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P25987 (KITH_MEHV1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismMeleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus)
Taxonomic identifier37108 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]
Meleagris gallopavo (Common turkey) [TaxID: 9103]

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Thymidine kinase
PRO_0000175080

Regions

Nucleotide binding17 – 248ATP By similarity

Sites

Active site451Proton acceptor Potential
Binding site861Substrate By similarity
Binding site1311Substrate By similarity
Binding site1761ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P25987 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: AD3B8F96E431EB83

FASTA35039,968
        10         20         30         40         50         60 
MALPRRPPTL TRVYLDGPFG IGKTSILNAM PDHTPDGAPI LKVYEPMKYW RCQSTDLVVA 

        70         80         90        100        110        120 
ANETPERRRG GALSRFQSDM IMASIQARFA DPYLLFHERL SSKCRGKIEI CDTPAIILML 

       130        140        150        160        170        180 
DRHPVAAILC FPITRYLLGE YSLEMLISSI IRLPLESPGC NLTVTILPDE KEHVNRICSR 

       190        200        210        220        230        240 
DRPGETADRN MLRTLNAVYA SLVDTVKYAN LTCPYEKESW EMEWLGLPWF EESLLEEFIS 

       250        260        270        280        290        300 
RPRPVICSRT RMPLDRTLLA IFKRKELCSE NGELLTQYSW ILWGLLTKLH TINVELFDIS 

       310        320        330        340        350 
GMSRRECASA IMHTMPERLS TLASWNDLCE LEDDVISYNK GMCNEVGASR 

« Hide

References

[1]"Nucleotide and predicted amino acid sequences of the Marek's disease virus and turkey herpesvirus thymidine kinase genes; comparison with thymidine kinase genes of other herpesviruses."
Scott S.D., Ross N.L.J., Binns M.M.
J. Gen. Virol. 70:3055-3065(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

RefSeqNP_073316.1. NC_002641.1.

3D structure databases

ProteinModelPortalP25987.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP25987.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID918500.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_MEHV1
AccessionPrimary (citable) accession number: P25987
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families