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P26010

- ITB7_HUMAN

UniProt

P26010 - ITB7_HUMAN

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Protein

Integrin beta-7

Gene

ITGB7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi159 – 1591Magnesium; MIDAS motifBy similarity
Metal bindingi161 – 1611Magnesium; MIDAS motifBy similarity
Metal bindingi163 – 1631Magnesium; MIDAS motifBy similarity
Metal bindingi166 – 1661Magnesium or calcium; ADMIDAS motifBy similarity
Metal bindingi167 – 1671Magnesium or calcium; ADMIDAS motifBy similarity
Metal bindingi198 – 1981Magnesium; LIMBS motifBy similarity
Metal bindingi254 – 2541Magnesium; LIMBS motifBy similarity
Metal bindingi256 – 2561Magnesium; LIMBS motifBy similarity
Metal bindingi259 – 2591Magnesium; LIMBS motifBy similarity
Metal bindingi289 – 2891Magnesium; MIDAS motifBy similarity

GO - Molecular functioni

  1. cell adhesion molecule binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: ProtInc
  2. cell-matrix adhesion Source: UniProtKB
  3. cell-matrix adhesion involved in ameboidal cell migration Source: UniProtKB
  4. extracellular matrix organization Source: Reactome
  5. heterotypic cell-cell adhesion Source: UniProtKB
  6. integrin-mediated signaling pathway Source: UniProtKB
  7. leukocyte tethering or rolling Source: UniProtKB
  8. multicellular organismal development Source: InterPro
  9. receptor clustering Source: UniProtKB
  10. regulation of immune response Source: Reactome
  11. substrate adhesion-dependent cell spreading Source: UniProtKB
  12. T cell migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_13552. Integrin cell surface interactions.
SignaLinkiP26010.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-7
Alternative name(s):
Gut homing receptor beta subunit
Gene namesi
Name:ITGB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6162. ITGB7.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. integrin alpha4-beta7 complex Source: UniProtKB
  4. integrin complex Source: ProtInc
  5. membrane Source: UniProtKB
  6. plasma membrane Source: Reactome
  7. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi159 – 1591D → A: Loss of integrin alpha-E/beta-7 binding to E-cadherin and of integrin alpha-4/beta-7 binding to MADCAM1. 1 Publication

Organism-specific databases

PharmGKBiPA29961.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19192 PublicationsAdd
BLAST
Chaini20 – 798779Integrin beta-7PRO_0000016352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 476By similarity
Disulfide bondi51 ↔ 61By similarity
Disulfide bondi54 ↔ 91By similarity
Disulfide bondi64 ↔ 80By similarity
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi216 ↔ 223By similarity
Disulfide bondi271 ↔ 311By similarity
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi412 ↔ 428By similarity
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi448 ↔ 688By similarity
Disulfide bondi474 ↔ 478By similarity
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi488 ↔ 500By similarity
Disulfide bondi497 ↔ 537By similarity
Disulfide bondi502 ↔ 511By similarity
Disulfide bondi513 ↔ 527By similarity
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi543 ↔ 548By similarity
Disulfide bondi545 ↔ 574By similarity
Disulfide bondi550 ↔ 559By similarity
Disulfide bondi561 ↔ 566By similarity
Disulfide bondi580 ↔ 585By similarity
Disulfide bondi582 ↔ 613By similarity
Disulfide bondi587 ↔ 596By similarity
Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi598 ↔ 605By similarity
Disulfide bondi619 ↔ 624By similarity
Disulfide bondi621 ↔ 666By similarity
Disulfide bondi626 ↔ 635By similarity
Disulfide bondi638 ↔ 641By similarity
Disulfide bondi645 ↔ 654By similarity
Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis
Modified residuei778 – 7781Phosphotyrosine; by Tyr-kinasesBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP26010.
PaxDbiP26010.
PRIDEiP26010.

PTM databases

PhosphoSiteiP26010.

Expressioni

Tissue specificityi

Expressed in a variety of leukocyte lines.

Inductioni

Integrin alpha-E/beta-7 is induced by TGFB1.1 Publication

Gene expression databases

BgeeiP26010.
CleanExiHS_ITGB7.
ExpressionAtlasiP26010. baseline and differential.
GenevestigatoriP26010.

Organism-specific databases

HPAiHPA042277.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNAP213336EBI-702932,EBI-350432

Protein-protein interaction databases

BioGridi109901. 5 interactions.
DIPiDIP-34970N.
IntActiP26010. 3 interactions.
MINTiMINT-258650.
STRINGi9606.ENSP00000267082.

Structurei

Secondary structure

1
798
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi102 – 1054
Turni114 – 1163
Beta strandi117 – 1193
Beta strandi127 – 1315
Beta strandi138 – 1458
Beta strandi152 – 1598
Helixi162 – 1643
Helixi165 – 1739
Helixi176 – 1827
Turni183 – 1853
Beta strandi189 – 1968
Turni202 – 2043
Helixi209 – 2135
Beta strandi219 – 2213
Beta strandi228 – 23710
Helixi240 – 2467
Beta strandi255 – 2595
Helixi261 – 27010
Helixi272 – 2754
Beta strandi279 – 29012
Helixi297 – 2993
Turni300 – 3023
Beta strandi317 – 3193
Helixi320 – 3245
Helixi330 – 33910
Beta strandi342 – 3487
Beta strandi350 – 3523
Helixi353 – 3608
Beta strandi367 – 3704
Helixi378 – 39013
Beta strandi393 – 3964
Beta strandi404 – 4085
Beta strandi413 – 4153
Beta strandi423 – 4286
Beta strandi436 – 44510
Beta strandi454 – 4607
Beta strandi465 – 4695
Beta strandi777 – 78610

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BRQX-ray2.10C/D768-798[»]
3V4PX-ray3.15B/D20-512[»]
3V4VX-ray3.10B/D20-512[»]
ProteinModelPortaliP26010.
SMRiP26010. Positions 50-689.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26010.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 723704ExtracellularSequence AnalysisAdd
BLAST
Topological domaini747 – 79852CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei724 – 74623HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 389240VWFAAdd
BLAST
Repeati478 – 52649IAdd
BLAST
Repeati527 – 56539IIAdd
BLAST
Repeati566 – 60439IIIAdd
BLAST
Repeati605 – 64036IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni478 – 640163Cysteine-rich tandem repeatsAdd
BLAST

Domaini

Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287997.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP26010.
KOiK06590.
OMAiDHTQAIV.
OrthoDBiEOG7T7GSB.
PhylomeDBiP26010.
TreeFamiTF105392.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR015812. Integrin_bsu.
IPR015437. Integrin_bsu-7.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF36. PTHR10082:SF36. 1 hit.
PfamiPF08725. Integrin_b_cyt. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 4 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P26010-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVALPMVLVL LLVLSRGESE LDAKIPSTGD ATEWRNPHLS MLGSCQPAPS
60 70 80 90 100
CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPLEELEEPR
110 120 130 140 150
GQQEVLQDQP LSQGARGEGA TQLAPQRVRV TLRPGEPQQL QVRFLRAEGY
160 170 180 190 200
PVDLYYLMDL SYSMKDDLER VRQLGHALLV RLQEVTHSVR IGFGSFVDKT
210 220 230 240 250
VLPFVSTVPS KLRHPCPTRL ERCQSPFSFH HVLSLTGDAQ AFEREVGRQS
260 270 280 290 300
VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL
310 320 330 340 350
GGIFMPSDGH CHLDSNGLYS RSTEFDYPSV GQVAQALSAA NIQPIFAVTS
360 370 380 390 400
AALPVYQELS KLIPKSAVGE LSEDSSNVVQ LIMDAYNSLS STVTLEHSSL
410 420 430 440 450
PPGVHISYES QCEGPEKREG KAEDRGQCNH VRINQTVTFW VSLQATHCLP
460 470 480 490 500
EPHLLRLRAL GFSEELIVEL HTLCDCNCSD TQPQAPHCSD GQGHLQCGVC
510 520 530 540 550
SCAPGRLGRL CECSVAELSS PDLESGCRAP NGTGPLCSGK GHCQCGRCSC
560 570 580 590 600
SGQSSGHLCE CDDASCERHE GILCGGFGRC QCGVCHCHAN RTGRACECSG
610 620 630 640 650
DMDSCISPEG GLCSGHGRCK CNRCQCLDGY YGALCDQCPG CKTPCERHRD
660 670 680 690 700
CAECGAFRTG PLATNCSTAC AHTNVTLALA PILDDGWCKE RTLDNQLFFF
710 720 730 740 750
LVEDDARGTV VLRVRPQEKG ADHTQAIVLG CVGGIVAVGL GLVLAYRLSV
760 770 780 790
EIYDRREYSR FEKEQQQLNW KQDSNPLYKS AITTTINPRF QEADSPTL
Length:798
Mass (Da):86,903
Last modified:May 1, 1992 - v1
Checksum:iCBE275E0E9992385
GO
Isoform Short (identifier: P26010-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     501-648: Missing.

