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P26114 (PB2_I77AC) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polymerase basic protein 2
Alternative name(s):
RNA-directed RNA polymerase subunit P3
Gene names
Name:PB2
OrganismInfluenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
Taxonomic identifier385606 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length759 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication By similarity.

Subunit structure

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.

Subcellular location

Virion. Host nucleus. Host mitochondrion By similarity.

Sequence similarities

Belongs to the influenza viruses PB2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 759759Polymerase basic protein 2
PRO_0000078843

Regions

Motif736 – 7394Nuclear localization signal By similarity

Sequences

Sequence LengthMass (Da)Tools
P26114 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: CC0B1677BC5FB80B

FASTA75985,732
        10         20         30         40         50         60 
MERIKELRNL MSQSRTRGIL TRTTVDHMAI IKKYTSGRQE KNPALRMKWM MAMKYPITAD 

        70         80         90        100        110        120 
KRITETIPER NEQGQTLWSR TSDAGSDRVM VSPLAVTWWN RNGPTASTIH YPKVYRTYFE 

       130        140        150        160        170        180 
KVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSSKEAQ DVIMEVVFPN EVGARILTSE 

       190        200        210        220        230        240 
SQLMITKEKK EELQECKISP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGACW 

       250        260        270        280        290        300 
EQLYTPGGEV RNDDVDQSLI IAARSIVRRA TVSADPLASL LEMCHSTQIG GVRMVDILKQ 

       310        320        330        340        350        360 
NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSTKR EEEVLTGNLQ TLKIRVHEGY 

       370        380        390        400        410        420 
EEFTMVGKKA TAILRKATRR LVQLIVSGRD EQSIAEAIIV AMVFSQEDCV IKAVRGDLNF 

       430        440        450        460        470        480 
VNRANQRLNP MHQLLRHFQK DAKILFQNWG IESIDNVMGM IGILPDLTPS TEKSMRGIRI 

       490        500        510        520        530        540 
SKMGVDEYSS TERVVVSIDR FLRVRDQQGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEVN 

       550        560        570        580        590        600 
GPESVLVNTY QWIIRNWETV KIQWSQDPTM LYNKMEFEPF QSLVPKAARG QYSGFVRTLF 

       610        620        630        640        650        660 
QQMRDVLGTF DTVQIIKLLP FAAAPPKQSR MQFSSLTVNV RGSGMRILIR GNSPVFNYNK 

       670        680        690        700        710        720 
STKRLTVLGK DAGALNEDPD EGTAGVESAV LRGFLILGRE DRRYGPALSI NQLSSLAKGE 

       730        740        750 
KANVLIGQGD VVLVMKRKRD SSILTDSQTA TKRIRMAIN 

« Hide

References

[1]"Evolution of influenza A virus PB2 genes: implications for evolution of the ribonucleoprotein complex and origin of human influenza A virus."
Gorman O.T., Donis R.O., Kawaoka Y., Webster R.G.
J. Virol. 64:4893-4902(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73513 Genomic RNA. Translation: AAA43125.1.

3D structure databases

ProteinModelPortalP26114.
SMRP26114. Positions 319-483, 685-759.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001591. RNA_pol_PB2_orthomyxovir.
[Graphical view]
PfamPF00604. Flu_PB2. 1 hit.
[Graphical view]
ProDomPD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry namePB2_I77AC
AccessionPrimary (citable) accession number: P26114
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families