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P26113

- PB2_I30A0

UniProt

P26113 - PB2_I30A0

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Protein
Polymerase basic protein 2
Gene
PB2
Organism
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication By similarity.

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: InterPro

GO - Biological processi

  1. 7-methylguanosine mRNA capping Source: UniProtKB-KW
  2. cap snatching Source: UniProtKB-KW
  3. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
  4. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cap snatching, Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus, mRNA capping, mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase basic protein 2
Alternative name(s):
RNA-directed RNA polymerase subunit P3
Gene namesi
Name:PB2
OrganismiInfluenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
Taxonomic identifieri380342 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

GO - Cellular componenti

  1. host cell mitochondrion Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host mitochondrion, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Polymerase basic protein 2
PRO_0000078842Add
BLAST

Interactioni

Subunit structurei

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.

Structurei

3D structure databases

ProteinModelPortaliP26113.
SMRiP26113. Positions 319-483, 685-759.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi736 – 7394Nuclear localization signal By similarity

Sequence similaritiesi

Family and domain databases

InterProiIPR001591. RNA_pol_PB2_orthomyxovir.
[Graphical view]
PfamiPF00604. Flu_PB2. 1 hit.
[Graphical view]
ProDomiPD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P26113-1 [UniParc]FASTAAdd to Basket

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MERIKELRDL MSQSRTREIL TRTTVDHMAI IKKYTSGRQE KNPALRMKWM    50
MAMKYPITAD KRIIETIPER NEQGQTLWSK TSDAGSDRVM VSPLAVTWWN 100
RNGPTTSTVH YPKIYKTYFE KAERLKHGTF GPVHFGNQVK IRRRVDINPG 150
HADLSAKEAQ DVIMEVVFPN EVGARILTSE SQLMITKEKK EELQDCKISP 200
LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW EQLYTPGGEV 250
RNDDVDQSLI IAARSIVRRA TVSADPLASL LEMCHSTQIG GIRMVDILRQ 300
NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKK EEEVLTGNLQ 350
TLKIRVHEGY EEFTMVGRRA TAILRKATRR LVQLIVSGRD EQSIAEAIIV 400
AMVFSQEDCM IKAVRGDLNF INRANQRLNP MHQLLRHFQK DAKVLFQNWG 450
IEPIDNVMGM IGILPDLTPS TEMSMRGVRI SKMGVDEYSS TERVVVSIDR 500
FLRVRDQRGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEVN GPESVLVNTY 550
QWIIRNWETV KIQWSQDPTM LYNKMEFEPF QSLVPKAARG QYSGFVRTLF 600
QQMRDVLGTF DTVQIIKLLP FAAAPPKQSR MQFSSLAVNV RGSGMRILVR 650
GNSPVFNYNR TTKRLTVLGK DAGALTEDPD EGTTGVESAV LRGFLILGKE 700
DRRYGPALSI NELSNLAKGE KANVLIGQGD VVLVMKRKRD SSILTDSQTA 750
TKRIRMAIN 759
Length:759
Mass (Da):85,806
Last modified:May 1, 1992 - v1
Checksum:i1BE5F0592355CBDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73515 Genomic RNA. Translation: AAA43126.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73515 Genomic RNA. Translation: AAA43126.1 .

3D structure databases

ProteinModelPortali P26113.
SMRi P26113. Positions 319-483, 685-759.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001591. RNA_pol_PB2_orthomyxovir.
[Graphical view ]
Pfami PF00604. Flu_PB2. 1 hit.
[Graphical view ]
ProDomi PD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of influenza A virus PB2 genes: implications for evolution of the ribonucleoprotein complex and origin of human influenza A virus."
    Gorman O.T., Donis R.O., Kawaoka Y., Webster R.G.
    J. Virol. 64:4893-4902(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPB2_I30A0
AccessioniPrimary (citable) accession number: P26113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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