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Protein

Integrin alpha-6

Gene

ITGA6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells. It plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi318 – 326Sequence analysis9
Calcium bindingi380 – 388Sequence analysis9
Calcium bindingi438 – 446Sequence analysis9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-6
Alternative name(s):
VLA-6
Cleaved into the following 2 chains:
Gene namesi
Name:ITGA6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
  • Cell membrane By similarity; Lipid-anchor By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 1010ExtracellularSequence analysisAdd BLAST992
Transmembranei1011 – 1036HelicalSequence analysisAdd BLAST26
Topological domaini1037 – 1072CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

  • cell surface Source: AgBase
  • integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001626419 – 1072Integrin alpha-6Add BLAST1054
ChainiPRO_000001626519 – 898Integrin alpha-6 heavy chainSequence analysisAdd BLAST880
ChainiPRO_0000016266902 – 1072Integrin alpha-6 light chainSequence analysisAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi79 ↔ 88By similarity
Disulfide bondi125 ↔ 148By similarity
Disulfide bondi169 ↔ 182By similarity
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1
Glycosylationi364N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi498 ↔ 557By similarity
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Glycosylationi609N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi625 ↔ 631By similarity
Disulfide bondi725 ↔ 736By similarity
Glycosylationi730N-linked (GlcNAc...)Sequence analysis1
Glycosylationi747N-linked (GlcNAc...)Sequence analysis1
Glycosylationi780N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi880 ↔ 927Interchain (between heavy and light chains)By similarity
Disulfide bondi933 ↔ 938By similarity
Glycosylationi957N-linked (GlcNAc...)Sequence analysis1
Lipidationi1038S-palmitoyl cysteine; by DHHC3By similarity1
Modified residuei1070Phosphoserine; by CaMK2Sequence analysis1

Post-translational modificationi

Phosphorylated in vivo.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP26007.
PRIDEiP26007.

Expressioni

Developmental stagei

Alpha-6 levels decrease with age.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015231.

Structurei

3D structure databases

ProteinModelPortaliP26007.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 88FG-GAP 1PROSITE-ProRule annotationAdd BLAST66
Repeati94 – 160FG-GAP 2PROSITE-ProRule annotationAdd BLAST67
Repeati170 – 223FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati238 – 295FG-GAP 4PROSITE-ProRule annotationAdd BLAST58
Repeati296 – 357FG-GAP 5PROSITE-ProRule annotationAdd BLAST62
Repeati358 – 413FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati414 – 476FG-GAP 7PROSITE-ProRule annotationAdd BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1039 – 1043GFFKR motif5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
HOGENOMiHOG000015786.
HOVERGENiHBG108011.
InParanoidiP26007.
KOiK06485.
PhylomeDBiP26007.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26007-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALLLYLP LLPGLAGAFN LDAENVIGRR GEPGSLFGFS LAMHRQLQPQ
60 70 80 90 100
EKRLLLVGAP REKAFPSQQA NRTGGLYSCD ITSSDTRCTR VVFDEDTDPK
110 120 130 140 150
MESKEDQWMG VTVQSQGPGG NVVTCAHRYE KRQYVNTVQE TRDIIGRCYV
160 170 180 190 200
LSQDLTIKDD MDNGVWSFCD GRLRGHEKFG SCQQGVAATF TRDYHYIVFG
210 220 230 240 250
APGTYNWKGV VRAEQKNQTF YDLGIFDDGP YEVGDESRQD KNLVPVPANS
260 270 280 290 300
YLGFSLDSGK GIVSQDEMTF VSGAPRANHS GAVVLLKKEK NQRALSLEHM
310 320 330 340 350
FEGEGLASSF GYDVAVVDLN SDGWQDIVVG APQYFDRSGD IGGAVYIYIN
360 370 380 390 400
QRGKWEGIKP IRLNGTADSM FGLAVENVGD INQDGYPDIA VGAPYDGFGK
410 420 430 440 450
VYIYHGSKNG INTEPAQILD GEKTGTNFFG YSIAGNMDLD KNSYPDIAVG
460 470 480 490 500
SLSDSVSVFR SRPVISITKS ITVQPDKLDL KKKNPEDPSE IWMDVKACFQ
510 520 530 540 550
YTANPRNLNP RIKINYTFEA ENERRQLGLP SRVRFKDYLS DQFTASTTLI
560 570 580 590 600
GQNSKRCVTA KLVLQEKIKD KLRPIPIAVS VNIAGLESGS SSTRKERALP
610 620 630 640 650
DLIPILNSNE SETKITKVEF LKEGCGEDNE CHSNLKLQYR FCTREGNEDR
660 670 680 690 700
FTYLPIENGI PVLVLKDQKD IALEITVTNN PSDARNPQKD GEDAYEAKLI
710 720 730 740 750
ATFPDSLTYS AFREMRGYPE KQLTCGANQN GSQAECELGN PFKRNSNVTF
760 770 780 790 800
YLILSTTKVN VDTTDLDINL KLETTSTQVN STAITASAKV VLELLLSLTG
810 820 830 840 850
VAKPSQVYFG GNIVGESAMK SEDNIGNLIE YEFRVTNLGR PLKTFGTASL
860 870 880 890 900
DIQWPKEISN GKWLLYLMKI ESKGLEKVSC QPQNEINVLH VAESHNSRRK
910 920 930 940 950
REIAEKQLTD SKTFSLFSER KYKTLDCKVN AQCVDIRCPL KGFDSKASIL
960 970 980 990 1000
LRSRLWNSTF LEEFSKMNYL DILVRASISV PAAAKNVKLT NEAAQVRVTV
1010 1020 1030 1040 1050
FPAKPVALYT GVPWWIIAVA IFAGVLMLAL LVFLLWKCGF FKRSKKDHYD
1060 1070
ATYHKAEIHA QPSDKERLTS DA
Length:1,072
Mass (Da):119,200
Last modified:May 1, 1992 - v1
Checksum:i6DE2B99ECD8B3E44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56559 mRNA. Translation: CAA39909.1.
PIRiA38457.
RefSeqiNP_990620.1. NM_205289.1.
UniGeneiGga.44589.

Genome annotation databases

GeneIDi396226.
KEGGigga:396226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56559 mRNA. Translation: CAA39909.1.
PIRiA38457.
RefSeqiNP_990620.1. NM_205289.1.
UniGeneiGga.44589.

3D structure databases

ProteinModelPortaliP26007.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015231.

Proteomic databases

PaxDbiP26007.
PRIDEiP26007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396226.
KEGGigga:396226.

Organism-specific databases

CTDi3655.

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
HOGENOMiHOG000015786.
HOVERGENiHBG108011.
InParanoidiP26007.
KOiK06485.
PhylomeDBiP26007.

Miscellaneous databases

PROiP26007.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA6_CHICK
AccessioniPrimary (citable) accession number: P26007
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.