P26012 (ITB8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Integrin beta-8

Gene names

Name:

ITGB8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	769 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Integrin alpha-V/beta-8 is a receptor for fibronectin.
Subunit structure	Heterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.
Sequence similarities	Belongs to the integrin beta chain family. Contains 1 VWFA domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Integrin Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Traceable author statement Ref.1. Source: ProtInc cell-matrix adhesion Inferred from electronic annotation. Source: InterPro ganglioside metabolic process Inferred from electronic annotation. Source: Compara integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW placenta blood vessel development Traceable author statement PubMed 19267251. Source: BHF-UCL
Cellular_component	integrin complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 42	42	Potential
	Chain	43 – 769	727	Integrin beta-8		PRO_0000016354
Regions
	Topological domain	43 – 684	642	Extracellular Potential
	Transmembrane	685 – 704	20	Helical; Potential
	Topological domain	705 – 769	65	Cytoplasmic Potential
	Domain	146 – 384	239	VWFA
	Repeat	471 – 510	40	I
	Repeat	511 – 552	42	II
	Repeat	553 – 592	40	III
	Repeat	593 – 629	37	IV
	Region	471 – 629	159	Cysteine-rich tandem repeats
Amino acid modifications
	Glycosylation	233	1	N-linked (GlcNAc...) Potential
	Glycosylation	402	1	N-linked (GlcNAc...) Potential
	Glycosylation	421	1	N-linked (GlcNAc...) Potential
	Glycosylation	431	1	N-linked (GlcNAc...) Potential
	Glycosylation	456	1	N-linked (GlcNAc...) Potential
	Glycosylation	466	1	N-linked (GlcNAc...) Potential
	Glycosylation	648	1	N-linked (GlcNAc...) Potential
	Disulfide bond	47 ↔ 469		By similarity
	Disulfide bond	55 ↔ 65		By similarity
	Disulfide bond	58 ↔ 94		By similarity
	Disulfide bond	68 ↔ 83		By similarity
	Disulfide bond	211 ↔ 218		By similarity
	Disulfide bond	266 ↔ 307		By similarity
	Disulfide bond	407 ↔ 419		By similarity
	Disulfide bond	467 ↔ 471		By similarity
	Disulfide bond	494 ↔ 499		By similarity
	Disulfide bond	526 ↔ 531		By similarity
	Disulfide bond	528 ↔ 561		By similarity
	Disulfide bond	533 ↔ 546		By similarity
	Disulfide bond	567 ↔ 572		By similarity
	Disulfide bond	574 ↔ 583		By similarity
	Disulfide bond	585 ↔ 593		By similarity
	Disulfide bond	607 ↔ 612		By similarity
	Disulfide bond	609 ↔ 657		By similarity
	Disulfide bond	614 ↔ 624		By similarity
	Disulfide bond	627 ↔ 630		By similarity
	Disulfide bond	634 ↔ 643		By similarity
Natural variations
	Natural variant	552	1	S → F. Corresponds to variant rs5002476 [ dbSNP | Ensembl ].		VAR_034028

