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Protein

Mitochondrial brown fat uncoupling protein 1

Gene

UCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_6196. The proton buffering model.
REACT_6258. The fatty acid cycling model.

Protein family/group databases

TCDBi2.A.29.3.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1
Short name:
UCP 1
Alternative name(s):
Solute carrier family 25 member 7
Thermogenin
Gene namesi
Name:UCP1
Synonyms:SLC25A7, UCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:12517. UCP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3222Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei74 – 9623Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei117 – 13317Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei179 – 19517Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei213 – 23220Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei267 – 28923Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: Reactome
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus, Obesity

Organism-specific databases

PharmGKBiPA37164.

Polymorphism and mutation databases

BioMutaiUCP1.
DMDMi71153184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 307306Mitochondrial brown fat uncoupling protein 1PRO_0000090657Add
BLAST

Proteomic databases

PaxDbiP25874.
PRIDEiP25874.

PTM databases

PhosphoSiteiP25874.

Expressioni

Tissue specificityi

Brown adipose tissue.1 Publication

Gene expression databases

BgeeiP25874.
CleanExiHS_UCP1.
GenevisibleiP25874. HS.

Organism-specific databases

HPAiCAB037199.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.

Protein-protein interaction databases

BioGridi113197. 3 interactions.
STRINGi9606.ENSP00000262999.

Structurei

3D structure databases

ProteinModelPortaliP25874.
SMRiP25874. Positions 13-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10292Solcar 1Add
BLAST
Repeati111 – 20191Solcar 2Add
BLAST
Repeati210 – 29586Solcar 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni274 – 29623Purine nucleotide bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277477.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP25874.
KOiK08769.
OMAiKMFTNEG.
OrthoDBiEOG793B7Z.
PhylomeDBiP25874.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS
60 70 80 90 100
SVIRYKGVLG TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ
110 120 130 140 150
EFLTAGKETA PSLGSKILAG LTTGGVAVFI GQPTEVVKVR LQAQSHLHGI
160 170 180 190 200
KPRYTGTYNA YRIIATTEGL TGLWKGTTPN LMRSVIINCT ELVTYDLMKE
210 220 230 240 250
AFVKNNILAD DVPCHLVSAL IAGFCATAMS SPVDVVKTRF INSPPGQYKS
260 270 280 290 300
VPNCAMKVFT NEGPTAFFKG LVPSFLRLGS WNVIMFVCFE QLKRELSKSR

QTMDCAT
Length:307
Mass (Da):33,005
Last modified:July 19, 2005 - v3
Checksum:iBCC99AB27171FC67
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211G → P in CAA36214 (PubMed:2380264).Curated

Polymorphismi

The Thr-64 polymorphism is associated with an increased waist-to-hip ratio. The Leu-229 polymorphism is associated with susceptibility to type II diabetes mellitus.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641A → T.1 Publication
Corresponds to variant rs45539933 [ dbSNP | Ensembl ].
VAR_022840
Natural varianti229 – 2291M → L.1 Publication
Corresponds to variant rs2270565 [ dbSNP | Ensembl ].
VAR_022841

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51952
, X51953, X51954, X51955 Genomic DNA. Translation: CAA36214.1.
U28480 mRNA. Translation: AAA85271.1.
AC108019 Genomic DNA. Translation: AAY41026.1.
BC069556 mRNA. Translation: AAH69556.1.
BC098168 mRNA. Translation: AAH98168.1.
BC098258 mRNA. Translation: AAH98258.1.
CCDSiCCDS3753.1.
PIRiG01858.
RefSeqiNP_068605.1. NM_021833.4.
UniGeneiHs.249211.

Genome annotation databases

EnsembliENST00000262999; ENSP00000262999; ENSG00000109424.
GeneIDi7350.
KEGGihsa:7350.
UCSCiuc011chj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51952
, X51953, X51954, X51955 Genomic DNA. Translation: CAA36214.1.
U28480 mRNA. Translation: AAA85271.1.
AC108019 Genomic DNA. Translation: AAY41026.1.
BC069556 mRNA. Translation: AAH69556.1.
BC098168 mRNA. Translation: AAH98168.1.
BC098258 mRNA. Translation: AAH98258.1.
CCDSiCCDS3753.1.
PIRiG01858.
RefSeqiNP_068605.1. NM_021833.4.
UniGeneiHs.249211.

3D structure databases

ProteinModelPortaliP25874.
SMRiP25874. Positions 13-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113197. 3 interactions.
STRINGi9606.ENSP00000262999.

Protein family/group databases

TCDBi2.A.29.3.2. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteiP25874.

Polymorphism and mutation databases

BioMutaiUCP1.
DMDMi71153184.

Proteomic databases

PaxDbiP25874.
PRIDEiP25874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262999; ENSP00000262999; ENSG00000109424.
GeneIDi7350.
KEGGihsa:7350.
UCSCiuc011chj.2. human.

Organism-specific databases

CTDi7350.
GeneCardsiGC04M141480.
HGNCiHGNC:12517. UCP1.
HPAiCAB037199.
MIMi113730. gene.
neXtProtiNX_P25874.
PharmGKBiPA37164.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG277477.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP25874.
KOiK08769.
OMAiKMFTNEG.
OrthoDBiEOG793B7Z.
PhylomeDBiP25874.
TreeFamiTF323211.

Enzyme and pathway databases

ReactomeiREACT_6196. The proton buffering model.
REACT_6258. The fatty acid cycling model.

Miscellaneous databases

GeneWikiiThermogenin.
GenomeRNAii7350.
NextBioi28774.
PROiP25874.
SOURCEiSearch...

Gene expression databases

BgeeiP25874.
CleanExiHS_UCP1.
GenevisibleiP25874. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4."
    Cassard A.M., Bouillaud F., Mattei M.-G., Hentz E., Raimbault S., Thomas M., Ricquier D.
    J. Cell. Biochem. 43:255-264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Bouillaud F.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Sequence of the cDNA coding for the human uncoupling protein UCP."
    Bouillaud F., Ricquier D., Raimbault S.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brown adipose tissue.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe."
    Bouillaud F., Villarroya F., Hentz E., Raimbault S., Cassard A.M., Ricquier D.
    Clin. Sci. 75:21-27(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-196, TISSUE SPECIFICITY.
    Tissue: Brown adipose tissue.
  7. "A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus."
    Mori H., Okazawa H., Iwamoto K., Maeda E., Hashiramoto M., Kasuga M.
    Diabetologia 44:373-376(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-229.
  8. "Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio."
    Herrmann S.M., Wang J.G., Staessen J.A., Kertmen E., Schmidt-Petersen K., Zidek W., Paul M., Brand E.
    J. Mol. Med. 81:327-332(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT THR-64.

Entry informationi

Entry nameiUCP1_HUMAN
AccessioniPrimary (citable) accession number: P25874
Secondary accession number(s): Q13218, Q4KMZ3, Q68G66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 19, 2005
Last modified: July 22, 2015
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.