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P26022

- PTX3_HUMAN

UniProt

P26022 - PTX3_HUMAN

Protein

Pentraxin-related protein PTX3

Gene

PTX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.By similarity

    GO - Molecular functioni

    1. (1->3)-beta-D-glucan binding Source: Ensembl
    2. complement component C1q binding Source: BHF-UCL
    3. virion binding Source: BHF-UCL

    GO - Biological processi

    1. inflammatory response Source: ProtInc
    2. innate immune response Source: BHF-UCL
    3. negative regulation of exo-alpha-sialidase activity Source: BHF-UCL
    4. negative regulation of glycoprotein metabolic process Source: BHF-UCL
    5. negative regulation of viral entry into host cell Source: BHF-UCL
    6. opsonization Source: Ensembl
    7. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    8. positive regulation of phagocytosis Source: Ensembl
    9. response to yeast Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pentraxin-related protein PTX3
    Alternative name(s):
    Pentaxin-related protein PTX3
    Tumor necrosis factor alpha-induced protein 5
    Short name:
    TNF alpha-induced protein 5
    Tumor necrosis factor-inducible gene 14 protein
    Short name:
    TSG-14
    Gene namesi
    Name:PTX3
    Synonyms:TNFAIP5, TSG14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:9692. PTX3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: ProtInc
    2. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34036.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 381364Pentraxin-related protein PTX3PRO_0000023545Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 – 47Interchain1 Publication
    Disulfide bondi49 – 49Interchain1 Publication
    Disulfide bondi103 – 103Interchain1 Publication
    Disulfide bondi179 ↔ 3571 Publication
    Disulfide bondi210 ↔ 2711 Publication
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi317 – 317Interchain1 Publication
    Disulfide bondi318 – 318Interchain1 Publication

    Post-translational modificationi

    Glycosylated.Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP26022.
    PaxDbiP26022.
    PRIDEiP26022.

    PTM databases

    PhosphoSiteiP26022.

    Miscellaneous databases

    PMAP-CutDBB2R6T6.

    Expressioni

    Inductioni

    By IL1B/interleukin-1 beta and TNF.

    Gene expression databases

    BgeeiP26022.
    CleanExiHS_PTX3.
    GenevestigatoriP26022.

    Organism-specific databases

    HPAiCAB022226.

    Interactioni

    Subunit structurei

    Homooctamer; disulfide-linked. Binds to C1q By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000295927.

    Structurei

    3D structure databases

    ProteinModelPortaliP26022.
    SMRiP26022. Positions 182-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini183 – 381199PentaxinAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili74 – 10128Sequence AnalysisAdd
    BLAST
    Coiled coili143 – 16725Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG40461.
    HOGENOMiHOG000247046.
    HOVERGENiHBG008331.
    InParanoidiP26022.
    OMAiNIVGWGV.
    OrthoDBiEOG74XS6F.
    PhylomeDBiP26022.
    TreeFamiTF330208.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00289. PENTAXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P26022-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLLAILFCA LWSAVLAENS DDYDLMYVNL DNEIDNGLHP TEDPTPCACG    50
    QEHSEWDKLF IMLENSQMRE RMLLQATDDV LRGELQRLRE ELGRLAESLA 100
    RPCAPGAPAE ARLTSALDEL LQATRDAGRR LARMEGAEAQ RPEEAGRALA 150
    AVLEELRQTR ADLHAVQGWA ARSWLPAGCE TAILFPMRSK KIFGSVHPVR 200
    PMRLESFSAC IWVKATDVLN KTILFSYGTK RNPYEIQLYL SYQSIVFVVG 250
    GEENKLVAEA MVSLGRWTHL CGTWNSEEGL TSLWVNGELA ATTVEMATGH 300
    IVPEGGILQI GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE 350
    TGGAESCHIR GNIVGWGVTE IQPHGGAQYV S 381
    Length:381
    Mass (Da):41,976
    Last modified:May 18, 2010 - v3
    Checksum:i09BCE02E2A62D62A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021M → L in AAA61234. (PubMed:7679696)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391H → Q.
    Corresponds to variant rs34655398 [ dbSNP | Ensembl ].
    VAR_043140
    Natural varianti48 – 481A → D.4 Publications
    Corresponds to variant rs3816527 [ dbSNP | Ensembl ].
    VAR_043141
    Natural varianti290 – 2901A → V.
    Corresponds to variant rs35415718 [ dbSNP | Ensembl ].
    VAR_043142
    Natural varianti313 – 3131E → K.
    Corresponds to variant rs4478039 [ dbSNP | Ensembl ].
    VAR_043143

