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P26018

- CHS1_HORVU

UniProt

P26018 - CHS1_HORVU

Protein

Chalcone synthase 1

Gene

CHS1

Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    • Comment

    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei167 – 1671PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase 1 (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase 1
    Gene namesi
    Name:CHS1
    Synonyms:CHS
    OrganismiHordeum vulgare (Barley)
    Taxonomic identifieri4513 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

    Organism-specific databases

    GrameneiP26018.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Chalcone synthase 1PRO_0000215979Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP26018.

    Structurei

    3D structure databases

    ProteinModelPortaliP26018.
    SMRiP26018. Positions 6-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26018-1 [UniParc]FASTAAdd to Basket

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    MAATMTVEEV RNAQRAEGPA TVLAIGTATP ANCVYQADYP DYYFKITKSD    50
    HMADLKEKFK RMCDKSQIRK RYMHLTEEIL EENPNMCAYM APSLDARQDI 100
    VVVEVPKLGK AAAQKAIKEW GQPRSKITHL VFCTTSGVDM PGADYQLTKM 150
    LGLRPSVKRL MMYQQGCFAG GTVLRLAKDL AENNRGARVL VVCSEITAVT 200
    FRGPHESHLD SLVGQALFGD GAAAVIIGAD PDLSVERPLF QLVSASQTIL 250
    PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIERALEEAF KPLGIDHWNS 300
    VFWIAHQGGP AILDMVEAKV NLNKERMRAT RHVLSEYGNM SSACVLFIMD 350
    EMRKRSAEDG HATTGEGMDW GVLFGFGPGL TVETVVLHSV PISAGATA 398
    Length:398
    Mass (Da):43,532
    Last modified:May 1, 1992 - v1
    Checksum:i01E7AC1656FCA70D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58339 Genomic DNA. Translation: CAA41250.1.
    PIRiS16275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58339 Genomic DNA. Translation: CAA41250.1 .
    PIRi S16275.

    3D structure databases

    ProteinModelPortali P26018.
    SMRi P26018. Positions 6-392.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei P26018.

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Gene expression databases

    Genevestigatori P26018.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of a chalcone synthase gene from Hordeum vulgare."
      Rohde W., Doerr S., Salamini F., Becker D.
      Plant Mol. Biol. 16:1103-1106(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. C2.
      Tissue: Leaf.

    Entry informationi

    Entry nameiCHS1_HORVU
    AccessioniPrimary (citable) accession number: P26018
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3