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Protein

Integrin beta-7

Gene

Itgb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.

GO - Molecular functioni

  1. cell adhesion molecule binding Source: MGI
  2. receptor activity Source: InterPro

GO - Biological processi

  1. cell-matrix adhesion Source: MGI
  2. cell-matrix adhesion involved in ameboidal cell migration Source: MGI
  3. heterotypic cell-cell adhesion Source: MGI
  4. integrin-mediated signaling pathway Source: MGI
  5. leukocyte migration Source: MGI
  6. leukocyte tethering or rolling Source: MGI
  7. multicellular organismal development Source: InterPro
  8. receptor clustering Source: MGI
  9. substrate adhesion-dependent cell spreading Source: MGI
  10. T cell migration Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_300990. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_319261. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-7
Alternative name(s):
Integrin beta-P
M290 IEL antigen
Gene namesi
Name:Itgb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96616. Itgb7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 724705ExtracellularSequence AnalysisAdd
BLAST
Transmembranei725 – 74521HelicalSequence AnalysisAdd
BLAST
Topological domaini746 – 80661CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. integrin alpha4-beta7 complex Source: MGI
  4. membrane Source: MGI
  5. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 806787Integrin beta-7PRO_0000016353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 476By similarity
Disulfide bondi51 ↔ 61By similarity
Disulfide bondi54 ↔ 91By similarity
Disulfide bondi64 ↔ 80By similarity
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi216 ↔ 223By similarity
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi271 ↔ 311By similarity
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi412 ↔ 428By similarity
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi448 ↔ 688By similarity
Disulfide bondi474 ↔ 478By similarity
Disulfide bondi488 ↔ 500By similarity
Disulfide bondi497 ↔ 537By similarity
Disulfide bondi502 ↔ 511By similarity
Disulfide bondi513 ↔ 527By similarity
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi543 ↔ 548By similarity
Disulfide bondi545 ↔ 574By similarity
Disulfide bondi550 ↔ 559By similarity
Disulfide bondi561 ↔ 566By similarity
Disulfide bondi580 ↔ 585By similarity
Disulfide bondi582 ↔ 613By similarity
Disulfide bondi587 ↔ 596By similarity
Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi598 ↔ 605By similarity
Disulfide bondi619 ↔ 624By similarity
Disulfide bondi621 ↔ 666By similarity
Disulfide bondi626 ↔ 635By similarity
Disulfide bondi638 ↔ 641By similarity
Disulfide bondi645 ↔ 654By similarity
Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP26011.
PRIDEiP26011.

PTM databases

PhosphoSiteiP26011.

Expressioni

Gene expression databases

BgeeiP26011.
CleanExiMM_ITGB7.
ExpressionAtlasiP26011. baseline and differential.
GenevestigatoriP26011.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E.

Structurei

3D structure databases

ProteinModelPortaliP26011.
SMRiP26011. Positions 48-691, 746-792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 389240VWFAAdd
BLAST
Repeati478 – 52649IAdd
BLAST
Repeati527 – 56539IIAdd
BLAST
Repeati566 – 60439IIIAdd
BLAST
Repeati605 – 64036IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni478 – 640163Cysteine-rich tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287997.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP26011.
KOiK06590.
OMAiDHTQAIV.
OrthoDBiEOG7T7GSB.
PhylomeDBiP26011.
TreeFamiTF105392.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015437. Integrin_bsu-7.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF36. PTHR10082:SF36. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 4 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDSSTVLIF LLVLGGGQSE LDTKITSSGE AAEWEDPDLS LQGSCQPVPS
60 70 80 90 100
CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPAQELEEPR
110 120 130 140 150
GRQEVLQDKP LSQGDRGEGA TQLAPQRIRV TLRPGEPQKF RVRFLRAAGY
160 170 180 190 200
PVDLYYLMDL SYSMKDDLER VRQLGHALLV RLQEVTHSVR IGFGSFVDKT
210 220 230 240 250
VLPFVSTVPS KLHHPCPSRL ERCQPPFSFH HVLSLTGDAQ AFEREVGRQN
260 270 280 290 300
VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL
310 320 330 340 350
GGIFMPSDGR CHLDSNGVYT NSAEFDYPSV GQVAQALTAA NIQPIFAVTG
360 370 380 390 400
ATLPVYQELR QLIPKSAVGE LSEDSSNVVQ LIMDAYDSLS STVTLEHSPL
410 420 430 440 450
PPGVSISFES HCKGPEKTEG EAGDRGQCND VRVNQTVDFW VTLQATHCLP
460 470 480 490 500
EAHVLRLWAL GFSEELTVEL HTVCDCNCGD AQPHAPYCSD GQGDLQCGIC
510 520 530 540 550
SCAPGRLGQL CECSEADLSS PDLESGCRAP NGTGPLCSGK GRCQCGRCSC
560 570 580 590 600
SGQSSGRLCE CDDASCERHE GILCGGFGHC QCGVCHCHAN HTGRACECSK
610 620 630 640 650
SVDSCVSPEG GLCSGHGYCK CNRCQCLDGY YGALCDQCLG CKSPCEQYRD
660 670 680 690 700
CAECGAFGTG PLAANCSVVC ADVNVTLTLA PNLDDGWCKE RTIDNQLFFF
710 720 730 740 750
LVEHAASGIV LRVRPQEKGV DHTRAIILGC TGGIVAVGLG LVLAYRLSVE
760 770 780 790 800
IYDRREYRRF EKEQQQLNWK QDNNPLYKSA ITTTVNPRFQ GTNGRSPSLS

