P25929 (NPY1R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropeptide Y receptor type 1
Short name=NPY1-R

Gene names

Name:	NPY1R
Synonyms:	NPYR, NPYY1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Traceable author statement Ref.2. Source: ProtInc feeding behavior Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara outflow tract morphogenesis Inferred from mutant phenotype PubMed 19593212. Source: BHF-UCL regulation of blood pressure Inferred from electronic annotation. Source: Compara regulation of multicellular organism growth Inferred from electronic annotation. Source: Compara sensory perception of pain Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	neuropeptide Y receptor activity Traceable author statement Ref.1. Source: ProtInc pancreatic polypeptide receptor activity Inferred from electronic annotation. Source: Compara peptide YY receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Neuropeptide Y receptor type 1		PRO_0000069920
Regions
	Topological domain	1 – 44	44	Extracellular Potential
	Transmembrane	45 – 65	21	Helical; Name=1; Potential
	Topological domain	66 – 76	11	Cytoplasmic Potential
	Transmembrane	77 – 97	21	Helical; Name=2; Potential
	Topological domain	98 – 116	19	Extracellular Potential
	Transmembrane	117 – 137	21	Helical; Name=3; Potential
	Topological domain	138 – 154	17	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Name=4; Potential
	Topological domain	176 – 211	36	Extracellular Potential
	Transmembrane	212 – 232	21	Helical; Name=5; Potential
	Topological domain	233 – 260	28	Cytoplasmic Potential
	Transmembrane	261 – 281	21	Helical; Name=6; Potential
	Topological domain	282 – 299	18	Extracellular Potential
	Transmembrane	300 – 320	21	Helical; Name=7; Potential
	Topological domain	321 – 384	64	Cytoplasmic Potential
Amino acid modifications
	Lipidation	338	1	S-palmitoyl cysteine Potential
	Glycosylation	2	1	N-linked (GlcNAc...) Potential
	Glycosylation	11	1	N-linked (GlcNAc...) Potential
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Disulfide bond	113 ↔ 198		By similarity
Natural variations
	Natural variant	374	1	K → T. Corresponds to variant rs5578 [ dbSNP | Ensembl ].		VAR_014681
Experimental info
	Sequence conflict	96	1	F → L in AAA59920. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P25929 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: 582B0DDB04490316	FASTA	384	44,392
	10 20 30 40 50 60 MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV IILGVSGNLA 70 80 90 100 110 120 LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY TLMDHWVFGE AMCKLNPFVQ 130 140 150 160 170 180 CVSITVSIFS LVLIAVERHQ LIINPRGWRP NNRHAYVGIA VIWVLAVASS LPFLIYQVMT 190 200 210 220 230 240 DEPFQNVTLD AYKDKYVCFD QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR 250 260 270 280 290 300 RNNMMDKMRD NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL 310 320 330 340 350 360 LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI AMSTMHTDVS 370 380 KTSLKQASPV AFKKINNNDD NEKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type." Larhammar D., Blomqvist A.G., Yee F., Jazin E.E., Yoo H., Wahlestedt C.R. J. Biol. Chem. 267:10935-10938(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Cloned human neuropeptide Y receptor couples to two different second messenger systems." Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A. Proc. Natl. Acad. Sci. U.S.A. 89:5794-5798(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor." Herzog H., Baumgartner M., Vivero C., Selbie L.A., Auer B., Shine J. J. Biol. Chem. 268:6703-6707(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M88461 mRNA. Translation: AAA73215.1.
M84755 mRNA. Translation: AAA59920.1.
L07614 mRNA. No translation available.
L07615 mRNA. Translation: AAA59947.1.
AY548168 mRNA. Translation: AAS55647.1.
AK312578 mRNA. Translation: BAG35472.1.
CH471056 Genomic DNA. Translation: EAX04841.1.
BC036657 mRNA. Translation: AAH36657.1.
BC071720 mRNA. Translation: AAH71720.1.

IPI

IPI00018252.

PIR

A45490.

RefSeq

NP_000900.1. NM_000909.5.

UniGene

Hs.519057.
Hs.733329.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2F1U	model	-	A	38-67	[»]
			B	74-103	[»]
			C	110-142	[»]
			D	153-175	[»]
			E	208-233	[»]
			F	258-288	[»]
			G	300-320	[»]
2IIL	model	-	@	1-384	[»]

ProteinModelPortal

P25929.

ModBase

Search...

Protein-protein interaction databases

IntAct

P25929. 2 interactions.

STRING

9606.ENSP00000354652.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

P25929.

Polymorphism databases

DMDM

128997.

Proteomic databases

PaxDb

P25929.

PRIDE

P25929.

Protocols and materials databases

DNASU

4886.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000296533; ENSP00000354652; ENSG00000164128.

GeneID

4886.

KEGG

hsa:4886.

UCSC

uc003iqm.2. human.

Organism-specific databases

CTD

4886.

GeneCards

GC04M164245.

HGNC

HGNC:7956. NPY1R.

HPA

HPA029903.

MIM

162641. gene.

neXtProt

NX_P25929.

PharmGKB

PA258.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG261951.

HOGENOM

HOG000050229.

HOVERGEN

HBG105676.

InParanoid

P25929.

KO

K04204.

OMA

DAFKDKY.

OrthoDB

EOG473PRP.

PhylomeDB

P25929.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

P25929.

Bgee

P25929.

CleanEx

HS_NPY1R.

Genevestigator

P25929.

GermOnline

ENSG00000164128. Homo sapiens.

Family and domain databases

InterPro

IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P25929.

ChEMBL

CHEMBL4777.

GenomeRNAi

4886.

NextBio

18810.

SOURCE

Search...

Entry information

Entry name

NPY1R_HUMAN

Accession

Primary (citable) accession number: P25929
Secondary accession number(s): B2R6H5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	May 1, 2013
This is version 131 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.