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Protein

Cryptic outer membrane porin BglH

Gene

bglH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of a cryptic operon that is poorly expressed in vivo. May be an ancestral sugar porin with a broad carbohydrate specificity; it binds aromatic beta-D-glucosides such as arbutin and salicin, but with low affinity compared to the binding of maltooligosaccharides to the LamB porin.

GO - Molecular functioni

  • carbohydrate transmembrane transporter activity Source: EcoCyc
  • porin activity Source: UniProtKB-KW

GO - Biological processi

  • carbohydrate transmembrane transport Source: EcoCyc
  • ion transport Source: UniProtKB-KW

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11364-MONOMER

Protein family/group databases

TCDBi1.B.3.1.3 the sugar porin (sp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cryptic outer membrane porin BglH
Gene namesi
Name:bglH
Synonyms:yieC
Ordered Locus Names:b3720, JW3698
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11364 bglH

Subcellular locationi

  • Cell outer membrane 1 Publication; Multi-pass membrane protein 1 Publication
  • Note: Can be easily removed from the outer membrane by treatment with detergent.

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • pore complex Source: UniProtKB-KW

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002518826 – 538Cryptic outer membrane porin BglHAdd BLAST513

Proteomic databases

PaxDbiP26218
PRIDEiP26218

Interactioni

Subunit structurei

Homomonomer; no physical evidence of a homotrimer has been found (PubMed:9426150, PubMed:10027967), however conductance experiments (PubMed:10027967) suggest it may be a homotrimer. The monomer probably consists of 18 antiparallel beta-strands.2 Publications

Protein-protein interaction databases

BioGridi4261194, 167 interactors
STRINGi316385.ECDH10B_3907

Structurei

3D structure databases

ProteinModelPortaliP26218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108P68 Bacteria
COG4580 LUCA
HOGENOMiHOG000120763
KOiK10124
OMAiNTHTIDL

Family and domain databases

CDDicd01346 Maltoporin-like, 1 hit
Gene3Di2.40.170.10, 1 hit
InterProiView protein in InterPro
IPR021570 LamB-type_porin_N_dom
IPR003192 Porin_LamB
IPR036998 Porin_LamB_sf
PfamiView protein in Pfam
PF02264 LamB, 1 hit
PF11471 Sugarporin_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD008788 Porin_LamB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRRNLITSA ILLMAPLAFS AQSLAESLTV EQRLELLEKA LRETQSELKK
60 70 80 90 100
YKDEEKKKYT PATVNRSVST NDQGYAANPF PTSSAAKPDA VLVKNEEKNA
110 120 130 140 150
SETGSIYSSM TLKDFSKFVK DEIGFSYNGY YRSGWGTASH GSPKSWAIGS
160 170 180 190 200
LGRFGNEYSG WFDLQLKQRV YNENGKRVDA VVMMDGNVGQ QYSTGWFGDN
210 220 230 240 250
AGGENYMQFS DMYVTTKGFL PFAPEADFWV GKHGAPKIEI QMLDWKTQRT
260 270 280 290 300
DAAAGVGLEN WKVGPGKIDI ALVREDVDDY DRSLQNKQQI NTNTIDLRYK
310 320 330 340 350
DIPLWDKATL MVSGRYVTAN ESASEKDNQD NNGYYDWKDT WMFGTSLTQK
360 370 380 390 400
FDKGGFNEFS FLVANNSIAS NFGRYAGASP FTTFNGRYYG DHTGGTAVRL
410 420 430 440 450
TSQGEAYIGD HFIVANAIVY SFGNDIYSYE TGAHSDFESI RAVVRPAYIW
460 470 480 490 500
DQYNQTGVEL GYFTQQNKDA NSNKFNESGY KTTLFHTFKV NTSMLTSRPE
510 520 530
IRFYATYIKA LENELDGFTF EDNKDDQFAV GAQAEIWW
Length:538
Mass (Da):60,657
Last modified:November 1, 1997 - v3
Checksum:iC537613D6D39B8F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202 – 251GGENY…TQRTD → VARTICSSPICTLPPKVSCP LAQRLISGWVNTVRRKLKSR CLTGKRSVLM in AAA62071 (PubMed:7686882).CuratedAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62071.1
U00096 Genomic DNA Translation: AAC76743.1
AP009048 Genomic DNA Translation: BAE77568.1
M16487 Genomic DNA No translation available.
PIRiA65175
RefSeqiNP_418176.1, NC_000913.3
WP_000489881.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76743; AAC76743; b3720
BAE77568; BAE77568; BAE77568
GeneIDi948228
KEGGiecj:JW3698
eco:b3720
PATRICifig|1411691.4.peg.2981

Similar proteinsi

Entry informationi

Entry nameiBGLH_ECOLI
AccessioniPrimary (citable) accession number: P26218
Secondary accession number(s): P76743, Q2M838
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health