P26003 (NSS_TSWVL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-structural protein NS-S

Gene names

Name:

NSS

Organism

Tomato spotted wilt virus (strain Bulgarian L3) (TSWV)

Taxonomic identifier

36415 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Bunyaviridae › Tospovirus › Tomato spotted wilt virus

Virus host

Frankliniella occidentalis (Western flower thrips) [TaxID: 133901]
Scirtothrips dorsalis [TaxID: 163899]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Thrips tabaci [TaxID: 161014]

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms filamentous inclusion bodies. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs By similarity.
Sequence similarities	Belongs to the tospovirus NS-S protein family.

Ontologies

Keywords
Molecular function	Suppressor of RNA silencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Non-structural protein NS-S		PRO_0000221985

Sequences

	Sequence		Length	Mass (Da)
	P26003 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: 38E5CA4E802DB6DC	FASTA	467	52,414
	10 20 30 40 50 60 MSSSVYESII QTRASVWGST ASGKAVVDSY WIHELGTGSL LVQTQLYSDS RSKSSFGYTA 70 80 90 100 110 120 KVGNLPCEEE EILSQHVYIP IFDDIDFSIN IDDSVLALSV CSNTVNTNGV KHQGHLKVLS 130 140 150 160 170 180 PDQLHSIGST MNRSDIKDRF QLQEKDIIPN DRYIEAANKG SLSCVKEHTY KIETCYNQAL 190 200 210 220 230 240 GKVNVLSPNR NVHEWLYSFK PSFNQVESNN RTVNSLAVKS LLMSAENNIM PNSQAFVKAS 250 260 270 280 290 300 TDSHFKLSLW LRVPKVLKQV SIQKLFKVAG DETNKTFYLS IVCIPNHNSV ETALNISVIC 310 320 330 340 350 360 KHQLPIRKCK APFELSMMFS DLKEPYNIVH DPSYPQRIVH ALLETHTSFA QVLCNNLQED 370 380 390 400 410 420 VIIYTLNNYE LTPGKLDLGE RTLNYSEDIC KRKYFLSKTL ECLPSNTQTM SYLDSIQIPS 430 440 450 460 WKIDFARGEI KISPQPVSVA KSLLKLDLSG IKKKGSKISE THASGSK

References

[1]	"Cloning and sequencing of the S RNA from a Bulgarian isolate of tomato spotted wilt virus." Maiss E., Ivanova L., Breyel E., Adam G. J. Gen. Virol. 72:461-464(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13926 Genomic RNA. Translation: BAA03024.1.
PIR	MNVUW1. JQ0954.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004915. NS-S_bunyaviral. [Graphical view]
Pfam	PF03231. Bunya_NS-S_2. 1 hit. [Graphical view]
PIRSF	PIRSF003958. NS-S_TospoV. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NSS_TSWVL

Accession

Primary (citable) accession number: P26003

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	April 3, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program