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P26049 (GBRA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor subunit alpha-3
Alternative name(s):
GABA(A) receptor subunit alpha-3
Gene names
Name:Gabra3
Synonyms:Gabra-3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily. [View classification]

RNA editing

Edited at position 342.
The extent of editing is low at birth but increases with age, reaching close to 100% in the adult brain. Ref.3

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 492464Gamma-aminobutyric acid receptor subunit alpha-3
PRO_0000000438

Regions

Topological domain29 – 276248Extracellular Probable
Transmembrane277 – 29822Helical; Probable
Transmembrane304 – 32522Helical; Probable
Transmembrane338 – 35922Helical; Probable
Topological domain360 – 45798Cytoplasmic Probable
Transmembrane458 – 47922Helical; Probable

Amino acid modifications

Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation2281N-linked (GlcNAc...) Potential
Disulfide bond191 ↔ 205 By similarity

Natural variations

Natural variant3421I → M in RNA edited version.

Sequences

Sequence LengthMass (Da)Tools
P26049 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 3CA193B97833CAE2

FASTA49255,398
        10         20         30         40         50         60 
MIITQMWHFY VTRVVLLLLI SILPGTTSQG ESRRQEPGDF VKQDIGGLSP KHAPDIPDDS 

        70         80         90        100        110        120 
TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT SFGPVSDTDM EYTIDVFFRQ 

       130        140        150        160        170        180 
TWHDERLKFD GPMKILPLNN LLASKIWTPD TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL 

       190        200        210        220        230        240 
YTMRLTIHAE CPMHLEDFPM DVHACPLKFG SYAYTKAEVI YSWTLGKNKS VEVAQDGSRL 

       250        260        270        280        290        300 
NQYDLLGHVV GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN 

       310        320        330        340        350        360 
RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FIAVCYAFVF SALIEFATVN 

       370        380        390        400        410        420 
YFTKRSWAWE GKKVPEALEM KKKTPAAPTK KNTTFNIVGT TYPINLAKDT EFSTISKSAA 

       430        440        450        460        470        480 
APSASSTPTA IASPKATYVQ DSPAETKTYN SVSKVDKISR IIFPVLFAIF NLVYWATYVN 

       490 
RESAIKGMIR KQ 

« Hide

References

[1]"The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development."
Wang J.B., Kofuji P., Fernando J.C., Moss S.J., Huganir R.L., Burt D.R.
J. Mol. Neurosci. 3:177-184(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J and DBA/2J.
Tissue: Brain.
[2]"GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1."
Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D., Wisden W., Triller A., Smart T.G., Moss S.J.
Nat. Neurosci. 4:908-916(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UBQLN1.
[3]"Editing modifies the GABA(A) receptor subunit alpha3."
Ohlson J., Pedersen J.S., Haussler D., Ohman M.
RNA 13:698-703(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA EDITING OF POSITION 342.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M86568 mRNA. Translation: AAA37651.1.
CCDSCCDS30187.1.
RefSeqNP_032093.3. NM_008067.4.
XP_006527885.1. XM_006527822.1.
XP_006527886.1. XM_006527823.1.
UniGeneMm.102286.
Mm.447666.

3D structure databases

ProteinModelPortalP26049.
SMRP26049. Positions 68-365.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP26049.
ChEMBLCHEMBL2094133.
GuidetoPHARMACOLOGY406.

PTM databases

PhosphoSiteP26049.

Proteomic databases

PaxDbP26049.
PRIDEP26049.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055966; ENSMUSP00000062638; ENSMUSG00000031343.
GeneID14396.
KEGGmmu:14396.
UCSCuc009tkp.2. mouse.

Organism-specific databases

CTD2556.
MGIMGI:95615. Gabra3.

Phylogenomic databases

eggNOGNOG238757.
GeneTreeENSGT00550000074441.
HOGENOMHOG000231337.
HOVERGENHBG051707.
InParanoidP26049.
KOK05175.
OrthoDBEOG7JX342.
PhylomeDBP26049.
TreeFamTF315453.

Gene expression databases

ArrayExpressP26049.
BgeeP26049.
GenevestigatorP26049.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005433. GABBAa3_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSPR01079. GABAARALPHA.
PR01616. GABAARALPHA3.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285931.
PROP26049.
SOURCESearch...

Entry information

Entry nameGBRA3_MOUSE
AccessionPrimary (citable) accession number: P26049
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot