ID   NPY1R_HUMAN             Reviewed;         384 AA.
AC   P25929; B2R6H5;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   11-NOV-2015, entry version 152.
DE   RecName: Full=Neuropeptide Y receptor type 1;
DE            Short=NPY1-R;
GN   Name=NPY1R; Synonyms=NPYR, NPYY1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=1317848;
RA   Larhammar D., Blomqvist A.G., Yee F., Jazin E.E., Yoo H.,
RA   Wahlestedt C.R.;
RT   "Cloning and functional expression of a human neuropeptide Y/peptide
RT   YY receptor of the Y1 type.";
RL   J. Biol. Chem. 267:10935-10938(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=1321422; DOI=10.1073/pnas.89.13.5794;
RA   Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A.;
RT   "Cloned human neuropeptide Y receptor couples to two different second
RT   messenger systems.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:5794-5798(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   PubMed=8095935;
RA   Herzog H., Baumgartner M., Vivero C., Selbie L.A., Auer B., Shine J.;
RT   "Genomic organization, localization, and allelic differences in the
RT   gene for the human neuropeptide Y Y1 receptor.";
RL   J. Biol. Chem. 268:6703-6707(1993).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction
RT   sequenced by the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pancreas, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank
CC       order of affinity of this receptor for pancreatic polypeptides is
CC       NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) >
CC       [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
CC   -!- INTERACTION:
CC       P10082:PYY; NbExp=2; IntAct=EBI-372227, EBI-6655667;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/NPY1RID44260ch4q32.html";
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DR   EMBL; M88461; AAA73215.1; -; mRNA.
DR   EMBL; M84755; AAA59920.1; -; mRNA.
DR   EMBL; L07614; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; L07615; AAA59947.1; -; mRNA.
DR   EMBL; AY548168; AAS55647.1; -; mRNA.
DR   EMBL; AK312578; BAG35472.1; -; mRNA.
DR   EMBL; CH471056; EAX04841.1; -; Genomic_DNA.
DR   EMBL; BC036657; AAH36657.1; -; mRNA.
DR   EMBL; BC071720; AAH71720.1; -; mRNA.
DR   CCDS; CCDS34089.1; -.
DR   PIR; A45490; A45490.
DR   RefSeq; NP_000900.1; NM_000909.5.
DR   RefSeq; XP_005263088.1; XM_005263031.2.
DR   RefSeq; XP_011530312.1; XM_011532010.1.
DR   UniGene; Hs.519057; -.
DR   UniGene; Hs.733329; -.
DR   PDB; 2F1U; Model; -; A=38-67, B=74-103, C=110-142, D=153-175, E=208-233, F=258-288, G=300-320.
DR   PDB; 2IIL; Model; -; @=1-384.
DR   PDBsum; 2F1U; -.
DR   PDBsum; 2IIL; -.
DR   ProteinModelPortal; P25929; -.
DR   SMR; P25929; 10-369.
DR   BioGrid; 110946; 3.
DR   IntAct; P25929; 5.
DR   STRING; 9606.ENSP00000354652; -.
DR   BindingDB; P25929; -.
DR   ChEMBL; CHEMBL4777; -.
DR   GuidetoPHARMACOLOGY; 305; -.
DR   PhosphoSite; P25929; -.
DR   BioMuta; NPY1R; -.
DR   DMDM; 128997; -.
DR   PaxDb; P25929; -.
DR   PRIDE; P25929; -.
DR   DNASU; 4886; -.
DR   Ensembl; ENST00000296533; ENSP00000354652; ENSG00000164128.
DR   GeneID; 4886; -.
DR   KEGG; hsa:4886; -.
DR   UCSC; uc003iqm.2; human.
DR   CTD; 4886; -.
DR   GeneCards; NPY1R; -.
DR   HGNC; HGNC:7956; NPY1R.
DR   HPA; HPA029903; -.
DR   MIM; 162641; gene.
DR   neXtProt; NX_P25929; -.
DR   PharmGKB; PA258; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   eggNOG; ENOG410XRW9; LUCA.
DR   GeneTree; ENSGT00760000118781; -.
DR   HOGENOM; HOG000050229; -.
DR   HOVERGEN; HBG105676; -.
DR   InParanoid; P25929; -.
DR   KO; K04204; -.
DR   OMA; QVENHSI; -.
DR   OrthoDB; EOG7C2R16; -.
DR   PhylomeDB; P25929; -.
DR   TreeFam; TF315303; -.
DR   Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   GeneWiki; Neuropeptide_Y_receptor_Y1; -.
DR   GenomeRNAi; 4886; -.
DR   NextBio; 18810; -.
DR   PRO; PR:P25929; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; P25929; -.
DR   CleanEx; HS_NPY1R; -.
DR   ExpressionAtlas; P25929; baseline and differential.
DR   Genevisible; P25929; HS.
DR   GO; GO:0030424; C:axon; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl.
DR   GO; GO:0004983; F:neuropeptide Y receptor activity; TAS:ProtInc.
DR   GO; GO:0001602; F:pancreatic polypeptide receptor activity; IBA:GO_Central.
DR   GO; GO:0001601; F:peptide YY receptor activity; IEA:Ensembl.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; TAS:ProtInc.
DR   GO; GO:0008015; P:blood circulation; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0046888; P:negative regulation of hormone secretion; IEA:Ensembl.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GOC.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0030432; P:peristalsis; IEA:Ensembl.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
DR   GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000351; NPY1_rcpt.
DR   InterPro; IPR000611; NPY_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01013; NRPEPTIDEY1R.
DR   PRINTS; PR01012; NRPEPTIDEYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
KW   Palmitate; Polymorphism; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    384       Neuropeptide Y receptor type 1.
FT                                /FTId=PRO_0000069920.
FT   TOPO_DOM      1     44       Extracellular. {ECO:0000255}.
FT   TRANSMEM     45     65       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     66     76       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     77     97       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     98    116       Extracellular. {ECO:0000255}.
FT   TRANSMEM    117    137       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    138    154       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    155    175       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    176    211       Extracellular. {ECO:0000255}.
FT   TRANSMEM    212    232       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    233    260       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    261    281       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    282    299       Extracellular. {ECO:0000255}.
FT   TRANSMEM    300    320       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    321    384       Cytoplasmic. {ECO:0000255}.
FT   LIPID       338    338       S-palmitoyl cysteine. {ECO:0000255}.
FT   CARBOHYD      2      2       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD     11     11       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD     17     17       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID    113    198       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   VARIANT     374    374       K -> T (in dbSNP:rs5578).
FT                                /FTId=VAR_014681.
FT   CONFLICT     96     96       F -> L (in Ref. 2; AAA59920).
FT                                {ECO:0000305}.
SQ   SEQUENCE   384 AA;  44392 MW;  582B0DDB04490316 CRC64;
     MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV IILGVSGNLA
     LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY TLMDHWVFGE AMCKLNPFVQ
     CVSITVSIFS LVLIAVERHQ LIINPRGWRP NNRHAYVGIA VIWVLAVASS LPFLIYQVMT
     DEPFQNVTLD AYKDKYVCFD QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR
     RNNMMDKMRD NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL
     LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI AMSTMHTDVS
     KTSLKQASPV AFKKINNNDD NEKI
//