##gff-version 3 P26196 UniProtKB Chain 1 483 . . . ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6 P26196 UniProtKB Domain 127 298 . . . Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 P26196 UniProtKB Domain 308 468 . . . Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542 P26196 UniProtKB Region 1 40 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P26196 UniProtKB Region 286 316 . . . Note=Gyf binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31439631;Dbxref=PMID:31439631 P26196 UniProtKB Region 307 483 . . . Note=RecA-like domain 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31439631;Dbxref=PMID:31439631 P26196 UniProtKB Motif 96 124 . . . Note=Q motif P26196 UniProtKB Motif 246 249 . . . Note=DEAD box P26196 UniProtKB Compositional bias 1 23 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P26196 UniProtKB Binding site 140 147 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 P26196 UniProtKB Modified residue 36 36 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17525332;Dbxref=PMID:17525332 P26196 UniProtKB Natural variant 372 372 . . . ID=VAR_083368;Note=In IDDILF. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31422817;Dbxref=PMID:31422817 P26196 UniProtKB Natural variant 373 373 . . . ID=VAR_083369;Note=In IDDILF%3B decreased P-body assembly%3B decreased interaction with LSM14A%3B decreased interaction with LSM14B%3B decreased interaction with EIF4ENIF1/4E-T%3B decreased interaction with PATL1. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31422817;Dbxref=PMID:31422817 P26196 UniProtKB Natural variant 390 390 . . . ID=VAR_083370;Note=In IDDILF%3B decreased P-body assembly%3B decreased interaction with LSM14A%3B decreased interaction with LSM14B%3B decreased interaction with EIF4ENIF1/4E-T. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31422817;Dbxref=PMID:31422817 P26196 UniProtKB Natural variant 391 391 . . . ID=VAR_083371;Note=In IDDILF%3B decreased P-body assembly. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31422817;Dbxref=PMID:31422817 P26196 UniProtKB Natural variant 391 391 . . . ID=VAR_083372;Note=In IDDILF%3B decreased P-body assembly. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31422817;Dbxref=PMID:31422817 P26196 UniProtKB Mutagenesis 247 247 . . . Note=Abolished helicase activity and ability to regulate RNA metabolism. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27342281;Dbxref=PMID:27342281 P26196 UniProtKB Mutagenesis 320 320 . . . Note=Abolishes interaction with EDC3%3B when associated with A-323%3B A-327 and A-331. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 P26196 UniProtKB Mutagenesis 323 323 . . . Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-327 and A-331. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 P26196 UniProtKB Mutagenesis 324 324 . . . Note=In CL-AA%3B abolishes interaction with PATL1 and reduces interaction with GIGYF1 and GIGYF2%2C but has no affect on interaction with EDC3%2C EIF4ENIF1 and LSM14A%3B when associated with A-328. In 4xmut%3B abolishes interaction with EDC3%3B when associated with A-328%2C A-349 and A-353. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31439631;Dbxref=PMID:31439631 P26196 UniProtKB Mutagenesis 327 327 . . . Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-323 and A-331. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 P26196 UniProtKB Mutagenesis 328 328 . . . Note=In CL-AA%3B abolishes interaction with PATL1 and reduces interaction with GIGYF1 and GIGYF2%2C but has no affect on interaction with EDC3%2C EIF4ENIF1 and LSM14A%3B when associated with A-324. In 4xmut%3B abolishes interaction with EDC3%3B when associated with A-324%2C A-349 and A-353. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31439631;Dbxref=PMID:31439631 P26196 UniProtKB Mutagenesis 331 331 . . . Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-323 and A-327. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948 P26196 UniProtKB Mutagenesis 349 349 . . . Note=In LK-AA%3B abolishes interaction with PATL1 and reduces interaction with GIGYF1%2C GIGYF2%2C EDC3%2C EIF4ENIF1 and LSM14A%3B when associated with A-353. In 4xmut%3B abolishes interaction with EDC3%3B when associated with A-324%2C A-328 and A-353. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31439631;Dbxref=PMID:31439631 P26196 UniProtKB Mutagenesis 353 353 . . . Note=In LK-AA%3B abolishes interaction with PATL1 and reduces interaction with GIGYF1%2C GIGYF2%2C EDC3%2C EIF4ENIF1 and LSM14A%3B when associated with A-349. In 4xmut%3B abolishes interaction with EDC3%3B when associated with A-324%3B A-328 and A-349. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31439631;Dbxref=PMID:31439631 P26196 UniProtKB Mutagenesis 386 386 . . . Note=Abolished ability to regulate RNA metabolism. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27342281;Dbxref=PMID:27342281 P26196 UniProtKB Sequence conflict 293 293 . . . Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 P26196 UniProtKB Helix 98 100 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Helix 105 112 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Turn 113 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Helix 121 131 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 136 139 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 142 144 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Helix 147 157 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 167 170 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Helix 174 187 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Turn 188 190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 191 193 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 196 199 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 201 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Helix 205 211 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 217 221 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Helix 223 231 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 242 247 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Helix 248 251 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Turn 254 256 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Helix 257 266 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 272 278 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Helix 282 291 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 296 298 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VEC P26196 UniProtKB Beta strand 309 315 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Helix 318 320 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Helix 321 331 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Beta strand 335 340 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Helix 344 356 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Beta strand 361 364 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Beta strand 366 368 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Helix 370 381 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Beta strand 384 390 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Helix 397 399 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CT4 P26196 UniProtKB Beta strand 403 410 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Helix 415 422 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Helix 423 425 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Beta strand 432 438 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Helix 440 442 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Helix 443 453 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CRW P26196 UniProtKB Helix 462 465 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CT4 P26196 UniProtKB Helix 466 468 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6S8S