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Protein

Polycomb group protein Pc

Gene

Pc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Promotes locus-specific chromatin compaction.

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • core promoter binding Source: FlyBase
  • methylated histone binding Source: FlyBase

GO - Biological processi

  • gene silencing Source: FlyBase
  • negative regulation of response to gamma radiation Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • neurogenesis Source: FlyBase
  • neuron remodeling Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • specification of segmental identity, abdomen Source: FlyBase
  • syncytial blastoderm mitotic cell cycle Source: FlyBase
  • ventral cord development Source: FlyBase
  • wound healing Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-2559580. Oxidative Stress Induced Senescence.
R-DME-3108214. SUMOylation of DNA damage response and repair proteins.
R-DME-4570464. SUMOylation of RNA binding proteins.
SignaLinkiP26017.

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group protein Pc
Short name:
Protein polycomb
Gene namesi
Name:Pc
ORF Names:CG7618
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0003042. Pc.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: FlyBase
  • intercalary heterochromatin Source: FlyBase
  • nucleolus Source: FlyBase
  • nucleus Source: FlyBase
  • PRC1 complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802181 – 390Polycomb group protein PcAdd BLAST390

Proteomic databases

PaxDbiP26017.
PRIDEiP26017.

Expressioni

Developmental stagei

Required during the entire larval period for normal adult development. It is found in almost all cells and tissues throughout gastrulation and organogenesis though at a much lower level than in early syncytial stages.

Gene expression databases

BgeeiFBgn0003042.
ExpressionAtlasiP26017. baseline.
GenevisibleiP26017. DM.

Interactioni

Subunit structurei

Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, Rpd3 and Caf1. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.2 Publications

GO - Molecular functioni

  • methylated histone binding Source: FlyBase

Protein-protein interaction databases

BioGridi65606. 46 interactors.
IntActiP26017. 1 interactor.
MINTiMINT-271335.
STRINGi7227.FBpp0078059.

Structurei

Secondary structure

1390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 37Combined sources14
Beta strandi40 – 47Combined sources8
Helixi52 – 54Combined sources3
Beta strandi56 – 59Combined sources4
Helixi60 – 62Combined sources3
Helixi67 – 73Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PDQX-ray1.76A15-77[»]
1PFBX-ray1.40A23-77[»]
ProteinModelPortaliP26017.
SMRiP26017.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26017.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 84ChromoPROSITE-ProRule annotationAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 143Poly-His10
Compositional biasi160 – 167Poly-His8

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2748. Eukaryota.
ENOG41122KC. LUCA.
InParanoidiP26017.
KOiK11455.
OMAiNNIPKPC.
OrthoDBiEOG091G0NOT.
PhylomeDBiP26017.

Family and domain databases

InterProiIPR033773. CBX7_C.
IPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF17218. CBX7_C. 1 hit.
PF00385. Chromo. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRGKGSKG KLGRDNATDD PVDLVYAAEK IIQKRVKKGV VEYRVKWKGW
60 70 80 90 100
NQRYNTWEPE VNILDRRLID IYEQTNKSSG TPSKRGIKKK EKEPDPEPES
110 120 130 140 150
EEDEYTFTEN DVDTHQATTS SATHDKESKK EKKHHHHHHH HHHIKSERNS
160 170 180 190 200
GRRSESPLTH HHHHHHHESK RQRIDHSSSS NSSFTHNSFV PEPDSNSSSS
210 220 230 240 250
EDQPLIGTKR KAEVLKESGK IGVTIKTSPD GPTIKPQPTQ QVTPSQQQPF
260 270 280 290 300
QDQQQAEKIA SEAATQLKSE QQATPLATEA INTTPAESGA EEEEVANEEG
310 320 330 340 350
NQQAPQVPSE NNNIPKPCNN LAINQKQPLT PLSPRALPPR FWLPAKCNIS
360 370 380 390
NRVVITDVTV NLETVTIREC KTERGFFRER DMKGDSSPVA
Length:390
Mass (Da):43,976
Last modified:May 1, 1992 - v1
Checksum:i5DB24AE4B326C3B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55702 Genomic DNA. Translation: CAA39229.1.
AE014296 Genomic DNA. Translation: AAF51707.1.
PIRiA38565.
RefSeqiNP_524199.1. NM_079475.3.
UniGeneiDm.13644.

Genome annotation databases

EnsemblMetazoaiFBtr0078405; FBpp0078059; FBgn0003042.
GeneIDi40358.
KEGGidme:Dmel_CG32443.
UCSCiCG32443-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55702 Genomic DNA. Translation: CAA39229.1.
AE014296 Genomic DNA. Translation: AAF51707.1.
PIRiA38565.
RefSeqiNP_524199.1. NM_079475.3.
UniGeneiDm.13644.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PDQX-ray1.76A15-77[»]
1PFBX-ray1.40A23-77[»]
ProteinModelPortaliP26017.
SMRiP26017.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65606. 46 interactors.
IntActiP26017. 1 interactor.
MINTiMINT-271335.
STRINGi7227.FBpp0078059.

Proteomic databases

PaxDbiP26017.
PRIDEiP26017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078405; FBpp0078059; FBgn0003042.
GeneIDi40358.
KEGGidme:Dmel_CG32443.
UCSCiCG32443-RA. d. melanogaster.

Organism-specific databases

CTDi5091.
FlyBaseiFBgn0003042. Pc.

Phylogenomic databases

eggNOGiKOG2748. Eukaryota.
ENOG41122KC. LUCA.
InParanoidiP26017.
KOiK11455.
OMAiNNIPKPC.
OrthoDBiEOG091G0NOT.
PhylomeDBiP26017.

Enzyme and pathway databases

ReactomeiR-DME-2559580. Oxidative Stress Induced Senescence.
R-DME-3108214. SUMOylation of DNA damage response and repair proteins.
R-DME-4570464. SUMOylation of RNA binding proteins.
SignaLinkiP26017.

Miscellaneous databases

EvolutionaryTraceiP26017.
GenomeRNAii40358.
PROiP26017.

Gene expression databases

BgeeiFBgn0003042.
ExpressionAtlasiP26017. baseline.
GenevisibleiP26017. DM.

Family and domain databases

InterProiIPR033773. CBX7_C.
IPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF17218. CBX7_C. 1 hit.
PF00385. Chromo. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPC_DROME
AccessioniPrimary (citable) accession number: P26017
Secondary accession number(s): Q9VP49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.