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P26007 (ITA6_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Integrin alpha-6
Alternative name(s):
VLA-6

Cleaved into the following 2 chains:

  1. Integrin alpha-6 heavy chain
  2. Integrin alpha-6 light chain
Gene names
Name:ITGA6
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length1072 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells. It plays a critical structural role in the hemidesmosome.

Subunit structure

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4.

Subcellular location

Membrane; Single-pass type I membrane protein.

Developmental stage

Alpha-6 levels decrease with age.

Post-translational modification

Phosphorylated in vivo.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionIntegrin
Receptor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegrin complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionreceptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 10721054Integrin alpha-6
PRO_0000016264
Chain19 – 898880Integrin alpha-6 heavy chain Potential
PRO_0000016265
Chain902 – 1072171Integrin alpha-6 light chain Potential
PRO_0000016266

Regions

Topological domain19 – 1010992Extracellular Potential
Transmembrane1011 – 103626Helical; Potential
Topological domain1037 – 107236Cytoplasmic Potential
Repeat23 – 8866FG-GAP 1
Repeat94 – 16067FG-GAP 2
Repeat170 – 22354FG-GAP 3
Repeat238 – 29558FG-GAP 4
Repeat296 – 35762FG-GAP 5
Repeat358 – 41356FG-GAP 6
Repeat414 – 47663FG-GAP 7
Calcium binding318 – 3269 Potential
Calcium binding380 – 3889 Potential
Calcium binding438 – 4469 Potential
Motif1039 – 10435GFFKR motif

Amino acid modifications

Modified residue10701Phosphoserine; by CaMK2 Potential
Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation2171N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Glycosylation6091N-linked (GlcNAc...) Potential
Glycosylation7301N-linked (GlcNAc...) Potential
Glycosylation7471N-linked (GlcNAc...) Potential
Glycosylation7801N-linked (GlcNAc...) Potential
Glycosylation9571N-linked (GlcNAc...) Potential
Disulfide bond79 ↔ 88 By similarity
Disulfide bond125 ↔ 148 By similarity
Disulfide bond169 ↔ 182 By similarity
Disulfide bond498 ↔ 557 By similarity
Disulfide bond625 ↔ 631 By similarity
Disulfide bond725 ↔ 736 By similarity
Disulfide bond880 ↔ 927Interchain (between heavy and light chains) By similarity
Disulfide bond933 ↔ 938 By similarity

Sequences

Sequence LengthMass (Da)Tools
P26007 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 6DE2B99ECD8B3E44

FASTA1,072119,200
        10         20         30         40         50         60 
MAAALLLYLP LLPGLAGAFN LDAENVIGRR GEPGSLFGFS LAMHRQLQPQ EKRLLLVGAP 

        70         80         90        100        110        120 
REKAFPSQQA NRTGGLYSCD ITSSDTRCTR VVFDEDTDPK MESKEDQWMG VTVQSQGPGG 

       130        140        150        160        170        180 
NVVTCAHRYE KRQYVNTVQE TRDIIGRCYV LSQDLTIKDD MDNGVWSFCD GRLRGHEKFG 

       190        200        210        220        230        240 
SCQQGVAATF TRDYHYIVFG APGTYNWKGV VRAEQKNQTF YDLGIFDDGP YEVGDESRQD 

       250        260        270        280        290        300 
KNLVPVPANS YLGFSLDSGK GIVSQDEMTF VSGAPRANHS GAVVLLKKEK NQRALSLEHM 

       310        320        330        340        350        360 
FEGEGLASSF GYDVAVVDLN SDGWQDIVVG APQYFDRSGD IGGAVYIYIN QRGKWEGIKP 

       370        380        390        400        410        420 
IRLNGTADSM FGLAVENVGD INQDGYPDIA VGAPYDGFGK VYIYHGSKNG INTEPAQILD 

       430        440        450        460        470        480 
GEKTGTNFFG YSIAGNMDLD KNSYPDIAVG SLSDSVSVFR SRPVISITKS ITVQPDKLDL 

       490        500        510        520        530        540 
KKKNPEDPSE IWMDVKACFQ YTANPRNLNP RIKINYTFEA ENERRQLGLP SRVRFKDYLS 

       550        560        570        580        590        600 
DQFTASTTLI GQNSKRCVTA KLVLQEKIKD KLRPIPIAVS VNIAGLESGS SSTRKERALP 

       610        620        630        640        650        660 
DLIPILNSNE SETKITKVEF LKEGCGEDNE CHSNLKLQYR FCTREGNEDR FTYLPIENGI 

       670        680        690        700        710        720 
PVLVLKDQKD IALEITVTNN PSDARNPQKD GEDAYEAKLI ATFPDSLTYS AFREMRGYPE 

       730        740        750        760        770        780 
KQLTCGANQN GSQAECELGN PFKRNSNVTF YLILSTTKVN VDTTDLDINL KLETTSTQVN 

       790        800        810        820        830        840 
STAITASAKV VLELLLSLTG VAKPSQVYFG GNIVGESAMK SEDNIGNLIE YEFRVTNLGR 

       850        860        870        880        890        900 
PLKTFGTASL DIQWPKEISN GKWLLYLMKI ESKGLEKVSC QPQNEINVLH VAESHNSRRK 

       910        920        930        940        950        960 
REIAEKQLTD SKTFSLFSER KYKTLDCKVN AQCVDIRCPL KGFDSKASIL LRSRLWNSTF 

       970        980        990       1000       1010       1020 
LEEFSKMNYL DILVRASISV PAAAKNVKLT NEAAQVRVTV FPAKPVALYT GVPWWIIAVA 

      1030       1040       1050       1060       1070 
IFAGVLMLAL LVFLLWKCGF FKRSKKDHYD ATYHKAEIHA QPSDKERLTS DA

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References

[1]"Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. Evidence for transcriptional and posttranslational regulation."
de Curtis I., Quaranta V., Tamura R.N., Reichardt L.F.
J. Cell Biol. 113:405-416(1991) [PubMed: 1826298] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: White leghorn.
Tissue: Retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X56559 mRNA. Translation: CAA39909.1.
IPIIPI00572250.
PIRA38457.
RefSeqNP_990620.1. NM_205289.1.
UniGeneGga.44589.

3D structure databases

ProteinModelPortalP26007.
ModBaseSearch...

Protein-protein interaction databases

STRINGP26007.

Proteomic databases

PRIDEP26007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396226.
KEGGgga:396226.

Organism-specific databases

CTD3655.

Phylogenomic databases

eggNOGveNOG09763.
GeneTreeENSGT00600000084082.
HOVERGENHBG108011.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
KOK06485.
PfamPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameITA6_CHICK
AccessionPrimary (citable) accession number: P26007
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 16, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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