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P26022 (PTX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pentraxin-related protein PTX3
Alternative name(s):
Pentaxin-related protein PTX3
Tumor necrosis factor alpha-induced protein 5
Short name=TNF alpha-induced protein 5
Tumor necrosis factor-inducible gene 14 protein
Short name=TSG-14
Gene names
Name:PTX3
Synonyms:TNFAIP5, TSG14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility By similarity.

Subunit structure

Homooctamer; disulfide-linked. Binds to C1q By similarity. Ref.11

Subcellular location

Secreted.

Induction

By IL1B/interleukin-1 beta and TNF.

Post-translational modification

Glycosylated Probable.

Sequence similarities

Contains 1 pentaxin domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinflammatory response

Traceable author statement Ref.1. Source: ProtInc

innate immune response

Inferred from direct assay PubMed 23544079. Source: BHF-UCL

negative regulation of exo-alpha-sialidase activity

Inferred from direct assay PubMed 23544079. Source: BHF-UCL

negative regulation of glycoprotein metabolic process

Inferred from direct assay PubMed 23544079. Source: BHF-UCL

negative regulation of viral entry into host cell

Inferred from direct assay PubMed 23544079. Source: BHF-UCL

opsonization

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric oxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of phagocytosis

Inferred from electronic annotation. Source: Ensembl

response to yeast

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Traceable author statement Ref.1. Source: ProtInc

extracellular space

Inferred from direct assay PubMed 23544079. Source: BHF-UCL

   Molecular_function(1->3)-beta-D-glucan binding

Inferred from electronic annotation. Source: Ensembl

complement component C1q binding

Inferred from direct assay PubMed 23544079. Source: BHF-UCL

virion binding

Inferred from direct assay PubMed 23544079. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 381364Pentraxin-related protein PTX3
PRO_0000023545

Regions

Domain183 – 381199Pentaxin
Coiled coil74 – 10128 Potential
Coiled coil143 – 16725 Potential

Amino acid modifications

Glycosylation2201N-linked (GlcNAc...) Potential
Disulfide bond47Interchain Ref.11
Disulfide bond49Interchain Ref.11
Disulfide bond103Interchain Ref.11
Disulfide bond179 ↔ 357 Ref.11
Disulfide bond210 ↔ 271 Ref.11
Disulfide bond317Interchain Ref.11
Disulfide bond318Interchain Ref.11

Natural variations

Natural variant391H → Q.
Corresponds to variant rs34655398 [ dbSNP | Ensembl ].
VAR_043140
Natural variant481A → D. Ref.1 Ref.2 Ref.3 Ref.8
Corresponds to variant rs3816527 [ dbSNP | Ensembl ].
VAR_043141
Natural variant2901A → V.
Corresponds to variant rs35415718 [ dbSNP | Ensembl ].
VAR_043142
Natural variant3131E → K.
Corresponds to variant rs4478039 [ dbSNP | Ensembl ].
VAR_043143

Experimental info

Sequence conflict2021M → L in AAA61234. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P26022 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 09BCE02E2A62D62A

FASTA38141,976
        10         20         30         40         50         60 
MHLLAILFCA LWSAVLAENS DDYDLMYVNL DNEIDNGLHP TEDPTPCACG QEHSEWDKLF 

        70         80         90        100        110        120 
IMLENSQMRE RMLLQATDDV LRGELQRLRE ELGRLAESLA RPCAPGAPAE ARLTSALDEL 

       130        140        150        160        170        180 
LQATRDAGRR LARMEGAEAQ RPEEAGRALA AVLEELRQTR ADLHAVQGWA ARSWLPAGCE 

       190        200        210        220        230        240 
TAILFPMRSK KIFGSVHPVR PMRLESFSAC IWVKATDVLN KTILFSYGTK RNPYEIQLYL 

       250        260        270        280        290        300 
SYQSIVFVVG GEENKLVAEA MVSLGRWTHL CGTWNSEEGL TSLWVNGELA ATTVEMATGH 

       310        320        330        340        350        360 
IVPEGGILQI GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE TGGAESCHIR 

       370        380 
GNIVGWGVTE IQPHGGAQYV S 

« Hide

References

« Hide 'large scale' references
[1]"Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component."
Breviario F., D'Aniello E.M., Golay J., Peri G., Bottazi B., Bairoch A., Saccone S., Marzella R., Predazzi V., Rocchi M., Della Valle G., Dejana E., Mantovani A., Introna M.
J. Biol. Chem. 267:22190-22197(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-48.
Tissue: Endothelial cell.
[2]"IL-1 inducible genes in human umbilical vein endothelial cells."
Introna M., Breviario F., D'Aniello E.M., Golay J., Dejana E., Mantovani A.
Eur. Heart J. 14:78-81(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-48.
Tissue: Endothelial cell.
[3]"TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins."
Lee G.W., Lee T.H., Vilcek J.
J. Immunol. 150:1804-1812(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-48.
Tissue: Foreskin.
[4]"Genetic variation in pentaxin-related protein PTX3."
Tan J., Davila S., Hibberd M.L., Seielstad M.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-48.
Tissue: Brain.
[9]"Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins."
Lee G.W., Goodman A.R., Lee T.H., Vilcek J.
J. Immunol. 153:3700-3707(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.
[10]"Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity."
Mantovani A., Garlanda C., Bottazzi B.
Vaccine 21:S43-S47(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[11]"Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization."
Inforzato A., Rivieccio V., Morreale A.P., Bastone A., Salustri A., Scarchilli L., Verdoliva A., Vincenti S., Gallo G., Chiapparino C., Pacello L., Nucera E., Serlupi-Crescenzi O., Day A.J., Bottazzi B., Mantovani A., De Santis R., Salvatori G.
J. Biol. Chem. 283:10147-10161(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63613 mRNA. Translation: CAA45158.1.
X63053 mRNA. Translation: CAA44778.1.
M31166 mRNA. Translation: AAA61234.1.
DQ207368 Genomic DNA. Translation: ABA64467.1.
AK312705 mRNA. Translation: BAG35583.1.
AC020630 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78708.1.
BC039733 mRNA. Translation: AAH39733.1.
CCDSCCDS3180.1.
PIRA44323.
RefSeqNP_002843.2. NM_002852.3.
UniGeneHs.591286.

3D structure databases

ProteinModelPortalP26022.
SMRP26022. Positions 182-375.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000295927.

PTM databases

PhosphoSiteP26022.

Polymorphism databases

DMDM296452984.

Proteomic databases

MaxQBP26022.
PaxDbP26022.
PRIDEP26022.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295927; ENSP00000295927; ENSG00000163661.
GeneID5806.
KEGGhsa:5806.
UCSCuc003fbl.4. human.

Organism-specific databases

CTD5806.
GeneCardsGC03P157154.
H-InvDBHIX0024325.
HGNCHGNC:9692. PTX3.
HPACAB022226.
MIM602492. gene.
neXtProtNX_P26022.
PharmGKBPA34036.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40461.
HOGENOMHOG000247046.
HOVERGENHBG008331.
InParanoidP26022.
OMANIVGWGV.
OrthoDBEOG74XS6F.
PhylomeDBP26022.
TreeFamTF330208.

Gene expression databases

BgeeP26022.
CleanExHS_PTX3.
GenevestigatorP26022.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPTX3.
GenomeRNAi5806.
NextBio22632.
PMAP-CutDBB2R6T6.
PROP26022.
SOURCESearch...

Entry information

Entry namePTX3_HUMAN
AccessionPrimary (citable) accession number: P26022
Secondary accession number(s): B2R6T6, Q38M82
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM