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Protein

Probable ATP-dependent RNA helicase DDX6

Gene

DDX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).2 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi140 – 147ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • cadherin binding Source: BHF-UCL
  • helicase activity Source: ProtInc
  • protein domain specific binding Source: BHF-UCL
  • RNA binding Source: UniProtKB
  • RNA helicase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.13 2681
ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
SIGNORiP26196

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX6Curated (EC:3.6.4.13Curated)
Alternative name(s):
ATP-dependent RNA helicase p54
DEAD box protein 6
Oncogene RCK
Gene namesi
Name:DDX6
Synonyms:HLR2, RCK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110367.11
HGNCiHGNC:2747 DDX6
MIMi600326 gene
neXtProtiNX_P26196

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi320Q → A: Abolishes interaction with EDC3; when associated with A-323; A-327 and A-331. 1 Publication1
Mutagenesisi323H → A: Abolishes interaction with EDC3; when associated with A-320; A-327 and A-331. 1 Publication1
Mutagenesisi327T → A: Abolishes interaction with EDC3; when associated with A-320; A-323 and A-331. 1 Publication1
Mutagenesisi331R → A: Abolishes interaction with EDC3; when associated with A-320; A-323 and A-327. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi1656
OpenTargetsiENSG00000110367
PharmGKBiPA27229

Chemistry databases

DrugBankiDB01694 D-tartaric acid

Polymorphism and mutation databases

BioMutaiDDX6
DMDMi116241327

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000549831 – 483Probable ATP-dependent RNA helicase DDX6Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphothreonineCombined sources1

Post-translational modificationi

Sumoylated (PubMed:26184334).1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP26196
MaxQBiP26196
PaxDbiP26196
PeptideAtlasiP26196
PRIDEiP26196

2D gel databases

DOSAC-COBS-2DPAGEiP26196

PTM databases

iPTMnetiP26196
PhosphoSitePlusiP26196
SwissPalmiP26196

Expressioni

Tissue specificityi

Abundantly expressed in most tissues.

Gene expression databases

BgeeiENSG00000110367
CleanExiHS_DDX6
ExpressionAtlasiP26196 baseline and differential
GenevisibleiP26196 HS

Organism-specific databases

HPAiCAB004668
HPA024201
HPA026644

Interactioni

Subunit structurei

Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS (PubMed:16364915, PubMed:19285948). Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599). Interacts with RC3H1 (By similarity). Interacts with ATXN2L (PubMed:23209657). Interacts with MCRIP1 (PubMed:26184334). Interacts with MCRIP2 (PubMed:26184334). Interacts with NUFIP2 (PubMed:26184334). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).By similarity7 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • protein domain specific binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi108022, 92 interactors
CORUMiP26196
DIPiDIP-29195N
IntActiP26196, 106 interactors
MINTiP26196
STRINGi9606.ENSP00000264018

Structurei

Secondary structure

1483
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi98 – 100Combined sources3
Helixi105 – 112Combined sources8
Turni113 – 115Combined sources3
Helixi121 – 131Combined sources11
Beta strandi136 – 139Combined sources4
Beta strandi142 – 144Combined sources3
Helixi147 – 157Combined sources11
Beta strandi167 – 170Combined sources4
Helixi174 – 187Combined sources14
Turni188 – 190Combined sources3
Beta strandi191 – 193Combined sources3
Beta strandi196 – 199Combined sources4
Beta strandi201 – 203Combined sources3
Helixi205 – 211Combined sources7
Beta strandi217 – 221Combined sources5
Helixi223 – 231Combined sources9
Beta strandi242 – 247Combined sources6
Helixi248 – 251Combined sources4
Turni254 – 256Combined sources3
Helixi257 – 266Combined sources10
Beta strandi272 – 278Combined sources7
Helixi282 – 291Combined sources10
Beta strandi296 – 298Combined sources3
Beta strandi309 – 315Combined sources7
Helixi318 – 320Combined sources3
Helixi321 – 331Combined sources11
Beta strandi335 – 340Combined sources6
Helixi344 – 356Combined sources13
Beta strandi361 – 364Combined sources4
Beta strandi366 – 368Combined sources3
Helixi370 – 381Combined sources12
Beta strandi384 – 390Combined sources7
Helixi397 – 399Combined sources3
Beta strandi403 – 410Combined sources8
Helixi415 – 422Combined sources8
Helixi423 – 425Combined sources3
Beta strandi432 – 438Combined sources7
Helixi440 – 442Combined sources3
Helixi443 – 453Combined sources11
Helixi462 – 465Combined sources4
Helixi466 – 468Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VECX-ray2.01A/B94-299[»]
2WAXX-ray2.30A/C296-483[»]
2WAYX-ray2.30A/C296-483[»]
4CRWX-ray1.75B307-483[»]
4CT4X-ray2.30B/D95-469[»]
4CT5X-ray3.00A/B95-469[»]
5ANRX-ray2.10B95-469[»]
6F9SX-ray3.03A301-469[»]
ProteinModelPortaliP26196
SMRiP26196
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26196