Show »
Length:650
Mass (Da):71,582
Checksum:iB247895C3772178D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341W → A AA sequence (PubMed:1750505)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti672 – 6721H → Y.
Corresponds to variant rs11539433 [ dbSNP | Ensembl ].
VAR_049637

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei501 – 648148Missing in isoform Short. 1 PublicationVSP_002753Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68892 mRNA. Translation: AAA59184.1.
S80335 mRNA. Translation: AAB21332.1.
M62880 mRNA. Translation: AAA59185.1.
L23823
, L23810, L23811, L23812, L23813, L23814, L23815, L23816, L23817, L23818, L23819, L23820, L23821, L23822 Genomic DNA. Translation: AAA36118.1.
S49378
, S49364, S49365, S49366, S49367, S49368, S49369, S49370, S49371, S49373, S49374, S49375, S49376, S49377 Genomic DNA. Translation: AAB23688.1.
BC015916 mRNA. Translation: AAH15916.1.
CCDSiCCDS8849.1. [P26010-1]
PIRiA40526.
RefSeqiNP_000880.1. NM_000889.2. [P26010-1]
XP_005268908.1. XM_005268851.1. [P26010-1]
XP_005268909.1. XM_005268852.2. [P26010-1]
UniGeneiHs.654470.

Genome annotation databases

EnsembliENST00000267082; ENSP00000267082; ENSG00000139626. [P26010-1]
ENST00000422257; ENSP00000408741; ENSG00000139626. [P26010-1]
ENST00000550743; ENSP00000455374; ENSG00000139626. [P26010-2]
GeneIDi3695.
KEGGihsa:3695.
UCSCiuc001scc.3. human. [P26010-1]

Polymorphism databases

DMDMi124973.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68892 mRNA. Translation: AAA59184.1 .
S80335 mRNA. Translation: AAB21332.1 .
M62880 mRNA. Translation: AAA59185.1 .
L23823
, L23810 , L23811 , L23812 , L23813 , L23814 , L23815 , L23816 , L23817 , L23818 , L23819 , L23820 , L23821 , L23822 Genomic DNA. Translation: AAA36118.1 .
S49378
, S49364 , S49365 , S49366 , S49367 , S49368 , S49369 , S49370 , S49371 , S49373 , S49374 , S49375 , S49376 , S49377 Genomic DNA. Translation: AAB23688.1 .
BC015916 mRNA. Translation: AAH15916.1 .
CCDSi CCDS8849.1. [P26010-1 ]
PIRi A40526.
RefSeqi NP_000880.1. NM_000889.2. [P26010-1 ]
XP_005268908.1. XM_005268851.1. [P26010-1 ]
XP_005268909.1. XM_005268852.2. [P26010-1 ]
UniGenei Hs.654470.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BRQ X-ray 2.10 C/D 768-798 [» ]
3V4P X-ray 3.15 B/D 20-512 [» ]
3V4V X-ray 3.10 B/D 20-512 [» ]
ProteinModelPortali P26010.
SMRi P26010. Positions 50-689.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109901. 5 interactions.
DIPi DIP-34970N.
IntActi P26010. 3 interactions.
MINTi MINT-258650.
STRINGi 9606.ENSP00000267082.

Chemistry

BindingDBi P26010.
ChEMBLi CHEMBL2095184.

PTM databases

PhosphoSitei P26010.

Polymorphism databases

DMDMi 124973.

Proteomic databases

MaxQBi P26010.
PaxDbi P26010.
PRIDEi P26010.

