P25987 (KITH_MEHV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:

TK

Organism

Meleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus)

Taxonomic identifier

37108 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Mardivirus

Virus host

Gallus gallus (Chicken) [TaxID: 9031]
Meleagris gallopavo (Common turkey) [TaxID: 9103]

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.
Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the herpesviruses thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW TMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Thymidine kinase		PRO_0000175080
Regions
	Nucleotide binding	17 – 24	8	ATP By similarity
Sites
	Active site	45	1	Proton acceptor Potential
	Binding site	86	1	Substrate By similarity
	Binding site	131	1	Substrate By similarity
	Binding site	176	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P25987 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: AD3B8F96E431EB83	FASTA	350	39,968
	10 20 30 40 50 60 MALPRRPPTL TRVYLDGPFG IGKTSILNAM PDHTPDGAPI LKVYEPMKYW RCQSTDLVVA 70 80 90 100 110 120 ANETPERRRG GALSRFQSDM IMASIQARFA DPYLLFHERL SSKCRGKIEI CDTPAIILML 130 140 150 160 170 180 DRHPVAAILC FPITRYLLGE YSLEMLISSI IRLPLESPGC NLTVTILPDE KEHVNRICSR 190 200 210 220 230 240 DRPGETADRN MLRTLNAVYA SLVDTVKYAN LTCPYEKESW EMEWLGLPWF EESLLEEFIS 250 260 270 280 290 300 RPRPVICSRT RMPLDRTLLA IFKRKELCSE NGELLTQYSW ILWGLLTKLH TINVELFDIS 310 320 330 340 350 GMSRRECASA IMHTMPERLS TLASWNDLCE LEDDVISYNK GMCNEVGASR

References

[1]

"Nucleotide and predicted amino acid sequences of the Marek's disease virus and turkey herpesvirus thymidine kinase genes; comparison with thymidine kinase genes of other herpesviruses." Scott S.D., Ross N.L.J., Binns M.M. J. Gen. Virol. 70:3055-3065(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
RefSeq	NP_073316.1. NC_002641.1.
3D structure databases
ProteinModelPortal	P25987.
ModBase	Search...
Proteomic databases
PRIDE	P25987.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	918500.
Phylogenomic databases
ProtClustDB	PHA3135.
Family and domain databases
InterPro	IPR001889. Herpes_TK. [Graphical view]
Pfam	PF00693. Herpes_TK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_MEHV1

Accession

Primary (citable) accession number: P25987

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program