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P26191

- VP2_ROTPC

UniProt

P26191 - VP2_ROTPC

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Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Taxonomic identifieri10916 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000008175: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
  2. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 872872Inner capsid protein VP2PRO_0000149534Add
BLAST

Interactioni

Subunit structurei

Dimer Reviewed prediction. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9696Interaction with VP1 and VP3 By similarityAdd
BLAST
Regioni417 – 43620Hydrophobic By similarityAdd
BLAST
Regioni494 – 51320Hydrophobic By similarityAdd
BLAST

Domaini

The N-terminus is involved in VP1 binding By similarity.

Sequence similaritiesi

Belongs to the rotavirus VP2 family.

Family and domain databases

InterProiIPR007779. Rotavirus_VP2.
[Graphical view]
PfamiPF05087. Rota_VP2. 1 hit.
[Graphical view]
ProDomiPD008866. Rota_VP2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P26191-1 [UniParc]FASTAAdd to Basket

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MISRNRRRNT QQKDAEKEKQ TENVEEKEIK EAKEQVKDEK QVITEENVDS    50
PKDVKEQSNT VNLQKNDLVK EVINIQNQTL NTIVAENKVE IEEVVKKYIP 100
SYSTDKLIVK NYRNSRIKCQ TYNKLFRLLH VKSYLYDVNG EKKLSTRWYW 150
KLLKDDLPAG DYSVRQFFLS LYLNVLDEMP DYVMLRDMAV DNPYSAEAGK 200
IVDEKSKEIL VEIYQDQMTE GYIRRYMSDL RHRISGETNT AKYPAILHPV 250
DEELNKYFLE HQLIQPLTTR NIAELIPTQL YHDPNYVFNI DAAFLTNSRF 300
VPPYLTQDRI GLHDGFESIW DAKTHADYVS ARRFVPDLTE LVDAEKQMKE 350
MLQCKLNHNS WQELVHGRNE AFKFIIGTVL STRTIAVEFI TSNYMSLASC 400
MYLMTIMPSE IFLRESLVAM QLAVINTLIY PALGLAQMHY QAGEIRRLEL 450
AEMQVANRPI RQWLHHCNTL QFGRQVTEGV THLRFTNDIM TGRIVNLFST 500
MLVALSSQPF ATYPLDYKRS VQRALQLLSN RTAQIADLTR LIVYNYTTLS 550
ACIVMNMHLV GTLTVERIQA TALTSLIMLI SNKTVIPEPS SLFSYFSSNI 600
NFLTNYNEQI DNVVAEIMAA YRLDLYQQKM LMLVTRFVSR LYIFDAPKIP 650
PDQMYRLRNR LRNIPVERRR ADVFRIIMNN RDLIEKTSER ICQGVLLSYS 700
PMPLTYVEDV GLTNVVNDTN GFQIINIEEI EKTGDYSAIT NALLRDTPII 750
LKGAIPYVTN SSVIDVLSKI DTTVFASIVK DRDISKLKPI KFTINSDSSE 800
YYLVHNNKWT PTTTTAVYKA RSQQFNIQHS VSMLESNLFF VVYNDLFKYI 850
KTTTVLPINA VSYDGARIMQ ET 872
Length:872
Mass (Da):101,019
Last modified:May 1, 1992 - v1
Checksum:i1AB1EF62AB9F51AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74217 Unassigned DNA. Translation: AAA19561.1.
PIRiB40822. P2XRCW.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74217 Unassigned DNA. Translation: AAA19561.1 .
PIRi B40822. P2XRCW.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007779. Rotavirus_VP2.
[Graphical view ]
Pfami PF05087. Rota_VP2. 1 hit.
[Graphical view ]
ProDomi PD008866. Rota_VP2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Sequences of the four larger proteins of a porcine group C rotavirus and comparison with the equivalent group A rotavirus proteins."
    Bremont M., Juste-Lesage P., Chabanne-Vautherot D., Charpilienne A., Cohen J.
    Virology 186:684-692(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTPC
AccessioniPrimary (citable) accession number: P26191
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 16, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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