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P26048 (GBRA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor subunit alpha-2
Alternative name(s):
GABA(A) receptor subunit alpha-2
Gene names
Name:Gabra2
Synonyms:Gabra-2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.

Subcellular location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 451423Gamma-aminobutyric acid receptor subunit alpha-2
PRO_0000000434

Regions

Topological domain29 – 251223Extracellular Probable
Transmembrane252 – 27322Helical; Probable
Transmembrane279 – 30022Helical; Probable
Transmembrane313 – 33422Helical; Probable
Topological domain335 – 41985Cytoplasmic Probable
Transmembrane420 – 44122Helical; Probable

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation1381N-linked (GlcNAc...) Potential
Disulfide bond166 ↔ 180 By similarity

Sequences

Sequence LengthMass (Da)Tools
P26048 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: C5E47898963A36CF

FASTA45151,139
        10         20         30         40         50         60 
MKTKLSTCNV WSLLLVLLVW DPVRLVLANI QEDEAKNNIT IFTRILDRLL DGYDNRLRPG 

        70         80         90        100        110        120 
LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE RLKFKGPMNI LRLNNLMASK 

       130        140        150        160        170        180 
IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD DGTLLYTMRL TVQAECPMHL EDFPMDAHSC 

       190        200        210        220        230        240 
PLKFGSYAYT TSEVTYIWTY NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM 

       250        260        270        280        290        300 
TAHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA 

       310        320        330        340        350        360 
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV NDKKKEKGSV 

       370        380        390        400        410        420 
MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP ENKPAEAKKT FNSVSKIDRM 

       430        440        450 
SRIVFPVLFG TFNLVYWATY LNREPVLGVS P

« Hide

References

[1]"The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development."
Wang J.B., Kofuji P., Fernando J.C., Moss S.J., Huganir R.L., Burt D.R.
J. Mol. Neurosci. 3:177-184(1992) [PubMed: 1356407] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J and DBA/2J.
Tissue: Brain.
[2]"GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1."
Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D., Wisden W., Triller A., Smart T.G., Moss S.J.
Nat. Neurosci. 4:908-916(2001) [PubMed: 11528422] [Abstract]
Cited for: INTERACTION WITH UBQLN1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M86567 mRNA. Translation: AAA37650.1.
IPIIPI00110598.
RefSeqNP_032092.1. NM_008066.3.
UniGeneMm.5304.

3D structure databases

ProteinModelPortalP26048.
SMRP26048. Positions 42-440.
ModBaseSearch...

Protein-protein interaction databases

STRINGP26048.

Proteomic databases

PRIDEP26048.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000572; ENSMUSP00000000572; ENSMUSG00000000560.
GeneID14395.
KEGGmmu:14395.

Organism-specific databases

CTD2555.
MGIMGI:95614. Gabra2.

Phylogenomic databases

eggNOGroNOG13930.
HOGENOMHBG506497.
HOVERGENHBG051707.
InParanoidP26048.
OMAMKMKLNI.
OrthoDBEOG4ZS935.
PhylomeDBP26048.

Gene expression databases

ArrayExpressP26048.
BgeeP26048.
GenevestigatorP26048.
GermOnlineENSMUSG00000000560. Mus musculus.

Family and domain databases

InterProIPR006028. GABAA_rcpt.
IPR001390. GABAAa_rcpt.
IPR005432. GABBAa2_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
Gene3DG3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.
KOK05175.
PANTHERPTHR18945. Neur_channel. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSPR01079. GABAARALPHA.
PR01615. GABAARALPHA2.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMSSF90112. Neu_channel_TM. 1 hit.
SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio460878.
SOURCESearch...

Entry information

Entry nameGBRA2_MOUSE
AccessionPrimary (citable) accession number: P26048
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 16, 2011
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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