Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P26049

- GBRA3_MOUSE

UniProt

P26049 - GBRA3_MOUSE

Protein

Gamma-aminobutyric acid receptor subunit alpha-3

Gene

Gabra3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. GABA-A receptor activity Source: InterPro

    GO - Biological processi

    1. gamma-aminobutyric acid signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_198558. Ligand-gated ion channel transport.
    REACT_198560. GABA A receptor activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit alpha-3
    Alternative name(s):
    GABA(A) receptor subunit alpha-3
    Gene namesi
    Name:Gabra3
    Synonyms:Gabra-3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:95615. Gabra3.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 492464Gamma-aminobutyric acid receptor subunit alpha-3PRO_0000000438Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi191 ↔ 205By similarity
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP26049.
    PRIDEiP26049.

    PTM databases

    PhosphoSiteiP26049.

    Expressioni

    Gene expression databases

    ArrayExpressiP26049.
    BgeeiP26049.
    GenevestigatoriP26049.

    Interactioni

    Subunit structurei

    Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.

    Structurei

    3D structure databases

    ProteinModelPortaliP26049.
    SMRiP26049. Positions 68-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 276248ExtracellularCuratedAdd
    BLAST
    Topological domaini360 – 45798CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei277 – 29822HelicalCuratedAdd
    BLAST
    Transmembranei304 – 32522HelicalCuratedAdd
    BLAST
    Transmembranei338 – 35922HelicalCuratedAdd
    BLAST
    Transmembranei458 – 47922HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238757.
    GeneTreeiENSGT00550000074441.
    HOGENOMiHOG000231337.
    HOVERGENiHBG051707.
    InParanoidiP26049.
    KOiK05175.
    OrthoDBiEOG7JX342.
    PhylomeDBiP26049.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005433. GABBAa3_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view]
    PRINTSiPR01079. GABAARALPHA.
    PR01616. GABAARALPHA3.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P26049-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIITQMWHFY VTRVVLLLLI SILPGTTSQG ESRRQEPGDF VKQDIGGLSP    50
    KHAPDIPDDS TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT 100
    SFGPVSDTDM EYTIDVFFRQ TWHDERLKFD GPMKILPLNN LLASKIWTPD 150
    TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL YTMRLTIHAE CPMHLEDFPM 200
    DVHACPLKFG SYAYTKAEVI YSWTLGKNKS VEVAQDGSRL NQYDLLGHVV 250
    GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN 300
    RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FIAVCYAFVF 350
    SALIEFATVN YFTKRSWAWE GKKVPEALEM KKKTPAAPTK KNTTFNIVGT 400
    TYPINLAKDT EFSTISKSAA APSASSTPTA IASPKATYVQ DSPAETKTYN 450
    SVSKVDKISR IIFPVLFAIF NLVYWATYVN RESAIKGMIR KQ 492
    Length:492
    Mass (Da):55,398
    Last modified:May 1, 1992 - v1
    Checksum:i3CA193B97833CAE2
    GO

    RNA editingi

    The extent of editing is low at birth but increases with age, reaching close to 100% in the adult brain.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti342 – 3421I → M in RNA edited version.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86568 mRNA. Translation: AAA37651.1.
    CCDSiCCDS30187.1.
    RefSeqiNP_032093.3. NM_008067.4.
    XP_006527885.1. XM_006527822.1.
    XP_006527886.1. XM_006527823.1.
    UniGeneiMm.102286.
    Mm.447666.

    Genome annotation databases

    EnsembliENSMUST00000055966; ENSMUSP00000062638; ENSMUSG00000031343.
    GeneIDi14396.
    KEGGimmu:14396.
    UCSCiuc009tkp.2. mouse.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86568 mRNA. Translation: AAA37651.1 .
    CCDSi CCDS30187.1.
    RefSeqi NP_032093.3. NM_008067.4.
    XP_006527885.1. XM_006527822.1.
    XP_006527886.1. XM_006527823.1.
    UniGenei Mm.102286.
    Mm.447666.

    3D structure databases

    ProteinModelPortali P26049.
    SMRi P26049. Positions 68-365.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P26049.
    ChEMBLi CHEMBL2094133.
    GuidetoPHARMACOLOGYi 406.

    PTM databases

    PhosphoSitei P26049.

    Proteomic databases

    PaxDbi P26049.
    PRIDEi P26049.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055966 ; ENSMUSP00000062638 ; ENSMUSG00000031343 .
    GeneIDi 14396.
    KEGGi mmu:14396.
    UCSCi uc009tkp.2. mouse.

    Organism-specific databases

    CTDi 2556.
    MGIi MGI:95615. Gabra3.

    Phylogenomic databases

    eggNOGi NOG238757.
    GeneTreei ENSGT00550000074441.
    HOGENOMi HOG000231337.
    HOVERGENi HBG051707.
    InParanoidi P26049.
    KOi K05175.
    OrthoDBi EOG7JX342.
    PhylomeDBi P26049.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_198558. Ligand-gated ion channel transport.
    REACT_198560. GABA A receptor activation.

    Miscellaneous databases

    NextBioi 285931.
    PROi P26049.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P26049.
    Bgeei P26049.
    Genevestigatori P26049.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005433. GABBAa3_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view ]
    PRINTSi PR01079. GABAARALPHA.
    PR01616. GABAARALPHA3.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development."
      Wang J.B., Kofuji P., Fernando J.C., Moss S.J., Huganir R.L., Burt D.R.
      J. Mol. Neurosci. 3:177-184(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J and DBA/2J.
      Tissue: Brain.
    2. "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1."
      Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D., Wisden W., Triller A., Smart T.G., Moss S.J.
      Nat. Neurosci. 4:908-916(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBQLN1.
    3. "Editing modifies the GABA(A) receptor subunit alpha3."
      Ohlson J., Pedersen J.S., Haussler D., Ohman M.
      RNA 13:698-703(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: RNA EDITING OF POSITION 342.

    Entry informationi

    Entry nameiGBRA3_MOUSE
    AccessioniPrimary (citable) accession number: P26049
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3