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Protein

Tyrosine-protein phosphatase non-receptor type 3

Gene

PTPN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei811SubstrateBy similarity1
Active sitei842Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei886SubstrateBy similarity1

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL
  • phosphotyrosine binding Source: BHF-UCL
  • protein tyrosine phosphatase activity Source: UniProtKB
  • sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

  • liver regeneration Source: Ensembl
  • negative regulation of membrane protein ectodomain proteolysis Source: BHF-UCL
  • negative regulation of mitotic cell cycle Source: BHF-UCL
  • protein dephosphorylation Source: BHF-UCL
  • regulation of membrane depolarization during action potential Source: BHF-UCL
  • regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:HS00986-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-182971. EGFR downregulation.
SIGNORiP26045.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 3 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase H1
Short name:
PTP-H1
Gene namesi
Name:PTPN3
Synonyms:PTPH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:9655. PTPN3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic side of plasma membrane Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5774.
MalaCardsiPTPN3.
OpenTargetsiENSG00000070159.
Orphaneti70567. Cholangiocarcinoma.
PharmGKBiPA33999.

Chemistry databases

ChEMBLiCHEMBL2396509.

Polymorphism and mutation databases

BioMutaiPTPN3.
DMDMi229462761.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194331 – 913Tyrosine-protein phosphatase non-receptor type 3Add BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei357PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei376PhosphothreonineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP26045.
MaxQBiP26045.
PaxDbiP26045.
PeptideAtlasiP26045.
PRIDEiP26045.

PTM databases

DEPODiP26045.
iPTMnetiP26045.
PhosphoSitePlusiP26045.

Expressioni

Gene expression databases

BgeeiENSG00000070159.
CleanExiHS_PTPN3.
ExpressionAtlasiP26045. baseline and differential.
GenevisibleiP26045. HS.

Organism-specific databases

HPAiHPA038343.
HPA046728.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AKR1C1Q048285EBI-1047946,EBI-2116455
DIP2AQ14689-63EBI-1047946,EBI-10233719
E6P064634EBI-1047946,EBI-1186926From a different organism.
GHRP109124EBI-1047946,EBI-286316
LMO1P258005EBI-1047946,EBI-8639312
NXT2Q9NPJ83EBI-1047946,EBI-752122
SCN5AQ145242EBI-1047946,EBI-726858
VCPP550722EBI-1047946,EBI-355164
VDRP114734EBI-1047946,EBI-286357
WDR6Q9NNW53EBI-1047946,EBI-1568315
ZCCHC10Q8TBK63EBI-1047946,EBI-597063

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL
  • phosphotyrosine binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi111740. 16 interactors.
DIPiDIP-38839N.
IntActiP26045. 31 interactors.
MINTiMINT-246110.
STRINGi9606.ENSP00000363667.

Chemistry databases

BindingDBiP26045.

Structurei

Secondary structure

1913
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi630 – 643Combined sources14
Helixi645 – 652Combined sources8
Helixi664 – 666Combined sources3
Helixi668 – 673Combined sources6
Beta strandi674 – 676Combined sources3
Turni683 – 685Combined sources3
Beta strandi686 – 688Combined sources3
Beta strandi690 – 692Combined sources3
Beta strandi695 – 705Combined sources11
Turni706 – 709Combined sources4
Beta strandi710 – 717Combined sources8
Helixi722 – 724Combined sources3
Helixi725 – 734Combined sources10
Beta strandi739 – 742Combined sources4
Beta strandi746 – 748Combined sources3
Beta strandi751 – 754Combined sources4
Beta strandi764 – 767Combined sources4
Beta strandi770 – 779Combined sources10
Beta strandi781 – 792Combined sources12
Turni793 – 795Combined sources3
Beta strandi798 – 806Combined sources9
Beta strandi811 – 813Combined sources3
Helixi818 – 831Combined sources14
Beta strandi838 – 841Combined sources4
Beta strandi843 – 846Combined sources4
Helixi847 – 863Combined sources17
Helixi870 – 878Combined sources9
Helixi888 – 907Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B49X-ray1.54A628-913[»]
4QUMX-ray2.52A628-909[»]
4QUNX-ray1.86A/B628-909[»]
4RH5X-ray1.60A628-909[»]
4RH9X-ray1.60A628-909[»]
4RHGX-ray1.58A628-909[»]
4RI4X-ray1.60A/B628-909[»]
4RI5X-ray1.26A/B628-909[»]
4S0GX-ray1.72A628-909[»]
ProteinModelPortaliP26045.
SMRiP26045.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26045.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 312FERMPROSITE-ProRule annotationAdd BLAST284
Domaini510 – 582PDZPROSITE-ProRule annotationAdd BLAST73
Domaini646 – 901Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni842 – 848Substrate bindingBy similarity7

