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P25874 (UCP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial brown fat uncoupling protein 1

Short name=UCP 1
Alternative name(s):
Solute carrier family 25 member 7
Thermogenin
Gene names
Name:UCP1
Synonyms:SLC25A7, UCP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Subunit structure

Acts as a dimer forming a proton channel.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Tissue specificity

Brown adipose tissue. Ref.6

Polymorphism

The Thr-64 polymorphism is associated with an increased waist-to-hip ratio. The Leu-229 polymorphism is associated with susceptibility to type II diabetes mellitus.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 307306Mitochondrial brown fat uncoupling protein 1
PRO_0000090657

Regions

Transmembrane11 – 3222Helical; Name=1; Potential
Transmembrane74 – 9623Helical; Name=2; Potential
Transmembrane117 – 13317Helical; Name=3; Potential
Transmembrane179 – 19517Helical; Name=4; Potential
Transmembrane213 – 23220Helical; Name=5; Potential
Transmembrane267 – 28923Helical; Name=6; Potential
Repeat11 – 10292Solcar 1
Repeat111 – 20191Solcar 2
Repeat210 – 29586Solcar 3
Region274 – 29623Purine nucleotide binding By similarity

Natural variations

Natural variant641A → T. Ref.8
Corresponds to variant rs45539933 [ dbSNP | Ensembl ].
VAR_022840
Natural variant2291M → L. Ref.7
Corresponds to variant rs2270565 [ dbSNP | Ensembl ].
VAR_022841

Experimental info

Sequence conflict211G → P in CAA36214. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P25874 [UniParc].

Last modified July 19, 2005. Version 3.
Checksum: BCC99AB27171FC67

FASTA30733,005
        10         20         30         40         50         60 
MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS SVIRYKGVLG 

        70         80         90        100        110        120 
TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ EFLTAGKETA PSLGSKILAG 

       130        140        150        160        170        180 
LTTGGVAVFI GQPTEVVKVR LQAQSHLHGI KPRYTGTYNA YRIIATTEGL TGLWKGTTPN 

       190        200        210        220        230        240 
LMRSVIINCT ELVTYDLMKE AFVKNNILAD DVPCHLVSAL IAGFCATAMS SPVDVVKTRF 

       250        260        270        280        290        300 
INSPPGQYKS VPNCAMKVFT NEGPTAFFKG LVPSFLRLGS WNVIMFVCFE QLKRELSKSR 


QTMDCAT 

« Hide

References

« Hide 'large scale' references
[1]"Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4."
Cassard A.M., Bouillaud F., Mattei M.-G., Hentz E., Raimbault S., Thomas M., Ricquier D.
J. Cell. Biochem. 43:255-264(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Bouillaud F.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Sequence of the cDNA coding for the human uncoupling protein UCP."
Bouillaud F., Ricquier D., Raimbault S.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brown adipose tissue.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe."
Bouillaud F., Villarroya F., Hentz E., Raimbault S., Cassard A.M., Ricquier D.
Clin. Sci. 75:21-27(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-196, TISSUE SPECIFICITY.
Tissue: Brown adipose tissue.
[7]"A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus."
Mori H., Okazawa H., Iwamoto K., Maeda E., Hashiramoto M., Kasuga M.
Diabetologia 44:373-376(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LEU-229.
[8]"Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio."
Herrmann S.M., Wang J.G., Staessen J.A., Kertmen E., Schmidt-Petersen K., Zidek W., Paul M., Brand E.
J. Mol. Med. 81:327-332(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT THR-64.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X51952 expand/collapse EMBL AC list , X51953, X51954, X51955 Genomic DNA. Translation: CAA36214.1.
U28480 mRNA. Translation: AAA85271.1.
AC108019 Genomic DNA. Translation: AAY41026.1.
BC069556 mRNA. Translation: AAH69556.1.
BC098168 mRNA. Translation: AAH98168.1.
BC098258 mRNA. Translation: AAH98258.1.
PIRG01858.
RefSeqNP_068605.1. NM_021833.4.
UniGeneHs.249211.

3D structure databases

ProteinModelPortalP25874.
SMRP25874. Positions 13-304.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113197. 1 interaction.
STRING9606.ENSP00000262999.

Protein family/group databases

TCDB2.A.29.3.2. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteP25874.

Polymorphism databases

DMDM71153184.

Proteomic databases

PaxDbP25874.
PRIDEP25874.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262999; ENSP00000262999; ENSG00000109424.
GeneID7350.
KEGGhsa:7350.
UCSCuc011chj.2. human.

Organism-specific databases

CTD7350.
GeneCardsGC04M141480.
HGNCHGNC:12517. UCP1.
HPACAB037199.
MIM113730. gene.
neXtProtNX_P25874.
PharmGKBPA37164.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277477.
HOGENOMHOG000165140.
HOVERGENHBG009528.
InParanoidP25874.
KOK08769.
OMARYTGTYN.
OrthoDBEOG793B7Z.
PhylomeDBP25874.
TreeFamTF323211.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressP25874.
BgeeP25874.
CleanExHS_UCP1.
GenevestigatorP25874.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00784. MTUNCOUPLING.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiThermogenin.
GenomeRNAi7350.
NextBio28774.
PROP25874.
SOURCESearch...

Entry information

Entry nameUCP1_HUMAN
AccessionPrimary (citable) accession number: P25874
Secondary accession number(s): Q13218, Q4KMZ3, Q68G66
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM