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Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis (By similarity).By similarity

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutinin
Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin glycoprotein
Gene namesi
Name:H
OrganismiMeasles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri11237 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37IntravirionSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 617Virion surfaceSequence analysisAdd BLAST559

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426011 – 617Hemagglutinin glycoproteinAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP26028

Interactioni

Subunit structurei

Interacts with human NECTIN4; this interaction allows virus infection of the respiratory epithelium. Interacts with human MCP/CD46 antigen and SLAMF1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP26028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

P26028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPQRDRINA FDKDNPHPXX XXXXXXXXXX XXXRPYVLLA VLFVMFLSLI
60 70 80 90 100
GLLAIAGIRF HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG
110 120 130 140 150
DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLTWCI NPPERIKLDY
160 170 180 190 200
DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN
210 220 230 240 250
MSLSLLDLYL SRSYNVSSIV TMTSQGMHGG TYLVGKPNLS NKGSELSQLS
260 270 280 290 300
MYRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDLSNCMVA LGELKLAALC
310 320 330 340 350
HGEDSITIPY QGSGKGVSIQ LVKLGVWKSP TDMQSWVPLS TDDPVIDRLY
360 370 380 390 400
LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACRGEV QALCEDPEWA
410 420 430 440 450
PLKDGRIPSY GVLSVDLSLT VELKIKIASG FGPLITRGSG MDLYRSNHNN
460 470 480 490 500
VCWLAVPPMK SLALGVVNTL EWMPGFKVGP YLFTVPIKEA GEDCHAPAYL
510 520 530 540 550
PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPGRSFS
560 570 580 590 600
YFYPFRLPIK GVPIELQVEC FTWDQKLWCR HFCVLADSES GGHITHSGMV
610
GMGVSCTVTR EDGTNCR
Length:617
Mass (Da):68,626
Last modified:May 1, 1992 - v1
Checksum:i8FF518CE4A4CB4F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16566 Genomic RNA Translation: CAA34569.1

Similar proteinsi

Entry informationi

Entry nameiHEMA_MEASI
AccessioniPrimary (citable) accession number: P26028
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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