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63613 mRNA. Translation: CAA45158.1.
    X63053 mRNA. Translation: CAA44778.1.
    M31166 mRNA. Translation: AAA61234.1.
    DQ207368 Genomic DNA. Translation: ABA64467.1.
    AK312705 mRNA. Translation: BAG35583.1.
    AC020630 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78708.1.
    BC039733 mRNA. Translation: AAH39733.1.
    CCDSiCCDS3180.1.
    PIRiA44323.
    RefSeqiNP_002843.2. NM_002852.3.
    UniGeneiHs.591286.

    Genome annotation databases

    EnsembliENST00000295927; ENSP00000295927; ENSG00000163661.
    GeneIDi5806.
    KEGGihsa:5806.
    UCSCiuc003fbl.4. human.

    Polymorphism databases

    DMDMi296452984.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63613 mRNA. Translation: CAA45158.1 .
    X63053 mRNA. Translation: CAA44778.1 .
    M31166 mRNA. Translation: AAA61234.1 .
    DQ207368 Genomic DNA. Translation: ABA64467.1 .
    AK312705 mRNA. Translation: BAG35583.1 .
    AC020630 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78708.1 .
    BC039733 mRNA. Translation: AAH39733.1 .
    CCDSi CCDS3180.1.
    PIRi A44323.
    RefSeqi NP_002843.2. NM_002852.3.
    UniGenei Hs.591286.

    3D structure databases

    ProteinModelPortali P26022.
    SMRi P26022. Positions 182-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000295927.

    PTM databases

    PhosphoSitei P26022.

    Polymorphism databases

    DMDMi 296452984.

    Proteomic databases

    MaxQBi P26022.
    PaxDbi P26022.
    PRIDEi P26022.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295927 ; ENSP00000295927 ; ENSG00000163661 .
    GeneIDi 5806.
    KEGGi hsa:5806.
    UCSCi uc003fbl.4. human.

    Organism-specific databases

    CTDi 5806.
    GeneCardsi GC03P157154.
    H-InvDB HIX0024325.
    HGNCi HGNC:9692. PTX3.
    HPAi CAB022226.
    MIMi 602492. gene.
    neXtProti NX_P26022.
    PharmGKBi PA34036.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40461.
    HOGENOMi HOG000247046.
    HOVERGENi HBG008331.
    InParanoidi P26022.
    OMAi NIVGWGV.
    OrthoDBi EOG74XS6F.
    PhylomeDBi P26022.
    TreeFami TF330208.

    Miscellaneous databases

    GeneWikii PTX3.
    GenomeRNAii 5806.
    NextBioi 22632.
    PMAP-CutDB B2R6T6.
    PROi P26022.
    SOURCEi Search...

    Gene expression databases

    Bgeei P26022.
    CleanExi HS_PTX3.
    Genevestigatori P26022.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00289. PENTAXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component."
      Breviario F., D'Aniello E.M., Golay J., Peri G., Bottazi B., Bairoch A., Saccone S., Marzella R., Predazzi V., Rocchi M., Della Valle G., Dejana E., Mantovani A., Introna M.
      J. Biol. Chem. 267:22190-22197(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-48.
      Tissue: Endothelial cell.
    2. "IL-1 inducible genes in human umbilical vein endothelial cells."
      Introna M., Breviario F., D'Aniello E.M., Golay J., Dejana E., Mantovani A.
      Eur. Heart J. 14:78-81(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-48.
      Tissue: Endothelial cell.
    3. "TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins."
      Lee G.W., Lee T.H., Vilcek J.
      J. Immunol. 150:1804-1812(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-48.
      Tissue: Foreskin.
    4. "Genetic variation in pentaxin-related protein PTX3."
      Tan J., Davila S., Hibberd M.L., Seielstad M.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-48.
      Tissue: Brain.
    9. "Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins."
      Lee G.W., Goodman A.R., Lee T.H., Vilcek J.
      J. Immunol. 153:3700-3707(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.
    10. "Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity."
      Mantovani A., Garlanda C., Bottazzi B.
      Vaccine 21:S43-S47(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    11. Cited for: SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiPTX3_HUMAN
    AccessioniPrimary (citable) accession number: P26022
    Secondary accession number(s): B2R6T6, Q38M82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3