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Protein

Chalcone synthase 1

Gene

CHS1

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei167PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 1
Gene namesi
Name:CHS1
Synonyms:CHS
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159791 – 398Chalcone synthase 1Add BLAST398

Expressioni

Gene expression databases

ExpressionAtlasiP26018 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliP26018
SMRiP26018
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiENOG410IKG2 Eukaryota
COG3424 LUCA

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR012328 Chalcone/stilbene_synth_C
IPR018088 Chalcone/stilbene_synthase_AS
IPR001099 Chalcone/stilbene_synthase_N
IPR011141 Polyketide_synthase_type-III
IPR016039 Thiolase-like
PANTHERiPTHR11877 PTHR11877, 1 hit
PfamiView protein in Pfam
PF02797 Chal_sti_synt_C, 1 hit
PF00195 Chal_sti_synt_N, 1 hit
PIRSFiPIRSF000451 PKS_III, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
PROSITEiView protein in PROSITE
PS00441 CHALCONE_SYNTH, 1 hit

Sequencei

Sequence statusi: Complete.

P26018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATMTVEEV RNAQRAEGPA TVLAIGTATP ANCVYQADYP DYYFKITKSD
60 70 80 90 100
HMADLKEKFK RMCDKSQIRK RYMHLTEEIL EENPNMCAYM APSLDARQDI
110 120 130 140 150
VVVEVPKLGK AAAQKAIKEW GQPRSKITHL VFCTTSGVDM PGADYQLTKM
160 170 180 190 200
LGLRPSVKRL MMYQQGCFAG GTVLRLAKDL AENNRGARVL VVCSEITAVT
210 220 230 240 250
FRGPHESHLD SLVGQALFGD GAAAVIIGAD PDLSVERPLF QLVSASQTIL
260 270 280 290 300
PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIERALEEAF KPLGIDHWNS
310 320 330 340 350
VFWIAHQGGP AILDMVEAKV NLNKERMRAT RHVLSEYGNM SSACVLFIMD
360 370 380 390
EMRKRSAEDG HATTGEGMDW GVLFGFGPGL TVETVVLHSV PISAGATA
Length:398
Mass (Da):43,532
Last modified:May 1, 1992 - v1
Checksum:i01E7AC1656FCA70D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58339 Genomic DNA Translation: CAA41250.1
PIRiS16275

Similar proteinsi

Entry informationi

Entry nameiCHS1_HORVU
AccessioniPrimary (citable) accession number: P26018
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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