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Protein

High affinity immunoglobulin gamma Fc receptor I

Gene

Fcgr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.2 Publications

GO - Molecular functioni

  • IgG binding Source: MGI
  • IgG receptor activity Source: MGI

GO - Biological processi

  • antibody-dependent cellular cytotoxicity Source: MGI
  • antigen processing and presentation of exogenous antigen Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • defense response to bacterium Source: MGI
  • Fc-gamma receptor signaling pathway Source: GOC
  • innate immune response Source: UniProtKB-KW
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
  • positive regulation of type III hypersensitivity Source: MGI
  • receptor-mediated endocytosis Source: MGI
  • regulation of immune response Source: MGI
  • response to bacterium Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

IgG-binding protein

Enzyme and pathway databases

ReactomeiR-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-MMU-2029481. FCGR activation.
R-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-2029485. Role of phospholipids in phagocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin gamma Fc receptor I
Short name:
IgG Fc receptor I
Alternative name(s):
Fc-gamma RI
Short name:
FcRI
CD_antigen: CD64
Gene namesi
Name:Fcgr1
Synonyms:Fcg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95498. Fcgr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 297273ExtracellularSequence analysisAdd
BLAST
Transmembranei298 – 32023HelicalSequence analysisAdd
BLAST
Topological domaini321 – 40484CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

According to PubMed:11911823, mice display altered endocytosis of monomeric IgG and impaired antibody-dependent killing of cells by macrophage. Antigen presentation is also affected and those mice develop only reduced inflammatory responses. An increased in IgG responses is also detected associated with an increased number of antibody-forming cells. PubMed:11911824, also reported that a variety of IgG2a-immune complex-dependent immune functions like protection against bacterial infection were impaired.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 404380High affinity immunoglobulin gamma Fc receptor IPRO_0000015140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi53 ↔ 95PROSITE-ProRule annotation
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi134 ↔ 177PROSITE-ProRule annotation
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Disulfide bondi221 ↔ 269PROSITE-ProRule annotation
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence analysis
Modified residuei347 – 3471PhosphoserineCombined sources
Modified residuei368 – 3681PhosphothreonineCombined sources

Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated on serine residues.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP26151.
PaxDbiP26151.
PRIDEiP26151.

PTM databases

iPTMnetiP26151.
PhosphoSiteiP26151.

Expressioni

Tissue specificityi

Macrophage-specific.

Gene expression databases

BgeeiP26151.
CleanExiMM_FCGR1.
ExpressionAtlasiP26151. baseline and differential.
GenevisibleiP26151. MM.

Interactioni

Subunit structurei

Interacts with FCERG1; forms a functional signaling complex (By similarity). Interacts with FLNA; prevents FCGR1A degradation (By similarity). Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN (By similarity).By similarity

GO - Molecular functioni

  • IgG binding Source: MGI

Protein-protein interaction databases

BioGridi199618. 1 interaction.
STRINGi10090.ENSMUSP00000029748.

Structurei

3D structure databases

ProteinModelPortaliP26151.
SMRiP26151. Positions 31-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 11180Ig-like C2-type 1Add
BLAST
Domaini117 – 19478Ig-like C2-type 2Add
BLAST
Domaini201 – 28686Ig-like C2-type 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni321 – 34222Interaction with EPB41L2By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVK2. Eukaryota.
ENOG410YF57. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP26151.
KOiK06498.
OMAiEYHIARA.
OrthoDBiEOG72C50S.
PhylomeDBiP26151.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILTSFGDDM WLLTTLLLWV PVGGEVVNAT KAVITLQPPW VSIFQKENVT
60 70 80 90 100
LWCEGPHLPG DSSTQWFING TAVQISTPSY SIPEASFQDS GEYRCQIGSS
110 120 130 140 150
MPSDPVQLQI HNDWLLLQAS RRVLTEGEPL ALRCHGWKNK LVYNVVFYRN
160 170 180 190 200
GKSFQFSSDS EVAILKTNLS HSGIYHCSGT GRHRYTSAGV SITVKELFTT
210 220 230 240 250
PVLRASVSSP FPEGSLVTLN CETNLLLQRP GLQLHFSFYV GSKILEYRNT
260 270 280 290 300
SSEYHIARAE REDAGFYWCE VATEDSSVLK RSPELELQVL GPQSSAPVWF
310 320 330 340 350
HILFYLSVGI MFSLNTVLYV KIHRLQREKK YNLEVPLVSE QGKKANSFQQ
360 370 380 390 400
VRSDGVYEEV TATASQTTPK EAPDGPRSSV GDCGPEQPEP LPPSDSTGAQ

TSQS
Length:404
Mass (Da):44,888
Last modified:May 1, 1992 - v1
Checksum:i1C4F0033842767E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31314 mRNA. Translation: AAA40056.1.
CCDSiCCDS17639.1.
PIRiA46480.
RefSeqiNP_034316.1. NM_010186.5.
UniGeneiMm.150.

Genome annotation databases

EnsembliENSMUST00000029748; ENSMUSP00000029748; ENSMUSG00000015947.
GeneIDi14129.
KEGGimmu:14129.
UCSCiuc008qmr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31314 mRNA. Translation: AAA40056.1.
CCDSiCCDS17639.1.
PIRiA46480.
RefSeqiNP_034316.1. NM_010186.5.
UniGeneiMm.150.

3D structure databases

ProteinModelPortaliP26151.
SMRiP26151. Positions 31-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199618. 1 interaction.
STRINGi10090.ENSMUSP00000029748.

PTM databases

iPTMnetiP26151.
PhosphoSiteiP26151.

Proteomic databases

MaxQBiP26151.
PaxDbiP26151.
PRIDEiP26151.

Protocols and materials databases

DNASUi14129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029748; ENSMUSP00000029748; ENSMUSG00000015947.
GeneIDi14129.
KEGGimmu:14129.
UCSCiuc008qmr.1. mouse.

Organism-specific databases

CTDi14129.
MGIiMGI:95498. Fcgr1.

Phylogenomic databases

eggNOGiENOG410IVK2. Eukaryota.
ENOG410YF57. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP26151.
KOiK06498.
OMAiEYHIARA.
OrthoDBiEOG72C50S.
PhylomeDBiP26151.
TreeFamiTF335097.

Enzyme and pathway databases

ReactomeiR-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-MMU-2029481. FCGR activation.
R-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-2029485. Role of phospholipids in phagocytosis.

Miscellaneous databases

PROiP26151.
SOURCEiSearch...

Gene expression databases

BgeeiP26151.
CleanExiMM_FCGR1.
ExpressionAtlasiP26151. baseline and differential.
GenevisibleiP26151. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of the mouse high affinity Fc receptor for IgG."
    Sears D.W., Osman N., Tate B., McKenzie I.F.C., Hogarth P.M.
    J. Immunol. 144:371-378(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and mapping of the gene encoding mouse high affinity Fc gamma RI and chromosomal location of the human Fc gamma RI gene."
    Osman N., Kozak C.A., McKenzie I.F.C., Hogarth P.M.
    J. Immunol. 148:1570-1575(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Biochemical characterization of murine Fc gamma RI."
    Quilliam A.L., Osman N., McKenzie I.F.C., Hogarth P.M.
    Immunology 78:358-363(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, PHOSPHORYLATION.
  4. "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347 AND THR-368, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFCGR1_MOUSE
AccessioniPrimary (citable) accession number: P26151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 8, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.