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P25942

- TNR5_HUMAN

UniProt

P25942 - TNR5_HUMAN

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Protein

Tumor necrosis factor receptor superfamily member 5

Gene

CD40

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

GO - Molecular functioni

  1. antigen binding Source: Ensembl
  2. enzyme binding Source: UniProtKB
  3. receptor activity Source: ProtInc
  4. signal transducer activity Source: ProtInc
  5. ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  1. B cell proliferation Source: UniProtKB
  2. cellular calcium ion homeostasis Source: BHF-UCL
  3. cellular response to lipopolysaccharide Source: Ensembl
  4. cellular response to mechanical stimulus Source: UniProtKB
  5. defense response to virus Source: Ensembl
  6. immune response-regulating cell surface receptor signaling pathway Source: Ensembl
  7. inflammatory response Source: ProtInc
  8. platelet activation Source: UniProtKB
  9. positive regulation of B cell proliferation Source: Ensembl
  10. positive regulation of Cdc42 GTPase activity Source: BHF-UCL
  11. positive regulation of endothelial cell apoptotic process Source: BHF-UCL
  12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  13. positive regulation of interleukin-12 production Source: Ensembl
  14. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  15. positive regulation of MAP kinase activity Source: BHF-UCL
  16. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  17. positive regulation of protein kinase C signaling Source: BHF-UCL
  18. positive regulation of protein phosphorylation Source: BHF-UCL
  19. positive regulation of Rac GTPase activity Source: BHF-UCL
  20. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  21. positive regulation of tyrosine phosphorylation of Stat1 protein Source: BHF-UCL
  22. protein complex assembly Source: ProtInc
  23. regulation of immune response Source: Reactome
  24. regulation of immunoglobulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 5
Alternative name(s):
B-cell surface antigen CD40
Bp50
CD40L receptor
CDw40
CD_antigen: CD40
Gene namesi
Name:CD40
Synonyms:TNFRSF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:11919. CD40.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 193173ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21522HelicalSequence AnalysisAdd
BLAST
Topological domaini216 – 27762CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. CD40 receptor complex Source: BHF-UCL
  2. cell surface Source: UniProtKB
  3. cytoplasm Source: Ensembl
  4. external side of plasma membrane Source: Ensembl
  5. extracellular space Source: Ensembl
  6. extracellular vesicular exosome Source: UniProt
  7. integral component of plasma membrane Source: ProtInc
  8. intracellular membrane-bounded organelle Source: Ensembl
  9. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831C → R in HIGM3. 1 Publication
Corresponds to variant rs28931586 [ dbSNP | Ensembl ].
VAR_013628

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi606843. phenotype.
Orphaneti101090. Hyper-IgM syndrome type 3.
PharmGKBiPA36612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20203 PublicationsAdd
BLAST
Chaini21 – 277257Tumor necrosis factor receptor superfamily member 5PRO_0000034559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 37
Disulfide bondi38 ↔ 51
Disulfide bondi41 ↔ 59
Disulfide bondi62 ↔ 77
Disulfide bondi83 ↔ 103
Disulfide bondi105 ↔ 119
Disulfide bondi111 ↔ 116
Disulfide bondi125 ↔ 143
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP25942.
PaxDbiP25942.
PRIDEiP25942.

PTM databases

PhosphoSiteiP25942.

Miscellaneous databases

PMAP-CutDBP25942.

Expressioni

Tissue specificityi

B-cells and in primary carcinomas.

Gene expression databases

BgeeiP25942.
CleanExiHS_CD40.
ExpressionAtlasiP25942. baseline and differential.
GenevestigatoriP25942.

Organism-specific databases

HPAiCAB002495.
HPA031567.
HPA031568.

Interactioni

Subunit structurei

Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF3Q131143EBI-525714,EBI-357631
TRAF6Q9Y4K32EBI-525714,EBI-359276

Protein-protein interaction databases

BioGridi107396. 42 interactions.
DIPiDIP-3014N.
IntActiP25942. 5 interactions.
MINTiMINT-1505936.
STRINGi9606.ENSP00000361359.

Structurei

Secondary structure

1
277
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 385Combined sources
Beta strandi64 – 674Combined sources
Beta strandi70 – 723Combined sources
Helixi85 – 873Combined sources
Beta strandi89 – 935Combined sources
Beta strandi102 – 1054Combined sources
Beta strandi109 – 1157Combined sources
Beta strandi119 – 1213Combined sources
Beta strandi234 – 2363Combined sources
Beta strandi258 – 2603Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CDFmodel-A24-144[»]
1CZZX-ray2.70D/E250-258[»]
1D00X-ray2.00I/J/K/L/M/N/O/P250-254[»]
1FLLX-ray3.50X/Y246-266[»]
1LB6X-ray1.80B230-236[»]
3QD6X-ray3.50R/S/T/U21-190[»]
ProteinModelPortaliP25942.
SMRiP25942. Positions 21-185.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25942.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 6036TNFR-Cys 1Add
BLAST
Repeati61 – 10343TNFR-Cys 2Add
BLAST
Repeati104 – 14441TNFR-Cys 3Add
BLAST
Repeati145 – 18743TNFR-Cys 4Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28193.
GeneTreeiENSGT00760000119204.
HOVERGENiHBG005117.
InParanoidiP25942.
KOiK03160.
OMAiEKCHPWT.
OrthoDBiEOG786H2Q.
PhylomeDBiP25942.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01922. TNFACTORR5.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform I (identifier: P25942-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRLPLQCVL WGCLLTAVHP EPPTACREKQ YLINSQCCSL CQPGQKLVSD
60 70 80 90 100
CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD
110 120 130 140 150
TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF
160 170 180 190 200
FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLRALVVIPI
210 220 230 240 250
IFGILFAILL VLVFIKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP
260 270
VQETLHGCQP VTQEDGKESR ISVQERQ
Length:277
Mass (Da):30,619
Last modified:May 1, 1992 - v1
Checksum:iBC8776EC2C4A5680
GO
Isoform II (identifier: P25942-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-203: SCETKDLVVQ...ALVVIPIIFG → RSPGSAESPG...YQKGGQEANQ
     204-277: Missing.

Show »
Length:203
Mass (Da):22,259
Checksum:i07399D5F79D59A4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121T → A in BAD96616. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261C → Q in bladder carcinoma cell line Hu549; requires 2 nucleotide substitutions. 1 Publication
VAR_039301
Natural varianti35 – 351S → G in bladder carcinoma cell line Hu549. 1 Publication
VAR_039302
Natural varianti39 – 391S → T in bladder carcinoma cell line Hu549. 1 Publication
VAR_039303
Natural varianti83 – 831C → R in HIGM3. 1 Publication
Corresponds to variant rs28931586 [ dbSNP | Ensembl ].
VAR_013628
Natural varianti124 – 1241S → L.1 Publication
Corresponds to variant rs11569321 [ dbSNP | Ensembl ].
VAR_018751
Natural varianti227 – 2271P → A.1 Publication
Corresponds to variant rs11086998 [ dbSNP | Ensembl ].
VAR_018752

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei166 – 20338SCETK…PIIFG → RSPGSAESPGGDPHHLRDPV CHPLGAGLYQKGGQEANQ in isoform II. 1 PublicationVSP_006472Add
BLAST
Alternative sequencei204 – 27774Missing in isoform II. 1 PublicationVSP_006473Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60592 mRNA. Translation: CAA43045.1.
AJ300189 mRNA. Translation: CAC29424.1.
BT019901 mRNA. Translation: AAV38704.1.
AK222896 mRNA. Translation: BAD96616.1.
AY504960 Genomic DNA. Translation: AAR84238.1.
EF064754 Genomic DNA. Translation: ABK41937.1.
AL035662 Genomic DNA. Translation: CAC17670.1.
AL035662 Genomic DNA. Translation: CAI42973.1.
CH471077 Genomic DNA. Translation: EAW75758.1.
CH471077 Genomic DNA. Translation: EAW75760.1.
CH471077 Genomic DNA. Translation: EAW75762.1.
BC012419 mRNA. Translation: AAH12419.1.
AY225405 mRNA. Translation: AAO43990.1.
CCDSiCCDS13393.1. [P25942-1]
CCDS13394.1. [P25942-2]
PIRiB60771.
S04460. A60771.
RefSeqiNP_001241.1. NM_001250.4. [P25942-1]
NP_690593.1. NM_152854.2. [P25942-2]
UniGeneiHs.472860.

