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P26018 (CHS1_HORVU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 1

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 1
Gene names
Name:CHS1
Synonyms:CHS
OrganismHordeum vulgare (Barley)
Taxonomic identifier4513 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Chalcone synthase 1
PRO_0000215979

Sites

Active site1671 By similarity

Sequences

Sequence LengthMass (Da)Tools
P26018 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 01E7AC1656FCA70D

FASTA39843,532
        10         20         30         40         50         60 
MAATMTVEEV RNAQRAEGPA TVLAIGTATP ANCVYQADYP DYYFKITKSD HMADLKEKFK 

        70         80         90        100        110        120 
RMCDKSQIRK RYMHLTEEIL EENPNMCAYM APSLDARQDI VVVEVPKLGK AAAQKAIKEW 

       130        140        150        160        170        180 
GQPRSKITHL VFCTTSGVDM PGADYQLTKM LGLRPSVKRL MMYQQGCFAG GTVLRLAKDL 

       190        200        210        220        230        240 
AENNRGARVL VVCSEITAVT FRGPHESHLD SLVGQALFGD GAAAVIIGAD PDLSVERPLF 

       250        260        270        280        290        300 
QLVSASQTIL PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIERALEEAF KPLGIDHWNS 

       310        320        330        340        350        360 
VFWIAHQGGP AILDMVEAKV NLNKERMRAT RHVLSEYGNM SSACVLFIMD EMRKRSAEDG 

       370        380        390 
HATTGEGMDW GVLFGFGPGL TVETVVLHSV PISAGATA 

« Hide

References

[1]"Structure of a chalcone synthase gene from Hordeum vulgare."
Rohde W., Doerr S., Salamini F., Becker D.
Plant Mol. Biol. 16:1103-1106(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. C2.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58339 Genomic DNA. Translation: CAA41250.1.
PIRS16275.

3D structure databases

ProteinModelPortalP26018.
SMRP26018. Positions 6-392.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP26018.

Enzyme and pathway databases

UniPathwayUPA00154.

Gene expression databases

GenevestigatorP26018.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS1_HORVU
AccessionPrimary (citable) accession number: P26018
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 16, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways