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Protein

Neuropeptide Y receptor type 1

Gene

NPY1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP25929.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Gene namesi
Name:NPY1R
Synonyms:NPYR, NPYY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164128.6.
HGNCiHGNC:7956. NPY1R.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularIEP:Add BLAST44
Transmembranei45 – 65Helical; Name=1IEP:Add BLAST21
Topological domaini66 – 76CytoplasmicIEP:Add BLAST11
Transmembranei77 – 97Helical; Name=2IEP:Add BLAST21
Topological domaini98 – 116ExtracellularIEP:Add BLAST19
Transmembranei117 – 137Helical; Name=3IEP:Add BLAST21
Topological domaini138 – 154CytoplasmicIEP:Add BLAST17
Transmembranei155 – 175Helical; Name=4IEP:Add BLAST21
Topological domaini176 – 211ExtracellularIEP:Add BLAST36
Transmembranei212 – 232Helical; Name=5IEP:Add BLAST21
Topological domaini233 – 260CytoplasmicIEP:Add BLAST28
Transmembranei261 – 281Helical; Name=6IEP:Add BLAST21
Topological domaini282 – 299ExtracellularIEP:Add BLAST18
Transmembranei300 – 320Helical; Name=7IEP:Add BLAST21
Topological domaini321 – 384CytoplasmicIEP:Add BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4886.
OpenTargetsiENSG00000164128.
PharmGKBiPA258.

Chemistry databases

ChEMBLiCHEMBL4777.
DrugBankiDB05004. AC162352.
GuidetoPHARMACOLOGYi305.

Polymorphism and mutation databases

BioMutaiNPY1R.
DMDMi128997.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699201 – 384Neuropeptide Y receptor type 1Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineIEP:1
Glycosylationi11N-linked (GlcNAc...) asparagineIEP:1
Glycosylationi17N-linked (GlcNAc...) asparagineIEP:1
Disulfide bondi113 ↔ 198IEP:
Lipidationi338S-palmitoyl cysteineIEP:1
Modified residuei368PhosphoserineHMP:1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP25929.
PeptideAtlasiP25929.
PRIDEiP25929.

PTM databases

iPTMnetiP25929.
PhosphoSitePlusiP25929.

Expressioni

Gene expression databases

BgeeiENSG00000164128.
CleanExiHS_NPY1R.
ExpressionAtlasiP25929. baseline and differential.
GenevisibleiP25929. HS.

Organism-specific databases

HPAiHPA029903.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PYYP100822EBI-372227,EBI-6655667

Protein-protein interaction databases

BioGridi110946. 3 interactors.
IntActiP25929. 5 interactors.
STRINGi9606.ENSP00000354652.

Chemistry databases

BindingDBiP25929.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F1Umodel-A38-67[»]
B74-103[»]
C110-142[»]
D153-175[»]
E208-233[»]
F258-288[»]
G300-320[»]
2IILmodel-@1-384[»]
ProteinModelPortaliP25929.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.IEP:

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00900000140797.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiP25929.
KOiK04204.
OMAiQVENHSI.
OrthoDBiEOG091G0A5E.
PhylomeDBiP25929.
TreeFamiTF315303.

Family and domain databases

CDDicd15395. 7tmA_NPY1R. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
PANTHERiPTHR43916:SF5. PTHR43916:SF5. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P25929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV
60 70 80 90 100
IILGVSGNLA LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY
110 120 130 140 150
TLMDHWVFGE AMCKLNPFVQ CVSITVSIFS LVLIAVERHQ LIINPRGWRP
160 170 180 190 200
NNRHAYVGIA VIWVLAVASS LPFLIYQVMT DEPFQNVTLD AYKDKYVCFD
210 220 230 240 250
QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR RNNMMDKMRD
260 270 280 290 300
NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL
310 320 330 340 350
LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI
360 370 380
AMSTMHTDVS KTSLKQASPV AFKKINNNDD NEKI
Length:384
Mass (Da):44,392
Last modified:May 1, 1992 - v1
Checksum:i582B0DDB04490316
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96F → L in AAA59920 (PubMed:1321422).IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014681374K → T. Corresponds to variant dbSNP:rs5578Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88461 mRNA. Translation: AAA73215.1.
M84755 mRNA. Translation: AAA59920.1.
L07614 mRNA. No translation available.
L07615 mRNA. Translation: AAA59947.1.
AY548168 mRNA. Translation: AAS55647.1.
AK312578 mRNA. Translation: BAG35472.1.
CH471056 Genomic DNA. Translation: EAX04841.1.
BC036657 mRNA. Translation: AAH36657.1.
BC071720 mRNA. Translation: AAH71720.1.
CCDSiCCDS34089.1.
PIRiA45490.
RefSeqiNP_000900.1. NM_000909.5.
XP_005263088.1. XM_005263031.3.
XP_011530312.1. XM_011532010.2.
UniGeneiHs.519057.
Hs.733329.

Genome annotation databases

EnsembliENST00000296533; ENSP00000354652; ENSG00000164128.
GeneIDi4886.
KEGGihsa:4886.
UCSCiuc003iqm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNPY1R_HUMAN
AccessioniPrimary (citable) accession number: P25929
Secondary accession number(s): B2R6H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 22, 2017
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families