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Protein

B-lymphocyte antigen CD19

Gene

Cd19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

GO - Molecular functioni

GO - Biological processi

  • B cell receptor signaling pathway Source: MGI
  • cellular defense response Source: GO_Central
  • chromosome breakage Source: MGI
  • positive regulation of release of sequestered calcium ion into cytosol Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
B-lymphocyte antigen CD19
Alternative name(s):
Differentiation antigen CD19
CD_antigen: CD19
Gene namesi
Name:Cd19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88319. Cd19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 287ExtracellularSequence analysisAdd BLAST269
Transmembranei288 – 311HelicalSequence analysisAdd BLAST24
Topological domaini312 – 547CytoplasmicSequence analysisAdd BLAST236

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
PropeptideiPRO_000001464917 – 18Sequence analysis2
ChainiPRO_000001465019 – 547B-lymphocyte antigen CD19Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 97PROSITE-ProRule annotation
Glycosylationi56N-linked (GlcNAc...)1
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Glycosylationi177N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi197 ↔ 259PROSITE-ProRule annotation
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Modified residuei225Phosphoserine1 Publication1
Glycosylationi263N-linked (GlcNAc...)Sequence analysis1
Modified residuei346PhosphotyrosineBy similarity1
Modified residuei376PhosphotyrosineBy similarity1
Modified residuei402PhosphotyrosineBy similarity1
Modified residuei432PhosphotyrosineBy similarity1
Modified residuei493PhosphotyrosineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP25918.
PeptideAtlasiP25918.
PRIDEiP25918.

PTM databases

iPTMnetiP25918.
PhosphoSitePlusiP25918.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030724.
CleanExiMM_CD19.
ExpressionAtlasiP25918. baseline and differential.
GenevisibleiP25918. MM.

Interactioni

Subunit structurei

Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-346 and/or Tyr-376. Interacts with PLCG2 when phosphorylated on Tyr-402. Interacts with LYN (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
P018823EBI-644463,EBI-10683684
IghmP018723EBI-644463,EBI-645833

Protein-protein interaction databases

BioGridi198576. 1 interactor.
IntActiP25918. 3 interactors.
MINTiMINT-1757394.
STRINGi10090.ENSMUSP00000032968.

Structurei

3D structure databases

ProteinModelPortaliP25918.
SMRiP25918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 113Ig-like C2-type 1Add BLAST94
Domaini171 – 271Ig-like C2-type 2Add BLAST101

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ3V. Eukaryota.
ENOG41115SQ. LUCA.
GeneTreeiENSGT00390000014991.
HOGENOMiHOG000111478.
HOVERGENiHBG003388.
InParanoidiP25918.
KOiK06465.
OMAiLYVWAKD.
OrthoDBiEOG091G08D8.
TreeFamiTF338293.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPLPVSFL LFLTLVGGRP QKSLLVEVEE GGNVVLPCLP DSSPVSSEKL
60 70 80 90 100
AWYRGNQSTP FLELSPGSPG LGLHVGSLGI LLVIVNVSDH MGGFYLCQKR
110 120 130 140 150
PPFKDIWQPA WTVNVEDSGE MFRWNASDVR DLDCDLRNRS SGSHRSTSGS
160 170 180 190 200
QLYVWAKDHP KVWGTKPVCA PRGSSLNQSL INQDLTVAPG STLWLSCGVP
210 220 230 240 250
PVPVAKGSIS WTHVHPRRPN VSLLSLSLGG EHPVREMWVW GSLLLLPQAT
260 270 280 290 300
ALDEGTYYCL RGNLTIERHV KVIARSAVWL WLLRTGGWIV PVVTLVYVIF
310 320 330 340 350
CMVSLVAFLY CQRAFILRRK RKRMTDPARR FFKVTPPSGN GTQNQYGNVL
360 370 380 390 400
SLPTSTSGQA HAQRWAAGLG SVPGSYGNPR IQVQDTGAQS HETGLEEEGE
410 420 430 440 450
AYEEPDSEEG SEFYENDSNL GQDQVSQDGS GYENPEDEPM GPEEEDSFSN
460 470 480 490 500
AESYENADEE LAQPVGRMMD FLSPHGSAWD PSREASSLGS QSYEDMRGIL
510 520 530 540
YAAPQLHSIQ SGPSHEEDAD SYENMDKSDD LEPAWEGEGH MGTWGTT
Length:547
Mass (Da):60,149
Last modified:July 27, 2011 - v3
Checksum:iDDC34A3E23410C8D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207G → A in AAA37390 (PubMed:1370948).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62542 Genomic DNA. Translation: AAA37388.1.
M62553, M62551, M62552 Genomic DNA. Translation: AAA37390.1.
AK089835 mRNA. Translation: BAC40973.1.
CH466531 Genomic DNA. Translation: EDL17351.1.
M28240 Genomic DNA. Translation: AAA74753.1.
M84372 Genomic DNA. Translation: AAA37389.1.
CCDSiCCDS21828.1.
PIRiB45808.
RefSeqiNP_033974.2. NM_009844.2.
XP_006507346.1. XM_006507283.2.
UniGeneiMm.4360.

Genome annotation databases

EnsembliENSMUST00000206325; ENSMUSP00000145803; ENSMUSG00000030724.
GeneIDi12478.
KEGGimmu:12478.
UCSCiuc009jrb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62542 Genomic DNA. Translation: AAA37388.1.
M62553, M62551, M62552 Genomic DNA. Translation: AAA37390.1.
AK089835 mRNA. Translation: BAC40973.1.
CH466531 Genomic DNA. Translation: EDL17351.1.
M28240 Genomic DNA. Translation: AAA74753.1.
M84372 Genomic DNA. Translation: AAA37389.1.
CCDSiCCDS21828.1.
PIRiB45808.
RefSeqiNP_033974.2. NM_009844.2.
XP_006507346.1. XM_006507283.2.
UniGeneiMm.4360.

3D structure databases

ProteinModelPortaliP25918.
SMRiP25918.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198576. 1 interactor.
IntActiP25918. 3 interactors.
MINTiMINT-1757394.
STRINGi10090.ENSMUSP00000032968.

PTM databases

iPTMnetiP25918.
PhosphoSitePlusiP25918.

Proteomic databases

PaxDbiP25918.
PeptideAtlasiP25918.
PRIDEiP25918.

Protocols and materials databases

DNASUi12478.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000206325; ENSMUSP00000145803; ENSMUSG00000030724.
GeneIDi12478.
KEGGimmu:12478.
UCSCiuc009jrb.1. mouse.

Organism-specific databases

CTDi930.
MGIiMGI:88319. Cd19.

Phylogenomic databases

eggNOGiENOG410IJ3V. Eukaryota.
ENOG41115SQ. LUCA.
GeneTreeiENSGT00390000014991.
HOGENOMiHOG000111478.
HOVERGENiHBG003388.
InParanoidiP25918.
KOiK06465.
OMAiLYVWAKD.
OrthoDBiEOG091G08D8.
TreeFamiTF338293.

Enzyme and pathway databases

ReactomeiR-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

PROiP25918.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030724.
CleanExiMM_CD19.
ExpressionAtlasiP25918. baseline and differential.
GenevisibleiP25918. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD19_MOUSE
AccessioniPrimary (citable) accession number: P25918
Secondary accession number(s): Q542B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.