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P26011

- ITB7_MOUSE

UniProt

P26011 - ITB7_MOUSE

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Protein
Integrin beta-7
Gene
Itgb7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. T cell migration Source: MGI
  2. cell-matrix adhesion Source: InterPro
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
  4. leukocyte migration Source: MGI
  5. multicellular organismal development Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-7
Alternative name(s):
Integrin beta-P
M290 IEL antigen
Gene namesi
Name:Itgb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96616. Itgb7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 724705Extracellular Reviewed prediction
Add
BLAST
Transmembranei725 – 74521Helical; Reviewed prediction
Add
BLAST
Topological domaini746 – 80661Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integrin complex Source: InterPro
  2. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 Publication
Add
BLAST
Chaini20 – 806787Integrin beta-7
PRO_0000016353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 476 By similarity
Disulfide bondi51 ↔ 61 By similarity
Disulfide bondi54 ↔ 91 By similarity
Disulfide bondi64 ↔ 80 By similarity
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi216 ↔ 223 By similarity
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi271 ↔ 311 By similarity
Glycosylationi279 – 2791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi412 ↔ 428 By similarity
Glycosylationi434 – 4341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi448 ↔ 688 By similarity
Disulfide bondi474 ↔ 478 By similarity
Disulfide bondi488 ↔ 500 By similarity
Disulfide bondi497 ↔ 537 By similarity
Disulfide bondi502 ↔ 511 By similarity
Disulfide bondi513 ↔ 527 By similarity
Glycosylationi531 – 5311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi543 ↔ 548 By similarity
Disulfide bondi545 ↔ 574 By similarity
Disulfide bondi550 ↔ 559 By similarity
Disulfide bondi561 ↔ 566 By similarity
Disulfide bondi580 ↔ 585 By similarity
Disulfide bondi582 ↔ 613 By similarity
Disulfide bondi587 ↔ 596 By similarity
Glycosylationi590 – 5901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi598 ↔ 605 By similarity
Disulfide bondi619 ↔ 624 By similarity
Disulfide bondi621 ↔ 666 By similarity
Disulfide bondi626 ↔ 635 By similarity
Disulfide bondi638 ↔ 641 By similarity
Disulfide bondi645 ↔ 654 By similarity
Glycosylationi665 – 6651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi674 – 6741N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP26011.
PRIDEiP26011.

PTM databases

PhosphoSiteiP26011.

Expressioni

Gene expression databases

ArrayExpressiP26011.
BgeeiP26011.
CleanExiMM_ITGB7.
GenevestigatoriP26011.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E.

Structurei

3D structure databases

ProteinModelPortaliP26011.
SMRiP26011. Positions 48-691, 746-792.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 389240VWFA
Add
BLAST
Repeati478 – 52649I
Add
BLAST
Repeati527 – 56539II
Add
BLAST
Repeati566 – 60439III
Add
BLAST
Repeati605 – 64036IV
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni478 – 640163Cysteine-rich tandem repeats
Add
BLAST

Sequence similaritiesi

Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287997.
GeneTreeiENSGT00730000110513.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP26011.
KOiK06590.
OMAiDHTQAIV.
OrthoDBiEOG7T7GSB.
PhylomeDBiP26011.
TreeFamiTF105392.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015437. Integrin_bsu-7.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF36. PTHR10082:SF36. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 4 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26011-1 [UniParc]FASTAAdd to Basket

« Hide

MVDSSTVLIF LLVLGGGQSE LDTKITSSGE AAEWEDPDLS LQGSCQPVPS    50
CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPAQELEEPR 100
GRQEVLQDKP LSQGDRGEGA TQLAPQRIRV TLRPGEPQKF RVRFLRAAGY 150
PVDLYYLMDL SYSMKDDLER VRQLGHALLV RLQEVTHSVR IGFGSFVDKT 200
VLPFVSTVPS KLHHPCPSRL ERCQPPFSFH HVLSLTGDAQ AFEREVGRQN 250
VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL 300
GGIFMPSDGR CHLDSNGVYT NSAEFDYPSV GQVAQALTAA NIQPIFAVTG 350
ATLPVYQELR QLIPKSAVGE LSEDSSNVVQ LIMDAYDSLS STVTLEHSPL 400
PPGVSISFES HCKGPEKTEG EAGDRGQCND VRVNQTVDFW VTLQATHCLP 450
EAHVLRLWAL GFSEELTVEL HTVCDCNCGD AQPHAPYCSD GQGDLQCGIC 500
SCAPGRLGQL CECSEADLSS PDLESGCRAP NGTGPLCSGK GRCQCGRCSC 550
SGQSSGRLCE CDDASCERHE GILCGGFGHC QCGVCHCHAN HTGRACECSK 600
SVDSCVSPEG GLCSGHGYCK CNRCQCLDGY YGALCDQCLG CKSPCEQYRD 650
CAECGAFGTG PLAANCSVVC ADVNVTLTLA PNLDDGWCKE RTIDNQLFFF 700
LVEHAASGIV LRVRPQEKGV DHTRAIILGC TGGIVAVGLG LVLAYRLSVE 750
IYDRREYRRF EKEQQQLNWK QDNNPLYKSA ITTTVNPRFQ GTNGRSPSLS 800
LTREAD 806
Length:806
Mass (Da):87,411
Last modified:July 1, 1993 - v2
Checksum:iE793A3F3BA0B5C18
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811A → E AA sequence 1 Publication
Sequence conflicti81 – 811A → G in AAB23193. 1 Publication
Sequence conflicti124 – 1241Missing in AAA02749. 1 Publication
Sequence conflicti538 – 5381S → C in AAB23193. 1 Publication
Sequence conflicti557 – 5571R → H in AAA02749. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68903 mRNA. Translation: AAA02749.1.
M95632 mRNA. Translation: AAA39323.1.
M95633 mRNA. Translation: AAA39324.1.
S44607 mRNA. Translation: AAB23193.1.
AK078871 mRNA. Translation: BAC37433.1.
AK154766 mRNA. Translation: BAE32815.1.
AK155207 mRNA. Translation: BAE33119.1.
BC011184 mRNA. Translation: AAH11184.1.
S63504 Genomic DNA. Translation: AAB27396.1.
CCDSiCCDS49740.1.
PIRiA46271.
I54754.
RefSeqiNP_038594.2. NM_013566.2.
UniGeneiMm.58.

