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P26018

- CHS1_HORVU

UniProt

P26018 - CHS1_HORVU

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Protein

Chalcone synthase 1

Gene

CHS1

Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei167 – 1671PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 1
Gene namesi
Name:CHS1
Synonyms:CHS
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Organism-specific databases

GrameneiP26018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Chalcone synthase 1PRO_0000215979Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP26018.

Structurei

3D structure databases

ProteinModelPortaliP26018.
SMRiP26018. Positions 6-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26018 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATMTVEEV RNAQRAEGPA TVLAIGTATP ANCVYQADYP DYYFKITKSD
60 70 80 90 100
HMADLKEKFK RMCDKSQIRK RYMHLTEEIL EENPNMCAYM APSLDARQDI
110 120 130 140 150
VVVEVPKLGK AAAQKAIKEW GQPRSKITHL VFCTTSGVDM PGADYQLTKM
160 170 180 190 200
LGLRPSVKRL MMYQQGCFAG GTVLRLAKDL AENNRGARVL VVCSEITAVT
210 220 230 240 250
FRGPHESHLD SLVGQALFGD GAAAVIIGAD PDLSVERPLF QLVSASQTIL
260 270 280 290 300
PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIERALEEAF KPLGIDHWNS
310 320 330 340 350
VFWIAHQGGP AILDMVEAKV NLNKERMRAT RHVLSEYGNM SSACVLFIMD
360 370 380 390
EMRKRSAEDG HATTGEGMDW GVLFGFGPGL TVETVVLHSV PISAGATA
Length:398
Mass (Da):43,532
Last modified:May 1, 1992 - v1
Checksum:i01E7AC1656FCA70D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58339 Genomic DNA. Translation: CAA41250.1.
PIRiS16275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58339 Genomic DNA. Translation: CAA41250.1 .
PIRi S16275.

3D structure databases

ProteinModelPortali P26018.
SMRi P26018. Positions 6-392.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P26018.

Enzyme and pathway databases

UniPathwayi UPA00154 .

Gene expression databases

Genevestigatori P26018.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of a chalcone synthase gene from Hordeum vulgare."
    Rohde W., Doerr S., Salamini F., Becker D.
    Plant Mol. Biol. 16:1103-1106(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. C2.
    Tissue: Leaf.

Entry informationi

Entry nameiCHS1_HORVU
AccessioniPrimary (citable) accession number: P26018
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3