P26002 (NSS_TSWV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-structural protein NS-S

Gene names

Name:

NSS

Organism

Tomato spotted wilt virus (strain Brazilian Br-01) (TSWV) [Reference proteome]

Taxonomic identifier

36413 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Bunyaviridae › Tospovirus › Tomato spotted wilt virus

Virus host

Frankliniella occidentalis (Western flower thrips) [TaxID: 133901]
Scirtothrips dorsalis [TaxID: 163899]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Thrips tabaci [TaxID: 161014]

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms filamentous inclusion bodies. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Ref.2
Sequence similarities	Belongs to the tospovirus NS-S protein family.

Ontologies

Keywords
Molecular function	Suppressor of RNA silencing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Non-structural protein NS-S		PRO_0000221984

Sequences

	Sequence		Length	Mass (Da)
	P26002 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: AE5519179F9EF377	FASTA	464	52,448
	10 20 30 40 50 60 MSSSVYESII QTRASVWGST ASGKAVVDSY WIHELGTGSQ LVQTQLYSDS RSKVVLWLYC 70 80 90 100 110 120 KVGIFPVKKK RFLSQHVYIP IFDDIDFSIN IDNSVLALSV CSNTVNANGV KHQGHLKVLS 130 140 150 160 170 180 PAQLHSIESI MNRSDITDRF QLQEKDIIPN DKYIEAANKG SLSCVKEHTY KIEMCYNQAL 190 200 210 220 230 240 GKVNVLSPNR NVHEWLYSFK PNFNQVESNN RTVNSLAVKS LLMSAENNIM PNSQASTDSH 250 260 270 280 290 300 FKLSLWLRVP KVLKQVSIQK LFKVAGDETN KTFYLSIACI PNHNSVETAL NITVICKHQL 310 320 330 340 350 360 PIRKCKAPFE LSMMFSDLKE PYNIVHDPSY PKGSVPMLWL ETHTSLHKFF ATNLQEDVII 370 380 390 400 410 420 YTLNNLELTP GKLDLGERTL NYSEDAYKRK YFLSKTLECL PSNTQTMSYL DSIQIPSWKI 430 440 450 460 DFARGEIKIS PQSISVAKSL LKLDLSGIKK KESKVKEAYA SGSK

References

[1]	"The S RNA segment of tomato spotted wilt virus has an ambisense character." de Haan P., Wagemakers L., Peters D., Goldbach R. J. Gen. Virol. 71:1001-1007(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Negative-strand tospoviruses and tenuiviruses carry a gene for a suppressor of gene silencing at analogous genomic positions." Bucher E., Sijen T., De Haan P., Goldbach R., Prins M. J. Virol. 77:1329-1336(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D00645 Genomic RNA. Translation: BAA00540.1.
PIR	MNVUWC. JQ0547.
RefSeq	NP_049360.1. NC_002051.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	956580.
Family and domain databases
InterPro	IPR004915. NS-S_bunyaviral. [Graphical view]
Pfam	PF03231. Bunya_NS-S_2. 1 hit. [Graphical view]
PIRSF	PIRSF003958. NS-S_TospoV. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NSS_TSWV1

Accession

Primary (citable) accession number: P26002

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program