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Protein

Integrin alpha-3

Gene

ITGA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi315 – 3239Sequence analysis
Calcium bindingi378 – 3869Sequence analysis
Calcium bindingi439 – 4479Sequence analysis

GO - Molecular functioni

  • glycoprotein binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protease binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  • cell-matrix adhesion Source: ProtInc
  • dendritic spine maintenance Source: Ensembl
  • exploration behavior Source: Ensembl
  • extracellular matrix organization Source: Reactome
  • heart development Source: Ensembl
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • leukocyte migration Source: Reactome
  • lung development Source: UniProtKB
  • maternal process involved in female pregnancy Source: Ensembl
  • memory Source: Ensembl
  • mesodermal cell differentiation Source: UniProtKB
  • negative regulation of cell projection organization Source: Ensembl
  • negative regulation of Rho protein signal transduction Source: Ensembl
  • nephron development Source: UniProtKB
  • neuron migration Source: Ensembl
  • positive regulation of cell-substrate adhesion Source: Ensembl
  • positive regulation of epithelial cell migration Source: Ensembl
  • positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  • positive regulation of gene expression Source: Ensembl
  • positive regulation of neuron projection development Source: Ensembl
  • regulation of BMP signaling pathway Source: UniProtKB
  • regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • regulation of Wnt signaling pathway Source: UniProtKB
  • renal filtration Source: UniProtKB
  • response to drug Source: Ensembl
  • response to gonadotropin Source: Ensembl
  • skin development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-210991. Basigin interactions.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-3000157. Laminin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-3
Alternative name(s):
CD49 antigen-like family member C
FRP-2
Galactoprotein B3
Short name:
GAPB3
VLA-3 subunit alpha
CD_antigen: CD49c
Cleaved into the following 2 chains:
Gene namesi
Name:ITGA3
Synonyms:MSK18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6139. ITGA3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 991959ExtracellularSequence analysisAdd
BLAST
Transmembranei992 – 101423HelicalSequence analysisAdd
BLAST
Topological domaini1015 – 105137CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: Ensembl
  • cell periphery Source: UniProtKB
  • cell surface Source: UniProtKB
  • excitatory synapse Source: Ensembl
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • filopodium membrane Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • growth cone Source: Ensembl
  • integrin alpha3-beta1 complex Source: UniProtKB
  • integrin complex Source: ProtInc
  • invadopodium membrane Source: UniProtKB
  • perinuclear region of cytoplasm Source: Ensembl
  • plasma membrane Source: BHF-UCL
  • receptor complex Source: MGI
  • synaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Involvement in diseasei

Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease.
See also OMIM:614748
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti628 – 6281R → P in ILNEB. 1 Publication
Corresponds to variant rs140781106 [ dbSNP | Ensembl ].
VAR_068808

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1016 – 10161C → S: Abolishes palmitoylation. 1 Publication

Keywords - Diseasei

Epidermolysis bullosa

Organism-specific databases

MalaCardsiITGA3.
MIMi614748. phenotype.
Orphaneti306504. Congenital nephrotic syndrome-interstitial lung disease-epidermolysis bullosa syndrome.
PharmGKBiPA29939.

Chemistry

ChEMBLiCHEMBL3525.
GuidetoPHARMACOLOGYi2442.

Polymorphism and mutation databases

BioMutaiITGA3.
DMDMi347595830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32323 PublicationsAdd
BLAST
Chaini33 – 10511019Integrin alpha-3PRO_0000016238Add
BLAST
Chaini33 – 872840Integrin alpha-3 heavy chainSequence analysisPRO_0000016239Add
BLAST
Chaini876 – 1051176Integrin alpha-3 light chainSequence analysisPRO_0000016240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 1031 Publication
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi140 ↔ 1621 Publication
Disulfide bondi185 ↔ 1971 Publication
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi485 ↔ 490By similarity
Disulfide bondi496 ↔ 550By similarity
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence analysis
Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence analysis
Glycosylationi573 – 5731N-linked (GlcNAc...)Sequence analysis
Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence analysis
Disulfide bondi615 ↔ 6211 Publication
Glycosylationi656 – 6561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi694 ↔ 7021 Publication
Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence analysis
Glycosylationi841 – 8411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi846 ↔ 904Interchain (between heavy and light chains)1 Publication
Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi911 ↔ 9161 Publication
Glycosylationi926 – 9261N-linked (GlcNAc...)Sequence analysis
Glycosylationi935 – 9351N-linked (GlcNAc...)Sequence analysis
Glycosylationi969 – 9691N-linked (GlcNAc...)Sequence analysis
Lipidationi1016 – 10161S-palmitoyl cysteine1 Publication

Post-translational modificationi

Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP26006.
MaxQBiP26006.
PaxDbiP26006.
PeptideAtlasiP26006.
PRIDEiP26006.

PTM databases

iPTMnetiP26006.
PhosphoSiteiP26006.
SwissPalmiP26006.
UniCarbKBiP26006.

Miscellaneous databases

PMAP-CutDBP26006.

Expressioni

Tissue specificityi

Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.1 Publication

Gene expression databases

BgeeiENSG00000005884.
CleanExiHS_ITGA3.
ExpressionAtlasiP26006. baseline and differential.

Organism-specific databases

HPAiCAB018594.
HPA008572.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner.2 Publications

GO - Molecular functioni

  • glycoprotein binding Source: UniProtKB
  • protease binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi109882. 16 interactions.
DIPiDIP-140N.
IntActiP26006. 5 interactions.
MINTiMINT-140288.
STRINGi9606.ENSP00000007722.

Chemistry

BindingDBiP26006.

Structurei

3D structure databases

ProteinModelPortaliP26006.
SMRiP26006. Positions 33-862.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati38 – 10366FG-GAP 1PROSITE-ProRule annotationAdd
BLAST
Repeati110 – 17162FG-GAP 2PROSITE-ProRule annotationAdd
BLAST
Repeati185 – 23551FG-GAP 3PROSITE-ProRule annotationAdd
BLAST
Repeati236 – 29257FG-GAP 4PROSITE-ProRule annotationAdd
BLAST
Repeati293 – 35462FG-GAP 5PROSITE-ProRule annotationAdd
BLAST
Repeati356 – 41156FG-GAP 6PROSITE-ProRule annotationAdd
BLAST
Repeati415 – 47763FG-GAP 7PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1015 – 10217Interaction with HPS5

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1017 – 10215GFFKR motif

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPB6. Eukaryota.
ENOG410ZZD8. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000015786.
HOVERGENiHBG108011.
InParanoidiP26006.
KOiK06482.
OMAiYIGYTMQ.
OrthoDBiEOG091G012D.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26006-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPGPSRAPR APRLMLCALA LMVAAGGCVV SAFNLDTRFL VVKEAGNPGS
60 70 80 90 100
LFGYSVALHR QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK
110 120 130 140 150
DDCERMNITV KNDPGHHIIE DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS
160 170 180 190 200
GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY HNEMCNSNTD YLETGMCQLG
210 220 230 240 250
TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK DPEDQGNLYI
260 270 280 290 300
GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG
310 320 330 340 350
SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG
360 370 380 390 400
TSFPAHPSLL LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY
410 420 430 440 450
IYHSSSKGLL RQPQQVIHGE KLGLPGLATF GYSLSGQMDV DENFYPDLLV
460 470 480 490 500
GSLSDHIVLL RARPVINIVH KTLVPRPAVL DPALCTATSC VQVELCFAYN
510 520 530 540 550
QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH GFFSMPEMRC
560 570 580 590 600
QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA
610 620 630 640 650
QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK
660 670 680 690 700
LLLSINVTNT RTSERSGEDA HEALLTLVVP PALLLSSVRP PGACQANETI
710 720 730 740 750
FCELGNPFKR NQRMELLIAF EVIGVTLHTR DLQVQLQLST SSHQDNLWPM
760 770 780 790 800
ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM GESGMKTVED VGSPLKYEFQ
810 820 830 840 850
VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG NGSWPCRPPG
860 870 880 890 900
DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET
910 920 930 940 950
VLTCATGRAH CVWLECPIPD APVVTNVTVK ARVWNSTFIE DYRDFDRVRV
960 970 980 990 1000
NGWATLFLRT SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG
1010 1020 1030 1040 1050
AGLLLLGLII LLLWKCGFFK RARTRALYEA KRQKAEMKSQ PSETERLTDD

Y
Length:1,051
Mass (Da):116,612
Last modified:September 21, 2011 - v5
Checksum:iEEAFA7778EF17B21
GO
Isoform 2 (identifier: P26006-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-3B

The sequence of this isoform differs from the canonical sequence as follows:
     1017-1051: GFFKRARTRALYEAKRQKAEMKSQPSETERLTDDY → DFFKRTRYYQ...TSWQTRDQYY

Show »
Length:1,066
Mass (Da):118,756
Checksum:i18F243887966B8CE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti268 – 2681I → F.
Corresponds to variant rs2230390 [ dbSNP | Ensembl ].
VAR_055967
Natural varianti628 – 6281R → P in ILNEB. 1 Publication
Corresponds to variant rs140781106 [ dbSNP | Ensembl ].
VAR_068808
Natural varianti719 – 7191A → T.
Corresponds to variant rs2230392 [ dbSNP | Ensembl ].
VAR_055968
Natural varianti840 – 8401G → S.
Corresponds to variant rs2301626 [ dbSNP | Ensembl ].
VAR_055969

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1017 – 105135GFFKR…LTDDY → DFFKRTRYYQIMPKYHAVRI REEERYPPPGSTLPTKKHWV TSWQTRDQYY in isoform 2. 1 PublicationVSP_002721Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59911 mRNA. Translation: AAA36120.1.
AK289961 mRNA. Translation: BAF82650.1.
AC002401 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94645.1.
CH471109 Genomic DNA. Translation: EAW94646.1.
CH471109 Genomic DNA. Translation: EAW94647.1.
CH471109 Genomic DNA. Translation: EAW94648.1.
BC136636 mRNA. Translation: AAI36637.1.
BC144328 mRNA. Translation: AAI44329.1.
BC150190 mRNA. Translation: AAI50191.1.
D01038 mRNA. Translation: BAA00845.1.
CCDSiCCDS11558.1. [P26006-2]
PIRiA40021.
RefSeqiNP_002195.1. NM_002204.3. [P26006-2]
UniGeneiHs.265829.
Hs.660689.

Genome annotation databases

EnsembliENST00000007722; ENSP00000007722; ENSG00000005884. [P26006-1]
ENST00000320031; ENSP00000315190; ENSG00000005884. [P26006-2]
GeneIDi3675.
KEGGihsa:3675.
UCSCiuc010dbl.4. human. [P26006-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59911 mRNA. Translation: AAA36120.1.
AK289961 mRNA. Translation: BAF82650.1.
AC002401 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94645.1.
CH471109 Genomic DNA. Translation: EAW94646.1.
CH471109 Genomic DNA. Translation: EAW94647.1.
CH471109 Genomic DNA. Translation: EAW94648.1.
BC136636 mRNA. Translation: AAI36637.1.
BC144328 mRNA. Translation: AAI44329.1.
BC150190 mRNA. Translation: AAI50191.1.
D01038 mRNA. Translation: BAA00845.1.
CCDSiCCDS11558.1. [P26006-2]
PIRiA40021.
RefSeqiNP_002195.1. NM_002204.3. [P26006-2]
UniGeneiHs.265829.
Hs.660689.

3D structure databases

ProteinModelPortaliP26006.
SMRiP26006. Positions 33-862.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109882. 16 interactions.
DIPiDIP-140N.
IntActiP26006. 5 interactions.
MINTiMINT-140288.
STRINGi9606.ENSP00000007722.

Chemistry

BindingDBiP26006.
ChEMBLiCHEMBL3525.
GuidetoPHARMACOLOGYi2442.

PTM databases

iPTMnetiP26006.
PhosphoSiteiP26006.
SwissPalmiP26006.
UniCarbKBiP26006.

Polymorphism and mutation databases

BioMutaiITGA3.
DMDMi347595830.

Proteomic databases

EPDiP26006.
MaxQBiP26006.
PaxDbiP26006.
PeptideAtlasiP26006.
PRIDEiP26006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000007722; ENSP00000007722; ENSG00000005884. [P26006-1]
ENST00000320031; ENSP00000315190; ENSG00000005884. [P26006-2]
GeneIDi3675.
KEGGihsa:3675.
UCSCiuc010dbl.4. human. [P26006-2]

Organism-specific databases

CTDi3675.
GeneCardsiITGA3.
HGNCiHGNC:6139. ITGA3.
HPAiCAB018594.
HPA008572.
MalaCardsiITGA3.
MIMi605025. gene.
614748. phenotype.
neXtProtiNX_P26006.
Orphaneti306504. Congenital nephrotic syndrome-interstitial lung disease-epidermolysis bullosa syndrome.
PharmGKBiPA29939.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPB6. Eukaryota.
ENOG410ZZD8. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000015786.
HOVERGENiHBG108011.
InParanoidiP26006.
KOiK06482.
OMAiYIGYTMQ.
OrthoDBiEOG091G012D.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-HSA-210991. Basigin interactions.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-3000157. Laminin interactions.

Miscellaneous databases

ChiTaRSiITGA3. human.
GeneWikiiCD49c.
GenomeRNAii3675.
PMAP-CutDBP26006.
PROiP26006.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000005884.
CleanExiHS_ITGA3.
ExpressionAtlasiP26006. baseline and differential.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA3_HUMAN
AccessioniPrimary (citable) accession number: P26006
Secondary accession number(s): A7E246
, B7ZM80, B9EGQ1, D3DTX4, D3DTX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: September 21, 2011
Last modified: September 7, 2016
This is version 179 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.