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410KDUQ. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000007048.
HOVERGENiHBG008322.
InParanoidiP26045.
KOiK18027.
OMAiHFGDYNS.
OrthoDBiEOG091G016K.
PhylomeDBiP26045.
TreeFamiTF315900.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000387. TYR_PHOSPHATASE_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26045-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSRLRALGG RINNIRTSEL PKEKTRSEVI CSIHFLDGVV QTFKVTKQDT
60 70 80 90 100
GQVLLDMVHN HLGVTEKEYF GLQHDDDSVD SPRWLEASKA IRKQLKGGFP
110 120 130 140 150
CTLHFRVRFF IPDPNTLQQE QTRHLYFLQL KMDICEGRLT CPLNSAVVLA
160 170 180 190 200
SYAVQSHFGD YNSSIHHPGY LSDSHFIPDQ NEDFLTKVES LHEQHSGLKQ
210 220 230 240 250
SEAESCYINI ARTLDFYGVE LHSGRDLHNL DLMIGIASAG VAVYRKYICT
260 270 280 290 300
SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS
310 320 330 340 350
CVEHHTFFQA KKLLPQEKNV LSQYWTMGSR NTKKSVNNQY CKKVIGGMVW
360 370 380 390 400
NPAMRRSLSV EHLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA
410 420 430 440 450
NEMTYITETE DVFYTYKGSL APQDSDSEVS QNRSPHQESL SENNPAQSYL
460 470 480 490 500
TQKSSSSVSP SSNAPGSCSP DGVDQQLLDD FHRVTKGGST EDASQYYCDK
510 520 530 540 550
NDNGDSYLVL IRITPDEDGK FGFNLKGGVD QKMPLVVSRI NPESPADTCI
560 570 580 590 600
PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRRAVR
610 620 630 640 650
SFADFKSEDE LNQLFPEAIF PMCPEGGDTL EGSMAQLKKG LESGTVLIQF
660 670 680 690 700
EQLYRKKPGL AITFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY
710 720 730 740 750
VNMEIPAANL VNKYIATQGP LPHTCAQFWQ VVWDQKLSLI VMLTTLTERG
760 770 780 790 800
RTKCHQYWPD PPDVMNHGGF HIQCQSEDCT IAYVSREMLV TNTQTGEEHT
810 820 830 840 850
VTHLQYVAWP DHGVPDDSSD FLEFVNYVRS LRVDSEPVLV HCSAGIGRTG
860 870 880 890 900
VLVTMETAMC LTERNLPIYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR
910
VYEEGLVQML DPS
Length:913
Mass (Da):103,990
Last modified:May 5, 2009 - v2
Checksum:i44FBBFA35A5F2AFF
GO
Isoform 2 (identifier: P26045-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Note: No experimental confirmation available.
Show »
Length:782
Mass (Da):88,814
Checksum:i00302B9F06B3568B
GO
Isoform 3 (identifier: P26045-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     335-379: Missing.

Note: No experimental confirmation available.
Show »
Length:737
Mass (Da):83,723
Checksum:i6A9CCF192920EDE7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti814V → I in AAA35647 (PubMed:1648725).Curated1
Sequence conflicti814V → I in AAB22439 (PubMed:1626183).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05525277D → N.Corresponds to variant rs35285139dbSNPEnsembl.1
Natural variantiVAR_05525390A → P.1 PublicationCorresponds to variant rs3793524dbSNPEnsembl.1
Natural variantiVAR_055254409T → A.Corresponds to variant rs10979858dbSNPEnsembl.1
Natural variantiVAR_055255605F → L.Corresponds to variant rs7859962dbSNPEnsembl.1
Natural variantiVAR_055256763D → N.Corresponds to variant rs10116806dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0463091 – 131Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_046310335 – 379Missing in isoform 3. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64572 mRNA. Translation: AAA35647.1.
BX648253 mRNA. No translation available.
BX648735 mRNA. No translation available.
AL359963, AL162733, AL450025 Genomic DNA. Translation: CAH71094.1.
AL450025, AL162733, AL359963 Genomic DNA. Translation: CAH73252.1.
AL162733, AL359963, AL450025 Genomic DNA. Translation: CAH73386.1.
CH471105 Genomic DNA. Translation: EAW59046.1.
BC126117 mRNA. Translation: AAI26118.1.
S39392 mRNA. Translation: AAB22439.2.
S76309 mRNA. Translation: AAB33583.1.
CCDSiCCDS48000.1. [P26045-3]
CCDS48001.1. [P26045-2]
CCDS6776.1. [P26045-1]
PIRiA41109.
RefSeqiNP_001138840.1. NM_001145368.1.
NP_001138841.1. NM_001145369.1. [P26045-2]
NP_001138842.1. NM_001145370.1. [P26045-3]
NP_001138843.1. NM_001145371.1.
NP_002820.3. NM_002829.3. [P26045-1]
XP_006717262.1. XM_006717199.3. [P26045-1]
XP_006717267.1. XM_006717204.3. [P26045-2]
XP_011517191.1. XM_011518889.2. [P26045-1]
XP_016870444.1. XM_017014955.1. [P26045-1]
XP_016870446.1. XM_017014957.1. [P26045-3]
UniGeneiHs.436429.

