PB2

Functionⁱ

Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.By similarity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Polymerase basic protein 2 Alternative name(s): RNA-directed RNA polymerase subunit P3
Gene namesⁱ	Name:PB2
Organismⁱ	Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
Taxonomic identifierⁱ	385606 [NCBI]
Taxonomic lineageⁱ	Viruses › ssRNA viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A › Influenza A virus › H1N1 subtype
Virus hostⁱ	Aves [TaxID: 8782] Homo sapiens (Human) [TaxID: 9606] Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationⁱ

Virion. Host nucleus By similarity. Host mitochondrion By similarity

GO - Cellular componentⁱ

host cell mitochondrion Source: UniProtKB-SubCell
host cell nucleus Source: UniProtKB-SubCell
virion Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Host mitochondrion, Host nucleus, Virion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 759	759	Polymerase basic protein 2		PRO_0000078843	Add BLAST

Interactionⁱ

Subunit structureⁱ

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts (via N-terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response.By similarity

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P26114.
SMRⁱ	P26114. Positions 319-483, 685-759.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Motifⁱ	736 – 739	4	Nuclear localization signalBy similarity

Sequence similaritiesⁱ

Belongs to the influenza viruses PB2 family.Curated

Family and domain databases

InterProⁱ	IPR001591. RNA_pol_PB2_orthomyxovir. [Graphical view]
Pfamⁱ	PF00604. Flu_PB2. 1 hit. [Graphical view]
ProDomⁱ	PD001667. RNA_pol_PB2_orthomyxovir. 1 hit. [Graphical view] [Entries sharing at least one domain]

Sequenceⁱ

Sequence statusⁱ: Complete.

P26114-1 [UniParc]FASTA Add to Basket

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        10         20         30         40         50
MERIKELRNL MSQSRTRGIL TRTTVDHMAI IKKYTSGRQE KNPALRMKWM 
        60         70         80         90        100
MAMKYPITAD KRITETIPER NEQGQTLWSR TSDAGSDRVM VSPLAVTWWN 
       110        120        130        140        150
RNGPTASTIH YPKVYRTYFE KVERLKHGTF GPVHFRNQVK IRRRVDINPG 
       160        170        180        190        200
HADLSSKEAQ DVIMEVVFPN EVGARILTSE SQLMITKEKK EELQECKISP 
       210        220        230        240        250
LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGACW EQLYTPGGEV 
       260        270        280        290        300
RNDDVDQSLI IAARSIVRRA TVSADPLASL LEMCHSTQIG GVRMVDILKQ 
       310        320        330        340        350
NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSTKR EEEVLTGNLQ 
       360        370        380        390        400
TLKIRVHEGY EEFTMVGKKA TAILRKATRR LVQLIVSGRD EQSIAEAIIV 
       410        420        430        440        450
AMVFSQEDCV IKAVRGDLNF VNRANQRLNP MHQLLRHFQK DAKILFQNWG 
       460        470        480        490        500
IESIDNVMGM IGILPDLTPS TEKSMRGIRI SKMGVDEYSS TERVVVSIDR 
       510        520        530        540        550
FLRVRDQQGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEVN GPESVLVNTY 
       560        570        580        590        600
QWIIRNWETV KIQWSQDPTM LYNKMEFEPF QSLVPKAARG QYSGFVRTLF 
       610        620        630        640        650
QQMRDVLGTF DTVQIIKLLP FAAAPPKQSR MQFSSLTVNV RGSGMRILIR 
       660        670        680        690        700
GNSPVFNYNK STKRLTVLGK DAGALNEDPD EGTAGVESAV LRGFLILGRE 
       710        720        730        740        750
DRRYGPALSI NQLSSLAKGE KANVLIGQGD VVLVMKRKRD SSILTDSQTA 

TKRIRMAIN

Length:759

Mass (Da):85,732

Last modified:May 1, 1992 - v1

Checksum:ⁱCC0B1677BC5FB80B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M73513 Genomic RNA. Translation: AAA43125.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

M73513 Genomic RNA. Translation: AAA43125.1.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M73513 Genomic RNA. Translation: AAA43125.1 .

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

M73513 Genomic RNA. Translation: AAA43125.1 .

3D structure databases

ProteinModelPortalⁱ	P26114.
SMRⁱ	P26114. Positions 319-483, 685-759.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

InterProⁱ	IPR001591. RNA_pol_PB2_orthomyxovir. [Graphical view ]
Pfamⁱ	PF00604. Flu_PB2. 1 hit. [Graphical view ]
ProDomⁱ	PD001667. RNA_pol_PB2_orthomyxovir. 1 hit. [Graphical view ] [Entries sharing at least one domain ]
ProtoNetⁱ	Search...

Publicationsⁱ

"Evolution of influenza A virus PB2 genes: implications for evolution of the ribonucleoprotein complex and origin of human influenza A virus."
Gorman O.T., Donis R.O., Kawaoka Y., Webster R.G.
J. Virol. 64:4893-4902(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationⁱ

Entry nameⁱ

PB2_I77AC

Accessionⁱ

Primary (citable) accession number: P26114

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	January 7, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program

Miscellaneousⁱ

Documents

SIMILARITY comments
Index of protein domains and families

External Data

Dasty 3

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

Proteomes

UniRef

Supporting data

UniParc

Help

P26114

- PB2_I77AC

UniProt

P26114 - PB2_I77AC

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Polymerase basic protein 2

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

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<p>Provides information on the tertiary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

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Family and domain databases

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Sequence databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p> Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Publicationsⁱ

Entry informationⁱ

Miscellaneousⁱ