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Reviewed, UniProtKB/Swiss-Prot P26022 (PTX3_HUMAN)

Last modified January 19, 2010. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Pentraxin-related protein PTX3
Alternative name(s):
    Pentaxin-related protein PTX3
    Tumor necrosis factor-inducible gene 14 protein
      Short name=TSG-14
Gene names
Name: PTX3
Synonyms: TNFAIP5, TSG14
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility By similarity.

Subunit structure

Homooctamer; disulfide-linked. Binds to C1q By similarity. Ref.10

Subcellular location

Secreted.

Induction

By interleukin-1 beta and TNF-alpha.

Post-translational modification

Glycosylated Probable.

Sequence similarities

Contains 1 pentaxin domain.

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Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processinflammatory response Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentextracellular region Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 381364Pentraxin-related protein PTX3
PRO_0000023545

Regions

Domain183 – 381199Pentaxin
Coiled coil74 – 10128 Potential
Coiled coil143 – 16725 Potential

Amino acid modifications

Glycosylation2201N-linked (GlcNAc...) Potential
Disulfide bond47Interchain Ref.10
Disulfide bond49Interchain Ref.10
Disulfide bond103Interchain Ref.10
Disulfide bond179 ↔ 357 Ref.10
Disulfide bond210 ↔ 271 Ref.10
Disulfide bond317Interchain Ref.10
Disulfide bond318Interchain Ref.10

Natural variations

Natural variant391H → Q: dbSNP rs34655398.
VAR_043140
Natural variant481D → A: dbSNP rs3816527. Ref.4 Ref.5 Ref.6
VAR_043141
Natural variant2901A → V: dbSNP rs35415718.
VAR_043142
Natural variant3131E → K: dbSNP rs4478039.
VAR_043143

Experimental info

Sequence conflict2021M → L in AAA61234. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
P26022-1 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 787F749DBC86D59B

FASTA38142,020
        10         20         30         40         50         60 
MHLLAILFCA LWSAVLAENS DDYDLMYVNL DNEIDNGLHP TEDPTPCDCG QEHSEWDKLF 

        70         80         90        100        110        120 
IMLENSQMRE RMLLQATDDV LRGELQRLRE ELGRLAESLA RPCAPGAPAE ARLTSALDEL 

       130        140        150        160        170        180 
LQATRDAGRR LARMEGAEAQ RPEEAGRALA AVLEELRQTR ADLHAVQGWA ARSWLPAGCE 

       190        200        210        220        230        240 
TAILFPMRSK KIFGSVHPVR PMRLESFSAC IWVKATDVLN KTILFSYGTK RNPYEIQLYL 

       250        260        270        280        290        300 
SYQSIVFVVG GEENKLVAEA MVSLGRWTHL CGTWNSEEGL TSLWVNGELA ATTVEMATGH 

       310        320        330        340        350        360 
IVPEGGILQI GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE TGGAESCHIR 

       370        380 
GNIVGWGVTE IQPHGGAQYV S

« Hide

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References

« Hide 'large scale' references
[1]"Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component."
Breviario F., D'Aniello E.M., Golay J., Peri G., Bottazi B., Bairoch A., Saccone S., Marzella R., Predazzi V., Rocchi M., Della Valle G., Dejana E., Mantovani A., Introna M.
J. Biol. Chem. 267:22190-22197(1992) [PubMed: 1429570] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Endothelial cell.
[2]"IL-1 inducible genes in human umbilical vein endothelial cells."
Introna M., Breviario F., D'Aniello E.M., Golay J., Dejana E., Mantovani A.
Eur. Heart J. 14:78-81(1993) [PubMed: 8131794] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Endothelial cell.
[3]"TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins."
Lee G.W., Lee T.H., Vilcek J.
J. Immunol. 150:1804-1812(1993) [PubMed: 7679696] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Foreskin.
[4]"Genetic variation in pentaxin-related protein PTX3."
Tan J., Davila S., Hibberd M.L., Seielstad M.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-48.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-48.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-48.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[8]"Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins."
Lee G.W., Goodman A.R., Lee T.H., Vilcek J.
J. Immunol. 153:3700-3707(1994) [PubMed: 7523502] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.
[9]"Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity."
Mantovani A., Garlanda C., Bottazzi B.
Vaccine 21:S43-S47(2003) [PubMed: 12763682] [Abstract]
Cited for: REVIEW.
[10]"Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization."
Inforzato A., Rivieccio V., Morreale A.P., Bastone A., Salustri A., Scarchilli L., Verdoliva A., Vincenti S., Gallo G., Chiapparino C., Pacello L., Nucera E., Serlupi-Crescenzi O., Day A.J., Bottazzi B., Mantovani A., De Santis R., Salvatori G.
J. Biol. Chem. 283:10147-10161(2008) [PubMed: 18223257] [Abstract]
Cited for: SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X63053 mRNA. Translation: CAA44778.1.
X63613 mRNA. Translation: CAA45158.1.
M31166 mRNA. Translation: AAA61234.1.
DQ207368 Genomic DNA. Translation: ABA64467.1.
AK312705 mRNA. Translation: BAG35583.1.
CH471052 Genomic DNA. Translation: EAW78708.1.
BC039733 mRNA. Translation: AAH39733.1.
IPIIPI00029568.
PIRA44323.
RefSeqNP_002843.2.
UniGeneHs.591286
Hs.658046

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP26022.

Proteomic databases

PRIDEP26022.

Genome annotation databases

EnsemblENST00000295927; ENSP00000295927; ENSG00000163661; Homo sapiens. [Genome view]
GeneID5806.
KEGGhsa:5806.

Organism-specific databases

CTD5806.
GeneCardsGC03P158637.
H-InvDBHIX0024325.
HGNCHGNC:9692. PTX3.
MIM602492. gene.
PharmGKBPA34036.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG10142.
HOGENOMHBG717861.
HOVERGENP26022.
InParanoidP26022.
OrthoDBEOG91VNN3.

Gene expression databases

ArrayExpressP26022.
BgeeP26022.
CleanExHS_PTX3.
GenevestigatorP26022.
GermOnlineENSG00000163661. Homo sapiens.

Family and domain databases

InterProIPR008985. ConA-like_lec_gl.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
Gene3DG3DSA:2.60.120.200. ConA_like_subgrp. 1 hit.
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio22632.
SOURCESearch...

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Entry information

Entry namePTX3_HUMAN
AccessionPrimary (citable) accession number: P26022
Secondary accession number(s): B2R6T6, Q38M82
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1996
Last modified: January 19, 2010
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents