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P26208

- BGLA_CLOTH

UniProt

P26208 - BGLA_CLOTH

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Protein

Beta-glucosidase A

Gene

bglA

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei166 – 1661Proton donorSequence Analysis
Active sitei355 – 3551NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciCTHE203119:GIW8-218-MONOMER.
UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase A (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene namesi
Name:bglA
Ordered Locus Names:Cthe_0212
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
ProteomesiUP000002145: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Beta-glucosidase APRO_0000063876Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_0212.

Structurei

3D structure databases

ProteinModelPortaliP26208.
SMRiP26208. Positions 4-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088630.
KOiK05350.
OMAiEVIAKKH.
OrthoDBiEOG60658J.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR03356. BGL. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26208-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKITFPKDF IWGSATAAYQ IEGAYNEDGK GESIWDRFSH TPGNIADGHT
60 70 80 90 100
GDVACDHYHR YEEDIKIMKE IGIKSYRFSI SWPRIFPEGT GKLNQKGLDF
110 120 130 140 150
YKRLTNLLLE NGIMPAITLY HWDLPQKLQD KGGWKNRDTT DYFTEYSEVI
160 170 180 190 200
FKNLGDIVPI WFTHNEPGVV SLLGHFLGIH APGIKDLRTS LEVSHNLLLS
210 220 230 240 250
HGKAVKLFRE MNIDAQIGIA LNLSYHYPAS EKAEDIEAAE LSFSLAGRWY
260 270 280 290 300
LDPVLKGRYP ENALKLYKKK GIELSFPEDD LKLISQPIDF IAFNNYSSEF
310 320 330 340 350
IKYDPSSESG FSPANSILEK FEKTDMGWII YPEGLYDLLM LLDRDYGKPN
360 370 380 390 400
IVISENGAAF KDEIGSNGKI EDTKRIQYLK DYLTQAHRAI QDGVNLKAYY
410 420 430 440
LWSLLDNFEW AYGYNKRFGI VHVNFDTLER KIKDSGYWYK EVIKNNGF
Length:448
Mass (Da):51,482
Last modified:May 1, 1992 - v1
Checksum:iD59B9EB7BEE67621
GO

Sequence cautioni

The sequence ABN51453.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60268 Genomic DNA. Translation: CAA42814.1.
CP000568 Genomic DNA. Translation: ABN51453.1. Different initiation.
PIRiS17215.
RefSeqiYP_001036646.1. NC_009012.1.

Genome annotation databases

EnsemblBacteriaiABN51453; ABN51453; Cthe_0212.
GeneIDi4808630.
KEGGicth:Cthe_0212.
PATRICi19514055. VBICloThe47081_0226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60268 Genomic DNA. Translation: CAA42814.1 .
CP000568 Genomic DNA. Translation: ABN51453.1 . Different initiation.
PIRi S17215.
RefSeqi YP_001036646.1. NC_009012.1.

3D structure databases

ProteinModelPortali P26208.
SMRi P26208. Positions 4-448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203119.Cthe_0212.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

DNASUi 4808630.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN51453 ; ABN51453 ; Cthe_0212 .
GeneIDi 4808630.
KEGGi cth:Cthe_0212.
PATRICi 19514055. VBICloThe47081_0226.

Phylogenomic databases

eggNOGi COG2723.
HOGENOMi HOG000088630.
KOi K05350.
OMAi EVIAKKH.
OrthoDBi EOG60658J.

Enzyme and pathway databases

UniPathwayi UPA00696 .
BioCyci CTHE203119:GIW8-218-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR03356. BGL. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the beta-glucosidase gene bglA of Clostridium thermocellum. Sequence analysis reveals a superfamily of cellulases and beta-glycosidases including human lactase/phlorizin hydrolase."
    Graebnitz F., Seiss M., Ruecknagel K.P., Staudenbauer W.L.
    Eur. J. Biochem. 200:301-309(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372.

Entry informationi

Entry nameiBGLA_CLOTH
AccessioniPrimary (citable) accession number: P26208
Secondary accession number(s): A3DBX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 1, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3