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P26015

- VP6_ROTGA

UniProt

P26015 - VP6_ROTGA

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Protein
Intermediate capsid protein VP6
Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate capsid protein VP6
OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Taxonomic identifieri10942 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion By similarity
Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Reviewed prediction.

GO - Cellular componenti

  1. viral intermediate capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Intermediate capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Intermediate capsid protein VP6
PRO_0000149566Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity. Interacts with VP2 By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP6 family.

Family and domain databases

InterProiIPR020245. Rotavirus_B_VP6.
[Graphical view]
ProDomiPD042229. Rotavirus_B_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P26015-1 [UniParc]FASTAAdd to Basket

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MDLIETVNAC VKLQKRVLGL APNTNLNTAE QSVLNDYNAL PSRVNGKTYA    50
LLNQIAVYTP YTINAPIISL AVRISTDDYD DMRSGIESIL DVLAAAIRTE 100
GSRPTRVIER RVLEQNVKQL VDDLRLKSLI SDLSIANLAA VDTAMIQPEV 150
IETENPLYAD IIEQIVHRPN IGMNGGNIRA TLGRWSGNKG VVTCMSGMDS 200
EHRFTVELKT RTCGIINIVY IPTAGTILIP MPAGRNREGD LIDVSAEMMA 250
DDFAIDFMDD DKIIQTETGV GVYSFPMCNR IRFRINPWNT QKDDDNLGTV 300
HMINWAQGTA PKQPAISFMF ETRRTFTEGN YQHLSRCAPK AQYMMDTQFN 350
DVSFTNRPAV DWNIQSLLTS NTQRVWCQKI AMLIAAFAAK I 391
Length:391
Mass (Da):43,671
Last modified:May 1, 1992 - v1
Checksum:iA20BBA506E9F1AC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55982 Genomic RNA. Translation: AAA47353.1.
PIRiA39993. VPXRHB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55982 Genomic RNA. Translation: AAA47353.1 .
PIRi A39993. VPXRHB.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR020245. Rotavirus_B_VP6.
[Graphical view ]
ProDomi PD042229. Rotavirus_B_VP6. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Expression of the major inner capsid protein of the group B rotavirus ADRV: primary characterization of genome segment 5."
    Chen G.-M., Werner-Eckert R., Tao H., Mackow E.R.
    Virology 182:820-829(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP6_ROTGA
AccessioniPrimary (citable) accession number: P26015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 16, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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