UniProtKB - P26114 (PB2_I77AC)
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Protein
Polymerase basic protein 2
Gene
PB2
Organism
Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
Status
Functioni
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 627 | Mammalian adaptationUniRule annotation | 1 |
GO - Molecular functioni
- RNA binding Source: InterPro
GO - Biological processi
- 7-methylguanosine mRNA capping Source: UniProtKB-KW
- cap snatching Source: UniProtKB-KW
- suppression by virus of host MAVS activity Source: UniProtKB-KW
- suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
- transcription, DNA-templated Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Polymerase basic protein 2UniRule annotationAlternative name(s): RNA-directed RNA polymerase subunit P3UniRule annotation |
Gene namesi | Name:PB2UniRule annotation |
Organismi | Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1) |
Taxonomic identifieri | 385606 [NCBI] |
Taxonomic lineagei | Viruses › ssRNA viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A › |
Virus hosti | Aves [TaxID: 8782] Homo sapiens (Human) [TaxID: 9606] Sus scrofa (Pig) [TaxID: 9823] |
Subcellular locationi
- Virion UniRule annotation
- Host nucleus UniRule annotation
- Host mitochondrion UniRule annotation
GO - Cellular componenti
- host cell mitochondrion Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
- virion Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host mitochondrion, Host nucleus, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000078843 | 1 – 759 | Polymerase basic protein 2Add BLAST | 759 |
Interactioni
Subunit structurei
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts (via N-terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response.UniRule annotation
Structurei
3D structure databases
ProteinModelPortali | P26114. |
SMRi | P26114. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 736 – 739 | Nuclear localization signalUniRule annotation | 4 |
Sequence similaritiesi
Belongs to the influenza viruses PB2 family.UniRule annotation
Family and domain databases
Gene3Di | 3.30.30.90. 1 hit. |
HAMAPi | MF_04062. INV_PB2. 1 hit. |
InterProi | View protein in InterPro IPR001591. INV_PB2. IPR037258. PDB2_C. |
Pfami | View protein in Pfam PF00604. Flu_PB2. 1 hit. |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD001667. RNA_pol_PB2_orthomyxovir. 1 hit. |
SUPFAMi | SSF160453. SSF160453. 1 hit. |
i Sequence
Sequence statusi: Complete.
P26114-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERIKELRNL MSQSRTRGIL TRTTVDHMAI IKKYTSGRQE KNPALRMKWM
60 70 80 90 100
MAMKYPITAD KRITETIPER NEQGQTLWSR TSDAGSDRVM VSPLAVTWWN
110 120 130 140 150
RNGPTASTIH YPKVYRTYFE KVERLKHGTF GPVHFRNQVK IRRRVDINPG
160 170 180 190 200
HADLSSKEAQ DVIMEVVFPN EVGARILTSE SQLMITKEKK EELQECKISP
210 220 230 240 250
LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGACW EQLYTPGGEV
260 270 280 290 300
RNDDVDQSLI IAARSIVRRA TVSADPLASL LEMCHSTQIG GVRMVDILKQ
310 320 330 340 350
NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSTKR EEEVLTGNLQ
360 370 380 390 400
TLKIRVHEGY EEFTMVGKKA TAILRKATRR LVQLIVSGRD EQSIAEAIIV
410 420 430 440 450
AMVFSQEDCV IKAVRGDLNF VNRANQRLNP MHQLLRHFQK DAKILFQNWG
460 470 480 490 500
IESIDNVMGM IGILPDLTPS TEKSMRGIRI SKMGVDEYSS TERVVVSIDR
510 520 530 540 550
FLRVRDQQGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEVN GPESVLVNTY
560 570 580 590 600
QWIIRNWETV KIQWSQDPTM LYNKMEFEPF QSLVPKAARG QYSGFVRTLF
610 620 630 640 650
QQMRDVLGTF DTVQIIKLLP FAAAPPKQSR MQFSSLTVNV RGSGMRILIR
660 670 680 690 700
GNSPVFNYNK STKRLTVLGK DAGALNEDPD EGTAGVESAV LRGFLILGRE
710 720 730 740 750
DRRYGPALSI NQLSSLAKGE KANVLIGQGD VVLVMKRKRD SSILTDSQTA
TKRIRMAIN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73513 Genomic RNA. Translation: AAA43125.1. |
Similar proteinsi
Entry informationi
Entry namei | PB2_I77AC | |
Accessioni | P26114Primary (citable) accession number: P26114 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | March 28, 2018 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |