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P26012 (ITB8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin beta-8
Gene names
Name:ITGB8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length769 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-V/beta-8 is a receptor for fibronectin.

Subunit structure

Heterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.

Sequence similarities

Belongs to the integrin beta chain family.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4242 Potential
Chain43 – 769727Integrin beta-8
PRO_0000016354

Regions

Topological domain43 – 684642Extracellular Potential
Transmembrane685 – 70420Helical; Potential
Topological domain705 – 76965Cytoplasmic Potential
Domain146 – 384239VWFA
Repeat471 – 51040I
Repeat511 – 55242II
Repeat553 – 59240III
Repeat593 – 62937IV
Region471 – 629159Cysteine-rich tandem repeats

Amino acid modifications

Glycosylation2331N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Potential
Glycosylation4211N-linked (GlcNAc...) Potential
Glycosylation4311N-linked (GlcNAc...) Potential
Glycosylation4561N-linked (GlcNAc...) Potential
Glycosylation4661N-linked (GlcNAc...) Potential
Glycosylation6481N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 469 By similarity
Disulfide bond55 ↔ 65 By similarity
Disulfide bond58 ↔ 94 By similarity
Disulfide bond68 ↔ 83 By similarity
Disulfide bond211 ↔ 218 By similarity
Disulfide bond266 ↔ 307 By similarity
Disulfide bond407 ↔ 419 By similarity
Disulfide bond467 ↔ 471 By similarity
Disulfide bond494 ↔ 499 By similarity
Disulfide bond526 ↔ 531 By similarity
Disulfide bond528 ↔ 561 By similarity
Disulfide bond533 ↔ 546 By similarity
Disulfide bond567 ↔ 572 By similarity
Disulfide bond574 ↔ 583 By similarity
Disulfide bond585 ↔ 593 By similarity
Disulfide bond607 ↔ 612 By similarity
Disulfide bond609 ↔ 657 By similarity
Disulfide bond614 ↔ 624 By similarity
Disulfide bond627 ↔ 630 By similarity
Disulfide bond634 ↔ 643 By similarity

Natural variations

Natural variant5521S → F.
Corresponds to variant rs5002476 [ dbSNP | Ensembl ].
VAR_034028

Sequences

Sequence LengthMass (Da)Tools
P26012 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: F7E3994F92B12A65

FASTA76985,632
        10         20         30         40         50         60 
MCGSALAFFT AAFVCLQNDR RGPASFLWAA WVFSLVLGLG QGEDNRCASS NAASCARCLA 

        70         80         90        100        110        120 
LGPECGWCVQ EDFISGGSRS ERCDIVSNLI SKGCSVDSIE YPSVHVIIPT ENEINTQVTP 

       130        140        150        160        170        180 
GEVSIQLRPG AEANFMLKVH PLKKYPVDLY YLVDVSASMH NNIEKLNSVG NDLSRKMAFF 

       190        200        210        220        230        240 
SRDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA 

       250        260        270        280        290        300 
VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 

       310        320        330        340        350        360 
VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG 

       370        380        390        400        410        420 
TIAGEIESKA ANLNNLVVEA YQKLISEVKV QVENQVQGIY FNITAICPDG SRKPGMEGCR 

       430        440        450        460        470        480 
NVTSNDEVLF NVTVTMKKCD VTGGKNYAII KPIGFNETAK IHIHRNCSCQ CEDNRGPKGK 

       490        500        510        520        530        540 
CVDETFLDSK CFQCDENKCH FDEDQFSSES CKSHKDQPVC SGRGVCVCGK CSCHKIKLGK 

       550        560        570        580        590        600 
VYGKYCEKDD FSCPYHHGNL CAGHGECEAG RCQCFSGWEG DRCQCPSAAA QHCVNSKGQV 

       610        620        630        640        650        660 
CSGRGTCVCG RCECTDPRSI GRFCEHCPTC YTACKENWNC MQCLHPHNLS QAILDQCKTS 

       670        680        690        700        710        720 
CALMEQQHYV DQTSECFSSP SYLRIFFIIF IVTFLIGLLK VLIIRQVILQ WNSNKIKSSS 

       730        740        750        760 
DYRVSASKKD KLILQSVCTR AVTYRREKPE EIKMDISKLN AHETFRCNF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a divergent integrin subunit beta 8."
Moyle M., Napier M.A., McLean J.W.
J. Biol. Chem. 266:19650-19658(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73780 mRNA. Translation: AAA36034.1.
CH236948 Genomic DNA. Translation: EAL24275.1.
CH471073 Genomic DNA. Translation: EAW93725.1.
AC004130 Genomic DNA. Translation: AAQ96845.1.
CCDSCCDS5370.1.
PIRA41029.
RefSeqNP_002205.1. NM_002214.2.
UniGeneHs.592171.

3D structure databases

ProteinModelPortalP26012.
SMRP26012. Positions 45-683.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109902. 1 interaction.
IntActP26012. 1 interaction.
STRING9606.ENSP00000222573.

PTM databases

PhosphoSiteP26012.

Polymorphism databases

DMDM124975.

Proteomic databases

MaxQBP26012.
PaxDbP26012.
PeptideAtlasP26012.
PRIDEP26012.

Protocols and materials databases

DNASU3696.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000222573; ENSP00000222573; ENSG00000105855.
GeneID3696.
KEGGhsa:3696.
UCSCuc003suu.3. human.

Organism-specific databases

CTD3696.
GeneCardsGC07P020370.
HGNCHGNC:6163. ITGB8.
HPAHPA027796.
HPA027797.
MIM604160. gene.
neXtProtNX_P26012.
PharmGKBPA29962.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG266569.
HOGENOMHOG000252936.
HOVERGENHBG006190.
InParanoidP26012.
KOK06591.
OMAIHPERIH.
OrthoDBEOG7T7GSB.
PhylomeDBP26012.
TreeFamTF105392.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.
SignaLinkP26012.

Gene expression databases

ArrayExpressP26012.
BgeeP26012.
CleanExHS_ITGB8.
GenevestigatorP26012.

Family and domain databases

Gene3D3.40.50.410. 1 hit.
InterProIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015442. Integrin_bsu-8.
IPR002369. Integrin_bsu_N.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF9. PTHR10082:SF9. 1 hit.
PfamPF07974. EGF_2. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFPIRSF002512. Integrin_B. 1 hit.
PRINTSPR01186. INTEGRINB.
SMARTSM00181. EGF. 1 hit.
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
PROSITEPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSITGB8. human.
GeneWikiITGB8.
GenomeRNAi3696.
NextBio14487.
PROP26012.
SOURCESearch...

Entry information

Entry nameITB8_HUMAN
AccessionPrimary (citable) accession number: P26012
Secondary accession number(s): A4D133
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM