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P25918 (CD19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B-lymphocyte antigen CD19
Alternative name(s):
Differentiation antigen CD19
CD_antigen=CD19
Gene names
Name:Cd19
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

Subunit structure

Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-346 and/or Tyr-376. Interacts with PLCG2 when phosphorylated on Tyr-402. Interacts with LYN By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Phosphorylated on tyrosine residues by LYN By similarity. Ref.7

Sequence similarities

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616
Propeptide17 – 182 Potential
PRO_0000014649
Chain19 – 547529B-lymphocyte antigen CD19
PRO_0000014650

Regions

Topological domain19 – 287269Extracellular Potential
Transmembrane288 – 31124Helical; Potential
Topological domain312 – 547236Cytoplasmic Potential
Domain20 – 11394Ig-like C2-type 1
Domain171 – 271101Ig-like C2-type 2

Amino acid modifications

Modified residue2251Phosphoserine Ref.7
Modified residue3461Phosphotyrosine By similarity
Modified residue3761Phosphotyrosine By similarity
Modified residue4021Phosphotyrosine By similarity
Modified residue4321Phosphotyrosine By similarity
Modified residue4901Phosphoserine By similarity
Glycosylation561N-linked (GlcNAc...)
Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation1251N-linked (GlcNAc...) Potential
Glycosylation1381N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2631N-linked (GlcNAc...) Potential
Disulfide bond38 ↔ 97 Potential
Disulfide bond197 ↔ 259 Potential

Experimental info

Sequence conflict2071G → A in AAA37390. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P25918 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: DDC34A3E23410C8D

FASTA54760,149
        10         20         30         40         50         60 
MPSPLPVSFL LFLTLVGGRP QKSLLVEVEE GGNVVLPCLP DSSPVSSEKL AWYRGNQSTP 

        70         80         90        100        110        120 
FLELSPGSPG LGLHVGSLGI LLVIVNVSDH MGGFYLCQKR PPFKDIWQPA WTVNVEDSGE 

       130        140        150        160        170        180 
MFRWNASDVR DLDCDLRNRS SGSHRSTSGS QLYVWAKDHP KVWGTKPVCA PRGSSLNQSL 

       190        200        210        220        230        240 
INQDLTVAPG STLWLSCGVP PVPVAKGSIS WTHVHPRRPN VSLLSLSLGG EHPVREMWVW 

       250        260        270        280        290        300 
GSLLLLPQAT ALDEGTYYCL RGNLTIERHV KVIARSAVWL WLLRTGGWIV PVVTLVYVIF 

       310        320        330        340        350        360 
CMVSLVAFLY CQRAFILRRK RKRMTDPARR FFKVTPPSGN GTQNQYGNVL SLPTSTSGQA 

       370        380        390        400        410        420 
HAQRWAAGLG SVPGSYGNPR IQVQDTGAQS HETGLEEEGE AYEEPDSEEG SEFYENDSNL 

       430        440        450        460        470        480 
GQDQVSQDGS GYENPEDEPM GPEEEDSFSN AESYENADEE LAQPVGRMMD FLSPHGSAWD 

       490        500        510        520        530        540 
PSREASSLGS QSYEDMRGIL YAAPQLHSIQ SGPSHEEDAD SYENMDKSDD LEPAWEGEGH 


MGTWGTT 

« Hide

References

« Hide 'large scale' references
[1]"Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain."
Zhou L.J., Ord D.C., Hughes A.L., Tedder T.F.
J. Immunol. 147:1424-1432(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Spleen.
[2]"Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes."
Zhou L.J., Ord D.C., Omori S.A., Tedder T.F.
Immunogenetics 35:102-111(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Spleen.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Spleen.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily."
Tedder T.F., Isaacs C.M.
J. Immunol. 143:712-717(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 302-547.
Strain: BALB/c.
Tissue: Spleen.
[6]"The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP."
Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M.
Mol. Cell. Biol. 12:2662-2672(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
[7]"Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry."
Jin W.-H., Dai J., Zhou H., Xia Q.-C., Zou H.-F., Zeng R.
Rapid Commun. Mass Spectrom. 18:2169-2176(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-225.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62542 Genomic DNA. Translation: AAA37388.1.
M62553, M62551, M62552 Genomic DNA. Translation: AAA37390.1.
AK089835 mRNA. Translation: BAC40973.1.
CH466531 Genomic DNA. Translation: EDL17351.1.
M28240 Genomic DNA. Translation: AAA74753.1.
M84372 Genomic DNA. Translation: AAA37389.1.
CCDSCCDS21828.1.
PIRB45808.
RefSeqNP_033974.2. NM_009844.2.
XP_006507346.1. XM_006507283.1.
UniGeneMm.4360.

3D structure databases

ProteinModelPortalP25918.
SMRP25918. Positions 182-262.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198576. 1 interaction.
IntActP25918. 1 interaction.
MINTMINT-1757394.
STRING10090.ENSMUSP00000032968.

PTM databases

PhosphoSiteP25918.

Proteomic databases

PaxDbP25918.
PRIDEP25918.

Protocols and materials databases

DNASU12478.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032968; ENSMUSP00000032968; ENSMUSG00000030724.
GeneID12478.
KEGGmmu:12478.
UCSCuc009jrb.1. mouse.

Organism-specific databases

CTD930.
MGIMGI:88319. Cd19.

Phylogenomic databases

eggNOGNOG46561.
GeneTreeENSGT00390000014991.
HOGENOMHOG000111478.
HOVERGENHBG003388.
InParanoidQ542B2.
KOK06465.
OMASPHGSAW.
OrthoDBEOG74N5GS.
TreeFamTF338293.

Gene expression databases

ArrayExpressP25918.
BgeeP25918.
CleanExMM_CD19.
GenevestigatorP25918.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio281366.
PROP25918.
SOURCESearch...

Entry information

Entry nameCD19_MOUSE
AccessionPrimary (citable) accession number: P25918
Secondary accession number(s): Q542B2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot