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P25987

- KITH_MEHV1

UniProt

P25987 - KITH_MEHV1

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Protein
Thymidine kinase
Gene
TK
Organism
Meleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptor Reviewed prediction
Binding sitei86 – 861Substrate By similarity
Binding sitei131 – 1311Substrate By similarity
Binding sitei176 – 1761ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 248ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiMeleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus)
Taxonomic identifieri37108 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Meleagris gallopavo (Common turkey) [TaxID: 9103]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Thymidine kinase
PRO_0000175080Add
BLAST

Proteomic databases

PRIDEiP25987.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP25987.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P25987-1 [UniParc]FASTAAdd to Basket

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MALPRRPPTL TRVYLDGPFG IGKTSILNAM PDHTPDGAPI LKVYEPMKYW    50
RCQSTDLVVA ANETPERRRG GALSRFQSDM IMASIQARFA DPYLLFHERL 100
SSKCRGKIEI CDTPAIILML DRHPVAAILC FPITRYLLGE YSLEMLISSI 150
IRLPLESPGC NLTVTILPDE KEHVNRICSR DRPGETADRN MLRTLNAVYA 200
SLVDTVKYAN LTCPYEKESW EMEWLGLPWF EESLLEEFIS RPRPVICSRT 250
RMPLDRTLLA IFKRKELCSE NGELLTQYSW ILWGLLTKLH TINVELFDIS 300
GMSRRECASA IMHTMPERLS TLASWNDLCE LEDDVISYNK GMCNEVGASR 350
Length:350
Mass (Da):39,968
Last modified:May 1, 1992 - v1
Checksum:iAD3B8F96E431EB83
GO

Sequence databases

RefSeqiNP_073316.1. NC_002641.1.

Genome annotation databases

GeneIDi918500.

Cross-referencesi

Sequence databases

RefSeqi NP_073316.1. NC_002641.1.

3D structure databases

ProteinModelPortali P25987.
ModBasei Search...

Proteomic databases

PRIDEi P25987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 918500.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide and predicted amino acid sequences of the Marek's disease virus and turkey herpesvirus thymidine kinase genes; comparison with thymidine kinase genes of other herpesviruses."
    Scott S.D., Ross N.L.J., Binns M.M.
    J. Gen. Virol. 70:3055-3065(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiKITH_MEHV1
AccessioniPrimary (citable) accession number: P25987
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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