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Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

Pth1r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.1 Publication

GO - Molecular functioni

  • parathyroid hormone receptor activity Source: BHF-UCL
  • peptide hormone binding Source: BHF-UCL
  • protein homodimerization activity Source: UniProtKB
  • protein self-association Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-373080 Class B/2 (Secretin family receptors)
R-RNO-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Alternative name(s):
PTH/PTHrP type I receptor
Short name:
PTH/PTHr receptor
Parathyroid hormone 1 receptor
Short name:
PTH1 receptor
Gene namesi
Name:Pth1r
Synonyms:Pthr, Pthr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3442 Pth1r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 188ExtracellularSequence analysisAdd BLAST162
Transmembranei189 – 212Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini213 – 219CytoplasmicSequence analysis7
Transmembranei220 – 239Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini240 – 282ExtracellularSequence analysisAdd BLAST43
Transmembranei283 – 306Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini307 – 320CytoplasmicSequence analysisAdd BLAST14
Transmembranei321 – 342Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini343 – 361ExtracellularSequence analysisAdd BLAST19
Transmembranei362 – 382Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini383 – 409CytoplasmicSequence analysisAdd BLAST27
Transmembranei410 – 428Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini429 – 440ExtracellularSequence analysisAdd BLAST12
Transmembranei441 – 463Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini464 – 591CytoplasmicSequence analysisAdd BLAST128

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6038
GuidetoPHARMACOLOGYi331

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001284827 – 591Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 117By similarity
Disulfide bondi108 ↔ 148By similarity
Disulfide bondi131 ↔ 170By similarity
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25961
PRIDEiP25961

PTM databases

iPTMnetiP25961
PhosphoSitePlusiP25961

Expressioni

Gene expression databases

BgeeiENSRNOG00000020948
GenevisibleiP25961 RN

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:1313566). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248587, 1 interactor
CORUMiP25961
DIPiDIP-46025N
STRINGi10116.ENSRNOP00000028435

Chemistry databases

BindingDBiP25961

Structurei

3D structure databases

ProteinModelPortaliP25961
SMRiP25961
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi474 – 477Important for interaction with G proteinsBy similarity4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008248
HOVERGENiHBG008318
InParanoidiP25961
KOiK04585
OMAiYAGCRVA
OrthoDBiEOG091G0NF8
PhylomeDBiP25961
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR002170 GPCR_2_parathyroid_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF24 PTHR12011:SF24, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR00393 PTRHORMONER
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAARIAPSL ALLLCCPVLS SAYALVDADD VFTKEEQIFL LHRAQAQCDK
60 70 80 90 100
LLKEVLHTAA NIMESDKGWT PASTSGKPRK EKASGKFYPE SKENKDVPTG
110 120 130 140 150
SRRRGRPCLP EWDNIVCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWEVVPGH NRTWANYSEC LKFMTNETRE REVFDRLGMI YTVGYSMSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHMFLSF MLRAASIFVK DAVLYSGFTL
260 270 280 290 300
DEAERLTEEE LHIIAQVPPP PAAAAVGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTIFGWG LPAVFVAVWV GVRATLANTG
360 370 380 390 400
CWDLSSGHKK WIIQVPILAS VVLNFILFIN IIRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLRST LVLVPLFGVH YTVFMALPYT EVSGTLWQIQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI RKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RAGLSLPLSP RLPPATTNGH SQLPGHAKPG APATETETLP
560 570 580 590
VTMAVPKDDG FLNGSCSGLD EEASGSARPP PLLQEEWETV M
Length:591
Mass (Da):66,261
Last modified:May 1, 1992 - v1
Checksum:i21944F3051B9E9C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77184 mRNA Translation: AAA41811.1
L19475 mRNA Translation: AAA68098.1
PIRiI54195
RefSeqiNP_064458.1, NM_020073.2
XP_006244060.1, XM_006243998.3
XP_006244061.1, XM_006243999.2
UniGeneiRn.48025

Genome annotation databases

EnsembliENSRNOT00000028435; ENSRNOP00000028435; ENSRNOG00000020948
GeneIDi56813
KEGGirno:56813
UCSCiRGD:3442 rat

Similar proteinsi

Entry informationi

Entry nameiPTH1R_RAT
AccessioniPrimary (citable) accession number: P25961
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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