Genome annotation databases

EnsembliENSMUST00000001327; ENSMUSP00000001327; ENSMUSG00000001281.
GeneIDi16421.
KEGGimmu:16421.
UCSCiuc012aaa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68903 mRNA. Translation: AAA02749.1 .
M95632 mRNA. Translation: AAA39323.1 .
M95633 mRNA. Translation: AAA39324.1 .
S44607 mRNA. Translation: AAB23193.1 .
AK078871 mRNA. Translation: BAC37433.1 .
AK154766 mRNA. Translation: BAE32815.1 .
AK155207 mRNA. Translation: BAE33119.1 .
BC011184 mRNA. Translation: AAH11184.1 .
S63504 Genomic DNA. Translation: AAB27396.1 .
CCDSi CCDS49740.1.
PIRi A46271.
I54754.
RefSeqi NP_038594.2. NM_013566.2.
UniGenei Mm.58.

3D structure databases

ProteinModelPortali P26011.
SMRi P26011. Positions 48-691, 746-792.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2111481.

PTM databases

PhosphoSitei P26011.

Proteomic databases

PaxDbi P26011.
PRIDEi P26011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001327 ; ENSMUSP00000001327 ; ENSMUSG00000001281 .
GeneIDi 16421.
KEGGi mmu:16421.
UCSCi uc012aaa.1. mouse.

Organism-specific databases

CTDi 3695.
MGIi MGI:96616. Itgb7.

Phylogenomic databases

eggNOGi NOG287997.
GeneTreei ENSGT00730000110513.
HOGENOMi HOG000252936.
HOVERGENi HBG006190.
InParanoidi P26011.
KOi K06590.
OMAi DHTQAIV.
OrthoDBi EOG7T7GSB.
PhylomeDBi P26011.
TreeFami TF105392.

Enzyme and pathway databases

Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSi ITGB7. mouse.
NextBioi 289629.
PROi P26011.
SOURCEi Search...

Gene expression databases

ArrayExpressi P26011.
Bgeei P26011.
CleanExi MM_ITGB7.
Genevestigatori P26011.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015437. Integrin_bsu-7.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF36. PTHR10082:SF36. 1 hit.
Pfami PF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing."
    Hu M.C.T., Crowe D.T., Weissman I.L., Holzmann B.
    Proc. Natl. Acad. Sci. U.S.A. 89:8254-8258(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of the mouse integrin beta 7 subunit."
    Yuan Q., Jiang W.-M., Leung E., Hollander D., Watson J.D., Krissansen G.W.
    J. Biol. Chem. 267:7352-7358(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Expression of murine beta 7, alpha 4, and beta 1 integrin genes by rodent mast cells."
    Gurish M.F., Bell A.F., Smith T.J., Ducharme L.A., Wang R.K., Weis J.H.
    J. Immunol. 149:1964-1972(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Colon.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  6. "Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine."
    Yuan Q., Jiang W.-M., Hollander D., Leung E., Watson J.D., Krissansen G.W.
    Biochem. Biophys. Res. Commun. 176:1443-1449(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-90, PROTEIN SEQUENCE OF 20-32.
  7. "The mouse beta 7 integrin gene promoter: transcriptional regulation of the leukocyte integrins LPAM-1 and M290."
    Leung E., Mead P.E., Yuan Q., Jiang W.M., Watson J.D., Krissansen G.W.
    Int. Immunol. 5:551-558(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-67.

Entry informationi

Entry nameiITB7_MOUSE
AccessioniPrimary (citable) accession number: P26011
Secondary accession number(s): Q3U2M1, Q64656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 1, 1993
Last modified: September 3, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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