Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuropeptide Y receptor type 1

Gene

NPY1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164128-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP25929.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Gene namesi
Name:NPY1R
Synonyms:NPYR, NPYY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:7956. NPY1R.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 76CytoplasmicSequence analysisAdd BLAST11
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini98 – 116ExtracellularSequence analysisAdd BLAST19
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 154CytoplasmicSequence analysisAdd BLAST17
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 211ExtracellularSequence analysisAdd BLAST36
Transmembranei212 – 232Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini233 – 260CytoplasmicSequence analysisAdd BLAST28
Transmembranei261 – 281Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini282 – 299ExtracellularSequence analysisAdd BLAST18
Transmembranei300 – 320Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini321 – 384CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4886.
OpenTargetsiENSG00000164128.
PharmGKBiPA258.

Chemistry databases

ChEMBLiCHEMBL4777.
GuidetoPHARMACOLOGYi305.

Polymorphism and mutation databases

BioMutaiNPY1R.
DMDMi128997.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699201 – 384Neuropeptide Y receptor type 1Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi17N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi113 ↔ 198PROSITE-ProRule annotation
Lipidationi338S-palmitoyl cysteineSequence analysis1
Modified residuei368PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP25929.
PeptideAtlasiP25929.
PRIDEiP25929.

PTM databases

iPTMnetiP25929.
PhosphoSitePlusiP25929.

Expressioni

Gene expression databases

BgeeiENSG00000164128.
CleanExiHS_NPY1R.
ExpressionAtlasiP25929. baseline and differential.
GenevisibleiP25929. HS.

Organism-specific databases

HPAiHPA029903.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PYYP100822EBI-372227,EBI-6655667

Protein-protein interaction databases

BioGridi110946. 3 interactors.
IntActiP25929. 5 interactors.
STRINGi9606.ENSP00000354652.

Chemistry databases

BindingDBiP25929.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F1Umodel-A38-67[»]
B74-103[»]
C110-142[»]
D153-175[»]
E208-233[»]
F258-288[»]
G300-320[»]
2IILmodel-@1-384[»]
ProteinModelPortaliP25929.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiP25929.
KOiK04204.
OMAiQVENHSI.
OrthoDBiEOG091G0A5E.
PhylomeDBiP25929.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV
60 70 80 90 100
IILGVSGNLA LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY
110 120 130 140 150
TLMDHWVFGE AMCKLNPFVQ CVSITVSIFS LVLIAVERHQ LIINPRGWRP
160 170 180 190 200
NNRHAYVGIA VIWVLAVASS LPFLIYQVMT DEPFQNVTLD AYKDKYVCFD
210 220 230 240 250
QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR RNNMMDKMRD
260 270 280 290 300
NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL
310 320 330 340 350
LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI
360 370 380
AMSTMHTDVS KTSLKQASPV AFKKINNNDD NEKI
Length:384
Mass (Da):44,392
Last modified:May 1, 1992 - v1
Checksum:i582B0DDB04490316
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96F → L in AAA59920 (PubMed:1321422).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014681374K → T.Corresponds to variant rs5578dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88461 mRNA. Translation: AAA73215.1.
M84755 mRNA. Translation: AAA59920.1.
L07614 mRNA. No translation available.
L07615 mRNA. Translation: AAA59947.1.
AY548168 mRNA. Translation: AAS55647.1.
AK312578 mRNA. Translation: BAG35472.1.
CH471056 Genomic DNA. Translation: EAX04841.1.
BC036657 mRNA. Translation: AAH36657.1.
BC071720 mRNA. Translation: AAH71720.1.
CCDSiCCDS34089.1.
PIRiA45490.
RefSeqiNP_000900.1. NM_000909.5.
XP_005263088.1. XM_005263031.3.
XP_011530312.1. XM_011532010.2.
UniGeneiHs.519057.
Hs.733329.

Genome annotation databases

EnsembliENST00000296533; ENSP00000354652; ENSG00000164128.
GeneIDi4886.
KEGGihsa:4886.
UCSCiuc003iqm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88461 mRNA. Translation: AAA73215.1.
M84755 mRNA. Translation: AAA59920.1.
L07614 mRNA. No translation available.
L07615 mRNA. Translation: AAA59947.1.
AY548168 mRNA. Translation: AAS55647.1.
AK312578 mRNA. Translation: BAG35472.1.
CH471056 Genomic DNA. Translation: EAX04841.1.
BC036657 mRNA. Translation: AAH36657.1.
BC071720 mRNA. Translation: AAH71720.1.
CCDSiCCDS34089.1.
PIRiA45490.
RefSeqiNP_000900.1. NM_000909.5.
XP_005263088.1. XM_005263031.3.
XP_011530312.1. XM_011532010.2.
UniGeneiHs.519057.
Hs.733329.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F1Umodel-A38-67[»]
B74-103[»]
C110-142[»]
D153-175[»]
E208-233[»]
F258-288[»]
G300-320[»]
2IILmodel-@1-384[»]
ProteinModelPortaliP25929.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110946. 3 interactors.
IntActiP25929. 5 interactors.
STRINGi9606.ENSP00000354652.

Chemistry databases

BindingDBiP25929.
ChEMBLiCHEMBL4777.
GuidetoPHARMACOLOGYi305.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25929.
PhosphoSitePlusiP25929.

Polymorphism and mutation databases

BioMutaiNPY1R.
DMDMi128997.

Proteomic databases

PaxDbiP25929.
PeptideAtlasiP25929.
PRIDEiP25929.

Protocols and materials databases

DNASUi4886.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296533; ENSP00000354652; ENSG00000164128.
GeneIDi4886.
KEGGihsa:4886.
UCSCiuc003iqm.3. human.

Organism-specific databases

CTDi4886.
DisGeNETi4886.
GeneCardsiNPY1R.
HGNCiHGNC:7956. NPY1R.
HPAiHPA029903.
MIMi162641. gene.
neXtProtiNX_P25929.
OpenTargetsiENSG00000164128.
PharmGKBiPA258.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiP25929.
KOiK04204.
OMAiQVENHSI.
OrthoDBiEOG091G0A5E.
PhylomeDBiP25929.
TreeFamiTF315303.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164128-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP25929.

Miscellaneous databases

GeneWikiiNeuropeptide_Y_receptor_Y1.
GenomeRNAii4886.
PROiP25929.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164128.
CleanExiHS_NPY1R.
ExpressionAtlasiP25929. baseline and differential.
GenevisibleiP25929. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPY1R_HUMAN
AccessioniPrimary (citable) accession number: P25929
Secondary accession number(s): B2R6H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.