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Protein

B-lymphocyte antigen CD19

Gene

Cd19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

GO - Molecular functioni

GO - Biological processi

  • B cell receptor signaling pathway Source: MGI
  • cellular defense response Source: GO_Central
  • positive regulation of release of sequestered calcium ion into cytosol Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-977606 Regulation of Complement cascade
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Recommended name:
B-lymphocyte antigen CD19
Alternative name(s):
Differentiation antigen CD19
CD_antigen: CD19
Gene namesi
Name:Cd19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88319 Cd19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 287ExtracellularSequence analysisAdd BLAST269
Transmembranei288 – 311HelicalSequence analysisAdd BLAST24
Topological domaini312 – 547CytoplasmicSequence analysisAdd BLAST236

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
PropeptideiPRO_000001464917 – 18Sequence analysis2
ChainiPRO_000001465019 – 547B-lymphocyte antigen CD19Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 97PROSITE-ProRule annotation
Glycosylationi56N-linked (GlcNAc...) asparagine1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi197 ↔ 259PROSITE-ProRule annotation
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei225Phosphoserine1 Publication1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei346PhosphotyrosineBy similarity1
Modified residuei376PhosphotyrosineBy similarity1
Modified residuei402PhosphotyrosineBy similarity1
Modified residuei432PhosphotyrosineBy similarity1
Modified residuei493PhosphotyrosineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP25918
PeptideAtlasiP25918
PRIDEiP25918

PTM databases

iPTMnetiP25918
PhosphoSitePlusiP25918

Expressioni

Gene expression databases

BgeeiENSMUSG00000030724
CleanExiMM_CD19
ExpressionAtlasiP25918 baseline and differential
GenevisibleiP25918 MM

Interactioni

Subunit structurei

Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-346 and/or Tyr-376. Interacts with PLCG2 when phosphorylated on Tyr-402. Interacts with LYN (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi1985761 interactor.
IntActiP25918 3 interactors.
STRINGi10090.ENSMUSP00000032968

Structurei

3D structure databases

ProteinModelPortaliP25918
SMRiP25918
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 113Ig-like C2-type 1Add BLAST94
Domaini171 – 271Ig-like C2-type 2Add BLAST101

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ3V Eukaryota
ENOG41115SQ LUCA
GeneTreeiENSGT00390000014991
HOGENOMiHOG000111478
HOVERGENiHBG003388
InParanoidiP25918
KOiK06465
OMAiLYVWAKD
OrthoDBiEOG091G08D8
TreeFamiTF338293

Family and domain databases

Gene3Di2.60.40.101 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPLPVSFL LFLTLVGGRP QKSLLVEVEE GGNVVLPCLP DSSPVSSEKL
60 70 80 90 100
AWYRGNQSTP FLELSPGSPG LGLHVGSLGI LLVIVNVSDH MGGFYLCQKR
110 120 130 140 150
PPFKDIWQPA WTVNVEDSGE MFRWNASDVR DLDCDLRNRS SGSHRSTSGS
160 170 180 190 200
QLYVWAKDHP KVWGTKPVCA PRGSSLNQSL INQDLTVAPG STLWLSCGVP
210 220 230 240 250
PVPVAKGSIS WTHVHPRRPN VSLLSLSLGG EHPVREMWVW GSLLLLPQAT
260 270 280 290 300
ALDEGTYYCL RGNLTIERHV KVIARSAVWL WLLRTGGWIV PVVTLVYVIF
310 320 330 340 350
CMVSLVAFLY CQRAFILRRK RKRMTDPARR FFKVTPPSGN GTQNQYGNVL
360 370 380 390 400
SLPTSTSGQA HAQRWAAGLG SVPGSYGNPR IQVQDTGAQS HETGLEEEGE
410 420 430 440 450
AYEEPDSEEG SEFYENDSNL GQDQVSQDGS GYENPEDEPM GPEEEDSFSN
460 470 480 490 500
AESYENADEE LAQPVGRMMD FLSPHGSAWD PSREASSLGS QSYEDMRGIL
510 520 530 540
YAAPQLHSIQ SGPSHEEDAD SYENMDKSDD LEPAWEGEGH MGTWGTT
Length:547
Mass (Da):60,149
Last modified:July 27, 2011 - v3
Checksum:iDDC34A3E23410C8D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207G → A in AAA37390 (PubMed:1370948).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62542 Genomic DNA Translation: AAA37388.1
M62553, M62551, M62552 Genomic DNA Translation: AAA37390.1
AK089835 mRNA Translation: BAC40973.1
CH466531 Genomic DNA Translation: EDL17351.1
M28240 Genomic DNA Translation: AAA74753.1
M84372 Genomic DNA Translation: AAA37389.1
CCDSiCCDS21828.1
PIRiB45808
RefSeqiNP_033974.2, NM_009844.2
XP_006507346.1, XM_006507283.2
UniGeneiMm.4360

Genome annotation databases

EnsembliENSMUST00000206325; ENSMUSP00000145803; ENSMUSG00000030724
GeneIDi12478
KEGGimmu:12478
UCSCiuc009jrb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCD19_MOUSE
AccessioniPrimary (citable) accession number: P25918
Secondary accession number(s): Q542B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome