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P25929 (NPY1R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropeptide Y receptor type 1

Short name=NPY1-R
Gene names
Name:NPY1R
Synonyms:NPYR, NPYY1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Traceable author statement Ref.1. Source: ProtInc

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Traceable author statement Ref.2. Source: ProtInc

feeding behavior

Inferred from electronic annotation. Source: Ensembl

glucose metabolic process

Inferred from electronic annotation. Source: Ensembl

locomotory behavior

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Traceable author statement Ref.1. Source: GOC

outflow tract morphogenesis

Inferred from mutant phenotype PubMed 19593212. Source: BHF-UCL

regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

regulation of multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionneuropeptide Y receptor activity

Traceable author statement Ref.1. Source: ProtInc

pancreatic polypeptide receptor activity

Inferred from electronic annotation. Source: Ensembl

peptide YY receptor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PYYP100822EBI-372227,EBI-6655667

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Neuropeptide Y receptor type 1
PRO_0000069920

Regions

Topological domain1 – 4444Extracellular Potential
Transmembrane45 – 6521Helical; Name=1; Potential
Topological domain66 – 7611Cytoplasmic Potential
Transmembrane77 – 9721Helical; Name=2; Potential
Topological domain98 – 11619Extracellular Potential
Transmembrane117 – 13721Helical; Name=3; Potential
Topological domain138 – 15417Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=4; Potential
Topological domain176 – 21136Extracellular Potential
Transmembrane212 – 23221Helical; Name=5; Potential
Topological domain233 – 26028Cytoplasmic Potential
Transmembrane261 – 28121Helical; Name=6; Potential
Topological domain282 – 29918Extracellular Potential
Transmembrane300 – 32021Helical; Name=7; Potential
Topological domain321 – 38464Cytoplasmic Potential

Amino acid modifications

Lipidation3381S-palmitoyl cysteine Potential
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation171N-linked (GlcNAc...) Potential
Disulfide bond113 ↔ 198 By similarity

Natural variations

Natural variant3741K → T.
Corresponds to variant rs5578 [ dbSNP | Ensembl ].
VAR_014681

Experimental info

Sequence conflict961F → L in AAA59920. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P25929 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 582B0DDB04490316

FASTA38444,392
        10         20         30         40         50         60 
MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV IILGVSGNLA 

        70         80         90        100        110        120 
LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY TLMDHWVFGE AMCKLNPFVQ 

       130        140        150        160        170        180 
CVSITVSIFS LVLIAVERHQ LIINPRGWRP NNRHAYVGIA VIWVLAVASS LPFLIYQVMT 

       190        200        210        220        230        240 
DEPFQNVTLD AYKDKYVCFD QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR 

       250        260        270        280        290        300 
RNNMMDKMRD NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL 

       310        320        330        340        350        360 
LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI AMSTMHTDVS 

       370        380 
KTSLKQASPV AFKKINNNDD NEKI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type."
Larhammar D., Blomqvist A.G., Yee F., Jazin E.E., Yoo H., Wahlestedt C.R.
J. Biol. Chem. 267:10935-10938(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Cloned human neuropeptide Y receptor couples to two different second messenger systems."
Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A.
Proc. Natl. Acad. Sci. U.S.A. 89:5794-5798(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor."
Herzog H., Baumgartner M., Vivero C., Selbie L.A., Auer B., Shine J.
J. Biol. Chem. 268:6703-6707(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Blood.
[4]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas and Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M88461 mRNA. Translation: AAA73215.1.
M84755 mRNA. Translation: AAA59920.1.
L07614 mRNA. No translation available.
L07615 mRNA. Translation: AAA59947.1.
AY548168 mRNA. Translation: AAS55647.1.
AK312578 mRNA. Translation: BAG35472.1.
CH471056 Genomic DNA. Translation: EAX04841.1.
BC036657 mRNA. Translation: AAH36657.1.
BC071720 mRNA. Translation: AAH71720.1.
PIRA45490.
RefSeqNP_000900.1. NM_000909.5.
XP_005263088.1. XM_005263031.1.
XP_005263089.1. XM_005263032.1.
UniGeneHs.519057.
Hs.733329.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2F1Umodel-A38-67[»]
B74-103[»]
C110-142[»]
D153-175[»]
E208-233[»]
F258-288[»]
G300-320[»]
2IILmodel-@1-384[»]
ProteinModelPortalP25929.
SMRP25929. Positions 10-369.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110946. 3 interactions.
IntActP25929. 4 interactions.
STRING9606.ENSP00000354652.

Chemistry

BindingDBP25929.
ChEMBLCHEMBL4777.
GuidetoPHARMACOLOGY305.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP25929.

Polymorphism databases

DMDM128997.

Proteomic databases

PaxDbP25929.
PRIDEP25929.

Protocols and materials databases

DNASU4886.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296533; ENSP00000354652; ENSG00000164128.
GeneID4886.
KEGGhsa:4886.
UCSCuc003iqm.2. human.

Organism-specific databases

CTD4886.
GeneCardsGC04M164245.
HGNCHGNC:7956. NPY1R.
HPAHPA029903.
MIM162641. gene.
neXtProtNX_P25929.
PharmGKBPA258.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG261951.
HOGENOMHOG000050229.
HOVERGENHBG105676.
InParanoidP25929.
KOK04204.
OMAQVENHSI.
OrthoDBEOG7C2R16.
PhylomeDBP25929.
TreeFamTF315303.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP25929.
BgeeP25929.
CleanExHS_NPY1R.
GenevestigatorP25929.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNeuropeptide_Y_receptor_Y1.
GenomeRNAi4886.
NextBio18810.
PROP25929.
SOURCESearch...

Entry information

Entry nameNPY1R_HUMAN
AccessionPrimary (citable) accession number: P25929
Secondary accession number(s): B2R6H5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 16, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries