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P26049

- GBRA3_MOUSE

UniProt

P26049 - GBRA3_MOUSE

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Protein

Gamma-aminobutyric acid receptor subunit alpha-3

Gene

Gabra3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: InterPro

GO - Biological processi

  1. gamma-aminobutyric acid signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_198558. Ligand-gated ion channel transport.
REACT_198560. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-3
Alternative name(s):
GABA(A) receptor subunit alpha-3
Gene namesi
Name:Gabra3
Synonyms:Gabra-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:95615. Gabra3.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 492464Gamma-aminobutyric acid receptor subunit alpha-3PRO_0000000438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi191 ↔ 205By similarity
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP26049.
PaxDbiP26049.
PRIDEiP26049.

PTM databases

PhosphoSiteiP26049.

Expressioni

Gene expression databases

BgeeiP26049.
ExpressionAtlasiP26049. baseline and differential.
GenevestigatoriP26049.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.

Structurei

3D structure databases

ProteinModelPortaliP26049.
SMRiP26049. Positions 67-480.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 276248ExtracellularCuratedAdd
BLAST
Topological domaini360 – 45798CytoplasmicCuratedAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei277 – 29822HelicalCuratedAdd
BLAST
Transmembranei304 – 32522HelicalCuratedAdd
BLAST
Transmembranei338 – 35922HelicalCuratedAdd
BLAST
Transmembranei458 – 47922HelicalCuratedAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238757.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP26049.
KOiK05175.
OrthoDBiEOG7JX342.
PhylomeDBiP26049.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005433. GABBAa3_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01616. GABAARALPHA3.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26049-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIITQMWHFY VTRVVLLLLI SILPGTTSQG ESRRQEPGDF VKQDIGGLSP
60 70 80 90 100
KHAPDIPDDS TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT
110 120 130 140 150
SFGPVSDTDM EYTIDVFFRQ TWHDERLKFD GPMKILPLNN LLASKIWTPD
160 170 180 190 200
TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL YTMRLTIHAE CPMHLEDFPM
210 220 230 240 250
DVHACPLKFG SYAYTKAEVI YSWTLGKNKS VEVAQDGSRL NQYDLLGHVV
260 270 280 290 300
GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN
310 320 330 340 350
RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FIAVCYAFVF
360 370 380 390 400
SALIEFATVN YFTKRSWAWE GKKVPEALEM KKKTPAAPTK KNTTFNIVGT
410 420 430 440 450
TYPINLAKDT EFSTISKSAA APSASSTPTA IASPKATYVQ DSPAETKTYN
460 470 480 490
SVSKVDKISR IIFPVLFAIF NLVYWATYVN RESAIKGMIR KQ
Length:492
Mass (Da):55,398
Last modified:May 1, 1992 - v1
Checksum:i3CA193B97833CAE2
GO

RNA editingi

The extent of editing is low at birth but increases with age, reaching close to 100% in the adult brain.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti342 – 3421I → M in RNA edited version.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86568 mRNA. Translation: AAA37651.1.
CCDSiCCDS30187.1.
RefSeqiNP_032093.3. NM_008067.4.
XP_006527885.1. XM_006527822.1.
XP_006527886.1. XM_006527823.1.
UniGeneiMm.102286.
Mm.447666.

Genome annotation databases

EnsembliENSMUST00000055966; ENSMUSP00000062638; ENSMUSG00000031343.
GeneIDi14396.
KEGGimmu:14396.
UCSCiuc009tkp.2. mouse.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86568 mRNA. Translation: AAA37651.1 .
CCDSi CCDS30187.1.
RefSeqi NP_032093.3. NM_008067.4.
XP_006527885.1. XM_006527822.1.
XP_006527886.1. XM_006527823.1.
UniGenei Mm.102286.
Mm.447666.

3D structure databases

ProteinModelPortali P26049.
SMRi P26049. Positions 67-480.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P26049.
ChEMBLi CHEMBL2094133.
GuidetoPHARMACOLOGYi 406.

PTM databases

PhosphoSitei P26049.

Proteomic databases

MaxQBi P26049.
PaxDbi P26049.
PRIDEi P26049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055966 ; ENSMUSP00000062638 ; ENSMUSG00000031343 .
GeneIDi 14396.
KEGGi mmu:14396.
UCSCi uc009tkp.2. mouse.

Organism-specific databases

CTDi 2556.
MGIi MGI:95615. Gabra3.

Phylogenomic databases

eggNOGi NOG238757.
GeneTreei ENSGT00760000119010.
HOGENOMi HOG000231337.
HOVERGENi HBG051707.
InParanoidi P26049.
KOi K05175.
OrthoDBi EOG7JX342.
PhylomeDBi P26049.
TreeFami TF315453.

Enzyme and pathway databases

Reactomei REACT_198558. Ligand-gated ion channel transport.
REACT_198560. GABA A receptor activation.

Miscellaneous databases

NextBioi 285931.
PROi P26049.
SOURCEi Search...

Gene expression databases

Bgeei P26049.
ExpressionAtlasi P26049. baseline and differential.
Genevestigatori P26049.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005433. GABBAa3_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view ]
PRINTSi PR01079. GABAARALPHA.
PR01616. GABAARALPHA3.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development."
    Wang J.B., Kofuji P., Fernando J.C., Moss S.J., Huganir R.L., Burt D.R.
    J. Mol. Neurosci. 3:177-184(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J and DBA/2J.
    Tissue: Brain.
  2. "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1."
    Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D., Wisden W., Triller A., Smart T.G., Moss S.J.
    Nat. Neurosci. 4:908-916(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBQLN1.
  3. "Editing modifies the GABA(A) receptor subunit alpha3."
    Ohlson J., Pedersen J.S., Haussler D., Ohman M.
    RNA 13:698-703(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING OF POSITION 342.

Entry informationi

Entry nameiGBRA3_MOUSE
AccessioniPrimary (citable) accession number: P26049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3