Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P26113

- PB2_I30A0

UniProt

P26113 - PB2_I30A0

Protein

Polymerase basic protein 2

Gene

PB2

Organism
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: InterPro
    2. RNA-directed RNA polymerase activity Source: InterPro

    GO - Biological processi

    1. 7-methylguanosine mRNA capping Source: UniProtKB-KW
    2. cap snatching Source: UniProtKB-KW
    3. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
    4. transcription, DNA-templated Source: InterPro

    Keywords - Biological processi

    Cap snatching, Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus, mRNA capping, mRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polymerase basic protein 2
    Alternative name(s):
    RNA-directed RNA polymerase subunit P3
    Gene namesi
    Name:PB2
    OrganismiInfluenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
    Taxonomic identifieri380342 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
    Virus hostiAves [TaxID: 8782]
    Homo sapiens (Human) [TaxID: 9606]
    Sus scrofa (Pig) [TaxID: 9823]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell mitochondrion Source: UniProtKB-SubCell
    2. host cell nucleus Source: UniProtKB-SubCell
    3. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host mitochondrion, Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759Polymerase basic protein 2PRO_0000078842Add
    BLAST

    Interactioni

    Subunit structurei

    Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.

    Structurei

    3D structure databases

    ProteinModelPortaliP26113.
    SMRiP26113. Positions 319-483, 685-759.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi736 – 7394Nuclear localization signalBy similarity

    Sequence similaritiesi

    Belongs to the influenza viruses PB2 family.Curated

    Family and domain databases

    InterProiIPR001591. RNA_pol_PB2_orthomyxovir.
    [Graphical view]
    PfamiPF00604. Flu_PB2. 1 hit.
    [Graphical view]
    ProDomiPD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P26113-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERIKELRDL MSQSRTREIL TRTTVDHMAI IKKYTSGRQE KNPALRMKWM    50
    MAMKYPITAD KRIIETIPER NEQGQTLWSK TSDAGSDRVM VSPLAVTWWN 100
    RNGPTTSTVH YPKIYKTYFE KAERLKHGTF GPVHFGNQVK IRRRVDINPG 150
    HADLSAKEAQ DVIMEVVFPN EVGARILTSE SQLMITKEKK EELQDCKISP 200
    LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW EQLYTPGGEV 250
    RNDDVDQSLI IAARSIVRRA TVSADPLASL LEMCHSTQIG GIRMVDILRQ 300
    NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKK EEEVLTGNLQ 350
    TLKIRVHEGY EEFTMVGRRA TAILRKATRR LVQLIVSGRD EQSIAEAIIV 400
    AMVFSQEDCM IKAVRGDLNF INRANQRLNP MHQLLRHFQK DAKVLFQNWG 450
    IEPIDNVMGM IGILPDLTPS TEMSMRGVRI SKMGVDEYSS TERVVVSIDR 500
    FLRVRDQRGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEVN GPESVLVNTY 550
    QWIIRNWETV KIQWSQDPTM LYNKMEFEPF QSLVPKAARG QYSGFVRTLF 600
    QQMRDVLGTF DTVQIIKLLP FAAAPPKQSR MQFSSLAVNV RGSGMRILVR 650
    GNSPVFNYNR TTKRLTVLGK DAGALTEDPD EGTTGVESAV LRGFLILGKE 700
    DRRYGPALSI NELSNLAKGE KANVLIGQGD VVLVMKRKRD SSILTDSQTA 750
    TKRIRMAIN 759
    Length:759
    Mass (Da):85,806
    Last modified:May 1, 1992 - v1
    Checksum:i1BE5F0592355CBDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73515 Genomic RNA. Translation: AAA43126.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73515 Genomic RNA. Translation: AAA43126.1 .

    3D structure databases

    ProteinModelPortali P26113.
    SMRi P26113. Positions 319-483, 685-759.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001591. RNA_pol_PB2_orthomyxovir.
    [Graphical view ]
    Pfami PF00604. Flu_PB2. 1 hit.
    [Graphical view ]
    ProDomi PD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of influenza A virus PB2 genes: implications for evolution of the ribonucleoprotein complex and origin of human influenza A virus."
      Gorman O.T., Donis R.O., Kawaoka Y., Webster R.G.
      J. Virol. 64:4893-4902(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiPB2_I30A0
    AccessioniPrimary (citable) accession number: P26113
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3