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Reviewed, UniProtKB/Swiss-Prot P26012 (ITB8_HUMAN)

Last modified June 16, 2009. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Integrin beta-8
Gene names
Name: ITGB8
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length769 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Integrin alpha-V/beta-8 is a receptor for fibronectin.

Subunit structure

Heterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.

Sequence similarities

Belongs to the integrin beta chain family.

Contains 1 VWFA domain.

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Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
   Molecular functionIntegrin
Receptor
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological processcell-matrix adhesion

Inferred from electronic annotation. Source: InterPro

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegrin complex Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionprotein binding

Inferred from electronic annotation. Source: UniProtKB-KW

receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4242 Potential
Chain43 – 769727Integrin beta-8
PRO_0000016354

Regions

Topological domain43 – 684642Extracellular Potential
Transmembrane685 – 70420 Potential
Topological domain705 – 76965Cytoplasmic Potential
Domain146 – 384239VWFA
Repeat471 – 51040I
Repeat511 – 55242II
Repeat553 – 59240III
Repeat593 – 62937IV
Region471 – 629159Cysteine-rich tandem repeats

Amino acid modifications

Glycosylation2331N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Potential
Glycosylation4211N-linked (GlcNAc...) Potential
Glycosylation4311N-linked (GlcNAc...) Potential
Glycosylation4561N-linked (GlcNAc...) Potential
Glycosylation4661N-linked (GlcNAc...) Potential
Glycosylation6481N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 469 By similarity
Disulfide bond55 ↔ 65 By similarity
Disulfide bond58 ↔ 94 By similarity
Disulfide bond68 ↔ 83 By similarity
Disulfide bond211 ↔ 218 By similarity
Disulfide bond266 ↔ 307 By similarity
Disulfide bond407 ↔ 419 By similarity
Disulfide bond467 ↔ 471 By similarity
Disulfide bond494 ↔ 499 By similarity
Disulfide bond526 ↔ 531 By similarity
Disulfide bond528 ↔ 561 By similarity
Disulfide bond533 ↔ 546 By similarity
Disulfide bond567 ↔ 572 By similarity
Disulfide bond574 ↔ 583 By similarity
Disulfide bond585 ↔ 593 By similarity
Disulfide bond607 ↔ 612 By similarity
Disulfide bond609 ↔ 657 By similarity
Disulfide bond614 ↔ 624 By similarity
Disulfide bond627 ↔ 630 By similarity
Disulfide bond634 ↔ 643 By similarity

Natural variations

Natural variant5521S → F: dbSNP rs5002476.
VAR_034028

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Sequences

Sequence LengthMass (Da)Tools
P26012-1 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: F7E3994F92B12A65

FASTA76985,632
        10         20         30         40         50         60 
MCGSALAFFT AAFVCLQNDR RGPASFLWAA WVFSLVLGLG QGEDNRCASS NAASCARCLA 

        70         80         90        100        110        120 
LGPECGWCVQ EDFISGGSRS ERCDIVSNLI SKGCSVDSIE YPSVHVIIPT ENEINTQVTP 

       130        140        150        160        170        180 
GEVSIQLRPG AEANFMLKVH PLKKYPVDLY YLVDVSASMH NNIEKLNSVG NDLSRKMAFF 

       190        200        210        220        230        240 
SRDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA 

       250        260        270        280        290        300 
VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 

       310        320        330        340        350        360 
VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG 

       370        380        390        400        410        420 
TIAGEIESKA ANLNNLVVEA YQKLISEVKV QVENQVQGIY FNITAICPDG SRKPGMEGCR 

       430        440        450        460        470        480 
NVTSNDEVLF NVTVTMKKCD VTGGKNYAII KPIGFNETAK IHIHRNCSCQ CEDNRGPKGK 

       490        500        510        520        530        540 
CVDETFLDSK CFQCDENKCH FDEDQFSSES CKSHKDQPVC SGRGVCVCGK CSCHKIKLGK 

       550        560        570        580        590        600 
VYGKYCEKDD FSCPYHHGNL CAGHGECEAG RCQCFSGWEG DRCQCPSAAA QHCVNSKGQV 

       610        620        630        640        650        660 
CSGRGTCVCG RCECTDPRSI GRFCEHCPTC YTACKENWNC MQCLHPHNLS QAILDQCKTS 

       670        680        690        700        710        720 
CALMEQQHYV DQTSECFSSP SYLRIFFIIF IVTFLIGLLK VLIIRQVILQ WNSNKIKSSS 

       730        740        750        760 
DYRVSASKKD KLILQSVCTR AVTYRREKPE EIKMDISKLN AHETFRCNF

« Hide

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References

« Hide 'large scale' references
[1]"Cloning and expression of a divergent integrin subunit beta 8."
Moyle M., Napier M.A., McLean J.W.
J. Biol. Chem. 266:19650-19658(1991) [PubMed: 1918072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed: 12853948] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

M73780 mRNA. Translation: AAA36034.1.
AC004130 Genomic DNA. Translation: AAQ96845.1.
IPIIPI00029533.
PIRA41029.
RefSeqNP_002205.1.
UniGeneHs.592171

3D structure databases

HSSPHSSP built from PDB template 1L5G based on UniProtKB P05106.
ModBaseSearch...

PTM databases

PhosphoSiteP26012.

Proteomic databases

PeptideAtlasP26012.
PRIDEP26012.

Genome annotation databases

EnsemblENSG00000105855. Homo sapiens. [Contig view]
GeneID3696.
KEGGhsa:3696.

Organism-specific databases

GeneCardsGC07P020337.
H-InvDBHIX0006506.
HGNCHGNC:6163. ITGB8.
MIM604160. gene.
PharmGKBPA29962.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP26012.
HOVERGENP26012.
OMAP26012. KPIGFNE.

Enzyme and pathway databases

ReactomeREACT_13552. Integrin cell surface interactions.

Gene expression databases

ArrayExpressP26012.
BgeeP26012.
CleanExHS_ITGB8.
GermOnlineENSG00000105855. Homo sapiens.

Family and domain databases

InterProIPR006210. EGF-like.
IPR013032. EGF-like_reg_CS.
IPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015442. Integrin_bsu-8-like_C.
IPR001169. Integrin_bsu_C.
IPR002369. Integrin_bsu_N.
IPR012012. Integrin_bsu_subgr.
IPR003659. Plexin-like.
IPR002035. VWF_A.
[Graphical view]
PANTHERPTHR10082. Integrin_beta_C. 1 hit.
PTHR10082:SF9. Integrin_bsu-8-like_C. 1 hit.
PfamPF07974. EGF_2. 3 hits.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFPIRSF002512. Integrin_B. 1 hit.
PRINTSPR01186. INTEGRINB.
SMARTSM00181. EGF. 1 hit.
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
PROSITEPS00022. EGF_1. 1 hit. Uncertain.
PS01186. EGF_2. 1 hit. Uncertain.
PS00243. INTEGRIN_BETA. 2 hits.
PS50234. VWFA. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio14487.
SOURCESearch...

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Entry information

Entry nameITB8_HUMAN
AccessionPrimary (citable) accession number: P26012
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 16, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents