Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin beta-8

Gene

ITGB8

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Integrin alpha-V/beta-8 is a receptor for fibronectin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-8
Gene namesi
Name:ITGB8
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 10

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini43 – 683ExtracellularSequence analysisAdd BLAST641
Transmembranei684 – 703HelicalSequence analysisAdd BLAST20
Topological domaini704 – 768CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42Sequence analysisAdd BLAST42
ChainiPRO_000001635543 – 768Integrin beta-8Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 469By similarity
Disulfide bondi55 ↔ 65By similarity
Disulfide bondi58 ↔ 94By similarity
Disulfide bondi68 ↔ 83By similarity
Disulfide bondi211 ↔ 218By similarity
Glycosylationi233N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi266 ↔ 307By similarity
Glycosylationi402N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi407 ↔ 419By similarity
Glycosylationi421N-linked (GlcNAc...)Sequence analysis1
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi467 ↔ 471By similarity
Disulfide bondi481 ↔ 491By similarity
Disulfide bondi494 ↔ 499By similarity
Disulfide bondi526 ↔ 531By similarity
Disulfide bondi528 ↔ 561By similarity
Disulfide bondi533 ↔ 546By similarity
Disulfide bondi567 ↔ 572By similarity
Disulfide bondi574 ↔ 583By similarity
Disulfide bondi585 ↔ 593By similarity
Disulfide bondi607 ↔ 612By similarity
Disulfide bondi609 ↔ 657By similarity
Disulfide bondi614 ↔ 624By similarity
Disulfide bondi627 ↔ 630By similarity
Disulfide bondi634 ↔ 643By similarity
Glycosylationi648N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Placenta, kidney, brain, ovary, uterus and in several transformed cells.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001898.

Structurei

3D structure databases

ProteinModelPortaliP26013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 384VWFAAdd BLAST239
Repeati471 – 510IAdd BLAST40
Repeati511 – 552IIAdd BLAST42
Repeati553 – 592IIIAdd BLAST40
Repeati593 – 629IVAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni471 – 629Cysteine-rich tandem repeatsAdd BLAST159

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP26013.
KOiK06591.
OMAiIHIHRNC.
OrthoDBiEOG091G029W.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR033760. Integin_beta_N.
IPR015812. Integrin_bsu.
IPR015442. Integrin_bsu-8.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF9. PTHR10082:SF9. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGSALGLPP AAFVRLRSCR PGPAAFLRAA WVLSLVLGLG RSENSRCASS
60 70 80 90 100
HAVSCSECLA LGPDCGWCVH EDFISGGPRS ERCDIVSNLI SKGCPVDSIE
110 120 130 140 150
YPSVHVTIPS ENEVNTQVTP GEVSIQLRPG AAANFMLKIH PLKKYPVDLY
160 170 180 190 200
YLVDVSASMH NNIEKLNSVG NDLSRKMAFF SRDFRLGFGS YVDKTVSPYI
210 220 230 240 250
SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFERA VHRQKISGNI
260 270 280 290 300
DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV
310 320 330 340 350
VPNDGNCHLR NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW
360 370 380 390 400
YKDLLPLLPG TIAGEIESKA ANLNNLVVEA YQKLISEVKV QVESKVPGVY
410 420 430 440 450
FNVTAICPDG ARKLGMEGCS NVTSSDEVLF NVTVTMEKCS VTGGKNYAII
460 470 480 490 500
KPIGFNETSK IHIHQNCGCE CEASRGGAAK CAEEAPLDST CPQCQESQCH
510 520 530 540 550
QEEAQSPSQG CKAHEDQPVC SGRGVCVCGK CLCHKMKLGK VYGKYCEKDD
560 570 580 590 600
FSCPYHHGSL CAGHGECEAG RCQCFSGWEG DRCQCPSAAA QHCVNSKGQV
610 620 630 640 650
CSGRGTCVCG RCECSDPRSI GRFCEHCPTC PTACSENWNC VQCLHPHNLS
660 670 680 690 700
QAILDQCRTS CASMEQPYVE QASECFSSPS YLRIFFIIFI VTFLIGLLKI
710 720 730 740 750
LIIRQVILQW NSSKIKSSSD YRVSASKKDK LILQSVCTRA VTYRREKPEE
760
IKLDISKLNA HETFRCNF
Length:768
Mass (Da):84,406
Last modified:May 1, 1992 - v1
Checksum:iC3F6DF0322FFB544
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73781 mRNA. Translation: AAA31280.1.
PIRiB41029.
RefSeqiNP_001075773.1. NM_001082304.1.
UniGeneiOcu.1889.

Genome annotation databases

EnsembliENSOCUT00000002200; ENSOCUP00000001898; ENSOCUG00000002197.
GeneIDi100009141.
KEGGiocu:100009141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73781 mRNA. Translation: AAA31280.1.
PIRiB41029.
RefSeqiNP_001075773.1. NM_001082304.1.
UniGeneiOcu.1889.

3D structure databases

ProteinModelPortaliP26013.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001898.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000002200; ENSOCUP00000001898; ENSOCUG00000002197.
GeneIDi100009141.
KEGGiocu:100009141.

Organism-specific databases

CTDi3696.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP26013.
KOiK06591.
OMAiIHIHRNC.
OrthoDBiEOG091G029W.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR033760. Integin_beta_N.
IPR015812. Integrin_bsu.
IPR015442. Integrin_bsu-8.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF9. PTHR10082:SF9. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITB8_RABIT
AccessioniPrimary (citable) accession number: P26013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.