LTREAD
Length:806
Mass (Da):87,411
Last modified:July 1, 1993 - v2
Checksum:iE793A3F3BA0B5C18
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811A → E AA sequence (PubMed:1710115).Curated
Sequence conflicti81 – 811A → G in AAB23193 (PubMed:1381390).Curated
Sequence conflicti124 – 1241Missing in AAA02749 (PubMed:1559978).Curated
Sequence conflicti538 – 5381S → C in AAB23193 (PubMed:1381390).Curated
Sequence conflicti557 – 5571R → H in AAA02749 (PubMed:1559978).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68903 mRNA. Translation: AAA02749.1.
M95632 mRNA. Translation: AAA39323.1.
M95633 mRNA. Translation: AAA39324.1.
S44607 mRNA. Translation: AAB23193.1.
AK078871 mRNA. Translation: BAC37433.1.
AK154766 mRNA. Translation: BAE32815.1.
AK155207 mRNA. Translation: BAE33119.1.
BC011184 mRNA. Translation: AAH11184.1.
S63504 Genomic DNA. Translation: AAB27396.1.
CCDSiCCDS49740.1.
PIRiA46271.
I54754.
RefSeqiNP_038594.2. NM_013566.2.
UniGeneiMm.58.

Genome annotation databases

EnsembliENSMUST00000001327; ENSMUSP00000001327; ENSMUSG00000001281.
GeneIDi16421.
KEGGimmu:16421.
UCSCiuc012aaa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68903 mRNA. Translation: AAA02749.1.
M95632 mRNA. Translation: AAA39323.1.
M95633 mRNA. Translation: AAA39324.1.
S44607 mRNA. Translation: AAB23193.1.
AK078871 mRNA. Translation: BAC37433.1.
AK154766 mRNA. Translation: BAE32815.1.
AK155207 mRNA. Translation: BAE33119.1.
BC011184 mRNA. Translation: AAH11184.1.
S63504 Genomic DNA. Translation: AAB27396.1.
CCDSiCCDS49740.1.
PIRiA46271.
I54754.
RefSeqiNP_038594.2. NM_013566.2.
UniGeneiMm.58.

3D structure databases

ProteinModelPortaliP26011.
SMRiP26011. Positions 48-691, 746-792.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP26011.
ChEMBLiCHEMBL2111481.

PTM databases

PhosphoSiteiP26011.

Proteomic databases

PaxDbiP26011.
PRIDEiP26011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001327; ENSMUSP00000001327; ENSMUSG00000001281.
GeneIDi16421.
KEGGimmu:16421.
UCSCiuc012aaa.1. mouse.

Organism-specific databases

CTDi3695.
MGIiMGI:96616. Itgb7.

Phylogenomic databases

eggNOGiNOG287997.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP26011.
KOiK06590.
OMAiDHTQAIV.
OrthoDBiEOG7T7GSB.
PhylomeDBiP26011.
TreeFamiTF105392.

Enzyme and pathway databases

ReactomeiREACT_300990. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_319261. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSiItgb7. mouse.
NextBioi289629.
PROiP26011.
SOURCEiSearch...

Gene expression databases

BgeeiP26011.
CleanExiMM_ITGB7.
ExpressionAtlasiP26011. baseline and differential.
GenevestigatoriP26011.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015437. Integrin_bsu-7.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF36. PTHR10082:SF36. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 4 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing."
    Hu M.C.T., Crowe D.T., Weissman I.L., Holzmann B.
    Proc. Natl. Acad. Sci. U.S.A. 89:8254-8258(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of the mouse integrin beta 7 subunit."
    Yuan Q., Jiang W.-M., Leung E., Hollander D., Watson J.D., Krissansen G.W.
    J. Biol. Chem. 267:7352-7358(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Expression of murine beta 7, alpha 4, and beta 1 integrin genes by rodent mast cells."
    Gurish M.F., Bell A.F., Smith T.J., Ducharme L.A., Wang R.K., Weis J.H.
    J. Immunol. 149:1964-1972(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Colon.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  6. "Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine."
    Yuan Q., Jiang W.-M., Hollander D., Leung E., Watson J.D., Krissansen G.W.
    Biochem. Biophys. Res. Commun. 176:1443-1449(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-90, PROTEIN SEQUENCE OF 20-32.
  7. "The mouse beta 7 integrin gene promoter: transcriptional regulation of the leukocyte integrins LPAM-1 and M290."
    Leung E., Mead P.E., Yuan Q., Jiang W.M., Watson J.D., Krissansen G.W.
    Int. Immunol. 5:551-558(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-67.

Entry informationi

Entry nameiITB7_MOUSE
AccessioniPrimary (citable) accession number: P26011
Secondary accession number(s): Q3U2M1, Q64656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 1, 1993
Last modified: April 29, 2015
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.