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Protein

Integrin beta-8

Gene

ITGB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Integrin alpha-V/beta-8 is a receptor for fibronectin.

GO - Molecular functioni

GO - Biological processi

  • cartilage development Source: UniProtKB
  • cell adhesion Source: ProtInc
  • extracellular matrix organization Source: Reactome
  • ganglioside metabolic process Source: Ensembl
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • negative regulation of gene expression Source: UniProtKB
  • placenta blood vessel development Source: BHF-UCL
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of gene expression Source: UniProtKB

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-2129379 Molecules associated with elastic fibres
R-HSA-216083 Integrin cell surface interactions
SignaLinkiP26012
SIGNORiP26012

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-8
Gene namesi
Name:ITGB8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105855.9
HGNCiHGNC:6163 ITGB8
MIMi604160 gene
neXtProtiNX_P26012

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini43 – 684ExtracellularSequence analysisAdd BLAST642
Transmembranei685 – 704HelicalSequence analysisAdd BLAST20
Topological domaini705 – 769CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3696
OpenTargetsiENSG00000105855
PharmGKBiPA29962

Polymorphism and mutation databases

BioMutaiITGB8
DMDMi124975

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42Sequence analysisAdd BLAST42
ChainiPRO_000001635443 – 769Integrin beta-8Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 469By similarity
Disulfide bondi55 ↔ 65By similarity
Disulfide bondi58 ↔ 94By similarity
Disulfide bondi68 ↔ 83By similarity
Disulfide bondi211 ↔ 218By similarity
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi266 ↔ 307By similarity
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi407 ↔ 419By similarity
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi466N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi467 ↔ 471By similarity
Disulfide bondi494 ↔ 499By similarity
Disulfide bondi526 ↔ 531By similarity
Disulfide bondi528 ↔ 561By similarity
Disulfide bondi533 ↔ 546By similarity
Disulfide bondi567 ↔ 572By similarity
Disulfide bondi574 ↔ 583By similarity
Disulfide bondi585 ↔ 593By similarity
Disulfide bondi607 ↔ 612By similarity
Disulfide bondi609 ↔ 657By similarity
Disulfide bondi614 ↔ 624By similarity
Disulfide bondi627 ↔ 630By similarity
Disulfide bondi634 ↔ 643By similarity
Glycosylationi648N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP26012
PaxDbiP26012
PeptideAtlasiP26012
PRIDEiP26012
ProteomicsDBi54309

PTM databases

iPTMnetiP26012
PhosphoSitePlusiP26012

Expressioni

Tissue specificityi

Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.

Gene expression databases

BgeeiENSG00000105855
CleanExiHS_ITGB8
GenevisibleiP26012 HS

Organism-specific databases

HPAiHPA027796
HPA027797

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V.

GO - Molecular functioni

  • extracellular matrix protein binding Source: UniProtKB
  • signaling receptor binding Source: Ensembl

Protein-protein interaction databases

BioGridi109902, 14 interactors
ComplexPortaliCPX-1821 Integrin alphav-beta8 complex
CORUMiP26012
IntActiP26012, 1 interactor
STRINGi9606.ENSP00000222573

Structurei

3D structure databases

ProteinModelPortaliP26012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 384VWFAAdd BLAST239
Repeati471 – 510IAdd BLAST40
Repeati511 – 552IIAdd BLAST42
Repeati553 – 592IIIAdd BLAST40
Repeati593 – 629IVAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni471 – 629Cysteine-rich tandem repeatsAdd BLAST159

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000252936
HOVERGENiHBG006190
InParanoidiP26012
KOiK06591
OMAiDDFSCPY
OrthoDBiEOG091G029W
PhylomeDBiP26012
TreeFamiTF105392

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR013111 EGF_extracell
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015442 Integrin_bsu-8
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF9 PTHR10082:SF9, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS00243 INTEGRIN_BETA, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26012-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCGSALAFFT AAFVCLQNDR RGPASFLWAA WVFSLVLGLG QGEDNRCASS
60 70 80 90 100
NAASCARCLA LGPECGWCVQ EDFISGGSRS ERCDIVSNLI SKGCSVDSIE
110 120 130 140 150
YPSVHVIIPT ENEINTQVTP GEVSIQLRPG AEANFMLKVH PLKKYPVDLY
160 170 180 190 200
YLVDVSASMH NNIEKLNSVG NDLSRKMAFF SRDFRLGFGS YVDKTVSPYI
210 220 230 240 250
SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA VHRQKISGNI
260 270 280 290 300
DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV
310 320 330 340 350
VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW
360 370 380 390 400
YKDLLPLLPG TIAGEIESKA ANLNNLVVEA YQKLISEVKV QVENQVQGIY
410 420 430 440 450
FNITAICPDG SRKPGMEGCR NVTSNDEVLF NVTVTMKKCD VTGGKNYAII
460 470 480 490 500
KPIGFNETAK IHIHRNCSCQ CEDNRGPKGK CVDETFLDSK CFQCDENKCH
510 520 530 540 550
FDEDQFSSES CKSHKDQPVC SGRGVCVCGK CSCHKIKLGK VYGKYCEKDD
560 570 580 590 600
FSCPYHHGNL CAGHGECEAG RCQCFSGWEG DRCQCPSAAA QHCVNSKGQV
610 620 630 640 650
CSGRGTCVCG RCECTDPRSI GRFCEHCPTC YTACKENWNC MQCLHPHNLS
660 670 680 690 700
QAILDQCKTS CALMEQQHYV DQTSECFSSP SYLRIFFIIF IVTFLIGLLK
710 720 730 740 750
VLIIRQVILQ WNSNKIKSSS DYRVSASKKD KLILQSVCTR AVTYRREKPE
760
EIKMDISKLN AHETFRCNF
Length:769
Mass (Da):85,632
Last modified:May 1, 1992 - v1
Checksum:iF7E3994F92B12A65
GO
Isoform 2 (identifier: P26012-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Note: No experimental confirmation available.
Show »
Length:634
Mass (Da):71,284
Checksum:i62E01B68236B2F76
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034028552S → F. Corresponds to variant dbSNP:rs5002476Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565311 – 135Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73780 mRNA Translation: AAA36034.1
AK295044 mRNA Translation: BAG58095.1
AC004130 Genomic DNA Translation: AAQ96845.1
CH236948 Genomic DNA Translation: EAL24275.1
CH471073 Genomic DNA Translation: EAW93725.1
CCDSiCCDS5370.1 [P26012-1]
PIRiA41029
RefSeqiNP_002205.1, NM_002214.2 [P26012-1]
XP_011513698.1, XM_011515396.1 [P26012-2]
XP_016867667.1, XM_017012178.1 [P26012-1]
XP_016867668.1, XM_017012179.1 [P26012-1]
XP_016867669.1, XM_017012180.1 [P26012-2]
XP_016867670.1, XM_017012181.1 [P26012-2]
XP_016867671.1, XM_017012182.1 [P26012-2]
XP_016867672.1, XM_017012183.1 [P26012-2]
UniGeneiHs.592171
Hs.686110

Genome annotation databases

EnsembliENST00000222573; ENSP00000222573; ENSG00000105855 [P26012-1]
ENST00000537992; ENSP00000441561; ENSG00000105855 [P26012-2]
GeneIDi3696
KEGGihsa:3696
UCSCiuc003suu.4 human [P26012-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiITB8_HUMAN
AccessioniPrimary (citable) accession number: P26012
Secondary accession number(s): A4D133, B4DHD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 20, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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