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P25929

- NPY1R_HUMAN

UniProt

P25929 - NPY1R_HUMAN

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Protein

Neuropeptide Y receptor type 1

Gene

NPY1R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

GO - Molecular functioni

  1. neuropeptide Y receptor activity Source: ProtInc
  2. pancreatic polypeptide receptor activity Source: Ensembl
  3. peptide YY receptor activity Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
  2. feeding behavior Source: Ensembl
  3. glucose metabolic process Source: Ensembl
  4. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  5. locomotory behavior Source: Ensembl
  6. neuropeptide signaling pathway Source: GOC
  7. outflow tract morphogenesis Source: BHF-UCL
  8. regulation of blood pressure Source: Ensembl
  9. regulation of multicellular organism growth Source: Ensembl
  10. sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Gene namesi
Name:NPY1R
Synonyms:NPYR, NPYY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7956. NPY1R.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Neuropeptide Y receptor type 1PRO_0000069920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi113 ↔ 198PROSITE-ProRule annotation
Lipidationi338 – 3381S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25929.
PRIDEiP25929.

PTM databases

PhosphoSiteiP25929.

Expressioni

Gene expression databases

BgeeiP25929.
CleanExiHS_NPY1R.
ExpressionAtlasiP25929. baseline and differential.
GenevestigatoriP25929.

Organism-specific databases

HPAiHPA029903.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PYYP100822EBI-372227,EBI-6655667

Protein-protein interaction databases

BioGridi110946. 3 interactions.
IntActiP25929. 4 interactions.
STRINGi9606.ENSP00000354652.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2F1Umodel-A38-67[»]
B74-103[»]
C110-142[»]
D153-175[»]
E208-233[»]
F258-288[»]
G300-320[»]
2IILmodel-@1-384[»]
ProteinModelPortaliP25929.
SMRiP25929. Positions 10-369.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
BLAST
Topological domaini66 – 7611CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini98 – 11619ExtracellularSequence AnalysisAdd
BLAST
Topological domaini138 – 15417CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini176 – 21136ExtracellularSequence AnalysisAdd
BLAST
Topological domaini233 – 26028CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini282 – 29918ExtracellularSequence AnalysisAdd
BLAST
Topological domaini321 – 38464CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei300 – 32021Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG261951.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiP25929.
KOiK04204.
OMAiQVENHSI.
OrthoDBiEOG7C2R16.
PhylomeDBiP25929.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25929-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV
60 70 80 90 100
IILGVSGNLA LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY
110 120 130 140 150
TLMDHWVFGE AMCKLNPFVQ CVSITVSIFS LVLIAVERHQ LIINPRGWRP
160 170 180 190 200
NNRHAYVGIA VIWVLAVASS LPFLIYQVMT DEPFQNVTLD AYKDKYVCFD
210 220 230 240 250
QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR RNNMMDKMRD
260 270 280 290 300
NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL
310 320 330 340 350
LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI
360 370 380
AMSTMHTDVS KTSLKQASPV AFKKINNNDD NEKI
Length:384
Mass (Da):44,392
Last modified:May 1, 1992 - v1
Checksum:i582B0DDB04490316
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961F → L in AAA59920. (PubMed:1321422)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti374 – 3741K → T.
Corresponds to variant rs5578 [ dbSNP | Ensembl ].
VAR_014681

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88461 mRNA. Translation: AAA73215.1.
M84755 mRNA. Translation: AAA59920.1.
L07614 mRNA. No translation available.
L07615 mRNA. Translation: AAA59947.1.
AY548168 mRNA. Translation: AAS55647.1.
AK312578 mRNA. Translation: BAG35472.1.
CH471056 Genomic DNA. Translation: EAX04841.1.
BC036657 mRNA. Translation: AAH36657.1.
BC071720 mRNA. Translation: AAH71720.1.
CCDSiCCDS34089.1.
PIRiA45490.
RefSeqiNP_000900.1. NM_000909.5.
XP_005263088.1. XM_005263031.1.
XP_005263089.1. XM_005263032.1.
UniGeneiHs.519057.
Hs.733329.

Genome annotation databases

EnsembliENST00000296533; ENSP00000354652; ENSG00000164128.
GeneIDi4886.
KEGGihsa:4886.
UCSCiuc003iqm.2. human.

Polymorphism databases

DMDMi128997.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88461 mRNA. Translation: AAA73215.1 .
M84755 mRNA. Translation: AAA59920.1 .
L07614 mRNA. No translation available.
L07615 mRNA. Translation: AAA59947.1 .
AY548168 mRNA. Translation: AAS55647.1 .
AK312578 mRNA. Translation: BAG35472.1 .
CH471056 Genomic DNA. Translation: EAX04841.1 .
BC036657 mRNA. Translation: AAH36657.1 .
BC071720 mRNA. Translation: AAH71720.1 .
CCDSi CCDS34089.1.
PIRi A45490.
RefSeqi NP_000900.1. NM_000909.5.
XP_005263088.1. XM_005263031.1.
XP_005263089.1. XM_005263032.1.
UniGenei Hs.519057.
Hs.733329.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2F1U model - A 38-67 [» ]
B 74-103 [» ]
C 110-142 [» ]
D 153-175 [» ]
E 208-233 [» ]
F 258-288 [» ]
G 300-320 [» ]
2IIL model - @ 1-384 [» ]
ProteinModelPortali P25929.
SMRi P25929. Positions 10-369.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110946. 3 interactions.
IntActi P25929. 4 interactions.
STRINGi 9606.ENSP00000354652.

Chemistry

BindingDBi P25929.
ChEMBLi CHEMBL4777.
GuidetoPHARMACOLOGYi 305.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P25929.

Polymorphism databases

DMDMi 128997.

Proteomic databases

PaxDbi P25929.
PRIDEi P25929.

Protocols and materials databases

DNASUi 4886.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296533 ; ENSP00000354652 ; ENSG00000164128 .
GeneIDi 4886.
KEGGi hsa:4886.
UCSCi uc003iqm.2. human.

Organism-specific databases

CTDi 4886.
GeneCardsi GC04M164245.
HGNCi HGNC:7956. NPY1R.
HPAi HPA029903.
MIMi 162641. gene.
neXtProti NX_P25929.
PharmGKBi PA258.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG261951.
GeneTreei ENSGT00760000118781.
HOGENOMi HOG000050229.
HOVERGENi HBG105676.
InParanoidi P25929.
KOi K04204.
OMAi QVENHSI.
OrthoDBi EOG7C2R16.
PhylomeDBi P25929.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Neuropeptide_Y_receptor_Y1.
GenomeRNAii 4886.
NextBioi 18810.
PROi P25929.
SOURCEi Search...

Gene expression databases

Bgeei P25929.
CleanExi HS_NPY1R.
ExpressionAtlasi P25929. baseline and differential.
Genevestigatori P25929.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type."
    Larhammar D., Blomqvist A.G., Yee F., Jazin E.E., Yoo H., Wahlestedt C.R.
    J. Biol. Chem. 267:10935-10938(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Cloned human neuropeptide Y receptor couples to two different second messenger systems."
    Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A.
    Proc. Natl. Acad. Sci. U.S.A. 89:5794-5798(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor."
    Herzog H., Baumgartner M., Vivero C., Selbie L.A., Auer B., Shine J.
    J. Biol. Chem. 268:6703-6707(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Testis.

Entry informationi

Entry nameiNPY1R_HUMAN
AccessioniPrimary (citable) accession number: P25929
Secondary accession number(s): B2R6H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3