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P26201

- CD36_BOVIN

UniProt

P26201 - CD36_BOVIN

Protein

Platelet glycoprotein 4

Gene

CD36

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 5 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects.1 Publication

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion, Transport

    Enzyme and pathway databases

    ReactomeiREACT_207237. PPARA activates gene expression.
    REACT_218962. Cross-presentation of particulate exogenous antigens (phagosomes).
    REACT_220799. Transcriptional regulation of white adipocyte differentiation.
    REACT_225653. Toll Like Receptor TLR6:TLR2 Cascade.
    REACT_227409. Scavenging by Class B Receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet glycoprotein 4
    Alternative name(s):
    Glycoprotein IIIb
    Short name:
    GPIIIB
    PAS IV
    PAS-4
    Platelet glycoprotein IV
    Short name:
    GPIV
    CD_antigen: CD36
    Gene namesi
    Name:CD36
    Synonyms:PAS4
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 472471Platelet glycoprotein 4PRO_0000144150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi3 – 31S-palmitoyl cysteineBy similarity
    Lipidationi7 – 71S-palmitoyl cysteineBy similarity
    Glycosylationi79 – 791N-linked (GlcNAc...)1 Publication
    Glycosylationi102 – 1021N-linked (GlcNAc...)1 Publication
    Glycosylationi172 – 1721N-linked (GlcNAc...)1 Publication
    Glycosylationi205 – 2051N-linked (GlcNAc...)1 Publication
    Glycosylationi235 – 2351N-linked (GlcNAc...)1 Publication
    Disulfide bondi243 ↔ 3111 Publication
    Glycosylationi247 – 2471N-linked (GlcNAc...)1 Publication
    Disulfide bondi272 ↔ 3331 Publication
    Disulfide bondi313 ↔ 3221 Publication
    Glycosylationi321 – 3211N-linked (GlcNAc...)1 Publication
    Glycosylationi417 – 4171N-linked (GlcNAc...)1 Publication
    Lipidationi464 – 4641S-palmitoyl cysteineBy similarity
    Lipidationi466 – 4661S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP26201.

    PTM databases

    UniCarbKBiP26201.

    Interactioni

    Subunit structurei

    Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 76CytoplasmicSequence Analysis
    Topological domaini30 – 439410ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini462 – 47211CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei440 – 46122HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2Add
    BLAST

    Sequence similaritiesi

    Belongs to the CD36 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257244.
    GeneTreeiENSGT00530000062927.
    HOGENOMiHOG000252951.
    HOVERGENiHBG002754.
    InParanoidiP26201.
    KOiK06259.
    OMAiKRNYIVP.
    OrthoDBiEOG79SDWX.
    TreeFamiTF317925.

    Family and domain databases

    InterProiIPR002159. CD36.
    IPR005428. CD36_antigen.
    [Graphical view]
    PANTHERiPTHR11923. PTHR11923. 1 hit.
    PfamiPF01130. CD36. 1 hit.
    [Graphical view]
    PRINTSiPR01610. CD36ANTIGEN.
    PR01609. CD36FAMILY.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P26201-1 [UniParc]FASTAAdd to Basket

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    MGCNRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKK EVVLEEGTIA    50
    FKNWVKTGTD VYRQFWIFDV QNPDEVTVNS SKIKVKQRGP YTYRVRYLAK 100
    ENITQDPETH TVSFLQPNGA IFEPSLSVGT EDDTFTILNL AVAAAPQLYP 150
    NTFMQGILNS FIKKSKSSMF QNRTLKELLW GYTDPFLNLV PYPITTTIGV 200
    FYPYNNTADG IYKVFNGKDD ISKVAIIDTY KGRKNLSYWS SYCDLINGTD 250
    AASFPPFVEK TRVLQFFSSD ICRSIYAVFG AEINLKGIPV YRFILPSFAF 300
    ASPFQNPDNH CFCTEKIISK NCTLYGVLDI GKCKEGKPVY ISLPHFLHGS 350
    PELAEPIESL SPNEEEHSTY LDVEPITGFT LRFAKRLQVN MLVKPAKKIE 400
    ALKNLKHNYI VPILWLNETG TIGDEKAEMF RNQVTGKINL LGLVEIVLLS 450
    VGVVMFIAFM ISYCACRSKR VN 472
    Length:472
    Mass (Da):52,940
    Last modified:January 23, 2007 - v5
    Checksum:iD864D6D3D6E8622F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391K → N in CAA62803. (PubMed:8950178)Curated
    Sequence conflicti110 – 1101H → N in BAA08224. 1 PublicationCurated
    Sequence conflicti125 – 1251S → L in BAA08224. 1 PublicationCurated
    Sequence conflicti134 – 1341T → K in BAA08224. 1 PublicationCurated
    Sequence conflicti257 – 2571F → L in BAA08224. 1 PublicationCurated
    Sequence conflicti294 – 2941I → V in BAA08224. 1 PublicationCurated
    Sequence conflicti305 – 3051Q → E in BAA08224. 1 PublicationCurated
    Sequence conflicti359 – 3591S → G in BAA08224. 1 PublicationCurated
    Sequence conflicti391 – 3966MLVKPA → TGQARQ in BAA08224. 1 PublicationCurated
    Sequence conflicti466 – 4661C → Y in BAA08224. 1 PublicationCurated
    Sequence conflicti470 – 4723RVN → TIK in BAA08224. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45364 mRNA. Translation: BAA08224.1.
    X91503 mRNA. Translation: CAA62803.1.
    BC103112 mRNA. Translation: AAI03113.1.
    RefSeqiNP_001265550.1. NM_001278621.1.
    NP_776435.2. NM_174010.3.
    XP_005205377.1. XM_005205320.1.
    XP_005205378.1. XM_005205321.1.
    XP_005205379.1. XM_005205322.1.
    XP_005205380.1. XM_005205323.1.
    XP_005205381.1. XM_005205324.1.
    XP_005205382.1. XM_005205325.1.
    XP_005205383.1. XM_005205326.1.
    XP_005205384.1. XM_005205327.1.
    UniGeneiBt.43948.

