P26045 (PTN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase non-receptor type 3
EC=3.1.3.48

Alternative name(s):
Protein-tyrosine phosphatase H1
Short name=PTP-H1

Gene names

Name:	PTPN3
Synonyms:	PTPH1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	913 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM domain. Contains 1 PDZ (DHR) domain. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of membrane protein ectodomain proteolysis Inferred from mutant phenotype PubMed 12207026. Source: BHF-UCL negative regulation of mitotic cell cycle Inferred from direct assay PubMed 10364224. Source: BHF-UCL
Cellular_component	cytoplasm Inferred from direct assay PubMed 10940933. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell internal side of plasma membrane Inferred from direct assay PubMed 10940933. Source: UniProtKB
Molecular_function	protein tyrosine phosphatase activity Inferred from direct assay Ref.9. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GHR	P10912	4	EBI-1047946,EBI-286316
VDR	P11473	4	EBI-1047946,EBI-286357

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P26045-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P26045-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: P26045-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     335-379: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 913

913

Tyrosine-protein phosphatase non-receptor type 3

PRO_0000219433

Regions

Domain

29 – 312

284

FERM

Domain

510 – 582

73

PDZ

Domain

646 – 901

256

Tyrosine-protein phosphatase

Region

842 – 848

7

Substrate binding By similarity

Sites

Active site

842

1

Phosphocysteine intermediate By similarity

Binding site

811

1

Substrate By similarity

Binding site

886

1

Substrate By similarity

Amino acid modifications

Modified residue

359

1

Phosphoserine Ref.8

Modified residue

367

1

Phosphoserine Ref.8

Modified residue

376

1

Phosphothreonine Ref.8

Modified residue

381

1

Phosphoserine Ref.8

Natural variations

Alternative sequence

1 – 131

131

Missing in isoform 2 and isoform 3.

VSP_046309

Alternative sequence

335 – 379

45

Missing in isoform 3.

VSP_046310

Natural variant

77

1

D → N.
Corresponds to variant rs35285139 [ dbSNP | Ensembl ].

VAR_055252

Natural variant

90

1

A → P. Ref.1
Corresponds to variant rs3793524 [ dbSNP | Ensembl ].

VAR_055253

Natural variant

409

1

T → A.
Corresponds to variant rs10979858 [ dbSNP | Ensembl ].

VAR_055254

Natural variant

605

1

F → L.
Corresponds to variant rs7859962 [ dbSNP | Ensembl ].

VAR_055255

Natural variant

763

1

D → N.
Corresponds to variant rs10116806 [ dbSNP | Ensembl ].

VAR_055256

Experimental info

Sequence conflict

814

1

V → I in AAA35647. Ref.1

Sequence conflict

814

1

V → I in AAB22439. Ref.6

Secondary structure

1

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913

Helix Strand Turn

Details...

