Reviewed, UniProtKB/Swiss-Prot P26219 (CDH_SALTY)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol pyrophosphatase
    EC=3.6.1.26
Alternative name(s):
    CDP-diacylglycerol phosphatidylhydrolase
    CDP-diglyceride hydrolase

Gene names

Name:	cdh
Synonyms:	ushB
Ordered Locus Names:	STM4064

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319
Pathway	Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319
Subcellular location	Cell inner membrane; Single-pass membrane protein. HAMAP MF_00319
Sequence similarities	Belongs to the cdh family.
Caution	Was originally (Ref.1) thought to be a UDP-sugar hydrolase.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	CDP-diacylglycerol pyrophosphatase HAMAP MF_00319		PRO_0000198583
Regions
	Transmembrane	5 – 25	21	Potential
Experimental info
	Sequence conflict	13	1	V → L in CAA31757. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P26219-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 2F4BBAB49BD870BE	FASTA	251	28,368
	10 20 30 40 50 60 MKKTGYFLLA VIVIVAAAGV GYWKFSGNPD ALREIVLEQC LPDQLQHQNP APCAEVKPRA 70 80 90 100 110 120 GYVVFKDRHG PLQYLLMPTY RINGTESPLL LEPATPNFFW LAWQARGYMS KKYGHDIPDS 130 140 150 160 170 180 AVSLAINSRL GRSQDHLHIH ISCIRPDVRE QLDNDLTRIS TRWLPLPGGL MGHEYLARRV 190 200 210 220 230 240 TESELAQRSP FMMLAEEVPE ARDHMGRYAL AVVRQSDDSF VLLATERNLL TFNRASAEEI 250 QDHSCAILSS R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane-bound UDP-sugar hydrolase." Garrett A.R., Johnson L.A., Beacham I.R. Mol. Microbiol. 3:177-186(1989) [PubMed: 2548058] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X13380 Genomic DNA. Translation: CAA31757.1. AE008889 Genomic DNA. Translation: AAL22904.1.
PIR	S04172.
RefSeq	NP_462945.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1255591.
GenomeReviews	Gene locus STM4064 in contig AE006468_GR.
KEGG	stm:STM4064.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P26219.
OMA	P26219. EIQDHEC.
Enzyme and pathway databases
BioCyc	STYP99287:STM4064-MON.
BRENDA	3.6.1.26. 2.
Family and domain databases
HAMAP	MF_00319. [Tree]
InterPro	IPR003763. CDP-diacylglyc_Pase_bac. IPR015993. CDP-diacylglyc_Pase_proteobac. [Graphical view]
Pfam	PF02611. CDH. 1 hit. [Graphical view]
PIRSF	PIRSF001273. CDH. 1 hit.
TIGRFAMs	TIGR00672. cdh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDH_SALTY

Accession

Primary (citable) accession number: P26219

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	January 23, 2002
Last modified:	June 16, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)