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P26045

- PTN3_HUMAN

UniProt

P26045 - PTN3_HUMAN

Protein

Tyrosine-protein phosphatase non-receptor type 3

Gene

PTPN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei811 – 8111SubstrateBy similarity
    Active sitei842 – 8421Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei886 – 8861SubstrateBy similarity

    GO - Molecular functioni

    1. ATPase binding Source: BHF-UCL
    2. phosphotyrosine binding Source: BHF-UCL
    3. protein binding Source: IntAct
    4. protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of membrane protein ectodomain proteolysis Source: BHF-UCL
    2. negative regulation of mitotic cell cycle Source: BHF-UCL
    3. peptidyl-tyrosine dephosphorylation Source: GOC
    4. protein dephosphorylation Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 3 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase H1
    Short name:
    PTP-H1
    Gene namesi
    Name:PTPN3
    Synonyms:PTPH1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:9655. PTPN3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoplasmic side of plasma membrane Source: UniProtKB
    3. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33999.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 913913Tyrosine-protein phosphatase non-receptor type 3PRO_0000219433Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei359 – 3591Phosphoserine1 Publication
    Modified residuei367 – 3671Phosphoserine1 Publication
    Modified residuei376 – 3761Phosphothreonine1 Publication
    Modified residuei381 – 3811Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP26045.
    PaxDbiP26045.
    PRIDEiP26045.

    PTM databases

    PhosphoSiteiP26045.

    Expressioni

    Gene expression databases

    ArrayExpressiP26045.
    BgeeiP26045.
    CleanExiHS_PTPN3.
    GenevestigatoriP26045.

    Organism-specific databases

    HPAiHPA038343.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    E6P064634EBI-1047946,EBI-1186926From a different organism.
    GHRP109124EBI-1047946,EBI-286316
    SCN5AQ145242EBI-1047946,EBI-726858
    VCPP550722EBI-1047946,EBI-355164
    VDRP114734EBI-1047946,EBI-286357

    Protein-protein interaction databases

    BioGridi111740. 7 interactions.
    IntActiP26045. 15 interactions.
    MINTiMINT-246110.
    STRINGi9606.ENSP00000262539.

    Structurei

    Secondary structure

    1
    913
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi649 – 6524
    Helixi664 – 6663
    Helixi668 – 6736
    Turni683 – 6853
    Beta strandi686 – 6883
    Beta strandi690 – 6923
    Beta strandi695 – 70511
    Helixi706 – 7083
    Beta strandi710 – 7178
    Turni722 – 7243
    Helixi725 – 73410
    Beta strandi739 – 7424
    Beta strandi746 – 7483
    Beta strandi764 – 7674
    Beta strandi770 – 77910
    Beta strandi781 – 79212
    Turni793 – 7953
    Beta strandi798 – 8069
    Beta strandi811 – 8133
    Helixi819 – 83113
    Beta strandi838 – 8414
    Beta strandi843 – 8464
    Helixi847 – 86317
    Helixi870 – 8789
    Helixi888 – 90316