Protocols and materials databases

DNASUi 3695.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267082 ; ENSP00000267082 ; ENSG00000139626 . [P26010-1 ]
ENST00000422257 ; ENSP00000408741 ; ENSG00000139626 . [P26010-1 ]
ENST00000550743 ; ENSP00000455374 ; ENSG00000139626 . [P26010-2 ]
GeneIDi 3695.
KEGGi hsa:3695.
UCSCi uc001scc.3. human. [P26010-1 ]

Organism-specific databases

CTDi 3695.
GeneCardsi GC12M053585.
HGNCi HGNC:6162. ITGB7.
HPAi HPA042277.
MIMi 147559. gene.
neXtProti NX_P26010.
PharmGKBi PA29961.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287997.
GeneTreei ENSGT00760000119064.
HOGENOMi HOG000252936.
HOVERGENi HBG006190.
InParanoidi P26010.
KOi K06590.
OMAi DHTQAIV.
OrthoDBi EOG7T7GSB.
PhylomeDBi P26010.
TreeFami TF105392.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_13552. Integrin cell surface interactions.
SignaLinki P26010.

Miscellaneous databases

ChiTaRSi ITGB7. human.
EvolutionaryTracei P26010.
GeneWikii ITGB7.
GenomeRNAii 3695.
NextBioi 14483.
PROi P26010.
SOURCEi Search...

Gene expression databases

Bgeei P26010.
CleanExi HS_ITGB7.
ExpressionAtlasi P26010. baseline and differential.
Genevestigatori P26010.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR015812. Integrin_bsu.
IPR015437. Integrin_bsu-7.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF36. PTHR10082:SF36. 1 hit.
Pfami PF08725. Integrin_b_cyt. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains."
    Yuan Q., Jiang W.-M., Krissansen G.W., Watson J.D.
    Int. Immunol. 2:1097-1108(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Tissue: T-cell.
  2. "Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains."
    Yuan Q., Jiang W.-M., Krissansen G.W., Watson J.D.
    Int. Immunol. 3:1373-1374(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes."
    Erle D.J., Rueegg C., Sheppard D., Pytela R.
    J. Biol. Chem. 266:11009-11016(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Tissue: Leukocyte.
  4. "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1."
    Jiang W.-M., Jenkins D., Yuan Q., Leung E., Choo K.H., Watson J.D., Krissansen G.W.
    Int. Immunol. 4:1031-1040(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Colon.
  6. Cited for: PROTEIN SEQUENCE OF 20-36, INTERACTION WITH INTEGRIN ALPHA-4 AND INTEGRIN ALPHA-E, INDUCTION.
  7. "HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta 7 subunit."
    Micklem K.J., Dong Y., Willis A., Pulford K.A., Visser L., Duerkop H., Poppema S., Stein H., Mason D.Y.
    Am. J. Pathol. 139:1297-1301(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-34.
    Tissue: Leukemia.
  8. "The role of alpha and beta chains in ligand recognition by beta 7 integrins."
    Higgins J.M.G., Cernadas M., Tan K., Irie A., Wang J.-H., Takada Y., Brenner M.B.
    J. Biol. Chem. 275:25652-25664(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ASP-159.
  9. "Integrins: bidirectional, allosteric signaling machines."
    Hynes R.O.
    Cell 110:673-687(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells."
    Arthos J., Cicala C., Martinelli E., Macleod K., Van Ryk D., Wei D., Xiao Z., Veenstra T.D., Conrad T.P., Lempicki R.A., McLaughlin S., Pascuccio M., Gopaul R., McNally J., Cruz C.C., Censoplano N., Chung E., Reitano K.N.
    , Kottilil S., Goode D.J., Fauci A.S.
    Nat. Immunol. 9:301-309(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIV-1 GP120.
  11. "The molecular basis of filamin binding to integrins and competition with talin."
    Kiema T., Lad Y., Jiang P., Oxley C.L., Baldassarre M., Wegener K.L., Campbell I.D., Ylanne J., Calderwood D.A.
    Mol. Cell 21:337-347(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 768-798.

Entry informationi

Entry nameiITB7_HUMAN
AccessioniPrimary (citable) accession number: P26010
Secondary accession number(s): Q9UCP7, Q9UCS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3