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P26208 (BGLA_CLOTH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-glucosidase A

EC=3.2.1.21
Alternative name(s):
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene names
Name:bglA
Ordered Locus Names:Cthe_0212
OrganismClostridium thermocellum (strain ATCC 27405 / DSM 1237) [Complete proteome] [HAMAP]
Taxonomic identifier203119 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway

Glycan metabolism; cellulose degradation.

Sequence similarities

Belongs to the glycosyl hydrolase 1 family.

Sequence caution

The sequence ABN51453.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionbeta-glucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Beta-glucosidase A
PRO_0000063876

Sites

Active site1661Proton donor Potential
Active site3551Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P26208 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: D59B9EB7BEE67621

FASTA44851,482
        10         20         30         40         50         60 
MSKITFPKDF IWGSATAAYQ IEGAYNEDGK GESIWDRFSH TPGNIADGHT GDVACDHYHR 

        70         80         90        100        110        120 
YEEDIKIMKE IGIKSYRFSI SWPRIFPEGT GKLNQKGLDF YKRLTNLLLE NGIMPAITLY 

       130        140        150        160        170        180 
HWDLPQKLQD KGGWKNRDTT DYFTEYSEVI FKNLGDIVPI WFTHNEPGVV SLLGHFLGIH 

       190        200        210        220        230        240 
APGIKDLRTS LEVSHNLLLS HGKAVKLFRE MNIDAQIGIA LNLSYHYPAS EKAEDIEAAE 

       250        260        270        280        290        300 
LSFSLAGRWY LDPVLKGRYP ENALKLYKKK GIELSFPEDD LKLISQPIDF IAFNNYSSEF 

       310        320        330        340        350        360 
IKYDPSSESG FSPANSILEK FEKTDMGWII YPEGLYDLLM LLDRDYGKPN IVISENGAAF 

       370        380        390        400        410        420 
KDEIGSNGKI EDTKRIQYLK DYLTQAHRAI QDGVNLKAYY LWSLLDNFEW AYGYNKRFGI 

       430        440 
VHVNFDTLER KIKDSGYWYK EVIKNNGF 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the beta-glucosidase gene bglA of Clostridium thermocellum. Sequence analysis reveals a superfamily of cellulases and beta-glycosidases including human lactase/phlorizin hydrolase."
Graebnitz F., Seiss M., Ruecknagel K.P., Staudenbauer W.L.
Eur. J. Biochem. 200:301-309(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of Clostridium thermocellum ATCC 27405."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Wu J.H.D., Newcomb M., Richardson P.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27405 / DSM 1237.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60268 Genomic DNA. Translation: CAA42814.1.
CP000568 Genomic DNA. Translation: ABN51453.1. Different initiation.
PIRS17215.
RefSeqYP_001036646.1. NC_009012.1.

3D structure databases

ProteinModelPortalP26208.
SMRP26208. Positions 4-448.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203119.Cthe_0212.

Protein family/group databases

CAZyGH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

DNASU4808630.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN51453; ABN51453; Cthe_0212.
GeneID4808630.
KEGGcth:Cthe_0212.
PATRIC19514055. VBICloThe47081_0226.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2723.
HOGENOMHOG000088630.
KOK05350.
OMAGEYTEMG.
OrthoDBEOG60658J.

Enzyme and pathway databases

BioCycCTHE203119:GIW8-218-MONOMER.
UniPathwayUPA00696.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10353. PTHR10353. 1 hit.
PfamPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSPR00131. GLHYDRLASE1.
SUPFAMSSF51445. SSF51445. 1 hit.
TIGRFAMsTIGR03356. BGL. 1 hit.
PROSITEPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGLA_CLOTH
AccessionPrimary (citable) accession number: P26208
Secondary accession number(s): A3DBX4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 13, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries