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P26002

- NSS_TSWV1

UniProt

P26002 - NSS_TSWV1

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Protein

Non-structural protein NS-S

Gene

NSS

Organism
Tomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Forms filamentous inclusion bodies. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.1 Publication

Keywords - Molecular functioni

Suppressor of RNA silencing

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein NS-S
Gene namesi
Name:NSS
OrganismiTomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Taxonomic identifieri36413 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeTospovirus
Virus hostiFrankliniella occidentalis (Western flower thrips) [TaxID: 133901]
Scirtothrips dorsalis [TaxID: 163899]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Thrips tabaci [TaxID: 161014]
ProteomesiUP000006674: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Non-structural protein NS-SPRO_0000221984Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the tospovirus NS-S protein family.Curated

Family and domain databases

InterProiIPR004915. NS-S_bunyaviral.
[Graphical view]
PfamiPF03231. Bunya_NS-S_2. 1 hit.
[Graphical view]
PIRSFiPIRSF003958. NS-S_TospoV. 1 hit.

Sequencei

Sequence statusi: Complete.

P26002-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSSSVYESII QTRASVWGST ASGKAVVDSY WIHELGTGSQ LVQTQLYSDS
60 70 80 90 100
RSKVVLWLYC KVGIFPVKKK RFLSQHVYIP IFDDIDFSIN IDNSVLALSV
110 120 130 140 150
CSNTVNANGV KHQGHLKVLS PAQLHSIESI MNRSDITDRF QLQEKDIIPN
160 170 180 190 200
DKYIEAANKG SLSCVKEHTY KIEMCYNQAL GKVNVLSPNR NVHEWLYSFK
210 220 230 240 250
PNFNQVESNN RTVNSLAVKS LLMSAENNIM PNSQASTDSH FKLSLWLRVP
260 270 280 290 300
KVLKQVSIQK LFKVAGDETN KTFYLSIACI PNHNSVETAL NITVICKHQL
310 320 330 340 350
PIRKCKAPFE LSMMFSDLKE PYNIVHDPSY PKGSVPMLWL ETHTSLHKFF
360 370 380 390 400
ATNLQEDVII YTLNNLELTP GKLDLGERTL NYSEDAYKRK YFLSKTLECL
410 420 430 440 450
PSNTQTMSYL DSIQIPSWKI DFARGEIKIS PQSISVAKSL LKLDLSGIKK
460
KESKVKEAYA SGSK
Length:464
Mass (Da):52,448
Last modified:May 1, 1992 - v1
Checksum:iAE5519179F9EF377
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00645 Genomic RNA. Translation: BAA00540.1.
PIRiJQ0547. MNVUWC.
RefSeqiNP_049360.1. NC_002051.1.

Genome annotation databases

GeneIDi956580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00645 Genomic RNA. Translation: BAA00540.1 .
PIRi JQ0547. MNVUWC.
RefSeqi NP_049360.1. NC_002051.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956580.

Family and domain databases

InterProi IPR004915. NS-S_bunyaviral.
[Graphical view ]
Pfami PF03231. Bunya_NS-S_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF003958. NS-S_TospoV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The S RNA segment of tomato spotted wilt virus has an ambisense character."
    de Haan P., Wagemakers L., Peters D., Goldbach R.
    J. Gen. Virol. 71:1001-1007(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Negative-strand tospoviruses and tenuiviruses carry a gene for a suppressor of gene silencing at analogous genomic positions."
    Bucher E., Sijen T., De Haan P., Goldbach R., Prins M.
    J. Virol. 77:1329-1336(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNSS_TSWV1
AccessioniPrimary (citable) accession number: P26002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3