Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P26191

- VP2_ROTPC

UniProt

P26191 - VP2_ROTPC

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
    Taxonomic identifieri10916 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiSus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000008175: Genome

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW
    2. viral nucleocapsid Source: InterPro

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 872872Inner capsid protein VP2PRO_0000149534Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9696Interaction with VP1 and VP3By similarityAdd
    BLAST
    Regioni417 – 43620HydrophobicBy similarityAdd
    BLAST
    Regioni494 – 51320HydrophobicBy similarityAdd
    BLAST

    Domaini

    The N-terminus is involved in VP1 binding.By similarity

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Family and domain databases

    InterProiIPR007779. Rotavirus_VP2.
    [Graphical view]
    PfamiPF05087. Rota_VP2. 1 hit.
    [Graphical view]
    ProDomiPD008866. Rota_VP2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P26191-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISRNRRRNT QQKDAEKEKQ TENVEEKEIK EAKEQVKDEK QVITEENVDS    50
    PKDVKEQSNT VNLQKNDLVK EVINIQNQTL NTIVAENKVE IEEVVKKYIP 100
    SYSTDKLIVK NYRNSRIKCQ TYNKLFRLLH VKSYLYDVNG EKKLSTRWYW 150
    KLLKDDLPAG DYSVRQFFLS LYLNVLDEMP DYVMLRDMAV DNPYSAEAGK 200
    IVDEKSKEIL VEIYQDQMTE GYIRRYMSDL RHRISGETNT AKYPAILHPV 250
    DEELNKYFLE HQLIQPLTTR NIAELIPTQL YHDPNYVFNI DAAFLTNSRF 300
    VPPYLTQDRI GLHDGFESIW DAKTHADYVS ARRFVPDLTE LVDAEKQMKE 350
    MLQCKLNHNS WQELVHGRNE AFKFIIGTVL STRTIAVEFI TSNYMSLASC 400
    MYLMTIMPSE IFLRESLVAM QLAVINTLIY PALGLAQMHY QAGEIRRLEL 450
    AEMQVANRPI RQWLHHCNTL QFGRQVTEGV THLRFTNDIM TGRIVNLFST 500
    MLVALSSQPF ATYPLDYKRS VQRALQLLSN RTAQIADLTR LIVYNYTTLS 550
    ACIVMNMHLV GTLTVERIQA TALTSLIMLI SNKTVIPEPS SLFSYFSSNI 600
    NFLTNYNEQI DNVVAEIMAA YRLDLYQQKM LMLVTRFVSR LYIFDAPKIP 650
    PDQMYRLRNR LRNIPVERRR ADVFRIIMNN RDLIEKTSER ICQGVLLSYS 700
    PMPLTYVEDV GLTNVVNDTN GFQIINIEEI EKTGDYSAIT NALLRDTPII 750
    LKGAIPYVTN SSVIDVLSKI DTTVFASIVK DRDISKLKPI KFTINSDSSE 800
    YYLVHNNKWT PTTTTAVYKA RSQQFNIQHS VSMLESNLFF VVYNDLFKYI 850
    KTTTVLPINA VSYDGARIMQ ET 872
    Length:872
    Mass (Da):101,019
    Last modified:May 1, 1992 - v1
    Checksum:i1AB1EF62AB9F51AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74217 Unassigned DNA. Translation: AAA19561.1.
    PIRiB40822. P2XRCW.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74217 Unassigned DNA. Translation: AAA19561.1 .
    PIRi B40822. P2XRCW.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007779. Rotavirus_VP2.
    [Graphical view ]
    Pfami PF05087. Rota_VP2. 1 hit.
    [Graphical view ]
    ProDomi PD008866. Rota_VP2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences of the four larger proteins of a porcine group C rotavirus and comparison with the equivalent group A rotavirus proteins."
      Bremont M., Juste-Lesage P., Chabanne-Vautherot D., Charpilienne A., Cohen J.
      Virology 186:684-692(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP2_ROTPC
    AccessioniPrimary (citable) accession number: P26191
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3