYHD FAVRQINYAL
410 420 430 440 450
GDNPRNSSYV VGFGNNPPRN PHHRTAHGSW TDSIASPAEN RHVLYGALVG
460 470 480 490 500
GPGSPNDAYT DDRQDYVANE VATDYNAGFS SALAMLVEEY GGTPLADFPP
510 520 530 540 550
TEEPDGPEIF VEAQINTPGT TFTEIKAMIR NQSGWPARML DKGTFRYWFT
560 570 580 590 600
LDEGVDPADI TVSSAYNQCA TPEDVHHVSG DLYYVEIDCT GEKIFPGGQS
610 620 630 640 650
EHRREVQFRI AGGPGWDPSN DWSFQGIGNE LAPAPYIVLY DDGVPVWGTA
660 670 680 690 700
PEEGEEPGGG EGPGGGEEPG EDVTPPSAPG SPAVRDVTST SAVLTWSASS
710 720 730 740 750
DTGGSGVAGY DVFLRAGTGQ EQKVGSTTRT SFTLTGLEPD TTYIAAVVAR
760 770 780 790 800
DNAGNVSQRS TVSFTTLAEN GGGPDASCTV GYSTNDWDSG FTASIRITYH
810 820 830 840 850
GTAPLSSWEL SFTFPAGQQV THGWNATWRQ DGAAVTATPM SWNSSLAPGA
860 870 880
TVEVGFNGSW SGSNTPPTDF TLNGEPCALA
Length:880
Mass (Da):95,203
Last modified:November 1, 1997 - v2
Checksum:i5EA9A6ABF45A4D9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20093 Genomic DNA Translation: AAB42155.1
PIRiB42360
RefSeqiWP_011292599.1, NZ_JEMR01000003.1

Similar proteinsi

Entry informationi

Entry nameiGUN4_THEFU
AccessioniPrimary (citable) accession number: P26221
Secondary accession number(s): Q08167
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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