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P25961

- PTH1R_RAT

UniProt

P25961 - PTH1R_RAT

Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

Pth1r

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. parathyroid hormone receptor activity Source: BHF-UCL
    2. peptide hormone binding Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
    2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: BHF-UCL
    3. aging Source: RGD
    4. bone mineralization Source: Ensembl
    5. bone resorption Source: Ensembl
    6. cell maturation Source: Ensembl
    7. chondrocyte differentiation Source: Ensembl
    8. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
    9. negative regulation of cell proliferation Source: Ensembl
    10. osteoblast development Source: Ensembl
    11. phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
    12. positive regulation of cell proliferation Source: Ensembl
    13. positive regulation of cytosolic calcium ion concentration Source: RGD
    14. positive regulation of inositol phosphate biosynthetic process Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parathyroid hormone/parathyroid hormone-related peptide receptor
    Alternative name(s):
    PTH/PTHrP type I receptor
    Short name:
    PTH/PTHr receptor
    Parathyroid hormone 1 receptor
    Short name:
    PTH1 receptor
    Gene namesi
    Name:Pth1r
    Synonyms:Pthr, Pthr1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi3442. Pth1r.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: BHF-UCL
    2. basolateral plasma membrane Source: BHF-UCL
    3. brush border membrane Source: RGD
    4. cytoplasm Source: RGD
    5. integral component of plasma membrane Source: Ensembl
    6. nucleus Source: RGD
    7. plasma membrane Source: RGD
    8. receptor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 591565Parathyroid hormone/parathyroid hormone-related peptide receptorPRO_0000012848Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi48 ↔ 117By similarity
    Disulfide bondi108 ↔ 148By similarity
    Disulfide bondi131 ↔ 170By similarity
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP25961.

    PTM databases

    PhosphoSiteiP25961.

    Expressioni

    Gene expression databases

    GenevestigatoriP25961.

    Interactioni

    Subunit structurei

    Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer. Interacts (via C-terminus) with the heterodimer formed by GNG2 and GNB1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi248587. 2 interactions.
    DIPiDIP-46025N.
    STRINGi10116.ENSRNOP00000028435.

    Structurei

    3D structure databases

    ProteinModelPortaliP25961.
    SMRiP25961. Positions 24-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 188162ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 2197CytoplasmicSequence Analysis
    Topological domaini240 – 28243ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini307 – 32014CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini343 – 36119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini383 – 40927CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini429 – 44012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini464 – 591128CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei189 – 21224Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 23920Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30624Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei321 – 34222Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei410 – 42819Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei441 – 46323Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi474 – 4774Important for interaction with G proteinsBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293423.
    GeneTreeiENSGT00750000117453.
    HOGENOMiHOG000008248.
    HOVERGENiHBG008318.
    InParanoidiP25961.
    KOiK04585.
    OMAiWIIQVPI.
    OrthoDBiEOG7TF78W.
    PhylomeDBiP25961.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR002170. GPCR_2_parathyroid_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PANTHERiPTHR12011:SF24. PTHR12011:SF24. 1 hit.
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR00393. PTRHORMONER.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25961-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAARIAPSL ALLLCCPVLS SAYALVDADD VFTKEEQIFL LHRAQAQCDK    50
    LLKEVLHTAA NIMESDKGWT PASTSGKPRK EKASGKFYPE SKENKDVPTG 100
    SRRRGRPCLP EWDNIVCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR 150
    NGSWEVVPGH NRTWANYSEC LKFMTNETRE REVFDRLGMI YTVGYSMSLA 200
    SLTVAVLILA YFRRLHCTRN YIHMHMFLSF MLRAASIFVK DAVLYSGFTL 250
    DEAERLTEEE LHIIAQVPPP PAAAAVGYAG CRVAVTFFLY FLATNYYWIL 300
    VEGLYLHSLI FMAFFSEKKY LWGFTIFGWG LPAVFVAVWV GVRATLANTG 350
    CWDLSSGHKK WIIQVPILAS VVLNFILFIN IIRVLATKLR ETNAGRCDTR 400
    QQYRKLLRST LVLVPLFGVH YTVFMALPYT EVSGTLWQIQ MHYEMLFNSF 450
    QGFFVAIIYC FCNGEVQAEI RKSWSRWTLA LDFKRKARSG SSSYSYGPMV 500
    SHTSVTNVGP RAGLSLPLSP RLPPATTNGH SQLPGHAKPG APATETETLP 550
    VTMAVPKDDG FLNGSCSGLD EEASGSARPP PLLQEEWETV M 591
    Length:591
    Mass (Da):66,261
    Last modified:May 1, 1992 - v1
    Checksum:i21944F3051B9E9C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77184 mRNA. Translation: AAA41811.1.
    L19475 mRNA. Translation: AAA68098.1.
    PIRiI54195.
    RefSeqiNP_064458.1. NM_020073.2.
    XP_006244060.1. XM_006243998.1.
    XP_006244061.1. XM_006243999.1.
    UniGeneiRn.48025.

    Genome annotation databases

    EnsembliENSRNOT00000028435; ENSRNOP00000028435; ENSRNOG00000020948.
    GeneIDi56813.
    KEGGirno:56813.
    UCSCiRGD:3442. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77184 mRNA. Translation: AAA41811.1 .
    L19475 mRNA. Translation: AAA68098.1 .
    PIRi I54195.
    RefSeqi NP_064458.1. NM_020073.2.
    XP_006244060.1. XM_006243998.1.
    XP_006244061.1. XM_006243999.1.
    UniGenei Rn.48025.

    3D structure databases

    ProteinModelPortali P25961.
    SMRi P25961. Positions 24-175.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248587. 2 interactions.
    DIPi DIP-46025N.
    STRINGi 10116.ENSRNOP00000028435.

    Chemistry

    BindingDBi P25961.
    ChEMBLi CHEMBL6038.
    GuidetoPHARMACOLOGYi 331.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P25961.

    Proteomic databases

    PaxDbi P25961.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028435 ; ENSRNOP00000028435 ; ENSRNOG00000020948 .
    GeneIDi 56813.
    KEGGi rno:56813.
    UCSCi RGD:3442. rat.

    Organism-specific databases

    CTDi 5745.
    RGDi 3442. Pth1r.

    Phylogenomic databases

    eggNOGi NOG293423.
    GeneTreei ENSGT00750000117453.
    HOGENOMi HOG000008248.
    HOVERGENi HBG008318.
    InParanoidi P25961.
    KOi K04585.
    OMAi WIIQVPI.
    OrthoDBi EOG7TF78W.
    PhylomeDBi P25961.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 611215.
    PROi P25961.

    Gene expression databases

    Genevestigatori P25961.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR002170. GPCR_2_parathyroid_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    PANTHERi PTHR12011:SF24. PTHR12011:SF24. 1 hit.
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR00393. PTRHORMONER.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium."
      Abou-Samra A.-B., Jueppner H., Force T., Freeman M.W., Kong X.-F., Schipani E., Urena P., Richards J., Bonventre J.V., Potts J.T. Jr., Kronenberg H.M., Segre G.V.
      Proc. Natl. Acad. Sci. U.S.A. 89:2732-2736(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone.
    2. "Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes."
      Pausova Z., Bourdon J., Clayton D., Mattei M.-G., Seldin M.F., Janicic N., Riviere M., Szpirer J., Levan G., Szpirer C.
      Genomics 20:20-26(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPTH1R_RAT
    AccessioniPrimary (citable) accession number: P25961
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3