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P26011

- ITB7_MOUSE

UniProt

P26011 - ITB7_MOUSE

Protein

Integrin beta-7

Gene

Itgb7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. cell-matrix adhesion Source: InterPro
    2. integrin-mediated signaling pathway Source: UniProtKB-KW
    3. leukocyte migration Source: MGI
    4. multicellular organismal development Source: InterPro
    5. T cell migration Source: MGI

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin beta-7
    Alternative name(s):
    Integrin beta-P
    M290 IEL antigen
    Gene namesi
    Name:Itgb7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96616. Itgb7.

    Subcellular locationi

    GO - Cellular componenti

    1. integrin complex Source: InterPro
    2. receptor complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 806787Integrin beta-7PRO_0000016353Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi45 ↔ 476By similarity
    Disulfide bondi51 ↔ 61By similarity
    Disulfide bondi54 ↔ 91By similarity
    Disulfide bondi64 ↔ 80By similarity
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi216 ↔ 223By similarity
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi271 ↔ 311By similarity
    Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi412 ↔ 428By similarity
    Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi448 ↔ 688By similarity
    Disulfide bondi474 ↔ 478By similarity
    Disulfide bondi488 ↔ 500By similarity
    Disulfide bondi497 ↔ 537By similarity
    Disulfide bondi502 ↔ 511By similarity
    Disulfide bondi513 ↔ 527By similarity
    Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi543 ↔ 548By similarity
    Disulfide bondi545 ↔ 574By similarity
    Disulfide bondi550 ↔ 559By similarity
    Disulfide bondi561 ↔ 566By similarity
    Disulfide bondi580 ↔ 585By similarity
    Disulfide bondi582 ↔ 613By similarity
    Disulfide bondi587 ↔ 596By similarity
    Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi598 ↔ 605By similarity
    Disulfide bondi619 ↔ 624By similarity
    Disulfide bondi621 ↔ 666By similarity
    Disulfide bondi626 ↔ 635By similarity
    Disulfide bondi638 ↔ 641By similarity
    Disulfide bondi645 ↔ 654By similarity
    Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP26011.
    PRIDEiP26011.

    PTM databases

    PhosphoSiteiP26011.

    Expressioni

    Gene expression databases

    ArrayExpressiP26011.
    BgeeiP26011.
    CleanExiMM_ITGB7.
    GenevestigatoriP26011.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E.

    Structurei

    3D structure databases

    ProteinModelPortaliP26011.
    SMRiP26011. Positions 48-691, 746-792.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 724705ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini746 – 80661CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei725 – 74521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini150 – 389240VWFAAdd
    BLAST
    Repeati478 – 52649IAdd
    BLAST
    Repeati527 – 56539IIAdd
    BLAST
    Repeati566 – 60439IIIAdd
    BLAST
    Repeati605 – 64036IVAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni478 – 640163Cysteine-rich tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the integrin beta chain family.Curated
    Contains 1 VWFA domain.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287997.
    GeneTreeiENSGT00730000110513.
    HOGENOMiHOG000252936.
    HOVERGENiHBG006190.
    InParanoidiP26011.
    KOiK06590.
    OMAiDHTQAIV.
    OrthoDBiEOG7T7GSB.
    PhylomeDBiP26011.
    TreeFamiTF105392.

    Family and domain databases

    Gene3Di3.40.50.410. 1 hit.
    InterProiIPR013111. EGF_extracell.
    IPR015812. Integrin_bsu.
    IPR015437. Integrin_bsu-7.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view]
    PANTHERiPTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF36. PTHR10082:SF36. 1 hit.
    PfamiPF07974. EGF_2. 1 hit.
    PF08725. Integrin_b_cyt. 1 hit.
    PF00362. Integrin_beta. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002512. Integrin_B. 1 hit.
    PRINTSiPR01186. INTEGRINB.
    SMARTiSM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF103575. SSF103575. 1 hit.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEiPS00022. EGF_1. 4 hits.
    PS01186. EGF_2. 1 hit.
    PS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P26011-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDSSTVLIF LLVLGGGQSE LDTKITSSGE AAEWEDPDLS LQGSCQPVPS    50
    CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPAQELEEPR 100
    GRQEVLQDKP LSQGDRGEGA TQLAPQRIRV TLRPGEPQKF RVRFLRAAGY 150
    PVDLYYLMDL SYSMKDDLER VRQLGHALLV RLQEVTHSVR IGFGSFVDKT 200
    VLPFVSTVPS KLHHPCPSRL ERCQPPFSFH HVLSLTGDAQ AFEREVGRQN 250
    VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL 300
    GGIFMPSDGR CHLDSNGVYT NSAEFDYPSV GQVAQALTAA NIQPIFAVTG 350
    ATLPVYQELR QLIPKSAVGE LSEDSSNVVQ LIMDAYDSLS STVTLEHSPL 400
    PPGVSISFES HCKGPEKTEG EAGDRGQCND VRVNQTVDFW VTLQATHCLP 450
    EAHVLRLWAL GFSEELTVEL HTVCDCNCGD AQPHAPYCSD GQGDLQCGIC 500
    SCAPGRLGQL CECSEADLSS PDLESGCRAP NGTGPLCSGK GRCQCGRCSC 550
    SGQSSGRLCE CDDASCERHE GILCGGFGHC QCGVCHCHAN HTGRACECSK 600
    SVDSCVSPEG GLCSGHGYCK CNRCQCLDGY YGALCDQCLG CKSPCEQYRD 650
    CAECGAFGTG PLAANCSVVC ADVNVTLTLA PNLDDGWCKE RTIDNQLFFF 700
    LVEHAASGIV LRVRPQEKGV DHTRAIILGC TGGIVAVGLG LVLAYRLSVE 750
    IYDRREYRRF EKEQQQLNWK QDNNPLYKSA ITTTVNPRFQ GTNGRSPSLS 800
    LTREAD 806
    Length:806
    Mass (Da):87,411
    Last modified:July 1, 1993 - v2
    Checksum:iE793A3F3BA0B5C18
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811A → E AA sequence (PubMed:1710115)Curated
    Sequence conflicti81 – 811A → G in AAB23193. (PubMed:1381390)Curated
    Sequence conflicti124 – 1241Missing in AAA02749. (PubMed:1559978)Curated
    Sequence conflicti538 – 5381S → C in AAB23193. (PubMed:1381390)Curated
    Sequence conflicti557 – 5571R → H in AAA02749. (PubMed:1559978)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68903 mRNA. Translation: AAA02749.1.
    M95632 mRNA. Translation: AAA39323.1.
    M95633 mRNA. Translation: AAA39324.1.
    S44607 mRNA. Translation: AAB23193.1.
    AK078871 mRNA. Translation: BAC37433.1.
    AK154766 mRNA. Translation: BAE32815.1.
    AK155207 mRNA. Translation: BAE33119.1.
    BC011184 mRNA. Translation: AAH11184.1.
    S63504 Genomic DNA. Translation: AAB27396.1.
    CCDSiCCDS49740.1.
    PIRiA46271.
    I54754.
    RefSeqiNP_038594.2. NM_013566.2.
    UniGeneiMm.58.

    Genome annotation databases

    EnsembliENSMUST00000001327; ENSMUSP00000001327; ENSMUSG00000001281.
    GeneIDi16421.
    KEGGimmu:16421.
    UCSCiuc012aaa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68903 mRNA. Translation: AAA02749.1 .
    M95632 mRNA. Translation: AAA39323.1 .
    M95633 mRNA. Translation: AAA39324.1 .
    S44607 mRNA. Translation: AAB23193.1 .
    AK078871 mRNA. Translation: BAC37433.1 .
    AK154766 mRNA. Translation: BAE32815.1 .
    AK155207 mRNA. Translation: BAE33119.1 .
    BC011184 mRNA. Translation: AAH11184.1 .
    S63504 Genomic DNA. Translation: AAB27396.1 .
    CCDSi CCDS49740.1.
    PIRi A46271.
    I54754.
    RefSeqi NP_038594.2. NM_013566.2.
    UniGenei Mm.58.

    3D structure databases

    ProteinModelPortali P26011.
    SMRi P26011. Positions 48-691, 746-792.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2111481.

    PTM databases

    PhosphoSitei P26011.

    Proteomic databases

    PaxDbi P26011.
    PRIDEi P26011.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001327 ; ENSMUSP00000001327 ; ENSMUSG00000001281 .
    GeneIDi 16421.
    KEGGi mmu:16421.
    UCSCi uc012aaa.1. mouse.

    Organism-specific databases

    CTDi 3695.
    MGIi MGI:96616. Itgb7.

    Phylogenomic databases

    eggNOGi NOG287997.
    GeneTreei ENSGT00730000110513.
    HOGENOMi HOG000252936.
    HOVERGENi HBG006190.
    InParanoidi P26011.
    KOi K06590.
    OMAi DHTQAIV.
    OrthoDBi EOG7T7GSB.
    PhylomeDBi P26011.
    TreeFami TF105392.

    Enzyme and pathway databases

    Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    ChiTaRSi ITGB7. mouse.
    NextBioi 289629.
    PROi P26011.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P26011.
    Bgeei P26011.
    CleanExi MM_ITGB7.
    Genevestigatori P26011.

    Family and domain databases

    Gene3Di 3.40.50.410. 1 hit.
    InterProi IPR013111. EGF_extracell.
    IPR015812. Integrin_bsu.
    IPR015437. Integrin_bsu-7.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view ]
    PANTHERi PTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF36. PTHR10082:SF36. 1 hit.
    Pfami PF07974. EGF_2. 1 hit.
    PF08725. Integrin_b_cyt. 1 hit.
    PF00362. Integrin_beta. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002512. Integrin_B. 1 hit.
    PRINTSi PR01186. INTEGRINB.
    SMARTi SM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103575. SSF103575. 1 hit.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEi PS00022. EGF_1. 4 hits.
    PS01186. EGF_2. 1 hit.
    PS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing."
      Hu M.C.T., Crowe D.T., Weissman I.L., Holzmann B.
      Proc. Natl. Acad. Sci. U.S.A. 89:8254-8258(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of the mouse integrin beta 7 subunit."
      Yuan Q., Jiang W.-M., Leung E., Hollander D., Watson J.D., Krissansen G.W.
      J. Biol. Chem. 267:7352-7358(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Expression of murine beta 7, alpha 4, and beta 1 integrin genes by rodent mast cells."
      Gurish M.F., Bell A.F., Smith T.J., Ducharme L.A., Wang R.K., Weis J.H.
      J. Immunol. 149:1964-1972(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Colon.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    6. "Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine."
      Yuan Q., Jiang W.-M., Hollander D., Leung E., Watson J.D., Krissansen G.W.
      Biochem. Biophys. Res. Commun. 176:1443-1449(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-90, PROTEIN SEQUENCE OF 20-32.
    7. "The mouse beta 7 integrin gene promoter: transcriptional regulation of the leukocyte integrins LPAM-1 and M290."
      Leung E., Mead P.E., Yuan Q., Jiang W.M., Watson J.D., Krissansen G.W.
      Int. Immunol. 5:551-558(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-67.

    Entry informationi

    Entry nameiITB7_MOUSE
    AccessioniPrimary (citable) accession number: P26011
    Secondary accession number(s): Q3U2M1, Q64656
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 146 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3