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P26011 (ITB7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 144. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin beta-7
Alternative name(s):
Integrin beta-P
M290 IEL antigen
Gene names
Name:Itgb7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length806 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.

Subunit structure

Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the integrin beta chain family.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.6
Chain20 – 806787Integrin beta-7
PRO_0000016353

Regions

Topological domain20 – 724705Extracellular Potential
Transmembrane725 – 74521Helical; Potential
Topological domain746 – 80661Cytoplasmic Potential
Domain150 – 389240VWFA
Repeat478 – 52649I
Repeat527 – 56539II
Repeat566 – 60439III
Repeat605 – 64036IV
Region478 – 640163Cysteine-rich tandem repeats

Amino acid modifications

Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation2791N-linked (GlcNAc...) Potential
Glycosylation4341N-linked (GlcNAc...) Potential
Glycosylation5311N-linked (GlcNAc...) Potential
Glycosylation5901N-linked (GlcNAc...) Potential
Glycosylation6651N-linked (GlcNAc...) Potential
Glycosylation6741N-linked (GlcNAc...) Potential
Disulfide bond45 ↔ 476 By similarity
Disulfide bond51 ↔ 61 By similarity
Disulfide bond54 ↔ 91 By similarity
Disulfide bond64 ↔ 80 By similarity
Disulfide bond216 ↔ 223 By similarity
Disulfide bond271 ↔ 311 By similarity
Disulfide bond412 ↔ 428 By similarity
Disulfide bond448 ↔ 688 By similarity
Disulfide bond474 ↔ 478 By similarity
Disulfide bond488 ↔ 500 By similarity
Disulfide bond497 ↔ 537 By similarity
Disulfide bond502 ↔ 511 By similarity
Disulfide bond513 ↔ 527 By similarity
Disulfide bond543 ↔ 548 By similarity
Disulfide bond545 ↔ 574 By similarity
Disulfide bond550 ↔ 559 By similarity
Disulfide bond561 ↔ 566 By similarity
Disulfide bond580 ↔ 585 By similarity
Disulfide bond582 ↔ 613 By similarity
Disulfide bond587 ↔ 596 By similarity
Disulfide bond598 ↔ 605 By similarity
Disulfide bond619 ↔ 624 By similarity
Disulfide bond621 ↔ 666 By similarity
Disulfide bond626 ↔ 635 By similarity
Disulfide bond638 ↔ 641 By similarity
Disulfide bond645 ↔ 654 By similarity

Experimental info

Sequence conflict811A → E AA sequence Ref.6
Sequence conflict811A → G in AAB23193. Ref.3
Sequence conflict1241Missing in AAA02749. Ref.2
Sequence conflict5381S → C in AAB23193. Ref.3
Sequence conflict5571R → H in AAA02749. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P26011 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: E793A3F3BA0B5C18

FASTA80687,411
        10         20         30         40         50         60 
MVDSSTVLIF LLVLGGGQSE LDTKITSSGE AAEWEDPDLS LQGSCQPVPS CQKCILSHPS 

        70         80         90        100        110        120 
CAWCKQLNFT ASGEAEARRC ARREELLARG CPAQELEEPR GRQEVLQDKP LSQGDRGEGA 

       130        140        150        160        170        180 
TQLAPQRIRV TLRPGEPQKF RVRFLRAAGY PVDLYYLMDL SYSMKDDLER VRQLGHALLV 

       190        200        210        220        230        240 
RLQEVTHSVR IGFGSFVDKT VLPFVSTVPS KLHHPCPSRL ERCQPPFSFH HVLSLTGDAQ 

       250        260        270        280        290        300 
AFEREVGRQN VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL 

       310        320        330        340        350        360 
GGIFMPSDGR CHLDSNGVYT NSAEFDYPSV GQVAQALTAA NIQPIFAVTG ATLPVYQELR 

       370        380        390        400        410        420 
QLIPKSAVGE LSEDSSNVVQ LIMDAYDSLS STVTLEHSPL PPGVSISFES HCKGPEKTEG 

       430        440        450        460        470        480 
EAGDRGQCND VRVNQTVDFW VTLQATHCLP EAHVLRLWAL GFSEELTVEL HTVCDCNCGD 

       490        500        510        520        530        540 
AQPHAPYCSD GQGDLQCGIC SCAPGRLGQL CECSEADLSS PDLESGCRAP NGTGPLCSGK 

       550        560        570        580        590        600 
GRCQCGRCSC SGQSSGRLCE CDDASCERHE GILCGGFGHC QCGVCHCHAN HTGRACECSK 

       610        620        630        640        650        660 
SVDSCVSPEG GLCSGHGYCK CNRCQCLDGY YGALCDQCLG CKSPCEQYRD CAECGAFGTG 

       670        680        690        700        710        720 
PLAANCSVVC ADVNVTLTLA PNLDDGWCKE RTIDNQLFFF LVEHAASGIV LRVRPQEKGV 

       730        740        750        760        770        780 
DHTRAIILGC TGGIVAVGLG LVLAYRLSVE IYDRREYRRF EKEQQQLNWK QDNNPLYKSA 

       790        800 
ITTTVNPRFQ GTNGRSPSLS LTREAD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing."
Hu M.C.T., Crowe D.T., Weissman I.L., Holzmann B.
Proc. Natl. Acad. Sci. U.S.A. 89:8254-8258(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning of the mouse integrin beta 7 subunit."
Yuan Q., Jiang W.-M., Leung E., Hollander D., Watson J.D., Krissansen G.W.
J. Biol. Chem. 267:7352-7358(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Expression of murine beta 7, alpha 4, and beta 1 integrin genes by rodent mast cells."
Gurish M.F., Bell A.F., Smith T.J., Ducharme L.A., Wang R.K., Weis J.H.
J. Immunol. 149:1964-1972(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Colon.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
[6]"Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine."
Yuan Q., Jiang W.-M., Hollander D., Leung E., Watson J.D., Krissansen G.W.
Biochem. Biophys. Res. Commun. 176:1443-1449(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-90, PROTEIN SEQUENCE OF 20-32.
[7]"The mouse beta 7 integrin gene promoter: transcriptional regulation of the leukocyte integrins LPAM-1 and M290."
Leung E., Mead P.E., Yuan Q., Jiang W.M., Watson J.D., Krissansen G.W.
Int. Immunol. 5:551-558(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-67.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M68903 mRNA. Translation: AAA02749.1.
M95632 mRNA. Translation: AAA39323.1.
M95633 mRNA. Translation: AAA39324.1.
S44607 mRNA. Translation: AAB23193.1.
AK078871 mRNA. Translation: BAC37433.1.
AK154766 mRNA. Translation: BAE32815.1.
AK155207 mRNA. Translation: BAE33119.1.
BC011184 mRNA. Translation: AAH11184.1.
S63504 Genomic DNA. Translation: AAB27396.1.
CCDSCCDS49740.1.
PIRA46271.
I54754.
RefSeqNP_038594.2. NM_013566.2.
UniGeneMm.58.

3D structure databases

ProteinModelPortalP26011.
SMRP26011. Positions 48-691, 746-792.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2111481.

PTM databases

PhosphoSiteP26011.

Proteomic databases

PaxDbP26011.
PRIDEP26011.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001327; ENSMUSP00000001327; ENSMUSG00000001281.
GeneID16421.
KEGGmmu:16421.
UCSCuc012aaa.1. mouse.

Organism-specific databases

CTD3695.
MGIMGI:96616. Itgb7.

Phylogenomic databases

eggNOGNOG287997.
GeneTreeENSGT00730000110513.
HOGENOMHOG000252936.
HOVERGENHBG006190.
InParanoidP26011.
KOK06590.
OMADHTQAIV.
OrthoDBEOG7T7GSB.
PhylomeDBP26011.
TreeFamTF105392.

Gene expression databases

ArrayExpressP26011.
BgeeP26011.
CleanExMM_ITGB7.
GenevestigatorP26011.

Family and domain databases

Gene3D3.40.50.410. 1 hit.
InterProIPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015437. Integrin_bsu-7.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF36. PTHR10082:SF36. 1 hit.
PfamPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFPIRSF002512. Integrin_B. 1 hit.
PRINTSPR01186. INTEGRINB.
SMARTSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEPS00022. EGF_1. 4 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSITGB7. mouse.
NextBio289629.
PROP26011.
SOURCESearch...

Entry information

Entry nameITB7_MOUSE
AccessionPrimary (citable) accession number: P26011
Secondary accession number(s): Q3U2M1, Q64656
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot