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P25874

- UCP1_HUMAN

UniProt

P25874 - UCP1_HUMAN

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Protein
Mitochondrial brown fat uncoupling protein 1
Gene
UCP1, SLC25A7, UCP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

GO - Molecular functioni

  1. oxidative phosphorylation uncoupler activity Source: Ensembl

GO - Biological processi

  1. brown fat cell differentiation Source: HGNC
  2. cellular metabolic process Source: Reactome
  3. mitochondrial transport Source: InterPro
  4. proton transport Source: Reactome
  5. regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. respiratory electron transport chain Source: Reactome
  7. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_6196. The proton buffering model.
REACT_6258. The fatty acid cycling model.

Protein family/group databases

TCDBi2.A.29.3.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1
Short name:
UCP 1
Alternative name(s):
Solute carrier family 25 member 7
Thermogenin
Gene namesi
Name:UCP1
Synonyms:SLC25A7, UCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:12517. UCP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3222Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei74 – 9623Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei117 – 13317Helical; Name=3; Reviewed prediction
Add
BLAST
Transmembranei179 – 19517Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei213 – 23220Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei267 – 28923Helical; Name=6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus, Obesity

Organism-specific databases

PharmGKBiPA37164.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 307306Mitochondrial brown fat uncoupling protein 1
PRO_0000090657Add
BLAST

Proteomic databases

PaxDbiP25874.
PRIDEiP25874.

PTM databases

PhosphoSiteiP25874.

Expressioni

Tissue specificityi

Brown adipose tissue.1 Publication

Gene expression databases

ArrayExpressiP25874.
BgeeiP25874.
CleanExiHS_UCP1.
GenevestigatoriP25874.

Organism-specific databases

HPAiCAB037199.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.

Protein-protein interaction databases

BioGridi113197. 1 interaction.
STRINGi9606.ENSP00000262999.

Structurei

3D structure databases

ProteinModelPortaliP25874.
SMRiP25874. Positions 13-304.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10292Solcar 1
Add
BLAST
Repeati111 – 20191Solcar 2
Add
BLAST
Repeati210 – 29586Solcar 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni274 – 29623Purine nucleotide binding By similarity
Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277477.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP25874.
KOiK08769.
OMAiCSIVTMP.
OrthoDBiEOG793B7Z.
PhylomeDBiP25874.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25874-1 [UniParc]FASTAAdd to Basket

« Hide

MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS    50
SVIRYKGVLG TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ 100
EFLTAGKETA PSLGSKILAG LTTGGVAVFI GQPTEVVKVR LQAQSHLHGI 150
KPRYTGTYNA YRIIATTEGL TGLWKGTTPN LMRSVIINCT ELVTYDLMKE 200
AFVKNNILAD DVPCHLVSAL IAGFCATAMS SPVDVVKTRF INSPPGQYKS 250
VPNCAMKVFT NEGPTAFFKG LVPSFLRLGS WNVIMFVCFE QLKRELSKSR 300
QTMDCAT 307
Length:307
Mass (Da):33,005
Last modified:July 19, 2005 - v3
Checksum:iBCC99AB27171FC67
GO

Polymorphismi

The Thr-64 polymorphism is associated with an increased waist-to-hip ratio. The Leu-229 polymorphism is associated with susceptibility to type II diabetes mellitus.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641A → T.1 Publication
Corresponds to variant rs45539933 [ dbSNP | Ensembl ].
VAR_022840
Natural varianti229 – 2291M → L.1 Publication
Corresponds to variant rs2270565 [ dbSNP | Ensembl ].
VAR_022841

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211G → P in CAA36214. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51952
, X51953, X51954, X51955 Genomic DNA. Translation: CAA36214.1.
U28480 mRNA. Translation: AAA85271.1.
AC108019 Genomic DNA. Translation: AAY41026.1.
BC069556 mRNA. Translation: AAH69556.1.
BC098168 mRNA. Translation: AAH98168.1.
BC098258 mRNA. Translation: AAH98258.1.
CCDSiCCDS3753.1.
PIRiG01858.
RefSeqiNP_068605.1. NM_021833.4.
UniGeneiHs.249211.

Genome annotation databases

EnsembliENST00000262999; ENSP00000262999; ENSG00000109424.
GeneIDi7350.
KEGGihsa:7350.
UCSCiuc011chj.2. human.

Polymorphism databases

DMDMi71153184.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51952
, X51953 , X51954 , X51955 Genomic DNA. Translation: CAA36214.1 .
U28480 mRNA. Translation: AAA85271.1 .
AC108019 Genomic DNA. Translation: AAY41026.1 .
BC069556 mRNA. Translation: AAH69556.1 .
BC098168 mRNA. Translation: AAH98168.1 .
BC098258 mRNA. Translation: AAH98258.1 .
CCDSi CCDS3753.1.
PIRi G01858.
RefSeqi NP_068605.1. NM_021833.4.
UniGenei Hs.249211.

3D structure databases

ProteinModelPortali P25874.
SMRi P25874. Positions 13-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113197. 1 interaction.
STRINGi 9606.ENSP00000262999.

Protein family/group databases

TCDBi 2.A.29.3.2. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitei P25874.

Polymorphism databases

DMDMi 71153184.

Proteomic databases

PaxDbi P25874.
PRIDEi P25874.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262999 ; ENSP00000262999 ; ENSG00000109424 .
GeneIDi 7350.
KEGGi hsa:7350.
UCSCi uc011chj.2. human.

Organism-specific databases

CTDi 7350.
GeneCardsi GC04M141480.
HGNCi HGNC:12517. UCP1.
HPAi CAB037199.
MIMi 113730. gene.
neXtProti NX_P25874.
PharmGKBi PA37164.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277477.
HOGENOMi HOG000165140.
HOVERGENi HBG009528.
InParanoidi P25874.
KOi K08769.
OMAi CSIVTMP.
OrthoDBi EOG793B7Z.
PhylomeDBi P25874.
TreeFami TF323211.

Enzyme and pathway databases

Reactomei REACT_6196. The proton buffering model.
REACT_6258. The fatty acid cycling model.

Miscellaneous databases

GeneWikii Thermogenin.
GenomeRNAii 7350.
NextBioi 28774.
PROi P25874.
SOURCEi Search...

Gene expression databases

ArrayExpressi P25874.
Bgeei P25874.
CleanExi HS_UCP1.
Genevestigatori P25874.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00784. MTUNCOUPLING.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4."
    Cassard A.M., Bouillaud F., Mattei M.-G., Hentz E., Raimbault S., Thomas M., Ricquier D.
    J. Cell. Biochem. 43:255-264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Bouillaud F.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Sequence of the cDNA coding for the human uncoupling protein UCP."
    Bouillaud F., Ricquier D., Raimbault S.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brown adipose tissue.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe."
    Bouillaud F., Villarroya F., Hentz E., Raimbault S., Cassard A.M., Ricquier D.
    Clin. Sci. 75:21-27(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-196, TISSUE SPECIFICITY.
    Tissue: Brown adipose tissue.
  7. "A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus."
    Mori H., Okazawa H., Iwamoto K., Maeda E., Hashiramoto M., Kasuga M.
    Diabetologia 44:373-376(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-229.
  8. "Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio."
    Herrmann S.M., Wang J.G., Staessen J.A., Kertmen E., Schmidt-Petersen K., Zidek W., Paul M., Brand E.
    J. Mol. Med. 81:327-332(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT THR-64.

Entry informationi

Entry nameiUCP1_HUMAN
AccessioniPrimary (citable) accession number: P25874
Secondary accession number(s): Q13218, Q4KMZ3, Q68G66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 19, 2005
Last modified: September 3, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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