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P26208

- BGLA_CLOTH

UniProt

P26208 - BGLA_CLOTH

Protein

Beta-glucosidase A

Gene

bglA

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei166 – 1661Proton donorSequence Analysis
    Active sitei355 – 3551NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    BioCyciCTHE203119:GIW8-218-MONOMER.
    UniPathwayiUPA00696.

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-glucosidase A (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase
    Cellobiase
    Gentiobiase
    Gene namesi
    Name:bglA
    Ordered Locus Names:Cthe_0212
    OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
    Taxonomic identifieri203119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
    ProteomesiUP000002145: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Beta-glucosidase APRO_0000063876Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203119.Cthe_0212.

    Structurei

    3D structure databases

    ProteinModelPortaliP26208.
    SMRiP26208. Positions 4-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.Curated

    Phylogenomic databases

    eggNOGiCOG2723.
    HOGENOMiHOG000088630.
    KOiK05350.
    OMAiEVIAKKH.
    OrthoDBiEOG60658J.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR017736. Glyco_hydro_1_beta-glucosidase.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 1 hit.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    TIGRFAMsiTIGR03356. BGL. 1 hit.
    PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26208-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKITFPKDF IWGSATAAYQ IEGAYNEDGK GESIWDRFSH TPGNIADGHT    50
    GDVACDHYHR YEEDIKIMKE IGIKSYRFSI SWPRIFPEGT GKLNQKGLDF 100
    YKRLTNLLLE NGIMPAITLY HWDLPQKLQD KGGWKNRDTT DYFTEYSEVI 150
    FKNLGDIVPI WFTHNEPGVV SLLGHFLGIH APGIKDLRTS LEVSHNLLLS 200
    HGKAVKLFRE MNIDAQIGIA LNLSYHYPAS EKAEDIEAAE LSFSLAGRWY 250
    LDPVLKGRYP ENALKLYKKK GIELSFPEDD LKLISQPIDF IAFNNYSSEF 300
    IKYDPSSESG FSPANSILEK FEKTDMGWII YPEGLYDLLM LLDRDYGKPN 350
    IVISENGAAF KDEIGSNGKI EDTKRIQYLK DYLTQAHRAI QDGVNLKAYY 400
    LWSLLDNFEW AYGYNKRFGI VHVNFDTLER KIKDSGYWYK EVIKNNGF 448
    Length:448
    Mass (Da):51,482
    Last modified:May 1, 1992 - v1
    Checksum:iD59B9EB7BEE67621
    GO

    Sequence cautioni

    The sequence ABN51453.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60268 Genomic DNA. Translation: CAA42814.1.
    CP000568 Genomic DNA. Translation: ABN51453.1. Different initiation.
    PIRiS17215.
    RefSeqiYP_001036646.1. NC_009012.1.

    Genome annotation databases

    EnsemblBacteriaiABN51453; ABN51453; Cthe_0212.
    GeneIDi4808630.
    KEGGicth:Cthe_0212.
    PATRICi19514055. VBICloThe47081_0226.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60268 Genomic DNA. Translation: CAA42814.1 .
    CP000568 Genomic DNA. Translation: ABN51453.1 . Different initiation.
    PIRi S17215.
    RefSeqi YP_001036646.1. NC_009012.1.

    3D structure databases

    ProteinModelPortali P26208.
    SMRi P26208. Positions 4-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203119.Cthe_0212.

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    Protocols and materials databases

    DNASUi 4808630.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN51453 ; ABN51453 ; Cthe_0212 .
    GeneIDi 4808630.
    KEGGi cth:Cthe_0212.
    PATRICi 19514055. VBICloThe47081_0226.

    Phylogenomic databases

    eggNOGi COG2723.
    HOGENOMi HOG000088630.
    KOi K05350.
    OMAi EVIAKKH.
    OrthoDBi EOG60658J.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .
    BioCyci CTHE203119:GIW8-218-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR017736. Glyco_hydro_1_beta-glucosidase.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    TIGRFAMsi TIGR03356. BGL. 1 hit.
    PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the beta-glucosidase gene bglA of Clostridium thermocellum. Sequence analysis reveals a superfamily of cellulases and beta-glycosidases including human lactase/phlorizin hydrolase."
      Graebnitz F., Seiss M., Ruecknagel K.P., Staudenbauer W.L.
      Eur. J. Biochem. 200:301-309(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372.

    Entry informationi

    Entry nameiBGLA_CLOTH
    AccessioniPrimary (citable) accession number: P26208
    Secondary accession number(s): A3DBX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3