    Genome annotation databases

    EnsembliENSBTAT00000023750; ENSBTAP00000023750; ENSBTAG00000017866.
    GeneIDi281052.
    KEGGibta:281052.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45364 mRNA. Translation: BAA08224.1 .
    X91503 mRNA. Translation: CAA62803.1 .
    BC103112 mRNA. Translation: AAI03113.1 .
    RefSeqi NP_001265550.1. NM_001278621.1.
    NP_776435.2. NM_174010.3.
    XP_005205377.1. XM_005205320.1.
    XP_005205378.1. XM_005205321.1.
    XP_005205379.1. XM_005205322.1.
    XP_005205380.1. XM_005205323.1.
    XP_005205381.1. XM_005205324.1.
    XP_005205382.1. XM_005205325.1.
    XP_005205383.1. XM_005205326.1.
    XP_005205384.1. XM_005205327.1.
    UniGenei Bt.43948.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    UniCarbKBi P26201.

    Proteomic databases

    PaxDbi P26201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000023750 ; ENSBTAP00000023750 ; ENSBTAG00000017866 .
    GeneIDi 281052.
    KEGGi bta:281052.

    Organism-specific databases

    CTDi 948.

    Phylogenomic databases

    eggNOGi NOG257244.
    GeneTreei ENSGT00530000062927.
    HOGENOMi HOG000252951.
    HOVERGENi HBG002754.
    InParanoidi P26201.
    KOi K06259.
    OMAi KRNYIVP.
    OrthoDBi EOG79SDWX.
    TreeFami TF317925.

    Enzyme and pathway databases

    Reactomei REACT_207237. PPARA activates gene expression.
    REACT_218962. Cross-presentation of particulate exogenous antigens (phagosomes).
    REACT_220799. Transcriptional regulation of white adipocyte differentiation.
    REACT_225653. Toll Like Receptor TLR6:TLR2 Cascade.
    REACT_227409. Scavenging by Class B Receptors.

    Miscellaneous databases

    NextBioi 20805136.

    Family and domain databases

    InterProi IPR002159. CD36.
    IPR005428. CD36_antigen.
    [Graphical view ]
    PANTHERi PTHR11923. PTHR11923. 1 hit.
    Pfami PF01130. CD36. 1 hit.
    [Graphical view ]
    PRINTSi PR01610. CD36ANTIGEN.
    PR01609. CD36FAMILY.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of PAS-4 from bovine fat globule membrane."
      Hwangbo S., Ametani M., Kanno C.
      Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Holstein.
      Tissue: Mammary gland.
    2. "Structural characterization of bovine CD36 from the milk fat globule membrane."
      Berglund L., Petersen T.E., Ramussen J.T.
      Biochim. Biophys. Acta 1309:63-68(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION AT ASN-79; ASN-102; ASN-172; ASN-205; ASN-235; ASN-247; ASN-321 AND ASN-417.
      Tissue: Mammary gland.
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Heart ventricle.
    4. "Structural, functional, and antigenic differences between bovine heart endothelial CD36 and human platelet CD36."
      Greenwalt D.E., Watt K.W.K., Hasler T., Howard R.J., Patel S.
      J. Biol. Chem. 265:16296-16299(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-22, FUNCTION.
      Tissue: Heart.
    5. "PAS IV, an integral membrane protein of mammary epithelial cells, is related to platelet and endothelial cell CD36 (GP IV)."
      Greenwalt D.E., Watt K.W., So O.Y., Jiwani N.
      Biochemistry 29:7054-7059(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 4-22 AND 214-223.
      Tissue: Mammary epithelium.
    6. Cited for: DISULFIDE BONDS.
      Tissue: Milk.

    Entry informationi

    Entry nameiCD36_BOVIN
    AccessioniPrimary (citable) accession number: P26201
    Secondary accession number(s): P79111, Q28154, Q3ZBT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3