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P26045

- PTN3_HUMAN

UniProt

P26045 - PTN3_HUMAN

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Protein
Tyrosine-protein phosphatase non-receptor type 3
Gene
PTPN3, PTPH1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei811 – 8111Substrate By similarity
Active sitei842 – 8421Phosphocysteine intermediate By similarity
Binding sitei886 – 8861Substrate By similarity

GO - Molecular functioni

  1. ATPase binding Source: BHF-UCL
  2. phosphotyrosine binding Source: BHF-UCL
  3. protein binding Source: IntAct
  4. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of membrane protein ectodomain proteolysis Source: BHF-UCL
  2. negative regulation of mitotic cell cycle Source: BHF-UCL
  3. peptidyl-tyrosine dephosphorylation Source: GOC
  4. protein dephosphorylation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 3 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase H1
Short name:
PTP-H1
Gene namesi
Name:PTPN3
Synonyms:PTPH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:9655. PTPN3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic side of plasma membrane Source: UniProtKB
  3. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 913913Tyrosine-protein phosphatase non-receptor type 3
PRO_0000219433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei359 – 3591Phosphoserine1 Publication
Modified residuei367 – 3671Phosphoserine1 Publication
Modified residuei376 – 3761Phosphothreonine1 Publication
Modified residuei381 – 3811Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP26045.
PaxDbiP26045.
PRIDEiP26045.

PTM databases

PhosphoSiteiP26045.

Expressioni

Gene expression databases

ArrayExpressiP26045.
BgeeiP26045.
CleanExiHS_PTPN3.
GenevestigatoriP26045.

Organism-specific databases

HPAiHPA038343.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
E6P064634EBI-1047946,EBI-1186926From a different organism.
GHRP109124EBI-1047946,EBI-286316
SCN5AQ145242EBI-1047946,EBI-726858
VCPP550722EBI-1047946,EBI-355164
VDRP114734EBI-1047946,EBI-286357

Protein-protein interaction databases

BioGridi111740. 7 interactions.
IntActiP26045. 15 interactions.
MINTiMINT-246110.
STRINGi9606.ENSP00000262539.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi649 – 6524
Helixi664 – 6663
Helixi668 – 6736
Turni683 – 6853
Beta strandi686 – 6883
Beta strandi690 – 6923
Beta strandi695 – 70511
Helixi706 – 7083
Beta strandi710 – 7178
Turni722 – 7243
Helixi725 – 73410
Beta strandi739 – 7424
Beta strandi746 – 7483
Beta strandi764 – 7674
Beta strandi770 – 77910
Beta strandi781 – 79212
Turni793 – 7953
Beta strandi798 – 8069
Beta strandi811 – 8133
Helixi819 – 83113
Beta strandi838 – 8414
Beta strandi843 – 8464
Helixi847 – 86317
Helixi870 – 8789
Helixi888 – 90316

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B49X-ray1.54A628-913[»]
ProteinModelPortaliP26045.
SMRiP26045. Positions 31-309, 508-595, 646-904.

Miscellaneous databases

EvolutionaryTraceiP26045.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 312284FERM
Add
BLAST
Domaini510 – 58273PDZ
Add
BLAST
Domaini646 – 901256Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni842 – 8487Substrate binding By similarity