Genome annotation databases

EnsembliENST00000374541; ENSP00000363667; ENSG00000070159. [P26045-1]
ENST00000412145; ENSP00000416654; ENSG00000070159. [P26045-2]
ENST00000446349; ENSP00000395384; ENSG00000070159. [P26045-3]
GeneIDi5774.
KEGGihsa:5774.
UCSCiuc004beb.2. human. [P26045-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64572 mRNA. Translation: AAA35647.1.
BX648253 mRNA. No translation available.
BX648735 mRNA. No translation available.
AL359963, AL162733, AL450025 Genomic DNA. Translation: CAH71094.1.
AL450025, AL162733, AL359963 Genomic DNA. Translation: CAH73252.1.
AL162733, AL359963, AL450025 Genomic DNA. Translation: CAH73386.1.
CH471105 Genomic DNA. Translation: EAW59046.1.
BC126117 mRNA. Translation: AAI26118.1.
S39392 mRNA. Translation: AAB22439.2.
S76309 mRNA. Translation: AAB33583.1.
CCDSiCCDS48000.1. [P26045-3]
CCDS48001.1. [P26045-2]
CCDS6776.1. [P26045-1]
PIRiA41109.
RefSeqiNP_001138840.1. NM_001145368.1.
NP_001138841.1. NM_001145369.1. [P26045-2]
NP_001138842.1. NM_001145370.1. [P26045-3]
NP_001138843.1. NM_001145371.1.
NP_002820.3. NM_002829.3. [P26045-1]
XP_006717262.1. XM_006717199.3. [P26045-1]
XP_006717267.1. XM_006717204.3. [P26045-2]
XP_011517191.1. XM_011518889.2. [P26045-1]
XP_016870444.1. XM_017014955.1. [P26045-1]
XP_016870446.1. XM_017014957.1. [P26045-3]
UniGeneiHs.436429.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B49X-ray1.54A628-913[»]
4QUMX-ray2.52A628-909[»]
4QUNX-ray1.86A/B628-909[»]
4RH5X-ray1.60A628-909[»]
4RH9X-ray1.60A628-909[»]
4RHGX-ray1.58A628-909[»]
4RI4X-ray1.60A/B628-909[»]
4RI5X-ray1.26A/B628-909[»]
4S0GX-ray1.72A628-909[»]
ProteinModelPortaliP26045.
SMRiP26045.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111740. 16 interactors.
DIPiDIP-38839N.
IntActiP26045. 31 interactors.
MINTiMINT-246110.
STRINGi9606.ENSP00000363667.

Chemistry databases

BindingDBiP26045.
ChEMBLiCHEMBL2396509.

PTM databases

DEPODiP26045.
iPTMnetiP26045.
PhosphoSitePlusiP26045.

Polymorphism and mutation databases

BioMutaiPTPN3.
DMDMi229462761.

Proteomic databases

EPDiP26045.
MaxQBiP26045.
PaxDbiP26045.
PeptideAtlasiP26045.
PRIDEiP26045.

Protocols and materials databases

DNASUi5774.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374541; ENSP00000363667; ENSG00000070159. [P26045-1]
ENST00000412145; ENSP00000416654; ENSG00000070159. [P26045-2]
ENST00000446349; ENSP00000395384; ENSG00000070159. [P26045-3]
GeneIDi5774.
KEGGihsa:5774.
UCSCiuc004beb.2. human. [P26045-1]

Organism-specific databases

CTDi5774.
DisGeNETi5774.
GeneCardsiPTPN3.
H-InvDBHIX0025742.
HGNCiHGNC:9655. PTPN3.
HPAiHPA038343.
HPA046728.
MalaCardsiPTPN3.
MIMi176877. gene.
neXtProtiNX_P26045.
OpenTargetsiENSG00000070159.
Orphaneti70567. Cholangiocarcinoma.
PharmGKBiPA33999.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDUQ. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000007048.
HOVERGENiHBG008322.
InParanoidiP26045.
KOiK18027.
OMAiHFGDYNS.
OrthoDBiEOG091G016K.
PhylomeDBiP26045.
TreeFamiTF315900.

Enzyme and pathway databases

BioCyciZFISH:HS00986-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-182971. EGFR downregulation.
SIGNORiP26045.

Miscellaneous databases

ChiTaRSiPTPN3. human.
EvolutionaryTraceiP26045.
GeneWikiiPTPN3.
GenomeRNAii5774.
PROiP26045.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070159.
CleanExiHS_PTPN3.
ExpressionAtlasiP26045. baseline and differential.
GenevisibleiP26045. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000387. TYR_PHOSPHATASE_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTN3_HUMAN
AccessioniPrimary (citable) accession number: P26045
Secondary accession number(s): A0AUW9, E7EN99, E9PGU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.