Platelet glycoprotein 4 - Bos taurus (Bovine)

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P26201 (CD36_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Platelet glycoprotein 4

Alternative name(s):
Glycoprotein IIIb
Short name=GPIIIB
PAS IV
PAS-4
Platelet glycoprotein IV
Short name=GPIV
CD_antigen=CD36

Gene names

Name:	CD36
Synonyms:	PAS4

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Ref.4
Subunit structure	Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the CD36 family.

Ontologies

Keywords
Biological process	Cell adhesion Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.4

Chain

2 – 472

471

Platelet glycoprotein 4

PRO_0000144150

Regions

Topological domain

2 – 7

Cytoplasmic Potential

Transmembrane

8 – 29

Helical; Potential

Topological domain

30 – 439

410

Extracellular Potential

Transmembrane

440 – 461

Helical; Potential

Topological domain

462 – 472

Cytoplasmic Potential

Region

93 – 120

Required for interaction with thrombospondins, THBS1 and THBS2

Amino acid modifications

Lipidation

S-palmitoyl cysteine By similarity

Lipidation

S-palmitoyl cysteine By similarity

Lipidation

464

S-palmitoyl cysteine By similarity

Lipidation

466

S-palmitoyl cysteine By similarity

Glycosylation

N-linked (GlcNAc...) Ref.2

Glycosylation

102

N-linked (GlcNAc...) Ref.2

Glycosylation

172

N-linked (GlcNAc...) Ref.2

Glycosylation

205

N-linked (GlcNAc...) Ref.2

Glycosylation

235

N-linked (GlcNAc...) Ref.2

Glycosylation

247

N-linked (GlcNAc...) Ref.2

Glycosylation

321

N-linked (GlcNAc...) Ref.2

Glycosylation

417

N-linked (GlcNAc...) Ref.2

Disulfide bond

Disulfide bond

Disulfide bond

Experimental info

Sequence conflict

K → N in CAA62803. Ref.2

Sequence conflict

110

H → N in BAA08224. Ref.1

Sequence conflict

125

S → L in BAA08224. Ref.1

Sequence conflict

134

T → K in BAA08224. Ref.1

Sequence conflict

257

F → L in BAA08224. Ref.1

Sequence conflict

294

I → V in BAA08224. Ref.1

Sequence conflict

305

Q → E in BAA08224. Ref.1

Sequence conflict

359

S → G in BAA08224. Ref.1

Sequence conflict

391 – 396

MLVKPA → TGQARQ in BAA08224. Ref.1

Sequence conflict

466

C → Y in BAA08224. Ref.1

Sequence conflict

470 – 472

RVN → TIK in BAA08224. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P26201 [UniParc].

Last modified January 23, 2007. Version 5.
Checksum: D864D6D3D6E8622F
Show »

FASTA

472

52,940

        10         20         30         40         50         60 
MGCNRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKK EVVLEEGTIA FKNWVKTGTD 

        70         80         90        100        110        120 
VYRQFWIFDV QNPDEVTVNS SKIKVKQRGP YTYRVRYLAK ENITQDPETH TVSFLQPNGA 

       130        140        150        160        170        180 
IFEPSLSVGT EDDTFTILNL AVAAAPQLYP NTFMQGILNS FIKKSKSSMF QNRTLKELLW 

       190        200        210        220        230        240 
GYTDPFLNLV PYPITTTIGV FYPYNNTADG IYKVFNGKDD ISKVAIIDTY KGRKNLSYWS 

       250        260        270        280        290        300 
SYCDLINGTD AASFPPFVEK TRVLQFFSSD ICRSIYAVFG AEINLKGIPV YRFILPSFAF 

       310        320        330        340        350        360 
ASPFQNPDNH CFCTEKIISK NCTLYGVLDI GKCKEGKPVY ISLPHFLHGS PELAEPIESL 

       370        380        390        400        410        420 
SPNEEEHSTY LDVEPITGFT LRFAKRLQVN MLVKPAKKIE ALKNLKHNYI VPILWLNETG 

       430        440        450        460        470 
TIGDEKAEMF RNQVTGKINL LGLVEIVLLS VGVVMFIAFM ISYCACRSKR VN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of PAS-4 from bovine fat globule membrane." Hwangbo S., Ametani M., Kanno C. Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Holstein. Tissue: Mammary gland.
[2]	"Structural characterization of bovine CD36 from the milk fat globule membrane." Berglund L., Petersen T.E., Ramussen J.T. Biochim. Biophys. Acta 1309:63-68(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION AT ASN-79; ASN-102; ASN-172; ASN-205; ASN-235; ASN-247; ASN-321 AND ASN-417. Tissue: Mammary gland.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.
[4]	"Structural, functional, and antigenic differences between bovine heart endothelial CD36 and human platelet CD36." Greenwalt D.E., Watt K.W.K., Hasler T., Howard R.J., Patel S. J. Biol. Chem. 265:16296-16299(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-22, FUNCTION. Tissue: Heart.
[5]	"PAS IV, an integral membrane protein of mammary epithelial cells, is related to platelet and endothelial cell CD36 (GP IV)." Greenwalt D.E., Watt K.W., So O.Y., Jiwani N. Biochemistry 29:7054-7059(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 4-22 AND 214-223. Tissue: Mammary epithelium.
[6]	"Assignment of disulfide bridges in bovine CD36." Rasmussen J.T., Berglund L., Rasmussen M.S., Petersen T.E. Eur. J. Biochem. 257:488-494(1998) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BONDS. Tissue: Milk.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D45364 mRNA. Translation: BAA08224.1. X91503 mRNA. Translation: CAA62803.1. BC103112 mRNA. Translation: AAI03113.1.
IPI	IPI00710204.
RefSeq	NP_776435.1. NM_174010.2.
UniGene	Bt.43948.
3D structure databases
ModBase	Search...
PTM databases
GlycoSuiteDB	P26201.
Proteomic databases
PaxDb	P26201.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000023750; ENSBTAP00000023750; ENSBTAG00000017866.
GeneID	281052.
KEGG	bta:281052.
Organism-specific databases
CTD	948.
Phylogenomic databases
eggNOG	NOG257244.
GeneTree	ENSGT00530000062927.
HOGENOM	HOG000252951.
HOVERGEN	HBG002754.
InParanoid	P26201.
KO	K06259.
OMA	KRNYIVP.
OrthoDB	EOG4KWJT5.
Enzyme and pathway databases
BioCyc	CATTLE:281052-MONOMER.
Family and domain databases
InterPro	IPR002159. CD36. IPR005428. CD36_antigen. [Graphical view]
PANTHER	PTHR11923. PTHR11923. 1 hit.
Pfam	PF01130. CD36. 1 hit. [Graphical view]
PRINTS	PR01610. CD36ANTIGEN. PR01609. CD36FAMILY.
ProtoNet	Search...
Other
NextBio	20805136.

Entry information

Entry name

CD36_BOVIN

Accession

Primary (citable) accession number: P26201
Secondary accession number(s): P79111, Q28154, Q3ZBT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 98 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Other

Entry information

Relevant documents