Helix

649 – 652

4

Helix

664 – 666

3

Helix

668 – 673

6

Turn

683 – 685

3

Beta strand

686 – 688

3

Beta strand

690 – 692

3

Beta strand

695 – 705

11

Helix

706 – 708

3

Beta strand

710 – 717

8

Turn

722 – 724

3

Helix

725 – 734

10

Beta strand

739 – 742

4

Beta strand

746 – 748

3

Beta strand

764 – 767

4

Beta strand

770 – 779

10

Beta strand

781 – 792

12

Turn

793 – 795

3

Beta strand

798 – 806

9

Beta strand

811 – 813

3

Helix

819 – 831

13

Beta strand

838 – 841

4

Beta strand

843 – 846

4

Helix

847 – 863

17

Helix

870 – 878

9

Helix

888 – 903

16

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 44FBBFA35A5F2AFF	FASTA	913	103,990
	10 20 30 40 50 60 MTSRLRALGG RINNIRTSEL PKEKTRSEVI CSIHFLDGVV QTFKVTKQDT GQVLLDMVHN 70 80 90 100 110 120 HLGVTEKEYF GLQHDDDSVD SPRWLEASKA IRKQLKGGFP CTLHFRVRFF IPDPNTLQQE 130 140 150 160 170 180 QTRHLYFLQL KMDICEGRLT CPLNSAVVLA SYAVQSHFGD YNSSIHHPGY LSDSHFIPDQ 190 200 210 220 230 240 NEDFLTKVES LHEQHSGLKQ SEAESCYINI ARTLDFYGVE LHSGRDLHNL DLMIGIASAG 250 260 270 280 290 300 VAVYRKYICT SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS 310 320 330 340 350 360 CVEHHTFFQA KKLLPQEKNV LSQYWTMGSR NTKKSVNNQY CKKVIGGMVW NPAMRRSLSV 370 380 390 400 410 420 EHLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA NEMTYITETE DVFYTYKGSL 430 440 450 460 470 480 APQDSDSEVS QNRSPHQESL SENNPAQSYL TQKSSSSVSP SSNAPGSCSP DGVDQQLLDD 490 500 510 520 530 540 FHRVTKGGST EDASQYYCDK NDNGDSYLVL IRITPDEDGK FGFNLKGGVD QKMPLVVSRI 550 560 570 580 590 600 NPESPADTCI PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRRAVR 610 620 630 640 650 660 SFADFKSEDE LNQLFPEAIF PMCPEGGDTL EGSMAQLKKG LESGTVLIQF EQLYRKKPGL 670 680 690 700 710 720 AITFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY VNMEIPAANL VNKYIATQGP 730 740 750 760 770 780 LPHTCAQFWQ VVWDQKLSLI VMLTTLTERG RTKCHQYWPD PPDVMNHGGF HIQCQSEDCT 790 800 810 820 830 840 IAYVSREMLV TNTQTGEEHT VTHLQYVAWP DHGVPDDSSD FLEFVNYVRS LRVDSEPVLV 850 860 870 880 890 900 HCSAGIGRTG VLVTMETAMC LTERNLPIYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR 910 VYEEGLVQML DPS
	Isoform 2 [UniParc]. Checksum: 00302B9F06B3568B	FASTA	782	88,814
	10 20 30 40 50 60 MDICEGRLTC PLNSAVVLAS YAVQSHFGDY NSSIHHPGYL SDSHFIPDQN EDFLTKVESL 70 80 90 100 110 120 HEQHSGLKQS EAESCYINIA RTLDFYGVEL HSGRDLHNLD LMIGIASAGV AVYRKYICTS 130 140 150 160 170 180 FYPWVNILKI SFKRKKFFIH QRQKQAESRE HIVAFNMLNY RSCKNLWKSC VEHHTFFQAK 190 200 210 220 230 240 KLLPQEKNVL SQYWTMGSRN TKKSVNNQYC KKVIGGMVWN PAMRRSLSVE HLETKSLPSR 250 260 270 280 290 300 SPPITPNWRS PRLRHEIRKP RHSSADNLAN EMTYITETED VFYTYKGSLA PQDSDSEVSQ 310 320 330 340 350 360 NRSPHQESLS ENNPAQSYLT QKSSSSVSPS SNAPGSCSPD GVDQQLLDDF HRVTKGGSTE 370 380 390 400 410 420 DASQYYCDKN DNGDSYLVLI RITPDEDGKF GFNLKGGVDQ KMPLVVSRIN PESPADTCIP 430 440 450 460 470 480 KLNEGDQIVL INGRDISEHT HDQVVMFIKA SRESHSRELA LVIRRRAVRS FADFKSEDEL 490 500 510 520 530 540 NQLFPEAIFP MCPEGGDTLE GSMAQLKKGL ESGTVLIQFE QLYRKKPGLA ITFAKLPQNL 550 560 570 580 590 600 DKNRYKDVLP YDTTRVLLQG NEDYINASYV NMEIPAANLV NKYIATQGPL PHTCAQFWQV 610 620 630 640 650 660 VWDQKLSLIV MLTTLTERGR TKCHQYWPDP PDVMNHGGFH IQCQSEDCTI AYVSREMLVT 670 680 690 700 710 720 NTQTGEEHTV THLQYVAWPD HGVPDDSSDF LEFVNYVRSL RVDSEPVLVH CSAGIGRTGV 730 740 750 760 770 780 LVTMETAMCL TERNLPIYPL DIVRKMRDQR AMMVQTSSQY KFVCEAILRV YEEGLVQMLD PS
	Isoform 3 [UniParc]. Checksum: 6A9CCF192920EDE7	FASTA	737	83,723
	10 20 30 40 50 60 MDICEGRLTC PLNSAVVLAS YAVQSHFGDY NSSIHHPGYL SDSHFIPDQN EDFLTKVESL 70 80 90 100 110 120 HEQHSGLKQS EAESCYINIA RTLDFYGVEL HSGRDLHNLD LMIGIASAGV AVYRKYICTS 130 140 150 160 170 180 FYPWVNILKI SFKRKKFFIH QRQKQAESRE HIVAFNMLNY RSCKNLWKSC VEHHTFFQAK 190 200 210 220 230 240 KLLPQEKNVL SQYWTMGSRN TKKRSPRLRH EIRKPRHSSA DNLANEMTYI TETEDVFYTY 250 260 270 280 290 300 KGSLAPQDSD SEVSQNRSPH QESLSENNPA QSYLTQKSSS SVSPSSNAPG SCSPDGVDQQ 310 320 330 340 350 360 LLDDFHRVTK GGSTEDASQY YCDKNDNGDS YLVLIRITPD EDGKFGFNLK GGVDQKMPLV 370 380 390 400 410 420 VSRINPESPA DTCIPKLNEG DQIVLINGRD ISEHTHDQVV MFIKASRESH SRELALVIRR 430 440 450 460 470 480 RAVRSFADFK SEDELNQLFP EAIFPMCPEG GDTLEGSMAQ LKKGLESGTV LIQFEQLYRK 490 500 510 520 530 540 KPGLAITFAK LPQNLDKNRY KDVLPYDTTR VLLQGNEDYI NASYVNMEIP AANLVNKYIA 550 560 570 580 590 600 TQGPLPHTCA QFWQVVWDQK LSLIVMLTTL TERGRTKCHQ YWPDPPDVMN HGGFHIQCQS 610 620 630 640 650 660 EDCTIAYVSR EMLVTNTQTG EEHTVTHLQY VAWPDHGVPD DSSDFLEFVN YVRSLRVDSE 670 680 690 700 710 720 PVLVHCSAGI GRTGVLVTME TAMCLTERNL PIYPLDIVRK MRDQRAMMVQ TSSQYKFVCE 730 AILRVYEEGL VQMLDPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin." Yang Q., Tonks N.K. Proc. Natl. Acad. Sci. U.S.A. 88:5949-5953(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-90.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Fetal kidney and Testis.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	"cDNA cloning of new protein tyrosine phosphatases in the human colon." Arimura Y., Hinoda Y., Itoh F., Takekawa M., Tsujisaki M., Adachi M., Imai K., Yachi A. Tumor Biol. 13:180-186(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 194-896 (ISOFORM 1). Tissue: Colon.
[7]	"Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma." Ikuta S., Itoh F., Hinoda Y., Toyota M., Makiguchi Y., Imai K., Yachi A. J. Gastroenterol. 29:727-732(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 899-913 (ISOFORM 1).
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359; SER-367; THR-376 AND SER-381, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Large-scale structural analysis of the classical human protein tyrosine phosphatome." Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S. Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 628-913.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M64572 mRNA. Translation: AAA35647.1.
BX648253 mRNA. No translation available.
BX648735 mRNA. No translation available.
AL359963, AL162733, AL450025 Genomic DNA. Translation: CAH71094.1.
AL450025, AL162733, AL359963 Genomic DNA. Translation: CAH73252.1.
AL162733, AL359963, AL450025 Genomic DNA. Translation: CAH73386.1.
CH471105 Genomic DNA. Translation: EAW59046.1.
BC126117 mRNA. Translation: AAI26118.1.
S39392 mRNA. Translation: AAB22439.2.
S76309 mRNA. Translation: AAB33583.1.

IPI

IPI00289649.
IPI00480052.
IPI00922112.

PIR

A41109.

RefSeq

NP_001138840.1. NM_001145368.1.
NP_001138841.1. NM_001145369.1.
NP_001138842.1. NM_001145370.1.
NP_001138843.1. NM_001145371.1.
NP_002820.3. NM_002829.3.

UniGene

Hs.436429.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2B49	X-ray	1.54	A	628-913	[»]

ProteinModelPortal

P26045.

ModBase

Search...

Protein-protein interaction databases

IntAct

P26045. 5 interactions.

MINT

MINT-246110.

STRING

9606.ENSP00000262539.

PTM databases

PhosphoSite

P26045.

Polymorphism databases

DMDM

229462761.

Proteomic databases

PaxDb

P26045.

PRIDE

P26045.

Protocols and materials databases

DNASU

5774.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000374541; ENSP00000363667; ENSG00000070159.
ENST00000394831; ENSP00000378308; ENSG00000070159.
ENST00000412145; ENSP00000416654; ENSG00000070159.
ENST00000446349; ENSP00000395384; ENSG00000070159.

GeneID

5774.

KEGG

hsa:5774.

UCSC

uc004beb.2. human.

Organism-specific databases

CTD

5774.

GeneCards

GC09M112138.

H-InvDB

HIX0025742.

HGNC

HGNC:9655. PTPN3.

HPA

HPA038343.

MIM

176877. gene.

neXtProt

NX_P26045.

PharmGKB

PA33999.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5599.

HOGENOM

HOG000007048.

HOVERGEN

HBG008322.

InParanoid

P26045.

KO

K01104.

OMA

RSEVICS.

OrthoDB

EOG4RNB7S.

PhylomeDB

P26045.

Gene expression databases

ArrayExpress

P26045.

Bgee

P26045.

CleanEx

HS_PTPN3.

Genevestigator

P26045.

GermOnline

ENSG00000070159. Homo sapiens.

Family and domain databases

Gene3D

1.20.80.10. 1 hit.
2.30.29.30. 1 hit.

InterPro

IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Pfam

PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]

PIRSF

PIRSF000927. Tyr-Ptase_nr3. 1 hit.

PRINTS

PR00935. BAND41.
PR00700. PRTYPHPHTASE.

SMART

SM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]

SUPFAM

SSF47031. FERM_3-hlx. 1 hit.
SSF50156. PDZ. 1 hit.

PROSITE

PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PTPN3. human.

EvolutionaryTrace

P26045.

GenomeRNAi

5774.

NextBio

22458.

SOURCE

Search...

Entry information

Entry name

PTN3_HUMAN

Accession

Primary (citable) accession number: P26045
Secondary accession number(s): A0AUW9, E7EN99, E9PGU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 133 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.