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 298Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST172
Domaini308 – 468Helicase C-terminalPROSITE-ProRule annotationAdd BLAST161

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 124Q motifAdd BLAST29
Motifi246 – 249DEAD box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0326 Eukaryota
ENOG410XRAZ LUCA
GeneTreeiENSGT00900000141067
HOGENOMiHOG000268797
HOVERGENiHBG106685
InParanoidiP26196
KOiK12614
OMAiDWNLMSS
OrthoDBiEOG091G0623
PhylomeDBiP26196
TreeFamiTF300440

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

P26196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTARTENPV IMGLSSQNGQ LRGPVKPTGG PGGGGTQTQQ QMNQLKNTNT
60 70 80 90 100
INNGTQQQAQ SMTTTIKPGD DWKKTLKLPP KDLRIKTSDV TSTKGNEFED
110 120 130 140 150
YCLKRELLMG IFEMGWEKPS PIQEESIPIA LSGRDILARA KNGTGKSGAY
160 170 180 190 200
LIPLLERLDL KKDNIQAMVI VPTRELALQV SQICIQVSKH MGGAKVMATT
210 220 230 240 250
GGTNLRDDIM RLDDTVHVVI ATPGRILDLI KKGVAKVDHV QMIVLDEADK
260 270 280 290 300
LLSQDFVQIM EDIILTLPKN RQILLYSATF PLSVQKFMNS HLQKPYEINL
310 320 330 340 350
MEELTLKGVT QYYAYVTERQ KVHCLNTLFS RLQINQSIIF CNSSQRVELL
360 370 380 390 400
AKKISQLGYS CFYIHAKMRQ EHRNRVFHDF RNGLCRNLVC TDLFTRGIDI
410 420 430 440 450
QAVNVVINFD FPKLAETYLH RIGRSGRFGH LGLAINLITY DDRFNLKSIE
460 470 480
EQLGTEIKPI PSNIDKSLYV AEYHSEPVED EKP
Length:483
Mass (Da):54,417
Last modified:October 17, 2006 - v2
Checksum:iF802C642861793FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293Q → E in Z11685 (PubMed:1579499).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11685 mRNA No translation available.
BC065007 mRNA Translation: AAH65007.1
D17532 mRNA Translation: BAA04482.1
CCDSiCCDS44751.1
PIRiS22651
RefSeqiNP_001244120.1, NM_001257191.2
NP_004388.2, NM_004397.5
XP_005271474.1, XM_005271417.3
UniGeneiHs.408461

Genome annotation databases

EnsembliENST00000526070; ENSP00000433704; ENSG00000110367
ENST00000534980; ENSP00000442266; ENSG00000110367
ENST00000620157; ENSP00000478754; ENSG00000110367
GeneIDi1656
KEGGihsa:1656
UCSCiuc031ygs.2 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiDDX6_HUMAN
AccessioniPrimary (citable) accession number: P26196
Secondary accession number(s): Q5D048
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 193 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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