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Protein

Tripartite terminase subunit 1

Gene

TRM1

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.UniRule annotation1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 201C3H1-typeUniRule annotationAdd BLAST29
Nucleotide bindingi619 – 626ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processViral genome packaging, Viral release from host cell
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite terminase subunit 1UniRule annotation
Gene namesi
Name:TRM1UniRule annotation
ORF Names:BALF3
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000153037 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation1 Publication
  • Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001158891 – 685Tripartite terminase subunit 1Add BLAST685

Proteomic databases

PRIDEiP25939

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Associates with TRM2 and TRM3 to form the tripartite terminase complex. Interacts with portal protein.UniRule annotation

Protein-protein interaction databases

IntActiP25939, 16 interactors
MINTiP25939

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRM1 protein family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 201C3H1-typeUniRule annotationAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

OrthoDBiVOG09000047

Family and domain databases

HAMAPiMF_04014 HSV_TRM1, 1 hit
InterProiView protein in InterPro
IPR000501 UL28/UL56
PfamiView protein in Pfam
PF01366 PRTP, 1 hit

Sequencei

Sequence statusi: Complete.

P25939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLLAAAYS QVYALAVELS VCTRLDPRSL DVAAVVRNAG LLAELEAILL
60 70 80 90 100
PRLRRQNDRA CSALSLELVH LLENSREASA ALLAPGRKGT RVPPLRTPSV
110 120 130 140 150
AYSVEFYGGH KVDVSLCLIN DIEILMKRIN SVFYCMSHTM GLESLERALD
160 170 180 190 200
LLGRFRGVSP IPDPRLYITS VPCWRCVGEL MVLPNHGNPS TAEGTHVSCN
210 220 230 240 250
HLAVPVNPEP VSGLFENEVR QAGLGHLLEA EEKARPGGPE EGAVPGPGRP
260 270 280 290 300
EAEGATRALD TYNVFSTVPP EVAELSELLY WNSGGHAIGA TGQGEGGGHS
310 320 330 340 350
RLSALFARER RLALVRGACE EALAGARLTH LFDAVAPGAT ERLFCGGVYS
360 370 380 390 400
SSGDAVEALK ADCAAAFTAH PQYRAILQKR NELYTRLNRA MQRLGRGEEE
410 420 430 440 450
ASRESPEVPR PAGAREPGPS GALSDALKRK EQYLRQVATE GLAKLQSCLA
460 470 480 490 500
QQSETLTETL CLRVWGDVVY WELARMRNHF LYRRAFVSGP WEDRRAGEGA
510 520 530 540 550
AFENSKYIKT HLFTQTLSSE HLHALTHSLY TFITGPLAEE SGLFPPPSNV
560 570 580 590 600
ALARCCDAAG TLPHQKAFLT SLIWPGIEPS DWIETSFNSF YSVPGGSLAS
610 620 630 640 650
SQQILCRALR EAVLTVSLYN KTWGRSLILR RADAVSPGQA LPPDGLYLTY
660 670 680
DSDRPLILLY KGRGWVFKDL YALLYLHLQM RDDSA
Length:685
Mass (Da):74,764
Last modified:May 11, 2016 - v2
Checksum:i24F8371F54D16635
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24807.1
AJ507799 Genomic DNA Translation: CAD53465.1
PIRiS33056
RefSeqiYP_401715.2, NC_007605.1

Genome annotation databases

GeneIDi3783679
KEGGivg:3783679

Similar proteinsi

Entry informationi

Entry nameiTRM1_EBVB9
AccessioniPrimary (citable) accession number: P25939
Secondary accession number(s): Q777A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 11, 2016
Last modified: May 23, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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