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P26015

- VP6_ROTGA

UniProt

P26015 - VP6_ROTGA

Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intermediate capsid protein VP6
    OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
    Taxonomic identifieri10942 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion By similarity
    Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.Curated

    GO - Cellular componenti

    1. viral intermediate capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Intermediate capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Intermediate capsid protein VP6PRO_0000149566Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with VP2.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the rotavirus VP6 family.Curated

    Family and domain databases

    InterProiIPR020245. Rotavirus_B_VP6.
    [Graphical view]
    ProDomiPD042229. Rotavirus_B_VP6. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P26015-1 [UniParc]FASTAAdd to Basket

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    MDLIETVNAC VKLQKRVLGL APNTNLNTAE QSVLNDYNAL PSRVNGKTYA    50
    LLNQIAVYTP YTINAPIISL AVRISTDDYD DMRSGIESIL DVLAAAIRTE 100
    GSRPTRVIER RVLEQNVKQL VDDLRLKSLI SDLSIANLAA VDTAMIQPEV 150
    IETENPLYAD IIEQIVHRPN IGMNGGNIRA TLGRWSGNKG VVTCMSGMDS 200
    EHRFTVELKT RTCGIINIVY IPTAGTILIP MPAGRNREGD LIDVSAEMMA 250
    DDFAIDFMDD DKIIQTETGV GVYSFPMCNR IRFRINPWNT QKDDDNLGTV 300
    HMINWAQGTA PKQPAISFMF ETRRTFTEGN YQHLSRCAPK AQYMMDTQFN 350
    DVSFTNRPAV DWNIQSLLTS NTQRVWCQKI AMLIAAFAAK I 391
    Length:391
    Mass (Da):43,671
    Last modified:May 1, 1992 - v1
    Checksum:iA20BBA506E9F1AC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55982 Genomic RNA. Translation: AAA47353.1.
    PIRiA39993. VPXRHB.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55982 Genomic RNA. Translation: AAA47353.1 .
    PIRi A39993. VPXRHB.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR020245. Rotavirus_B_VP6.
    [Graphical view ]
    ProDomi PD042229. Rotavirus_B_VP6. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the major inner capsid protein of the group B rotavirus ADRV: primary characterization of genome segment 5."
      Chen G.-M., Werner-Eckert R., Tao H., Mackow E.R.
      Virology 182:820-829(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP6_ROTGA
    AccessioniPrimary (citable) accession number: P26015
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3