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P25987

- KITH_MEHV1

UniProt

P25987 - KITH_MEHV1

Protein

Thymidine kinase

Gene

TK

Organism
Meleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451Proton acceptorSequence Analysis
    Binding sitei86 – 861SubstrateBy similarity
    Binding sitei131 – 1311SubstrateBy similarity
    Binding sitei176 – 1761ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 248ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    OrganismiMeleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus)
    Taxonomic identifieri37108 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]
    Meleagris gallopavo (Common turkey) [TaxID: 9103]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Thymidine kinasePRO_0000175080Add
    BLAST

    Proteomic databases

    PRIDEiP25987.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP25987.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P25987-1 [UniParc]FASTAAdd to Basket

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    MALPRRPPTL TRVYLDGPFG IGKTSILNAM PDHTPDGAPI LKVYEPMKYW    50
    RCQSTDLVVA ANETPERRRG GALSRFQSDM IMASIQARFA DPYLLFHERL 100
    SSKCRGKIEI CDTPAIILML DRHPVAAILC FPITRYLLGE YSLEMLISSI 150
    IRLPLESPGC NLTVTILPDE KEHVNRICSR DRPGETADRN MLRTLNAVYA 200
    SLVDTVKYAN LTCPYEKESW EMEWLGLPWF EESLLEEFIS RPRPVICSRT 250
    RMPLDRTLLA IFKRKELCSE NGELLTQYSW ILWGLLTKLH TINVELFDIS 300
    GMSRRECASA IMHTMPERLS TLASWNDLCE LEDDVISYNK GMCNEVGASR 350
    Length:350
    Mass (Da):39,968
    Last modified:May 1, 1992 - v1
    Checksum:iAD3B8F96E431EB83
    GO

    Sequence databases

    RefSeqiNP_073316.1. NC_002641.1.

    Genome annotation databases

    GeneIDi918500.

    Cross-referencesi

    Sequence databases

    RefSeqi NP_073316.1. NC_002641.1.

    3D structure databases

    ProteinModelPortali P25987.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P25987.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 918500.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide and predicted amino acid sequences of the Marek's disease virus and turkey herpesvirus thymidine kinase genes; comparison with thymidine kinase genes of other herpesviruses."
      Scott S.D., Ross N.L.J., Binns M.M.
      J. Gen. Virol. 70:3055-3065(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiKITH_MEHV1
    AccessioniPrimary (citable) accession number: P25987
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3