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P25941

- AFSR_STRCO

UniProt

P25941 - AFSR_STRCO

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Protein
Regulatory protein AfsR
Gene
afsR, afsB, SCO4426, SCD6.04c
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Global regulatory protein for secondary metabolite formation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi330 – 3378ATP Reviewed prediction
DNA bindingi796 – 81116H-T-H motif Reviewed prediction
Add
BLAST
DNA bindingi974 – 98815H-T-H motif Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. ADP binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. DNA binding Source: UniProtKB-KW
  4. phosphorelay response regulator activity Source: InterPro
  5. pigment binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. antibiotic biosynthetic process Source: UniProtKB-KW
  2. defense response Source: InterPro
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Antibiotic biosynthesis, Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding, Pigment

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein AfsR
Gene namesi
Name:afsR
Synonyms:afsB
Ordered Locus Names:SCO4426
ORF Names:SCD6.04c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 993993Regulatory protein AfsR
PRO_0000110004Add
BLAST

Post-translational modificationi

Phosphorylated by AfsK.

Keywords - PTMi

Phosphoprotein

PTM databases

PhosSiteiP010470.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4426.

Structurei

3D structure databases

ProteinModelPortaliP25941.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini280 – 579300NB-ARC
Add
BLAST
Repeati823 – 85634TPR 1
Add
BLAST
Repeati863 – 89634TPR 2
Add
BLAST
Repeati942 – 97534TPR 3
Add
BLAST

Domaini

The N-terminal and the C-terminal regions are independently capable of directing actinorhodin production.

Sequence similaritiesi

Contains 1 NB-ARC domain.
Contains 3 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG3629.
HOGENOMiHOG000253135.
OMAiMMEREEG.
OrthoDBiEOG6PP9HC.
PhylomeDBiP25941.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR005158. BTAD.
IPR000767. Disease_R.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03704. BTAD. 1 hit.
PF00931. NB-ARC. 1 hit.
PF07719. TPR_2. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
PRINTSiPR00364. DISEASERSIST.
SMARTiSM01043. BTAD. 1 hit.
SM00028. TPR. 3 hits.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25941-1 [UniParc]FASTAAdd to Basket

« Hide

MDGGPRVPEQ RRPGFPAEEE ESGALRFGVL GPVRAWRDGE TLATGSPQQR    50
ALLAALLLRE GRTATAGELI DALWGEEPPS QALAAVRTYA SRLRKVLDPG 100
VLVSESGGYA VRGLAEGALD LARAQDLASA AEKARSAGDL CHARDLLRRA 150
LDLWDGEVLA GVPGPYAQTQ RVRLGEWRLQ LLETRLDMDL DQGCHAEAVS 200
ELTALTAAHP LRERLRELLM LALYRSGRQA EALAVYADTR RLLADELGVD 250
PRPGLQELQQ RILQADPALA ELSAATAETA TATLRPAQLP ATVSDFTGRA 300
AFVRELSDVL SAASGESASG RVMAVSALAG IGGVGKTTLA VHVAHRARAA 350
FPDGQLYVDL QGAGARPAEP ETVLGSFLRA LGTADSAIPD SLEERAALYR 400
SVLDGRRVLV LLDNARDAAQ VRPLLPGTDG CAALVTARVR MVDLAGAHLV 450
DLDVMAPEEA LALFTKIVGE ERVASERQAA LDVVGACGFL PLAIRIAASR 500
LAARRTWTVS VLAAKLADER RRLDELQAGD QAVEATFELG YGQLEPAQAR 550
AFRLLGLADG PDISLAAAAA VLDLPAQDTE DLLESLVDTS LLESAAPGRY 600
RFHDLVRLYA RACAERTERD GNAPSERGAA LSRLLDFYLA TAAGVYAIER 650
PGDRLVDGLE PTEYPGLTFT EGSAALDWLY TEAAPLLACV RQSAGTARLR 700
RAVDLLWAAK DLTESGANSH QYEATARAMC DATGSAADTR AEGRARTVLS 750
DVLLVSGRIE HAEEEARLAM RLAGSAEDSA AVSWVANNRG LVCLHQRRYA 800
EGKGLFHQAI AGFRATDNRA GEASALSNLS RAQLGMGNVA EAVDIARQGL 850
AVYAELGRTM RLANGHFALG VALTRAGRHE EALGEFAEAL DLFGDHRQRL 900
WEGATNFRLA EVHLAAGRPS SAAQHAEQAL ALGCIGGDRM RGNVLALLGR 950
ALSALGQADR ARACWREALS LYEQHDAQEV GEVRALLARS VAR 993
Length:993
Mass (Da):105,716
Last modified:October 18, 2001 - v2
Checksum:i8793CF27CEA7254C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti256 – 2561Q → R in BAA14186. 1 Publication
Sequence conflicti318 – 3181A → P in BAA14186. 1 Publication
Sequence conflicti751 – 76616DVLLV…AEEEA → MCSWCPVASSMPRKRH1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90155 Genomic DNA. Translation: BAA14186.1.
AL939120 Genomic DNA. Translation: CAB88433.1.
M16011 Genomic DNA. Translation: AAA26694.1.
PIRiA25037.
JQ0488.
RefSeqiNP_628593.1. NC_003888.3.
WP_011029645.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB88433; CAB88433; CAB88433.
GeneIDi1099866.
KEGGisco:SCO4426.
PATRICi23738662. VBIStrCoe124346_4495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90155 Genomic DNA. Translation: BAA14186.1 .
AL939120 Genomic DNA. Translation: CAB88433.1 .
M16011 Genomic DNA. Translation: AAA26694.1 .
PIRi A25037.
JQ0488.
RefSeqi NP_628593.1. NC_003888.3.
WP_011029645.1. NC_003888.3.

3D structure databases

ProteinModelPortali P25941.
ModBasei Search...

Protein-protein interaction databases

STRINGi 100226.SCO4426.

PTM databases

PhosSitei P010470.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB88433 ; CAB88433 ; CAB88433 .
GeneIDi 1099866.
KEGGi sco:SCO4426.
PATRICi 23738662. VBIStrCoe124346_4495.

Phylogenomic databases

eggNOGi COG3629.
HOGENOMi HOG000253135.
OMAi MMEREEG.
OrthoDBi EOG6PP9HC.
PhylomeDBi P25941.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.25.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProi IPR005158. BTAD.
IPR000767. Disease_R.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF03704. BTAD. 1 hit.
PF00931. NB-ARC. 1 hit.
PF07719. TPR_2. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view ]
PRINTSi PR00364. DISEASERSIST.
SMARTi SM01043. BTAD. 1 hit.
SM00028. TPR. 3 hits.
SM00862. Trans_reg_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2)."
    Horinouchi S., Kito M., Nishiyama M., Furuya K., Hong S.-K., Miyake K., Beppu T.
    Gene 95:49-56(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.
  3. "Nucleotide sequence of afsB, a pleiotropic gene involved in secondary metabolism in Streptomyces coelicolor A3(2) and 'Streptomyces lividans'."
    Horinouchi S., Suzuki H., Beppu T.
    J. Bacteriol. 168:257-269(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 751-993.
    Strain: A3(2) / NRRL B-16638.

Entry informationi

Entry nameiAFSR_STRCO
AccessioniPrimary (citable) accession number: P25941
Secondary accession number(s): P08467, Q9L000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 18, 2001
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi