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Protein

Integrin alpha-V

Gene

ITGAV

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi248 – 256Sequence analysis9
Calcium bindingi302 – 310Sequence analysis9
Calcium bindingi367 – 375Sequence analysis9
Calcium bindingi431 – 439Sequence analysis9

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: BHF-UCL
  • cell adhesion mediated by integrin Source: UniProtKB
  • integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-V
Alternative name(s):
Vitronectin receptor subunit alpha
Cleaved into the following 2 chains:
Gene namesi
Name:ITGAV
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 978ExtracellularSequence analysisAdd BLAST959
Transmembranei979 – 1002HelicalSequence analysisAdd BLAST24
Topological domaini1003 – 1034CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001630720 – 1034Integrin alpha-VAdd BLAST1015
ChainiPRO_000001630820 – 875Integrin alpha-V heavy chainSequence analysisAdd BLAST856
ChainiPRO_0000016309877 – 1034Integrin alpha-V light chainSequence analysisAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi77 ↔ 85By similarity
Disulfide bondi126 ↔ 146By similarity
Disulfide bondi160 ↔ 173By similarity
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1
Glycosylationi284N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi479 ↔ 488By similarity
Disulfide bondi494 ↔ 551By similarity
Glycosylationi540N-linked (GlcNAc...)Sequence analysis1
Glycosylationi601N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi612 ↔ 618By similarity
Disulfide bondi684 ↔ 697By similarity
Glycosylationi690N-linked (GlcNAc...)Sequence analysis1
Glycosylationi821N-linked (GlcNAc...)Sequence analysis1
Glycosylationi837N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi838 ↔ 890Interchain (between heavy and light chains)By similarity
Glycosylationi860N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi895 ↔ 900By similarity
Glycosylationi931N-linked (GlcNAc...)Sequence analysis1
Glycosylationi951N-linked (GlcNAc...)Sequence analysis1
Glycosylationi959N-linked (GlcNAc...)Sequence analysis1
Glycosylationi966N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP26008.
PRIDEiP26008.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004173.

Structurei

3D structure databases

ProteinModelPortaliP26008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 86FG-GAP 1PROSITE-ProRule annotationAdd BLAST66
Repeati97 – 158FG-GAP 2PROSITE-ProRule annotationAdd BLAST62
Repeati161 – 213FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati225 – 279FG-GAP 4PROSITE-ProRule annotationAdd BLAST55
Repeati280 – 345FG-GAP 5PROSITE-ProRule annotationAdd BLAST66
Repeati346 – 403FG-GAP 6PROSITE-ProRule annotationAdd BLAST58
Repeati407 – 470FG-GAP 7PROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1005 – 1009GFFKR motif5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPB5. Eukaryota.
ENOG410YR19. LUCA.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiP26008.
KOiK06487.
PhylomeDBiP26008.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALRASLLL SCALTAARAF NLDAERPAVY SGAEGSYFGF AVDFFAPDAS
60 70 80 90 100
SMFLLVGAPK ANTSQSNVVE GGQVLQCNWN SNRNCQPIIF DSTGNRDFAP
110 120 130 140 150
DDPLEFKSHQ WFGASVRSKN DKILACAPLY HWRTETKQER EPVGTCYLFD
160 170 180 190 200
GSKSVEYAPC RSTTIDADGQ GFCQGGFSID FTKGDRVLLG GPGSFYWQGQ
210 220 230 240 250
LISDRVAEIL AKYDSKVYST KYDDQLATRP ASAAFDDSYL GYSVAVGDFS
260 270 280 290 300
GDGIEDFVSG VPRAARTLGM VSIYNGKNMS SMYNFTGEQM AAYFGYSVAT
310 320 330 340 350
TDINGDDYTD LFIGAPLFMD RGSDGKLQEV GQVSICLQRA SGGFQIAKLN
360 370 380 390 400
GFEIFARFGS AIAPLGDLDQ DGFNDIAVAA PYGGEDKRGL VYIYNGRATG
410 420 430 440 450
LNAVPSRILE GQWAARTMPP SFGYSLKGAT DVDKNGYPDL IVGAFGVDTA
460 470 480 490 500
VLYRARPVIR VNAALEVNPT ILNPENKACS LADVKVSCFK VKFCLKADGK
510 520 530 540 550
GKLPNSLNFQ VELLLDKLKQ KGAIRRALFL HSKQPSHSKN MTITKGGKMN
560 570 580 590 600
CEELDAFLRD ESEFRDKLTP ITIFMEYRLD YKTAVDATGL HPILNQFIPA
610 620 630 640 650
NMSRQAHILL DCGEDNICKP KLEVSVRSDQ KKIYIGDDNP LTLIVTAENQ
660 670 680 690 700
GEGAYEAELF VIVPPQADFI GVVRNNEALA RLSCAFKTEN QTRMVVCDLG
710 720 730 740 750
NPMKAGTKLL AGLRFSVHQQ SEMDTSVKFD LQIRSSNLFD NLSPVAFYQV
760 770 780 790 800
DLAISAAVEI RGVSSPDHIF LPIANWQPKE NPETEDDIGP LVQHIYELRN
810 820 830 840 850
NGPSAFSKVM MTLQWPYKYK NYTLLYIVQY DIDGPMNCTS DMEINPLKIK
860 870 880 890 900
ISAPKEDEKN ETFSREDNRN HRISRRDLTA IEGDVQTLGC GNADCLKIVC
910 920 930 940 950
QVGHLERGKS AILYLKSRLW TQTFMNKENQ NHSYSLQSSA SFNVIEFPYK
960 970 980 990 1000
NLSFEDIHNS TVVTTNITWG IQPQPMPVPV WVIILAVLAG LLLLAVLVLV
1010 1020 1030
MYRMGFFKRV RPPQEEQERE QLQPHENGEG TSEA
Length:1,034
Mass (Da):114,389
Last modified:May 1, 1992 - v1
Checksum:iD76B0B8A692DC684
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60517 mRNA. Translation: AAA49138.1.
PIRiA36108.
RefSeqiNP_990770.1. NM_205439.1.
UniGeneiGga.815.

Genome annotation databases

GeneIDi396420.
KEGGigga:396420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60517 mRNA. Translation: AAA49138.1.
PIRiA36108.
RefSeqiNP_990770.1. NM_205439.1.
UniGeneiGga.815.

3D structure databases

ProteinModelPortaliP26008.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004173.

Proteomic databases

PaxDbiP26008.
PRIDEiP26008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396420.
KEGGigga:396420.

Organism-specific databases

CTDi3685.

Phylogenomic databases

eggNOGiENOG410IPB5. Eukaryota.
ENOG410YR19. LUCA.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiP26008.
KOiK06487.
PhylomeDBiP26008.

Miscellaneous databases

PROiP26008.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITAV_CHICK
AccessioniPrimary (citable) accession number: P26008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 5, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.