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P26012

- ITB8_HUMAN

UniProt

P26012 - ITB8_HUMAN

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Protein
Integrin beta-8
Gene
ITGB8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Integrin alpha-V/beta-8 is a receptor for fibronectin.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. cell adhesion Source: ProtInc
  2. cell-matrix adhesion Source: InterPro
  3. extracellular matrix organization Source: Reactome
  4. ganglioside metabolic process Source: Ensembl
  5. integrin-mediated signaling pathway Source: UniProtKB-KW
  6. placenta blood vessel development Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_13552. Integrin cell surface interactions.
REACT_150331. Molecules associated with elastic fibres.
SignaLinkiP26012.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-8
Gene namesi
Name:ITGB8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:6163. ITGB8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini43 – 684642Extracellular Reviewed prediction
Add
BLAST
Transmembranei685 – 70420Helical; Reviewed prediction
Add
BLAST
Topological domaini705 – 76965Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integrin complex Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29962.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242 Reviewed prediction
Add
BLAST
Chaini43 – 769727Integrin beta-8
PRO_0000016354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 469 By similarity
Disulfide bondi55 ↔ 65 By similarity
Disulfide bondi58 ↔ 94 By similarity
Disulfide bondi68 ↔ 83 By similarity
Disulfide bondi211 ↔ 218 By similarity
Glycosylationi233 – 2331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi266 ↔ 307 By similarity
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi407 ↔ 419 By similarity
Glycosylationi421 – 4211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi431 – 4311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi466 – 4661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi467 ↔ 471 By similarity
Disulfide bondi494 ↔ 499 By similarity
Disulfide bondi526 ↔ 531 By similarity
Disulfide bondi528 ↔ 561 By similarity
Disulfide bondi533 ↔ 546 By similarity
Disulfide bondi567 ↔ 572 By similarity
Disulfide bondi574 ↔ 583 By similarity
Disulfide bondi585 ↔ 593 By similarity
Disulfide bondi607 ↔ 612 By similarity
Disulfide bondi609 ↔ 657 By similarity
Disulfide bondi614 ↔ 624 By similarity
Disulfide bondi627 ↔ 630 By similarity
Disulfide bondi634 ↔ 643 By similarity
Glycosylationi648 – 6481N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP26012.
PaxDbiP26012.
PeptideAtlasiP26012.
PRIDEiP26012.

PTM databases

PhosphoSiteiP26012.

Expressioni

Tissue specificityi

Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.

Gene expression databases

ArrayExpressiP26012.
BgeeiP26012.
CleanExiHS_ITGB8.
GenevestigatoriP26012.

Organism-specific databases

HPAiHPA027796.
HPA027797.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V.

Protein-protein interaction databases

BioGridi109902. 1 interaction.
IntActiP26012. 1 interaction.
STRINGi9606.ENSP00000222573.

Structurei

3D structure databases

ProteinModelPortaliP26012.
SMRiP26012. Positions 45-683.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 384239VWFA
Add
BLAST
Repeati471 – 51040I
Add
BLAST
Repeati511 – 55242II
Add
BLAST
Repeati553 – 59240III
Add
BLAST
Repeati593 – 62937IV
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni471 – 629159Cysteine-rich tandem repeats
Add
BLAST

Sequence similaritiesi

Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG266569.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP26012.
KOiK06591.
OMAiIHPERIH.
OrthoDBiEOG7T7GSB.
PhylomeDBiP26012.
TreeFamiTF105392.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015442. Integrin_bsu-8.
IPR002369. Integrin_bsu_N.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF9. PTHR10082:SF9. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00181. EGF. 1 hit.
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26012-1 [UniParc]FASTAAdd to Basket

« Hide

MCGSALAFFT AAFVCLQNDR RGPASFLWAA WVFSLVLGLG QGEDNRCASS    50
NAASCARCLA LGPECGWCVQ EDFISGGSRS ERCDIVSNLI SKGCSVDSIE 100
YPSVHVIIPT ENEINTQVTP GEVSIQLRPG AEANFMLKVH PLKKYPVDLY 150
YLVDVSASMH NNIEKLNSVG NDLSRKMAFF SRDFRLGFGS YVDKTVSPYI 200
SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA VHRQKISGNI 250
DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 300
VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW 350
YKDLLPLLPG TIAGEIESKA ANLNNLVVEA YQKLISEVKV QVENQVQGIY 400
FNITAICPDG SRKPGMEGCR NVTSNDEVLF NVTVTMKKCD VTGGKNYAII 450
KPIGFNETAK IHIHRNCSCQ CEDNRGPKGK CVDETFLDSK CFQCDENKCH 500
FDEDQFSSES CKSHKDQPVC SGRGVCVCGK CSCHKIKLGK VYGKYCEKDD 550
FSCPYHHGNL CAGHGECEAG RCQCFSGWEG DRCQCPSAAA QHCVNSKGQV 600
CSGRGTCVCG RCECTDPRSI GRFCEHCPTC YTACKENWNC MQCLHPHNLS 650
QAILDQCKTS CALMEQQHYV DQTSECFSSP SYLRIFFIIF IVTFLIGLLK 700
VLIIRQVILQ WNSNKIKSSS DYRVSASKKD KLILQSVCTR AVTYRREKPE 750
EIKMDISKLN AHETFRCNF 769
Length:769
Mass (Da):85,632
Last modified:May 1, 1992 - v1
Checksum:iF7E3994F92B12A65
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti552 – 5521S → F.
Corresponds to variant rs5002476 [ dbSNP | Ensembl ].
VAR_034028

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73780 mRNA. Translation: AAA36034.1.
CH236948 Genomic DNA. Translation: EAL24275.1.
CH471073 Genomic DNA. Translation: EAW93725.1.
AC004130 Genomic DNA. Translation: AAQ96845.1.
CCDSiCCDS5370.1.
PIRiA41029.
RefSeqiNP_002205.1. NM_002214.2.
UniGeneiHs.592171.

Genome annotation databases

EnsembliENST00000222573; ENSP00000222573; ENSG00000105855.
GeneIDi3696.
KEGGihsa:3696.
UCSCiuc003suu.3. human.

Polymorphism databases

DMDMi124975.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73780 mRNA. Translation: AAA36034.1 .
CH236948 Genomic DNA. Translation: EAL24275.1 .
CH471073 Genomic DNA. Translation: EAW93725.1 .
AC004130 Genomic DNA. Translation: AAQ96845.1 .
CCDSi CCDS5370.1.
PIRi A41029.
RefSeqi NP_002205.1. NM_002214.2.
UniGenei Hs.592171.

3D structure databases

ProteinModelPortali P26012.
SMRi P26012. Positions 45-683.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109902. 1 interaction.
IntActi P26012. 1 interaction.
STRINGi 9606.ENSP00000222573.

PTM databases

PhosphoSitei P26012.

Polymorphism databases

DMDMi 124975.

Proteomic databases

MaxQBi P26012.
PaxDbi P26012.
PeptideAtlasi P26012.
PRIDEi P26012.

Protocols and materials databases

DNASUi 3696.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222573 ; ENSP00000222573 ; ENSG00000105855 .
GeneIDi 3696.
KEGGi hsa:3696.
UCSCi uc003suu.3. human.

Organism-specific databases

CTDi 3696.
GeneCardsi GC07P020370.
HGNCi HGNC:6163. ITGB8.
HPAi HPA027796.
HPA027797.
MIMi 604160. gene.
neXtProti NX_P26012.
PharmGKBi PA29962.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG266569.
HOGENOMi HOG000252936.
HOVERGENi HBG006190.
InParanoidi P26012.
KOi K06591.
OMAi IHPERIH.
OrthoDBi EOG7T7GSB.
PhylomeDBi P26012.
TreeFami TF105392.

Enzyme and pathway databases

Reactomei REACT_13552. Integrin cell surface interactions.
REACT_150331. Molecules associated with elastic fibres.
SignaLinki P26012.

Miscellaneous databases

ChiTaRSi ITGB8. human.
GeneWikii ITGB8.
GenomeRNAii 3696.
NextBioi 14487.
PROi P26012.
SOURCEi Search...

Gene expression databases

ArrayExpressi P26012.
Bgeei P26012.
CleanExi HS_ITGB8.
Genevestigatori P26012.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015442. Integrin_bsu-8.
IPR002369. Integrin_bsu_N.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF9. PTHR10082:SF9. 1 hit.
Pfami PF07974. EGF_2. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00181. EGF. 1 hit.
SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a divergent integrin subunit beta 8."
    Moyle M., Napier M.A., McLean J.W.
    J. Biol. Chem. 266:19650-19658(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiITB8_HUMAN
AccessioniPrimary (citable) accession number: P26012
Secondary accession number(s): A4D133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 3, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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