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P25929

- NPY1R_HUMAN

UniProt

P25929 - NPY1R_HUMAN

Protein

Neuropeptide Y receptor type 1

Gene

NPY1R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

    GO - Molecular functioni

    1. neuropeptide Y receptor activity Source: ProtInc
    2. pancreatic polypeptide receptor activity Source: Ensembl
    3. peptide YY receptor activity Source: Ensembl
    4. protein binding Source: IntAct

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
    2. feeding behavior Source: Ensembl
    3. glucose metabolic process Source: Ensembl
    4. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    5. locomotory behavior Source: Ensembl
    6. neuropeptide signaling pathway Source: GOC
    7. outflow tract morphogenesis Source: BHF-UCL
    8. regulation of blood pressure Source: Ensembl
    9. regulation of multicellular organism growth Source: Ensembl
    10. sensory perception of pain Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropeptide Y receptor type 1
    Short name:
    NPY1-R
    Gene namesi
    Name:NPY1R
    Synonyms:NPYR, NPYY1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:7956. NPY1R.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA258.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Neuropeptide Y receptor type 1PRO_0000069920Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi113 ↔ 198PROSITE-ProRule annotation
    Lipidationi338 – 3381S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP25929.
    PRIDEiP25929.

    PTM databases

    PhosphoSiteiP25929.

    Expressioni

    Gene expression databases

    ArrayExpressiP25929.
    BgeeiP25929.
    CleanExiHS_NPY1R.
    GenevestigatoriP25929.

    Organism-specific databases

    HPAiHPA029903.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PYYP100822EBI-372227,EBI-6655667

    Protein-protein interaction databases

    BioGridi110946. 3 interactions.
    IntActiP25929. 4 interactions.
    STRINGi9606.ENSP00000354652.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2F1Umodel-A38-67[»]
    B74-103[»]
    C110-142[»]
    D153-175[»]
    E208-233[»]
    F258-288[»]
    G300-320[»]
    2IILmodel-@1-384[»]
    ProteinModelPortaliP25929.
    SMRiP25929. Positions 10-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini66 – 7611CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 21136ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini233 – 26028CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini282 – 29918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini321 – 38464CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei300 – 32021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG261951.
    HOGENOMiHOG000050229.
    HOVERGENiHBG105676.
    InParanoidiP25929.
    KOiK04204.
    OMAiQVENHSI.
    OrthoDBiEOG7C2R16.
    PhylomeDBiP25929.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000351. NPY1_rcpt.
    IPR000611. NPY_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01013. NRPEPTIDEY1R.
    PR01012. NRPEPTIDEYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25929-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV    50
    IILGVSGNLA LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY 100
    TLMDHWVFGE AMCKLNPFVQ CVSITVSIFS LVLIAVERHQ LIINPRGWRP 150
    NNRHAYVGIA VIWVLAVASS LPFLIYQVMT DEPFQNVTLD AYKDKYVCFD 200
    QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR RNNMMDKMRD 250
    NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL 300
    LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI 350
    AMSTMHTDVS KTSLKQASPV AFKKINNNDD NEKI 384
    Length:384
    Mass (Da):44,392
    Last modified:May 1, 1992 - v1
    Checksum:i582B0DDB04490316
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961F → L in AAA59920. (PubMed:1321422)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti374 – 3741K → T.
    Corresponds to variant rs5578 [ dbSNP | Ensembl ].
    VAR_014681

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88461 mRNA. Translation: AAA73215.1.
    M84755 mRNA. Translation: AAA59920.1.
    L07614 mRNA. No translation available.
    L07615 mRNA. Translation: AAA59947.1.
    AY548168 mRNA. Translation: AAS55647.1.
    AK312578 mRNA. Translation: BAG35472.1.
    CH471056 Genomic DNA. Translation: EAX04841.1.
    BC036657 mRNA. Translation: AAH36657.1.
    BC071720 mRNA. Translation: AAH71720.1.
    CCDSiCCDS34089.1.
    PIRiA45490.
    RefSeqiNP_000900.1. NM_000909.5.
    XP_005263088.1. XM_005263031.1.
    XP_005263089.1. XM_005263032.1.
    UniGeneiHs.519057.
    Hs.733329.

    Genome annotation databases

    EnsembliENST00000296533; ENSP00000354652; ENSG00000164128.
    GeneIDi4886.
    KEGGihsa:4886.
    UCSCiuc003iqm.2. human.

    Polymorphism databases

    DMDMi128997.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88461 mRNA. Translation: AAA73215.1 .
    M84755 mRNA. Translation: AAA59920.1 .
    L07614 mRNA. No translation available.
    L07615 mRNA. Translation: AAA59947.1 .
    AY548168 mRNA. Translation: AAS55647.1 .
    AK312578 mRNA. Translation: BAG35472.1 .
    CH471056 Genomic DNA. Translation: EAX04841.1 .
    BC036657 mRNA. Translation: AAH36657.1 .
    BC071720 mRNA. Translation: AAH71720.1 .
    CCDSi CCDS34089.1.
    PIRi A45490.
    RefSeqi NP_000900.1. NM_000909.5.
    XP_005263088.1. XM_005263031.1.
    XP_005263089.1. XM_005263032.1.
    UniGenei Hs.519057.
    Hs.733329.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2F1U model - A 38-67 [» ]
    B 74-103 [» ]
    C 110-142 [» ]
    D 153-175 [» ]
    E 208-233 [» ]
    F 258-288 [» ]
    G 300-320 [» ]
    2IIL model - @ 1-384 [» ]
    ProteinModelPortali P25929.
    SMRi P25929. Positions 10-369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110946. 3 interactions.
    IntActi P25929. 4 interactions.
    STRINGi 9606.ENSP00000354652.

    Chemistry

    BindingDBi P25929.
    ChEMBLi CHEMBL4777.
    GuidetoPHARMACOLOGYi 305.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P25929.

    Polymorphism databases

    DMDMi 128997.

    Proteomic databases

    PaxDbi P25929.
    PRIDEi P25929.

    Protocols and materials databases

    DNASUi 4886.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296533 ; ENSP00000354652 ; ENSG00000164128 .
    GeneIDi 4886.
    KEGGi hsa:4886.
    UCSCi uc003iqm.2. human.

    Organism-specific databases

    CTDi 4886.
    GeneCardsi GC04M164245.
    HGNCi HGNC:7956. NPY1R.
    HPAi HPA029903.
    MIMi 162641. gene.
    neXtProti NX_P25929.
    PharmGKBi PA258.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261951.
    HOGENOMi HOG000050229.
    HOVERGENi HBG105676.
    InParanoidi P25929.
    KOi K04204.
    OMAi QVENHSI.
    OrthoDBi EOG7C2R16.
    PhylomeDBi P25929.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Neuropeptide_Y_receptor_Y1.
    GenomeRNAii 4886.
    NextBioi 18810.
    PROi P25929.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25929.
    Bgeei P25929.
    CleanExi HS_NPY1R.
    Genevestigatori P25929.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000351. NPY1_rcpt.
    IPR000611. NPY_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01013. NRPEPTIDEY1R.
    PR01012. NRPEPTIDEYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type."
      Larhammar D., Blomqvist A.G., Yee F., Jazin E.E., Yoo H., Wahlestedt C.R.
      J. Biol. Chem. 267:10935-10938(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Cloned human neuropeptide Y receptor couples to two different second messenger systems."
      Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A.
      Proc. Natl. Acad. Sci. U.S.A. 89:5794-5798(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor."
      Herzog H., Baumgartner M., Vivero C., Selbie L.A., Auer B., Shine J.
      J. Biol. Chem. 268:6703-6707(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Blood.
    4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas and Testis.

    Entry informationi

    Entry nameiNPY1R_HUMAN
    AccessioniPrimary (citable) accession number: P25929
    Secondary accession number(s): B2R6H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3