Genome annotation databases

EnsembliENST00000372276; ENSP00000361350; ENSG00000101017. [P25942-2]
ENST00000372285; ENSP00000361359; ENSG00000101017. [P25942-1]
GeneIDi958.
KEGGihsa:958.
UCSCiuc002xrf.1. human. [P25942-2]
uc002xrg.1. human. [P25942-1]

Polymorphism databases

DMDMi116000.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

CD40base

CD40 mutation db

NIEHS-SNPs
Wikipedia

CD40 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60592 mRNA. Translation: CAA43045.1 .
AJ300189 mRNA. Translation: CAC29424.1 .
BT019901 mRNA. Translation: AAV38704.1 .
AK222896 mRNA. Translation: BAD96616.1 .
AY504960 Genomic DNA. Translation: AAR84238.1 .
EF064754 Genomic DNA. Translation: ABK41937.1 .
AL035662 Genomic DNA. Translation: CAC17670.1 .
AL035662 Genomic DNA. Translation: CAI42973.1 .
CH471077 Genomic DNA. Translation: EAW75758.1 .
CH471077 Genomic DNA. Translation: EAW75760.1 .
CH471077 Genomic DNA. Translation: EAW75762.1 .
BC012419 mRNA. Translation: AAH12419.1 .
AY225405 mRNA. Translation: AAO43990.1 .
CCDSi CCDS13393.1. [P25942-1 ]
CCDS13394.1. [P25942-2 ]
PIRi B60771.
S04460. A60771.
RefSeqi NP_001241.1. NM_001250.4. [P25942-1 ]
NP_690593.1. NM_152854.2. [P25942-2 ]
UniGenei Hs.472860.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CDF model - A 24-144 [» ]
1CZZ X-ray 2.70 D/E 250-258 [» ]
1D00 X-ray 2.00 I/J/K/L/M/N/O/P 250-254 [» ]
1FLL X-ray 3.50 X/Y 246-266 [» ]
1LB6 X-ray 1.80 B 230-236 [» ]
3QD6 X-ray 3.50 R/S/T/U 21-190 [» ]
ProteinModelPortali P25942.
SMRi P25942. Positions 21-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107396. 42 interactions.
DIPi DIP-3014N.
IntActi P25942. 5 interactions.
MINTi MINT-1505936.
STRINGi 9606.ENSP00000361359.

Chemistry

BindingDBi P25942.
ChEMBLi CHEMBL1250358.
GuidetoPHARMACOLOGYi 1874.

PTM databases

PhosphoSitei P25942.

Polymorphism databases

DMDMi 116000.

Proteomic databases

MaxQBi P25942.
PaxDbi P25942.
PRIDEi P25942.

Protocols and materials databases

DNASUi 958.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372276 ; ENSP00000361350 ; ENSG00000101017 . [P25942-2 ]
ENST00000372285 ; ENSP00000361359 ; ENSG00000101017 . [P25942-1 ]
GeneIDi 958.
KEGGi hsa:958.
UCSCi uc002xrf.1. human. [P25942-2 ]
uc002xrg.1. human. [P25942-1 ]

Organism-specific databases

CTDi 958.
GeneCardsi GC20P044746.
HGNCi HGNC:11919. CD40.
HPAi CAB002495.
HPA031567.
HPA031568.
MIMi 109535. gene.
606843. phenotype.
neXtProti NX_P25942.
Orphaneti 101090. Hyper-IgM syndrome type 3.
PharmGKBi PA36612.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28193.
GeneTreei ENSGT00760000119204.
HOVERGENi HBG005117.
InParanoidi P25942.
KOi K03160.
OMAi EKCHPWT.
OrthoDBi EOG786H2Q.
PhylomeDBi P25942.
TreeFami TF331157.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTracei P25942.
GeneWikii CD40_(protein).
GenomeRNAii 958.
NextBioi 3990.
PMAP-CutDB P25942.
PROi P25942.
SOURCEi Search...

Gene expression databases

Bgeei P25942.
CleanExi HS_CD40.
ExpressionAtlasi P25942. baseline and differential.
Genevestigatori P25942.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
[Graphical view ]
Pfami PF00020. TNFR_c6. 1 hit.
[Graphical view ]
PRINTSi PR01922. TNFACTORR5.
SMARTi SM00208. TNFR. 4 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas."
    Stamenkovic I., Clark E.A., Seed B.
    EMBO J. 8:1403-1410(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM I).
  2. "Regulation of CD40 function by its isoforms generated through alternative splicing."
    Tone M., Tone Y., Fairchild P.J., Wykes M., Waldmann H.
    Proc. Natl. Acad. Sci. U.S.A. 98:1751-1756(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM II).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
    Tissue: Kidney.
  5. NIEHS SNPs program
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-124 AND ALA-227.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
    Tissue: Ovary.
  10. "Transcripts of CD40 isoform in peripheral mononuclear cells."
    He X., Xu L., Zeng Y.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-223 (ISOFORM I).
    Tissue: Leukocyte.
  11. "Biochemical characteristics and partial amino acid sequence of the receptor-like human B cell and carcinoma antigen CDw40."
    Braesch-Andersen S., Paulie S., Koho H., Nika H., Aspenstroem P., Perlmann P.
    J. Immunol. 142:562-567(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-50, SUBUNIT, VARIANTS GLN-26; GLY-35 AND THR-39.
    Tissue: Lymphoma and Urinary bladder carcinoma.
  12. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-35.
  13. "Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells."
    Khandekar S.S., Silverman C., Wells-Marani J., Bacon A.M., Birrell H., Brigham-Burke M., DeMarini D.J., Jonak Z.L., Camilleri P., Fishman-Lobell J.
    Protein Expr. Purif. 23:301-310(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-30.
  14. "A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40."
    Sato T., Irie S., Reed J.C.
    FEBS Lett. 358:113-118(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF3.
  15. "Involvement of CRAF1, a relative of TRAF, in CD40 signaling."
    Cheng G., Cleary A.M., Ye Z.S., Hong D.I., Lederman S., Baltimore D.
    Science 267:1494-1498(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF3.
  16. "CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization."
    Pullen S.S., Miller H.G., Everdeen D.S., Dang T.T., Crute J.J., Kehry M.R.
    Biochemistry 37:11836-11845(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF1; TRAF2; TRAF3 AND TRAF5.
  17. "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)."
    Mizushima S., Fujita M., Ishida T., Azuma S., Kato K., Hirai M., Otsuka M., Yamamoto T., Inoue J.
    Gene 207:135-140(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF5.
  18. "Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway."
    Kashiwada M., Shirakata Y., Inoue J., Nakano H., Okazaki K., Okumura K., Yamamoto T., Nagaoka H., Takemori T.
    J. Exp. Med. 187:237-244(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF6.
  19. "Construction and analysis of a detailed three-dimensional model of the ligand binding domain of the human B cell receptor CD40."
    Bajorath J., Aruffo A.
    Proteins 27:59-70(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 24-144.
  20. "The role of polar interactions in the molecular recognition of CD40L with its receptor CD40."
    Singh J., Garber E., van Vlijmen H., Karpsusas M., Hsu Y.-M., Zheng Z., Naismith J.H., Thomas D.
    Protein Sci. 7:1124-1135(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 26-186 IN COMPLEX WITH CD40LG.
  21. Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 247-266 IN COMPLEX WITH TRAF3.
  22. "Downstream regulator TANK binds to the CD40 recognition site on TRAF3."
    Li C., Ni C.Z., Havert M.L., Cabezas E., He J., Kaiser D., Reed J.C., Satterthwait A.C., Cheng G., Ely K.R.
    Structure 10:403-411(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 178-195 IN COMPLEX WITH TRAF3.
  23. Cited for: VARIANT HIGM3 ARG-83.

Entry informationi

Entry nameiTNR5_HUMAN
AccessioniPrimary (citable) accession number: P25942
Secondary accession number(s): E1P5S9
, Q53GN5, Q5JY15, Q5U007, Q7M4Q8, Q86YK5, Q9BYU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 26, 2014
This is version 175 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

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