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Reviewed, UniProtKB/Swiss-Prot P26045 (PTN3_HUMAN)

Last modified June 16, 2009. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tyrosine-protein phosphatase non-receptor type 3
    EC=3.1.3.48
Alternative name(s):
    Protein-tyrosine phosphatase H1
      Short name=PTP-H1
Gene names
Name: PTPN3
Synonyms: PTPH1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length913 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May act at junctions between the membrane and the cytoskeleton.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcytoskeleton.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 FERM domain.

Contains 1 PDZ (DHR) domain.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 913913Tyrosine-protein phosphatase non-receptor type 3
PRO_0000219433

Regions

Domain29 – 312284FERM
Domain510 – 58273PDZ
Domain646 – 901256Tyrosine-protein phosphatase

Sites

Active site8421Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue3591Phosphoserine Ref.7
Modified residue3671Phosphoserine Ref.7
Modified residue3701Phosphoserine Ref.7
Modified residue3721Phosphoserine Ref.7
Modified residue3761Phosphothreonine Ref.7
Modified residue3811Phosphoserine Ref.7

Natural variations

Natural variant771D → N: dbSNP rs35285139.
VAR_055252
Natural variant901A → P: dbSNP rs3793524.
VAR_055253
Natural variant4091T → A: dbSNP rs10979858.
VAR_055254
Natural variant6051F → L: dbSNP rs7859962.
VAR_055255
Natural variant7631D → N: dbSNP rs10116806.
VAR_055256

Experimental info

Sequence conflict8141V → I in AAA35647. Ref.1
Sequence conflict8141V → I in AAB22439. Ref.5

Secondary structure

.............................................. 913
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P26045-1 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 44FBBFA35A5F2AFF

FASTA913103,990
        10         20         30         40         50         60 
MTSRLRALGG RINNIRTSEL PKEKTRSEVI CSIHFLDGVV QTFKVTKQDT GQVLLDMVHN 

        70         80         90        100        110        120 
HLGVTEKEYF GLQHDDDSVD SPRWLEASKA IRKQLKGGFP CTLHFRVRFF IPDPNTLQQE 

       130        140        150        160        170        180 
QTRHLYFLQL KMDICEGRLT CPLNSAVVLA SYAVQSHFGD YNSSIHHPGY LSDSHFIPDQ 

       190        200        210        220        230        240 
NEDFLTKVES LHEQHSGLKQ SEAESCYINI ARTLDFYGVE LHSGRDLHNL DLMIGIASAG 

       250        260        270        280        290        300 
VAVYRKYICT SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS 

       310        320        330        340        350        360 
CVEHHTFFQA KKLLPQEKNV LSQYWTMGSR NTKKSVNNQY CKKVIGGMVW NPAMRRSLSV 

       370        380        390        400        410        420 
EHLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA NEMTYITETE DVFYTYKGSL 

       430        440        450        460        470        480 
APQDSDSEVS QNRSPHQESL SENNPAQSYL TQKSSSSVSP SSNAPGSCSP DGVDQQLLDD 

       490        500        510        520        530        540 
FHRVTKGGST EDASQYYCDK NDNGDSYLVL IRITPDEDGK FGFNLKGGVD QKMPLVVSRI 

       550        560        570        580        590        600 
NPESPADTCI PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRRAVR 

       610        620        630        640        650        660 
SFADFKSEDE LNQLFPEAIF PMCPEGGDTL EGSMAQLKKG LESGTVLIQF EQLYRKKPGL 

       670        680        690        700        710        720 
AITFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY VNMEIPAANL VNKYIATQGP 

       730        740        750        760        770        780 
LPHTCAQFWQ VVWDQKLSLI VMLTTLTERG RTKCHQYWPD PPDVMNHGGF HIQCQSEDCT 

       790        800        810        820        830        840 
IAYVSREMLV TNTQTGEEHT VTHLQYVAWP DHGVPDDSSD FLEFVNYVRS LRVDSEPVLV 

       850        860        870        880        890        900 
HCSAGIGRTG VLVTMETAMC LTERNLPIYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR 

       910 
VYEEGLVQML DPS 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin."
Yang Q., Tonks N.K.
Proc. Natl. Acad. Sci. U.S.A. 88:5949-5953(1991) [PubMed: 1648725] [Abstract]
Cited for: NUCLOTIDE SEQUENCE [MRNA], VARIANT PRO-90.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"cDNA cloning of new protein tyrosine phosphatases in the human colon."
Arimura Y., Hinoda Y., Itoh F., Takekawa M., Tsujisaki M., Adachi M., Imai K., Yachi A.
Tumor Biol. 13:180-186(1992) [PubMed: 1626183] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 194-896.
Tissue: Colon.
[6]"Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma."
Ikuta S., Itoh F., Hinoda Y., Toyota M., Makiguchi Y., Imai K., Yachi A.
J. Gastroenterol. 29:727-732(1994) [PubMed: 7874267] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 899-913.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359; SER-367; SER-370; SER-372; THR-376 AND SER-381, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

M64572 mRNA. Translation: AAA35647.1.
AL359963, AL162733, AL450025 Genomic DNA. Translation: CAH71094.1.
AL450025, AL162733, AL359963 Genomic DNA. Translation: CAH73252.1.
AL162733, AL359963, AL450025 Genomic DNA. Translation: CAH73386.1.
CH471105 Genomic DNA. Translation: EAW59046.1.
BC126117 mRNA. Translation: AAI26118.1.
S39392 mRNA. Translation: AAB22439.2.
S76309 mRNA. Translation: AAB33583.1.
IPIIPI00289649.
PIRA41109.
RefSeqNP_002820.3.
UniGeneHs.436429

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2B49X-ray1.54A628-913[»]
SMRP26045. Positions 508-599.
ModBaseSearch...

Protein-protein interaction databases

IntActP26045. 5 interactions.

PTM databases

PhosphoSiteP26045.

Proteomic databases

PRIDEP26045.

Genome annotation databases

EnsemblENSG00000070159. Homo sapiens. [Contig view]
GeneID5774.
KEGGhsa:5774.

Organism-specific databases

GeneCardsGC09M111177.
H-InvDBHIX0025742.
HGNCHGNC:9655. PTPN3.
MIM176877. gene.
PharmGKBPA33999.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP26045.
HOVERGENP26045.

Enzyme and pathway databases

BRENDA3.1.3.48. 247.

Gene expression databases

ArrayExpressP26045.
BgeeP26045.
CleanExHS_PTPN3.
GermOnlineENSG00000070159. Homo sapiens.

Family and domain databases

InterProIPR019749. Band_41_domain.
IPR019750. Band_41_sg.
IPR000798. Ez/rad/moesin.
IPR014352. FERM/acyl-CoA_bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ/DHR/GLGF.
IPR011993. PH_type.
IPR000387. Tyr_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
Gene3DG3DSA:1.20.80.10. ACBP. 1 hit.
G3DSA:2.30.29.30. PH_type. 1 hit.
PfamPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSPR00935. BAND41.
PR00661. ERMFAMILY.
PR00700. PRTYPHPHTASE.
SMARTSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio22458.
SOURCESearch...

Entry information

Entry namePTN3_HUMAN
AccessionPrimary (citable) accession number: P26045
Secondary accession number(s): A0AUW9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 5, 2009
Last modified: June 16, 2009
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents