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Protein

Polycomb group protein Pc

Gene

Pc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Promotes locus-specific chromatin compaction.

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • methylated histone binding Source: FlyBase

GO - Biological processi

  • gene silencing Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • negative regulation of response to gamma radiation Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • neurogenesis Source: FlyBase
  • neuron remodeling Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • specification of segmental identity, abdomen Source: FlyBase
  • syncytial blastoderm mitotic cell cycle Source: FlyBase
  • ventral cord development Source: FlyBase
  • wound healing Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-2559580 Oxidative Stress Induced Senescence
R-DME-3108214 SUMOylation of DNA damage response and repair proteins
R-DME-4570464 SUMOylation of RNA binding proteins
R-DME-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8943724 Regulation of PTEN gene transcription
SignaLinkiP26017

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group protein Pc
Short name:
Protein polycomb
Gene namesi
Name:Pc
ORF Names:CG7618
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0003042 Pc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802181 – 390Polycomb group protein PcAdd BLAST390

Proteomic databases

PaxDbiP26017
PRIDEiP26017

Expressioni

Developmental stagei

Required during the entire larval period for normal adult development. It is found in almost all cells and tissues throughout gastrulation and organogenesis though at a much lower level than in early syncytial stages.

Gene expression databases

BgeeiFBgn0003042
ExpressionAtlasiP26017 differential
GenevisibleiP26017 DM

Interactioni

Subunit structurei

Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, Rpd3 and Caf1. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing (PubMed:11493925, PubMed:11583617). Interacts with stx; the interaction targets Pc for ubiquitin-independent proteasomal degradation (PubMed:27326929).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
His3:CG33854P022996EBI-177152,EBI-522090

GO - Molecular functioni

  • methylated histone binding Source: FlyBase

Protein-protein interaction databases

BioGridi65606100 interactors.
IntActiP26017 6 interactors.
MINTiP26017
STRINGi7227.FBpp0078059

Structurei

Secondary structure

1390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 37Combined sources14
Beta strandi40 – 47Combined sources8
Helixi52 – 54Combined sources3
Beta strandi56 – 59Combined sources4
Helixi60 – 62Combined sources3
Helixi67 – 73Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PDQX-ray1.76A15-77[»]
1PFBX-ray1.40A23-77[»]
ProteinModelPortaliP26017
SMRiP26017
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26017

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 84ChromoPROSITE-ProRule annotationAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 143Poly-His10
Compositional biasi160 – 167Poly-His8

Phylogenomic databases

eggNOGiKOG2748 Eukaryota
ENOG41122KC LUCA
InParanoidiP26017
KOiK11455
OMAiNNIPKPC
OrthoDBiEOG091G0NOT
PhylomeDBiP26017

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR033773 CBX7_C
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR017984 Chromo_dom_subgr
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF17218 CBX7_C, 1 hit
PF00385 Chromo, 1 hit
PRINTSiPR00504 CHROMODOMAIN
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit

Sequencei

Sequence statusi: Complete.

P26017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRGKGSKG KLGRDNATDD PVDLVYAAEK IIQKRVKKGV VEYRVKWKGW
60 70 80 90 100
NQRYNTWEPE VNILDRRLID IYEQTNKSSG TPSKRGIKKK EKEPDPEPES
110 120 130 140 150
EEDEYTFTEN DVDTHQATTS SATHDKESKK EKKHHHHHHH HHHIKSERNS
160 170 180 190 200
GRRSESPLTH HHHHHHHESK RQRIDHSSSS NSSFTHNSFV PEPDSNSSSS
210 220 230 240 250
EDQPLIGTKR KAEVLKESGK IGVTIKTSPD GPTIKPQPTQ QVTPSQQQPF
260 270 280 290 300
QDQQQAEKIA SEAATQLKSE QQATPLATEA INTTPAESGA EEEEVANEEG
310 320 330 340 350
NQQAPQVPSE NNNIPKPCNN LAINQKQPLT PLSPRALPPR FWLPAKCNIS
360 370 380 390
NRVVITDVTV NLETVTIREC KTERGFFRER DMKGDSSPVA
Length:390
Mass (Da):43,976
Last modified:May 1, 1992 - v1
Checksum:i5DB24AE4B326C3B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55702 Genomic DNA Translation: CAA39229.1
AE014296 Genomic DNA Translation: AAF51707.1
PIRiA38565
RefSeqiNP_524199.1, NM_079475.3
UniGeneiDm.13644

Genome annotation databases

EnsemblMetazoaiFBtr0078405; FBpp0078059; FBgn0003042
GeneIDi40358
KEGGidme:Dmel_CG32443
UCSCiCG32443-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiPC_DROME
AccessioniPrimary (citable) accession number: P26017
Secondary accession number(s): Q9VP49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome