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P25918

- CD19_MOUSE

UniProt

P25918 - CD19_MOUSE

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Protein

B-lymphocyte antigen CD19

Gene

Cd19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

GO - Biological processi

  1. B cell receptor signaling pathway Source: MGI
  2. positive regulation of release of sequestered calcium ion into cytosol Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_226341. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
B-lymphocyte antigen CD19
Alternative name(s):
Differentiation antigen CD19
CD_antigen: CD19
Gene namesi
Name:Cd19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:88319. Cd19.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Propeptidei17 – 182Sequence AnalysisPRO_0000014649
Chaini19 – 547529B-lymphocyte antigen CD19PRO_0000014650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 97PROSITE-ProRule annotation
Glycosylationi56 – 561N-linked (GlcNAc...)
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi197 ↔ 259PROSITE-ProRule annotation
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Modified residuei225 – 2251Phosphoserine1 Publication
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
Modified residuei346 – 3461PhosphotyrosineBy similarity
Modified residuei376 – 3761PhosphotyrosineBy similarity
Modified residuei402 – 4021PhosphotyrosineBy similarity
Modified residuei432 – 4321PhosphotyrosineBy similarity
Modified residuei490 – 4901PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP25918.
PRIDEiP25918.

PTM databases

PhosphoSiteiP25918.

Expressioni

Gene expression databases

BgeeiP25918.
CleanExiMM_CD19.
ExpressionAtlasiP25918. baseline and differential.
GenevestigatoriP25918.

Interactioni

Subunit structurei

Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-346 and/or Tyr-376. Interacts with PLCG2 when phosphorylated on Tyr-402. Interacts with LYN By similarity.By similarity

Protein-protein interaction databases

BioGridi198576. 1 interaction.
IntActiP25918. 1 interaction.
MINTiMINT-1757394.
STRINGi10090.ENSMUSP00000032968.

Structurei

3D structure databases

ProteinModelPortaliP25918.
SMRiP25918. Positions 182-262.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 287269ExtracellularSequence AnalysisAdd
BLAST
Topological domaini312 – 547236CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei288 – 31124HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11394Ig-like C2-type 1Add
BLAST
Domaini171 – 271101Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46561.
GeneTreeiENSGT00390000014991.
HOGENOMiHOG000111478.
HOVERGENiHBG003388.
InParanoidiP25918.
KOiK06465.
OMAiSPHGSAW.
OrthoDBiEOG74N5GS.
TreeFamiTF338293.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25918-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSPLPVSFL LFLTLVGGRP QKSLLVEVEE GGNVVLPCLP DSSPVSSEKL
60 70 80 90 100
AWYRGNQSTP FLELSPGSPG LGLHVGSLGI LLVIVNVSDH MGGFYLCQKR
110 120 130 140 150
PPFKDIWQPA WTVNVEDSGE MFRWNASDVR DLDCDLRNRS SGSHRSTSGS
160 170 180 190 200
QLYVWAKDHP KVWGTKPVCA PRGSSLNQSL INQDLTVAPG STLWLSCGVP
210 220 230 240 250
PVPVAKGSIS WTHVHPRRPN VSLLSLSLGG EHPVREMWVW GSLLLLPQAT
260 270 280 290 300
ALDEGTYYCL RGNLTIERHV KVIARSAVWL WLLRTGGWIV PVVTLVYVIF
310 320 330 340 350
CMVSLVAFLY CQRAFILRRK RKRMTDPARR FFKVTPPSGN GTQNQYGNVL
360 370 380 390 400
SLPTSTSGQA HAQRWAAGLG SVPGSYGNPR IQVQDTGAQS HETGLEEEGE
410 420 430 440 450
AYEEPDSEEG SEFYENDSNL GQDQVSQDGS GYENPEDEPM GPEEEDSFSN
460 470 480 490 500
AESYENADEE LAQPVGRMMD FLSPHGSAWD PSREASSLGS QSYEDMRGIL
510 520 530 540
YAAPQLHSIQ SGPSHEEDAD SYENMDKSDD LEPAWEGEGH MGTWGTT
Length:547
Mass (Da):60,149
Last modified:July 27, 2011 - v3
Checksum:iDDC34A3E23410C8D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti207 – 2071G → A in AAA37390. (PubMed:1370948)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62542 Genomic DNA. Translation: AAA37388.1.
M62553, M62551, M62552 Genomic DNA. Translation: AAA37390.1.
AK089835 mRNA. Translation: BAC40973.1.
CH466531 Genomic DNA. Translation: EDL17351.1.
M28240 Genomic DNA. Translation: AAA74753.1.
M84372 Genomic DNA. Translation: AAA37389.1.
CCDSiCCDS21828.1.
PIRiB45808.
RefSeqiNP_033974.2. NM_009844.2.
XP_006507346.1. XM_006507283.1.
UniGeneiMm.4360.

Genome annotation databases

EnsembliENSMUST00000032968; ENSMUSP00000032968; ENSMUSG00000030724.
GeneIDi12478.
KEGGimmu:12478.
UCSCiuc009jrb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62542 Genomic DNA. Translation: AAA37388.1 .
M62553 , M62551 , M62552 Genomic DNA. Translation: AAA37390.1 .
AK089835 mRNA. Translation: BAC40973.1 .
CH466531 Genomic DNA. Translation: EDL17351.1 .
M28240 Genomic DNA. Translation: AAA74753.1 .
M84372 Genomic DNA. Translation: AAA37389.1 .
CCDSi CCDS21828.1.
PIRi B45808.
RefSeqi NP_033974.2. NM_009844.2.
XP_006507346.1. XM_006507283.1.
UniGenei Mm.4360.

3D structure databases

ProteinModelPortali P25918.
SMRi P25918. Positions 182-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198576. 1 interaction.
IntActi P25918. 1 interaction.
MINTi MINT-1757394.
STRINGi 10090.ENSMUSP00000032968.

PTM databases

PhosphoSitei P25918.

Proteomic databases

PaxDbi P25918.
PRIDEi P25918.

Protocols and materials databases

DNASUi 12478.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032968 ; ENSMUSP00000032968 ; ENSMUSG00000030724 .
GeneIDi 12478.
KEGGi mmu:12478.
UCSCi uc009jrb.1. mouse.

Organism-specific databases

CTDi 930.
MGIi MGI:88319. Cd19.

Phylogenomic databases

eggNOGi NOG46561.
GeneTreei ENSGT00390000014991.
HOGENOMi HOG000111478.
HOVERGENi HBG003388.
InParanoidi P25918.
KOi K06465.
OMAi SPHGSAW.
OrthoDBi EOG74N5GS.
TreeFami TF338293.

Enzyme and pathway databases

Reactomei REACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_226341. PIP3 activates AKT signaling.

Miscellaneous databases

NextBioi 281366.
PROi P25918.
SOURCEi Search...

Gene expression databases

Bgeei P25918.
CleanExi MM_CD19.
ExpressionAtlasi P25918. baseline and differential.
Genevestigatori P25918.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain."
    Zhou L.J., Ord D.C., Hughes A.L., Tedder T.F.
    J. Immunol. 147:1424-1432(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Spleen.
  2. "Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes."
    Zhou L.J., Ord D.C., Omori S.A., Tedder T.F.
    Immunogenetics 35:102-111(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Spleen.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily."
    Tedder T.F., Isaacs C.M.
    J. Immunol. 143:712-717(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 302-547.
    Strain: BALB/c.
    Tissue: Spleen.
  6. "The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP."
    Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M.
    Mol. Cell. Biol. 12:2662-2672(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
  7. "Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry."
    Jin W.-H., Dai J., Zhou H., Xia Q.-C., Zou H.-F., Zeng R.
    Rapid Commun. Mass Spectrom. 18:2169-2176(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-225.

Entry informationi

Entry nameiCD19_MOUSE
AccessioniPrimary (citable) accession number: P25918
Secondary accession number(s): Q542B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3