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P26113 (PB2_I30A0) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polymerase basic protein 2
Alternative name(s):
RNA-directed RNA polymerase subunit P3
Gene names
Name:PB2
OrganismInfluenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
Taxonomic identifier380342 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length759 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication By similarity.

Subunit structure

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.

Subcellular location

Virion. Host nucleus. Host mitochondrion By similarity.

Sequence similarities

Belongs to the influenza viruses PB2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 759759Polymerase basic protein 2
PRO_0000078842

Regions

Motif736 – 7394Nuclear localization signal By similarity

Sequences

Sequence LengthMass (Da)Tools
P26113 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 1BE5F0592355CBDA

FASTA75985,806
        10         20         30         40         50         60 
MERIKELRDL MSQSRTREIL TRTTVDHMAI IKKYTSGRQE KNPALRMKWM MAMKYPITAD 

        70         80         90        100        110        120 
KRIIETIPER NEQGQTLWSK TSDAGSDRVM VSPLAVTWWN RNGPTTSTVH YPKIYKTYFE 

       130        140        150        160        170        180 
KAERLKHGTF GPVHFGNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE 

       190        200        210        220        230        240 
SQLMITKEKK EELQDCKISP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW 

       250        260        270        280        290        300 
EQLYTPGGEV RNDDVDQSLI IAARSIVRRA TVSADPLASL LEMCHSTQIG GIRMVDILRQ 

       310        320        330        340        350        360 
NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKK EEEVLTGNLQ TLKIRVHEGY 

       370        380        390        400        410        420 
EEFTMVGRRA TAILRKATRR LVQLIVSGRD EQSIAEAIIV AMVFSQEDCM IKAVRGDLNF 

       430        440        450        460        470        480 
INRANQRLNP MHQLLRHFQK DAKVLFQNWG IEPIDNVMGM IGILPDLTPS TEMSMRGVRI 

       490        500        510        520        530        540 
SKMGVDEYSS TERVVVSIDR FLRVRDQRGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEVN 

       550        560        570        580        590        600 
GPESVLVNTY QWIIRNWETV KIQWSQDPTM LYNKMEFEPF QSLVPKAARG QYSGFVRTLF 

       610        620        630        640        650        660 
QQMRDVLGTF DTVQIIKLLP FAAAPPKQSR MQFSSLAVNV RGSGMRILVR GNSPVFNYNR 

       670        680        690        700        710        720 
TTKRLTVLGK DAGALTEDPD EGTTGVESAV LRGFLILGKE DRRYGPALSI NELSNLAKGE 

       730        740        750 
KANVLIGQGD VVLVMKRKRD SSILTDSQTA TKRIRMAIN 

« Hide

References

[1]"Evolution of influenza A virus PB2 genes: implications for evolution of the ribonucleoprotein complex and origin of human influenza A virus."
Gorman O.T., Donis R.O., Kawaoka Y., Webster R.G.
J. Virol. 64:4893-4902(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73515 Genomic RNA. Translation: AAA43126.1.

3D structure databases

ProteinModelPortalP26113.
SMRP26113. Positions 319-483, 685-759.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001591. RNA_pol_PB2_orthomyxovir.
[Graphical view]
PfamPF00604. Flu_PB2. 1 hit.
[Graphical view]
ProDomPD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry namePB2_I30A0
AccessionPrimary (citable) accession number: P26113
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families