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P26009 (ITA8_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Integrin alpha-8

Cleaved into the following 2 chains:

  1. Integrin alpha-8 heavy chain
  2. Integrin alpha-8 light chain
Gene names
Name:ITGA8
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length1044 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis By similarity. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Ref.1 Ref.2 Ref.3

Subunit structure

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Prominently expressed on axons and on cells in contact with basal laminae in embryos.

Developmental stage

Expressed in developing tectum (at protein level). Ref.3

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 10441021Integrin alpha-8
PRO_0000016313
Chain24 – 887864Integrin alpha-8 heavy chain Potential
PRO_0000016314
Chain888 – 1044157Integrin alpha-8 light chain Potential
PRO_0000016315

Regions

Topological domain24 – 991968Extracellular Potential
Transmembrane992 – 101524Helical; Potential
Topological domain1016 – 104429Cytoplasmic Potential
Repeat28 – 9063FG-GAP 1
Repeat104 – 16562FG-GAP 2
Repeat170 – 22253FG-GAP 3
Repeat236 – 29257FG-GAP 4
Repeat293 – 35462FG-GAP 5
Repeat355 – 41359FG-GAP 6
Repeat417 – 48064FG-GAP 7
Calcium binding311 – 3199 Potential
Calcium binding377 – 3859 Potential
Calcium binding441 – 4499 Potential
Motif437 – 4393Cell attachment site Potential

Amino acid modifications

Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Glycosylation2211N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation4861N-linked (GlcNAc...) Potential
Glycosylation5871N-linked (GlcNAc...) Potential
Glycosylation7011N-linked (GlcNAc...) Potential
Glycosylation7191N-linked (GlcNAc...) Potential
Glycosylation7511N-linked (GlcNAc...) Potential
Glycosylation7621N-linked (GlcNAc...) Potential
Glycosylation8181N-linked (GlcNAc...) Potential
Glycosylation8771N-linked (GlcNAc...) Potential
Glycosylation9041N-linked (GlcNAc...) Potential
Glycosylation9521N-linked (GlcNAc...) Potential
Glycosylation9861N-linked (GlcNAc...) Potential
Disulfide bond81 ↔ 88 By similarity
Disulfide bond132 ↔ 153 By similarity
Disulfide bond169 ↔ 182 By similarity
Disulfide bond489 ↔ 500 By similarity
Disulfide bond506 ↔ 562 By similarity
Disulfide bond623 ↔ 629 By similarity
Disulfide bond695 ↔ 708 By similarity
Disulfide bond849 ↔ 905Interchain (between heavy and light chains) By similarity
Disulfide bond910 ↔ 915 By similarity

Sequences

Sequence LengthMass (Da)Tools
P26009 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 3D59A318B51320CE

FASTA1,044116,142
        10         20         30         40         50         60 
MPRRQPPRPL LLLSALLCAP ASAFNLDEEK LTVYSGPPGS YFGYSVDFYI PDPSTVSVLV 

        70         80         90        100        110        120 
GAPRANTTQP DIVEGGAVYH CGWPAARCRQ IPFDNTNNRK IKVNGTREPI EFKTNQWFGA 

       130        140        150        160        170        180 
TVKAHKEKVV ACAPLYHWRT LKDSPEKDPV GTCYVAIQNF SAYAEYSPCR NSNADPEGQG 

       190        200        210        220        230        240 
FCQAGFSLDF YKNGDLIVGG PGSFYWQGQV ITASIADIIT NYSFKDILRK LAHEKQTGVA 

       250        260        270        280        290        300 
PPTYDDNYMG YSVAAGEFTG DSEEELVAGV PRGAQNFGYV SIINSSDLTF IQNFTGEQMA 

       310        320        330        340        350        360 
SYFGYTVAVS DVNNDGLDDI LVGAPLFMER EFESKPKEVG QVYLYLQESA FLFRDPQILT 

       370        380        390        400        410        420 
GTEVFGRFGS AITHLGDLNQ DGYNDIAVGA PFAGEDRRGK VLIYNGYSNG LKTDPSQVLN 

       430        440        450        460        470        480 
GAWASQSMPS GFGFTLRGDS DVDKNDYPDL IVGAFGAGKA VVYRARPVVT VNALLILNPM 

       490        500        510        520        530        540 
IVNPDNKTCQ PPGSPLFVAC FTVRVCAAFE GQSISDEIVL KGELQLDSLK QKGAVKRTLF 

       550        560        570        580        590        600 
FDYHQSHHYF SIVMERQKKL YCQDFLVYLR DETEFRDKLS PININLNYSL DESHFKDSLL 

       610        620        630        640        650        660 
VKPILNYYQR PSVTEQAYIL VDCGEDNLCI PDLHLSAVPD KDQLIIGEEN CVMLIINPRN 

       670        680        690        700        710        720 
DGEGAYEAEL HIKIPPEADY TGVERNNKAL RVLSCDYKME NETRMVVCDL GNPMVAGANF 

       730        740        750        760        770        780 
STGIRFSVQH FENSDFSINF ELQIKSSNKI NSTSNLVNLH INITAAAQVQ VRGVSHPPQI 

       790        800        810        820        830        840 
ILPLHNWEPK DEPTKEEEIG PLVEHIYELH NIGPSAINNT VLHVGWPVSS GEEFLLYILH 

       850        860        870        880        890        900 
IQTHGPLHCQ TSSPINIMQI NFAIPQDTPE LAAFLYNSTI SHYIRRREVA VAEPYRRNSA 

       910        920        930        940        950        960 
KILNCTNVKC ILISCNVGQL ERGKSAALKI RSRLWAETFL QRKNDPYTLS SNVSFKVKNM 

       970        980        990       1000       1010       1020 
PYKVQPAKLP EGSIAIRTSV IWSTPNVSFV IPLWVIILAI MLGLLVLAVL TLALWKCGFF 

      1030       1040 
DRARPPQDDM ADREQLTNNK TTDA

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References

[1]"Characterization of the integrin alpha 8 subunit: a new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos."
Bossy B., Bossy-Wetzel E., Reichardt L.F.
EMBO J. 10:2375-2385(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Tissue: Brain.
[2]"The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C."
Varnum-Finney B., Venstrom K., Mueller U., Kypta R., Backus C., Chiquet M., Reichardt L.F.
Neuron 14:1213-1222(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"Retroviral transfer of antisense integrin alpha6 or alpha8 sequences results in laminar redistribution or clonal cell death in developing brain."
Zhang Z., Galileo D.S.
J. Neurosci. 18:6928-6938(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X58519 mRNA. Translation: CAA41409.1.
IPIIPI00600247.
PIRS16516.
RefSeqNP_990619.1. NM_205288.1.
UniGeneGga.1784.

3D structure databases

ProteinModelPortalP26009.
ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000014220.

Proteomic databases

PaxDbP26009.
PRIDEP26009.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396225.
KEGGgga:396225.

Organism-specific databases

CTD8516.

Phylogenomic databases

eggNOGNOG26407.
HOGENOMHOG000231603.
HOVERGENHBG006186.
InParanoidP26009.
KOK06584.
OrthoDBEOG4548XV.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 6 hits.
[Graphical view]
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816277.

Entry information

Entry nameITA8_CHICK
AccessionPrimary (citable) accession number: P26009
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents