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P25961

- PTH1R_RAT

UniProt

P25961 - PTH1R_RAT

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Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

Pth1r

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. parathyroid hormone receptor activity Source: BHF-UCL
  2. peptide hormone binding Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: BHF-UCL
  3. aging Source: RGD
  4. bone mineralization Source: Ensembl
  5. bone resorption Source: Ensembl
  6. cell maturation Source: Ensembl
  7. chondrocyte differentiation Source: Ensembl
  8. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
  9. negative regulation of cell proliferation Source: Ensembl
  10. osteoblast development Source: Ensembl
  11. phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  12. positive regulation of cell proliferation Source: Ensembl
  13. positive regulation of cytosolic calcium ion concentration Source: RGD
  14. positive regulation of inositol phosphate biosynthetic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Alternative name(s):
PTH/PTHrP type I receptor
Short name:
PTH/PTHr receptor
Parathyroid hormone 1 receptor
Short name:
PTH1 receptor
Gene namesi
Name:Pth1r
Synonyms:Pthr, Pthr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi3442. Pth1r.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: BHF-UCL
  2. basolateral plasma membrane Source: BHF-UCL
  3. brush border membrane Source: RGD
  4. cytoplasm Source: RGD
  5. extracellular vesicular exosome Source: Ensembl
  6. integral component of plasma membrane Source: Ensembl
  7. nucleus Source: RGD
  8. plasma membrane Source: RGD
  9. receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 591565Parathyroid hormone/parathyroid hormone-related peptide receptorPRO_0000012848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 117By similarity
Disulfide bondi108 ↔ 148By similarity
Disulfide bondi131 ↔ 170By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25961.

PTM databases

PhosphoSiteiP25961.

Expressioni

Gene expression databases

ExpressionAtlasiP25961. baseline.
GenevestigatoriP25961.

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer. Interacts (via C-terminus) with the heterodimer formed by GNG2 and GNB1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi248587. 2 interactions.
DIPiDIP-46025N.
STRINGi10116.ENSRNOP00000028435.

Structurei

3D structure databases

ProteinModelPortaliP25961.
SMRiP25961. Positions 24-175.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 188162ExtracellularSequence AnalysisAdd
BLAST
Topological domaini213 – 2197CytoplasmicSequence Analysis
Topological domaini240 – 28243ExtracellularSequence AnalysisAdd
BLAST
Topological domaini307 – 32014CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini343 – 36119ExtracellularSequence AnalysisAdd
BLAST
Topological domaini383 – 40927CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini429 – 44012ExtracellularSequence AnalysisAdd
BLAST
Topological domaini464 – 591128CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei189 – 21224Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei220 – 23920Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei283 – 30624Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei321 – 34222Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei362 – 38221Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei410 – 42819Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei441 – 46323Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi474 – 4774Important for interaction with G proteinsBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293423.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiP25961.
KOiK04585.
OMAiWIIQVPI.
OrthoDBiEOG7TF78W.
PhylomeDBiP25961.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERiPTHR12011:SF24. PTHR12011:SF24. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25961-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAARIAPSL ALLLCCPVLS SAYALVDADD VFTKEEQIFL LHRAQAQCDK
60 70 80 90 100
LLKEVLHTAA NIMESDKGWT PASTSGKPRK EKASGKFYPE SKENKDVPTG
110 120 130 140 150
SRRRGRPCLP EWDNIVCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWEVVPGH NRTWANYSEC LKFMTNETRE REVFDRLGMI YTVGYSMSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHMFLSF MLRAASIFVK DAVLYSGFTL
260 270 280 290 300
DEAERLTEEE LHIIAQVPPP PAAAAVGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTIFGWG LPAVFVAVWV GVRATLANTG
360 370 380 390 400
CWDLSSGHKK WIIQVPILAS VVLNFILFIN IIRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLRST LVLVPLFGVH YTVFMALPYT EVSGTLWQIQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI RKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RAGLSLPLSP RLPPATTNGH SQLPGHAKPG APATETETLP
560 570 580 590
VTMAVPKDDG FLNGSCSGLD EEASGSARPP PLLQEEWETV M
Length:591
Mass (Da):66,261
Last modified:May 1, 1992 - v1
Checksum:i21944F3051B9E9C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M77184 mRNA. Translation: AAA41811.1.
L19475 mRNA. Translation: AAA68098.1.
PIRiI54195.
RefSeqiNP_064458.1. NM_020073.2.
XP_006244060.1. XM_006243998.2.
XP_006244061.1. XM_006243999.2.
UniGeneiRn.48025.

Genome annotation databases

EnsembliENSRNOT00000028435; ENSRNOP00000028435; ENSRNOG00000020948.
GeneIDi56813.
KEGGirno:56813.
UCSCiRGD:3442. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M77184 mRNA. Translation: AAA41811.1 .
L19475 mRNA. Translation: AAA68098.1 .
PIRi I54195.
RefSeqi NP_064458.1. NM_020073.2.
XP_006244060.1. XM_006243998.2.
XP_006244061.1. XM_006243999.2.
UniGenei Rn.48025.

3D structure databases

ProteinModelPortali P25961.
SMRi P25961. Positions 24-175.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248587. 2 interactions.
DIPi DIP-46025N.
STRINGi 10116.ENSRNOP00000028435.

Chemistry

BindingDBi P25961.
ChEMBLi CHEMBL6038.
GuidetoPHARMACOLOGYi 331.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P25961.

Proteomic databases

PaxDbi P25961.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028435 ; ENSRNOP00000028435 ; ENSRNOG00000020948 .
GeneIDi 56813.
KEGGi rno:56813.
UCSCi RGD:3442. rat.

Organism-specific databases

CTDi 5745.
RGDi 3442. Pth1r.

Phylogenomic databases

eggNOGi NOG293423.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008248.
HOVERGENi HBG008318.
InParanoidi P25961.
KOi K04585.
OMAi WIIQVPI.
OrthoDBi EOG7TF78W.
PhylomeDBi P25961.
TreeFami TF315710.

Miscellaneous databases

NextBioi 611215.
PROi P25961.

Gene expression databases

ExpressionAtlasi P25961. baseline.
Genevestigatori P25961.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
PANTHERi PTHR12011:SF24. PTHR12011:SF24. 1 hit.
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium."
    Abou-Samra A.-B., Jueppner H., Force T., Freeman M.W., Kong X.-F., Schipani E., Urena P., Richards J., Bonventre J.V., Potts J.T. Jr., Kronenberg H.M., Segre G.V.
    Proc. Natl. Acad. Sci. U.S.A. 89:2732-2736(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone.
  2. "Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes."
    Pausova Z., Bourdon J., Clayton D., Mattei M.-G., Seldin M.F., Janicic N., Riviere M., Szpirer J., Levan G., Szpirer C.
    Genomics 20:20-26(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPTH1R_RAT
AccessioniPrimary (citable) accession number: P25961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3