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B49X-ray1.54A628-913[»]
    ProteinModelPortaliP26045.
    SMRiP26045. Positions 31-309, 508-595, 646-904.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP26045.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 312284FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini510 – 58273PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini646 – 901256Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni842 – 8487Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000007048.
    HOVERGENiHBG008322.
    InParanoidiP26045.
    KOiK18027.
    OMAiHFGDYNS.
    OrthoDBiEOG76HQ1B.
    PhylomeDBiP26045.
    TreeFamiTF315900.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P26045-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSRLRALGG RINNIRTSEL PKEKTRSEVI CSIHFLDGVV QTFKVTKQDT    50
    GQVLLDMVHN HLGVTEKEYF GLQHDDDSVD SPRWLEASKA IRKQLKGGFP 100
    CTLHFRVRFF IPDPNTLQQE QTRHLYFLQL KMDICEGRLT CPLNSAVVLA 150
    SYAVQSHFGD YNSSIHHPGY LSDSHFIPDQ NEDFLTKVES LHEQHSGLKQ 200
    SEAESCYINI ARTLDFYGVE LHSGRDLHNL DLMIGIASAG VAVYRKYICT 250
    SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS 300
    CVEHHTFFQA KKLLPQEKNV LSQYWTMGSR NTKKSVNNQY CKKVIGGMVW 350
    NPAMRRSLSV EHLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA 400
    NEMTYITETE DVFYTYKGSL APQDSDSEVS QNRSPHQESL SENNPAQSYL 450
    TQKSSSSVSP SSNAPGSCSP DGVDQQLLDD FHRVTKGGST EDASQYYCDK 500
    NDNGDSYLVL IRITPDEDGK FGFNLKGGVD QKMPLVVSRI NPESPADTCI 550
    PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRRAVR 600
    SFADFKSEDE LNQLFPEAIF PMCPEGGDTL EGSMAQLKKG LESGTVLIQF 650
    EQLYRKKPGL AITFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY 700
    VNMEIPAANL VNKYIATQGP LPHTCAQFWQ VVWDQKLSLI VMLTTLTERG 750
    RTKCHQYWPD PPDVMNHGGF HIQCQSEDCT IAYVSREMLV TNTQTGEEHT 800
    VTHLQYVAWP DHGVPDDSSD FLEFVNYVRS LRVDSEPVLV HCSAGIGRTG 850
    VLVTMETAMC LTERNLPIYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR 900
    VYEEGLVQML DPS 913
    Length:913
    Mass (Da):103,990
    Last modified:May 5, 2009 - v2
    Checksum:i44FBBFA35A5F2AFF
    GO
    Isoform 2 (identifier: P26045-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-131: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:782
    Mass (Da):88,814
    Checksum:i00302B9F06B3568B
    GO
    Isoform 3 (identifier: P26045-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-131: Missing.
         335-379: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:737
    Mass (Da):83,723
    Checksum:i6A9CCF192920EDE7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti814 – 8141V → I in AAA35647. (PubMed:1648725)Curated
    Sequence conflicti814 – 8141V → I in AAB22439. (PubMed:1626183)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771D → N.
    Corresponds to variant rs35285139 [ dbSNP | Ensembl ].
    VAR_055252
    Natural varianti90 – 901A → P.1 Publication
    Corresponds to variant rs3793524 [ dbSNP | Ensembl ].
    VAR_055253
    Natural varianti409 – 4091T → A.
    Corresponds to variant rs10979858 [ dbSNP | Ensembl ].
    VAR_055254
    Natural varianti605 – 6051F → L.
    Corresponds to variant rs7859962 [ dbSNP | Ensembl ].
    VAR_055255
    Natural varianti763 – 7631D → N.
    Corresponds to variant rs10116806 [ dbSNP | Ensembl ].
    VAR_055256

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 131131Missing in isoform 2 and isoform 3. 1 PublicationVSP_046309Add
    BLAST
    Alternative sequencei335 – 37945Missing in isoform 3. 1 PublicationVSP_046310Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64572 mRNA. Translation: AAA35647.1.
    BX648253 mRNA. No translation available.
    BX648735 mRNA. No translation available.
    AL359963, AL162733, AL450025 Genomic DNA. Translation: CAH71094.1.
    AL450025, AL162733, AL359963 Genomic DNA. Translation: CAH73252.1.
    AL162733, AL359963, AL450025 Genomic DNA. Translation: CAH73386.1.
    CH471105 Genomic DNA. Translation: EAW59046.1.
    BC126117 mRNA. Translation: AAI26118.1.
    S39392 mRNA. Translation: AAB22439.2.
    S76309 mRNA. Translation: AAB33583.1.
    CCDSiCCDS48000.1. [P26045-3]
    CCDS48001.1. [P26045-2]
    CCDS6776.1. [P26045-1]
    PIRiA41109.
    RefSeqiNP_001138840.1. NM_001145368.1.
    NP_001138841.1. NM_001145369.1. [P26045-2]
    NP_001138842.1. NM_001145370.1. [P26045-3]
    NP_001138843.1. NM_001145371.1.
    NP_002820.3. NM_002829.3. [P26045-1]
    XP_006717261.1. XM_006717198.1. [P26045-1]
    XP_006717262.1. XM_006717199.1. [P26045-1]
    XP_006717267.1. XM_006717204.1. [P26045-2]
    XP_006717269.1. XM_006717206.1. [P26045-3]
    UniGeneiHs.436429.

    Genome annotation databases

    EnsembliENST00000374541; ENSP00000363667; ENSG00000070159. [P26045-1]
    ENST00000412145; ENSP00000416654; ENSG00000070159. [P26045-2]
    ENST00000446349; ENSP00000395384; ENSG00000070159. [P26045-3]
    GeneIDi5774.
    KEGGihsa:5774.
    UCSCiuc004beb.2. human. [P26045-1]

    Polymorphism databases

    DMDMi229462761.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64572 mRNA. Translation: AAA35647.1 .
    BX648253 mRNA. No translation available.
    BX648735 mRNA. No translation available.
    AL359963 , AL162733 , AL450025 Genomic DNA. Translation: CAH71094.1 .
    AL450025 , AL162733 , AL359963 Genomic DNA. Translation: CAH73252.1 .
    AL162733 , AL359963 , AL450025 Genomic DNA. Translation: CAH73386.1 .
    CH471105 Genomic DNA. Translation: EAW59046.1 .
    BC126117 mRNA. Translation: AAI26118.1 .
    S39392 mRNA. Translation: AAB22439.2 .
    S76309 mRNA. Translation: AAB33583.1 .
    CCDSi CCDS48000.1. [P26045-3 ]
    CCDS48001.1. [P26045-2 ]
    CCDS6776.1. [P26045-1 ]
    PIRi A41109.
    RefSeqi NP_001138840.1. NM_001145368.1.
    NP_001138841.1. NM_001145369.1. [P26045-2 ]
    NP_001138842.1. NM_001145370.1. [P26045-3 ]
    NP_001138843.1. NM_001145371.1.
    NP_002820.3. NM_002829.3. [P26045-1 ]
    XP_006717261.1. XM_006717198.1. [P26045-1 ]
    XP_006717262.1. XM_006717199.1. [P26045-1 ]
    XP_006717267.1. XM_006717204.1. [P26045-2 ]
    XP_006717269.1. XM_006717206.1. [P26045-3 ]
    UniGenei Hs.436429.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B49 X-ray 1.54 A 628-913 [» ]
    ProteinModelPortali P26045.
    SMRi P26045. Positions 31-309, 508-595, 646-904.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111740. 7 interactions.
    IntActi P26045. 15 interactions.
    MINTi MINT-246110.
    STRINGi 9606.ENSP00000262539.

    Chemistry

    ChEMBLi CHEMBL2396509.

    PTM databases

    PhosphoSitei P26045.

    Polymorphism databases

    DMDMi 229462761.

    Proteomic databases

    MaxQBi P26045.
    PaxDbi P26045.
    PRIDEi P26045.

    Protocols and materials databases

    DNASUi 5774.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374541 ; ENSP00000363667 ; ENSG00000070159 . [P26045-1 ]
    ENST00000412145 ; ENSP00000416654 ; ENSG00000070159 . [P26045-2 ]
    ENST00000446349 ; ENSP00000395384 ; ENSG00000070159 . [P26045-3 ]
    GeneIDi 5774.
    KEGGi hsa:5774.
    UCSCi uc004beb.2. human. [P26045-1 ]

    Organism-specific databases

    CTDi 5774.
    GeneCardsi GC09M112138.
    H-InvDB HIX0025742.
    HGNCi HGNC:9655. PTPN3.
    HPAi HPA038343.
    MIMi 176877. gene.
    neXtProti NX_P26045.
    PharmGKBi PA33999.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000007048.
    HOVERGENi HBG008322.
    InParanoidi P26045.
    KOi K18027.
    OMAi HFGDYNS.
    OrthoDBi EOG76HQ1B.
    PhylomeDBi P26045.
    TreeFami TF315900.

    Miscellaneous databases

    ChiTaRSi PTPN3. human.
    EvolutionaryTracei P26045.
    GeneWikii PTPN3.
    GenomeRNAii 5774.
    NextBioi 22458.
    PROi P26045.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P26045.
    Bgeei P26045.
    CleanExi HS_PTPN3.
    Genevestigatori P26045.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000927. Tyr-Ptase_nr3. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin."
      Yang Q., Tonks N.K.
      Proc. Natl. Acad. Sci. U.S.A. 88:5949-5953(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-90.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Fetal kidney and Testis.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. "cDNA cloning of new protein tyrosine phosphatases in the human colon."
      Arimura Y., Hinoda Y., Itoh F., Takekawa M., Tsujisaki M., Adachi M., Imai K., Yachi A.
      Tumor Biol. 13:180-186(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 194-896 (ISOFORM 1).
      Tissue: Colon.
    7. "Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma."
      Ikuta S., Itoh F., Hinoda Y., Toyota M., Makiguchi Y., Imai K., Yachi A.
      J. Gastroenterol. 29:727-732(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 899-913 (ISOFORM 1).
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359; SER-367; THR-376 AND SER-381, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
      Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
      Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 628-913.

    Entry informationi

    Entry nameiPTN3_HUMAN
    AccessioniPrimary (citable) accession number: P26045
    Secondary accession number(s): A0AUW9, E7EN99, E9PGU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 146 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3