Sequences

	Sequence		Length	Mass (Da)
	P26012 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: F7E3994F92B12A65	FASTA	769	85,632
	10 20 30 40 50 60 MCGSALAFFT AAFVCLQNDR RGPASFLWAA WVFSLVLGLG QGEDNRCASS NAASCARCLA 70 80 90 100 110 120 LGPECGWCVQ EDFISGGSRS ERCDIVSNLI SKGCSVDSIE YPSVHVIIPT ENEINTQVTP 130 140 150 160 170 180 GEVSIQLRPG AEANFMLKVH PLKKYPVDLY YLVDVSASMH NNIEKLNSVG NDLSRKMAFF 190 200 210 220 230 240 SRDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA 250 260 270 280 290 300 VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 310 320 330 340 350 360 VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG 370 380 390 400 410 420 TIAGEIESKA ANLNNLVVEA YQKLISEVKV QVENQVQGIY FNITAICPDG SRKPGMEGCR 430 440 450 460 470 480 NVTSNDEVLF NVTVTMKKCD VTGGKNYAII KPIGFNETAK IHIHRNCSCQ CEDNRGPKGK 490 500 510 520 530 540 CVDETFLDSK CFQCDENKCH FDEDQFSSES CKSHKDQPVC SGRGVCVCGK CSCHKIKLGK 550 560 570 580 590 600 VYGKYCEKDD FSCPYHHGNL CAGHGECEAG RCQCFSGWEG DRCQCPSAAA QHCVNSKGQV 610 620 630 640 650 660 CSGRGTCVCG RCECTDPRSI GRFCEHCPTC YTACKENWNC MQCLHPHNLS QAILDQCKTS 670 680 690 700 710 720 CALMEQQHYV DQTSECFSSP SYLRIFFIIF IVTFLIGLLK VLIIRQVILQ WNSNKIKSSS 730 740 750 760 DYRVSASKKD KLILQSVCTR AVTYRREKPE EIKMDISKLN AHETFRCNF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a divergent integrin subunit beta 8." Moyle M., Napier M.A., McLean J.W. J. Biol. Chem. 266:19650-19658(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73780 mRNA. Translation: AAA36034.1. CH236948 Genomic DNA. Translation: EAL24275.1. CH471073 Genomic DNA. Translation: EAW93725.1. AC004130 Genomic DNA. Translation: AAQ96845.1.
IPI	IPI00029533.
PIR	A41029.
RefSeq	NP_002205.1. NM_002214.2.
UniGene	Hs.592171.
3D structure databases
ProteinModelPortal	P26012.
ModBase	Search...
Protein-protein interaction databases
IntAct	P26012. 1 interaction.
STRING	9606.ENSP00000222573.
PTM databases
PhosphoSite	P26012.
Polymorphism databases
DMDM	124975.
Proteomic databases
PaxDb	P26012.
PeptideAtlas	P26012.
PRIDE	P26012.
Protocols and materials databases
DNASU	3696.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000222573; ENSP00000222573; ENSG00000105855.
GeneID	3696.
KEGG	hsa:3696.
UCSC	uc003suu.3. human.
Organism-specific databases
CTD	3696.
GeneCards	GC07P020370.
HGNC	HGNC:6163. ITGB8.
HPA	HPA027796. HPA027797.
MIM	604160. gene.
neXtProt	NX_P26012.
PharmGKB	PA29962.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG266569.
HOGENOM	HOG000252936.
HOVERGEN	HBG006190.
InParanoid	P26012.
KO	K06591.
OMA	ISIHPER.
OrthoDB	EOG44QT0W.
PhylomeDB	P26012.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_118779. Extracellular matrix organization.
Gene expression databases
ArrayExpress	P26012.
Bgee	P26012.
CleanEx	HS_ITGB8.
Genevestigator	P26012.
GermOnline	ENSG00000105855. Homo sapiens.
Family and domain databases
InterPro	IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR013111. EGF_extracell. IPR015812. Integrin_bsu. IPR015442. Integrin_bsu-8. IPR002369. Integrin_bsu_N. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR002035. VWF_A. [Graphical view]
PANTHER	PTHR10082. PTHR10082. 1 hit. PTHR10082:SF9. PTHR10082:SF9. 1 hit.
Pfam	PF07974. EGF_2. 1 hit. PF00362. Integrin_beta. 1 hit. [Graphical view]
PIRSF	PIRSF002512. Integrin_B. 1 hit.
PRINTS	PR01186. INTEGRINB.
SMART	SM00181. EGF. 1 hit. SM00187. INB. 1 hit. SM00423. PSI. 1 hit. SM00327. VWA. 1 hit. [Graphical view]
SUPFAM	SSF103575. Plexin-like_fold. 1 hit.
PROSITE	PS00022. EGF_1. 1 hit. Uncertain. PS01186. EGF_2. 1 hit. Uncertain. PS00243. INTEGRIN_BETA. 2 hits. PS50234. VWFA. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ITGB8. human.
GenomeRNAi	3696.
NextBio	14487.
SOURCE	Search...

Entry information

Entry name

ITB8_HUMAN

Accession

Primary (citable) accession number: P26012
Secondary accession number(s): A4D133

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	May 1, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.