Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin beta-7

Gene

Itgb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-7
Alternative name(s):
Integrin beta-P
M290 IEL antigen
Gene namesi
Name:Itgb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96616 Itgb7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 724ExtracellularSequence analysisAdd BLAST705
Transmembranei725 – 745HelicalSequence analysisAdd BLAST21
Topological domaini746 – 806CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001635320 – 806Integrin beta-7Add BLAST787

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 476By similarity
Disulfide bondi51 ↔ 61By similarity
Disulfide bondi54 ↔ 91By similarity
Disulfide bondi64 ↔ 80By similarity
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 223By similarity
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi271 ↔ 311By similarity
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi412 ↔ 428By similarity
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi448 ↔ 688By similarity
Disulfide bondi474 ↔ 478By similarity
Disulfide bondi488 ↔ 500By similarity
Disulfide bondi497 ↔ 537By similarity
Disulfide bondi502 ↔ 511By similarity
Disulfide bondi513 ↔ 527By similarity
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi543 ↔ 548By similarity
Disulfide bondi545 ↔ 574By similarity
Disulfide bondi550 ↔ 559By similarity
Disulfide bondi561 ↔ 566By similarity
Disulfide bondi580 ↔ 585By similarity
Disulfide bondi582 ↔ 613By similarity
Disulfide bondi587 ↔ 596By similarity
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi598 ↔ 605By similarity
Disulfide bondi619 ↔ 624By similarity
Disulfide bondi621 ↔ 666By similarity
Disulfide bondi626 ↔ 635By similarity
Disulfide bondi638 ↔ 641By similarity
Disulfide bondi645 ↔ 654By similarity
Glycosylationi665N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi674N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP26011
MaxQBiP26011
PaxDbiP26011
PeptideAtlasiP26011
PRIDEiP26011

PTM databases

iPTMnetiP26011
PhosphoSitePlusiP26011

Expressioni

Gene expression databases

BgeeiENSMUSG00000001281
CleanExiMM_ITGB7
ExpressionAtlasiP26011 baseline and differential
GenevisibleiP26011 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001327

Chemistry databases

BindingDBiP26011

Structurei

3D structure databases

ProteinModelPortaliP26011
SMRiP26011
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 389VWFAAdd BLAST240
Repeati478 – 526IAdd BLAST49
Repeati527 – 565IIAdd BLAST39
Repeati566 – 604IIIAdd BLAST39
Repeati605 – 640IVAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni478 – 640Cysteine-rich tandem repeatsAdd BLAST163

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000252936
HOVERGENiHBG006190
InParanoidiP26011
KOiK06590
OMAiTLCDCNC
OrthoDBiEOG091G029W
PhylomeDBiP26011
TreeFamiTF105392

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013111 EGF_extracell
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015437 Integrin_bsu-7
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF36 PTHR10082:SF36, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 1 hit
PF08725 Integrin_b_cyt, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 1 hit
PS00243 INTEGRIN_BETA, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDSSTVLIF LLVLGGGQSE LDTKITSSGE AAEWEDPDLS LQGSCQPVPS
60 70 80 90 100
CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPAQELEEPR
110 120 130 140 150
GRQEVLQDKP LSQGDRGEGA TQLAPQRIRV TLRPGEPQKF RVRFLRAAGY
160 170 180 190 200
PVDLYYLMDL SYSMKDDLER VRQLGHALLV RLQEVTHSVR IGFGSFVDKT
210 220 230 240 250
VLPFVSTVPS KLHHPCPSRL ERCQPPFSFH HVLSLTGDAQ AFEREVGRQN
260 270 280 290 300
VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL
310 320 330 340 350
GGIFMPSDGR CHLDSNGVYT NSAEFDYPSV GQVAQALTAA NIQPIFAVTG
360 370 380 390 400
ATLPVYQELR QLIPKSAVGE LSEDSSNVVQ LIMDAYDSLS STVTLEHSPL
410 420 430 440 450
PPGVSISFES HCKGPEKTEG EAGDRGQCND VRVNQTVDFW VTLQATHCLP
460 470 480 490 500
EAHVLRLWAL GFSEELTVEL HTVCDCNCGD AQPHAPYCSD GQGDLQCGIC
510 520 530 540 550
SCAPGRLGQL CECSEADLSS PDLESGCRAP NGTGPLCSGK GRCQCGRCSC
560 570 580 590 600
SGQSSGRLCE CDDASCERHE GILCGGFGHC QCGVCHCHAN HTGRACECSK
610 620 630 640 650
SVDSCVSPEG GLCSGHGYCK CNRCQCLDGY YGALCDQCLG CKSPCEQYRD
660 670 680 690 700
CAECGAFGTG PLAANCSVVC ADVNVTLTLA PNLDDGWCKE RTIDNQLFFF
710 720 730 740 750
LVEHAASGIV LRVRPQEKGV DHTRAIILGC TGGIVAVGLG LVLAYRLSVE
760 770 780 790 800
IYDRREYRRF EKEQQQLNWK QDNNPLYKSA ITTTVNPRFQ GTNGRSPSLS

LTREAD
Length:806
Mass (Da):87,411
Last modified:July 1, 1993 - v2
Checksum:iE793A3F3BA0B5C18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81A → E AA sequence (PubMed:1710115).Curated1
Sequence conflicti81A → G in AAB23193 (PubMed:1381390).Curated1
Sequence conflicti124Missing in AAA02749 (PubMed:1559978).Curated1
Sequence conflicti538S → C in AAB23193 (PubMed:1381390).Curated1
Sequence conflicti557R → H in AAA02749 (PubMed:1559978).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68903 mRNA Translation: AAA02749.1
M95632 mRNA Translation: AAA39323.1
M95633 mRNA Translation: AAA39324.1
S44607 mRNA Translation: AAB23193.1
AK078871 mRNA Translation: BAC37433.1
AK154766 mRNA Translation: BAE32815.1
AK155207 mRNA Translation: BAE33119.1
BC011184 mRNA Translation: AAH11184.1
S63504 Genomic DNA Translation: AAB27396.1
CCDSiCCDS49740.1
PIRiA46271
I54754
RefSeqiNP_038594.2, NM_013566.2
UniGeneiMm.58

Genome annotation databases

EnsembliENSMUST00000001327; ENSMUSP00000001327; ENSMUSG00000001281
GeneIDi16421
KEGGimmu:16421
UCSCiuc012aaa.1 mouse

Similar proteinsi

Entry informationi

Entry nameiITB7_MOUSE
AccessioniPrimary (citable) accession number: P26011
Secondary accession number(s): Q3U2M1, Q64656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health