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P26015 (VP6_ROTGA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Intermediate capsid protein VP6
OrganismRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Taxonomic identifier10942 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.

Subunit structure

Homotrimer By similarity. Interacts with VP2 By similarity.

Subcellular location

Virion By similarity. Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.

Sequence similarities

Belongs to the rotavirus VP6 family.

Ontologies

Keywords
   Cellular componentCapsid protein
Intermediate capsid protein
Virion
Gene Ontology (GO)
   Cellular_componentviral intermediate capsid

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Intermediate capsid protein VP6
PRO_0000149566

Sequences

Sequence LengthMass (Da)Tools
P26015 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: A20BBA506E9F1AC3

FASTA39143,671
        10         20         30         40         50         60 
MDLIETVNAC VKLQKRVLGL APNTNLNTAE QSVLNDYNAL PSRVNGKTYA LLNQIAVYTP 

        70         80         90        100        110        120 
YTINAPIISL AVRISTDDYD DMRSGIESIL DVLAAAIRTE GSRPTRVIER RVLEQNVKQL 

       130        140        150        160        170        180 
VDDLRLKSLI SDLSIANLAA VDTAMIQPEV IETENPLYAD IIEQIVHRPN IGMNGGNIRA 

       190        200        210        220        230        240 
TLGRWSGNKG VVTCMSGMDS EHRFTVELKT RTCGIINIVY IPTAGTILIP MPAGRNREGD 

       250        260        270        280        290        300 
LIDVSAEMMA DDFAIDFMDD DKIIQTETGV GVYSFPMCNR IRFRINPWNT QKDDDNLGTV 

       310        320        330        340        350        360 
HMINWAQGTA PKQPAISFMF ETRRTFTEGN YQHLSRCAPK AQYMMDTQFN DVSFTNRPAV 

       370        380        390 
DWNIQSLLTS NTQRVWCQKI AMLIAAFAAK I 

« Hide

References

[1]"Expression of the major inner capsid protein of the group B rotavirus ADRV: primary characterization of genome segment 5."
Chen G.-M., Werner-Eckert R., Tao H., Mackow E.R.
Virology 182:820-829(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55982 Genomic RNA. Translation: AAA47353.1.
PIRVPXRHB. A39993.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR020245. Rotavirus_B_VP6.
[Graphical view]
ProDomPD042229. Rotavirus_B_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameVP6_ROTGA
AccessionPrimary (citable) accession number: P26015
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 16, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families