Sequence similaritiesi

Contains 1 FERM domain.
Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000007048.
HOVERGENiHBG008322.
InParanoidiP26045.
KOiK18027.
OMAiHFGDYNS.
OrthoDBiEOG76HQ1B.
PhylomeDBiP26045.
TreeFamiTF315900.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P26045-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTSRLRALGG RINNIRTSEL PKEKTRSEVI CSIHFLDGVV QTFKVTKQDT    50
GQVLLDMVHN HLGVTEKEYF GLQHDDDSVD SPRWLEASKA IRKQLKGGFP 100
CTLHFRVRFF IPDPNTLQQE QTRHLYFLQL KMDICEGRLT CPLNSAVVLA 150
SYAVQSHFGD YNSSIHHPGY LSDSHFIPDQ NEDFLTKVES LHEQHSGLKQ 200
SEAESCYINI ARTLDFYGVE LHSGRDLHNL DLMIGIASAG VAVYRKYICT 250
SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS 300
CVEHHTFFQA KKLLPQEKNV LSQYWTMGSR NTKKSVNNQY CKKVIGGMVW 350
NPAMRRSLSV EHLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA 400
NEMTYITETE DVFYTYKGSL APQDSDSEVS QNRSPHQESL SENNPAQSYL 450
TQKSSSSVSP SSNAPGSCSP DGVDQQLLDD FHRVTKGGST EDASQYYCDK 500
NDNGDSYLVL IRITPDEDGK FGFNLKGGVD QKMPLVVSRI NPESPADTCI 550
PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRRAVR 600
SFADFKSEDE LNQLFPEAIF PMCPEGGDTL EGSMAQLKKG LESGTVLIQF 650
EQLYRKKPGL AITFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY 700
VNMEIPAANL VNKYIATQGP LPHTCAQFWQ VVWDQKLSLI VMLTTLTERG 750
RTKCHQYWPD PPDVMNHGGF HIQCQSEDCT IAYVSREMLV TNTQTGEEHT 800
VTHLQYVAWP DHGVPDDSSD FLEFVNYVRS LRVDSEPVLV HCSAGIGRTG 850
VLVTMETAMC LTERNLPIYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR 900
VYEEGLVQML DPS 913
Length:913
Mass (Da):103,990
Last modified:May 5, 2009 - v2
Checksum:i44FBBFA35A5F2AFF
GO
Isoform 2 (identifier: P26045-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Note: No experimental confirmation available.

Show »
Length:782
Mass (Da):88,814
Checksum:i00302B9F06B3568B
GO
Isoform 3 (identifier: P26045-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     335-379: Missing.

Note: No experimental confirmation available.

Show »
Length:737
Mass (Da):83,723
Checksum:i6A9CCF192920EDE7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771D → N.
Corresponds to variant rs35285139 [ dbSNP | Ensembl ].
VAR_055252
Natural varianti90 – 901A → P.1 Publication
Corresponds to variant rs3793524 [ dbSNP | Ensembl ].
VAR_055253
Natural varianti409 – 4091T → A.
Corresponds to variant rs10979858 [ dbSNP | Ensembl ].
VAR_055254
Natural varianti605 – 6051F → L.
Corresponds to variant rs7859962 [ dbSNP | Ensembl ].
VAR_055255
Natural varianti763 – 7631D → N.
Corresponds to variant rs10116806 [ dbSNP | Ensembl ].
VAR_055256

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 131131Missing in isoform 2 and isoform 3.
VSP_046309Add
BLAST
Alternative sequencei335 – 37945Missing in isoform 3.
VSP_046310Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti814 – 8141V → I in AAA35647. 1 Publication
Sequence conflicti814 – 8141V → I in AAB22439. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64572 mRNA. Translation: AAA35647.1.
BX648253 mRNA. No translation available.
BX648735 mRNA. No translation available.
AL359963, AL162733, AL450025 Genomic DNA. Translation: CAH71094.1.
AL450025, AL162733, AL359963 Genomic DNA. Translation: CAH73252.1.
AL162733, AL359963, AL450025 Genomic DNA. Translation: CAH73386.1.
CH471105 Genomic DNA. Translation: EAW59046.1.
BC126117 mRNA. Translation: AAI26118.1.
S39392 mRNA. Translation: AAB22439.2.
S76309 mRNA. Translation: AAB33583.1.
CCDSiCCDS48000.1. [P26045-3]
CCDS48001.1. [P26045-2]
CCDS6776.1. [P26045-1]
PIRiA41109.
RefSeqiNP_001138840.1. NM_001145368.1.
NP_001138841.1. NM_001145369.1. [P26045-2]
NP_001138842.1. NM_001145370.1. [P26045-3]
NP_001138843.1. NM_001145371.1.
NP_002820.3. NM_002829.3. [P26045-1]
XP_006717261.1. XM_006717198.1. [P26045-1]
XP_006717262.1. XM_006717199.1. [P26045-1]
XP_006717267.1. XM_006717204.1. [P26045-2]
XP_006717269.1. XM_006717206.1. [P26045-3]
UniGeneiHs.436429.

Genome annotation databases

EnsembliENST00000374541; ENSP00000363667; ENSG00000070159. [P26045-1]
ENST00000412145; ENSP00000416654; ENSG00000070159. [P26045-2]
ENST00000446349; ENSP00000395384; ENSG00000070159. [P26045-3]
GeneIDi5774.
KEGGihsa:5774.
UCSCiuc004beb.2. human. [P26045-1]

Polymorphism databases

DMDMi229462761.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64572 mRNA. Translation: AAA35647.1 .
BX648253 mRNA. No translation available.
BX648735 mRNA. No translation available.
AL359963 , AL162733 , AL450025 Genomic DNA. Translation: CAH71094.1 .
AL450025 , AL162733 , AL359963 Genomic DNA. Translation: CAH73252.1 .
AL162733 , AL359963 , AL450025 Genomic DNA. Translation: CAH73386.1 .
CH471105 Genomic DNA. Translation: EAW59046.1 .
BC126117 mRNA. Translation: AAI26118.1 .
S39392 mRNA. Translation: AAB22439.2 .
S76309 mRNA. Translation: AAB33583.1 .
CCDSi CCDS48000.1. [P26045-3 ]
CCDS48001.1. [P26045-2 ]
CCDS6776.1. [P26045-1 ]
PIRi A41109.
RefSeqi NP_001138840.1. NM_001145368.1.
NP_001138841.1. NM_001145369.1. [P26045-2 ]
NP_001138842.1. NM_001145370.1. [P26045-3 ]
NP_001138843.1. NM_001145371.1.
NP_002820.3. NM_002829.3. [P26045-1 ]
XP_006717261.1. XM_006717198.1. [P26045-1 ]
XP_006717262.1. XM_006717199.1. [P26045-1 ]
XP_006717267.1. XM_006717204.1. [P26045-2 ]
XP_006717269.1. XM_006717206.1. [P26045-3 ]
UniGenei Hs.436429.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2B49 X-ray 1.54 A 628-913 [» ]
ProteinModelPortali P26045.
SMRi P26045. Positions 31-309, 508-595, 646-904.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111740. 7 interactions.
IntActi P26045. 15 interactions.
MINTi MINT-246110.
STRINGi 9606.ENSP00000262539.

Chemistry

ChEMBLi CHEMBL2396509.

PTM databases

PhosphoSitei P26045.

Polymorphism databases

DMDMi 229462761.

Proteomic databases

MaxQBi P26045.
PaxDbi P26045.
PRIDEi P26045.

Protocols and materials databases

DNASUi 5774.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374541 ; ENSP00000363667 ; ENSG00000070159 . [P26045-1 ]
ENST00000412145 ; ENSP00000416654 ; ENSG00000070159 . [P26045-2 ]
ENST00000446349 ; ENSP00000395384 ; ENSG00000070159 . [P26045-3 ]
GeneIDi 5774.
KEGGi hsa:5774.
UCSCi uc004beb.2. human. [P26045-1 ]

Organism-specific databases

CTDi 5774.
GeneCardsi GC09M112138.
H-InvDB HIX0025742.
HGNCi HGNC:9655. PTPN3.
HPAi HPA038343.
MIMi 176877. gene.
neXtProti NX_P26045.
PharmGKBi PA33999.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000007048.
HOVERGENi HBG008322.
InParanoidi P26045.
KOi K18027.
OMAi HFGDYNS.
OrthoDBi EOG76HQ1B.
PhylomeDBi P26045.
TreeFami TF315900.

Miscellaneous databases

ChiTaRSi PTPN3. human.
EvolutionaryTracei P26045.
GeneWikii PTPN3.
GenomeRNAii 5774.
NextBioi 22458.
PROi P26045.
SOURCEi Search...

Gene expression databases

ArrayExpressi P26045.
Bgeei P26045.
CleanExi HS_PTPN3.
Genevestigatori P26045.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSi PR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTi SM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin."
    Yang Q., Tonks N.K.
    Proc. Natl. Acad. Sci. U.S.A. 88:5949-5953(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-90.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Fetal kidney and Testis.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "cDNA cloning of new protein tyrosine phosphatases in the human colon."
    Arimura Y., Hinoda Y., Itoh F., Takekawa M., Tsujisaki M., Adachi M., Imai K., Yachi A.
    Tumor Biol. 13:180-186(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 194-896 (ISOFORM 1).
    Tissue: Colon.
  7. "Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma."
    Ikuta S., Itoh F., Hinoda Y., Toyota M., Makiguchi Y., Imai K., Yachi A.
    J. Gastroenterol. 29:727-732(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 899-913 (ISOFORM 1).
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359; SER-367; THR-376 AND SER-381, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
    Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
    Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 628-913.

Entry informationi

Entry nameiPTN3_HUMAN
AccessioniPrimary (citable) accession number: P26045
Secondary accession number(s): A0AUW9, E7EN99, E9PGU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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