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P25874

- UCP1_HUMAN

UniProt

P25874 - UCP1_HUMAN

Protein

Mitochondrial brown fat uncoupling protein 1

Gene

UCP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

    GO - Molecular functioni

    1. oxidative phosphorylation uncoupler activity Source: Ensembl

    GO - Biological processi

    1. brown fat cell differentiation Source: HGNC
    2. cellular metabolic process Source: Reactome
    3. mitochondrial transport Source: InterPro
    4. proton transport Source: Reactome
    5. regulation of transcription from RNA polymerase II promoter Source: Ensembl
    6. respiratory electron transport chain Source: Reactome
    7. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_6196. The proton buffering model.
    REACT_6258. The fatty acid cycling model.

    Protein family/group databases

    TCDBi2.A.29.3.2. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial brown fat uncoupling protein 1
    Short name:
    UCP 1
    Alternative name(s):
    Solute carrier family 25 member 7
    Thermogenin
    Gene namesi
    Name:UCP1
    Synonyms:SLC25A7, UCP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:12517. UCP1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Diabetes mellitus, Obesity

    Organism-specific databases

    PharmGKBiPA37164.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 307306Mitochondrial brown fat uncoupling protein 1PRO_0000090657Add
    BLAST

    Proteomic databases

    PaxDbiP25874.
    PRIDEiP25874.

    PTM databases

    PhosphoSiteiP25874.

    Expressioni

    Tissue specificityi

    Brown adipose tissue.1 Publication

    Gene expression databases

    ArrayExpressiP25874.
    BgeeiP25874.
    CleanExiHS_UCP1.
    GenevestigatoriP25874.

    Organism-specific databases

    HPAiCAB037199.

    Interactioni

    Subunit structurei

    Acts as a dimer forming a proton channel.

    Protein-protein interaction databases

    BioGridi113197. 1 interaction.
    STRINGi9606.ENSP00000262999.

    Structurei

    3D structure databases

    ProteinModelPortaliP25874.
    SMRiP25874. Positions 13-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3222Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9623Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13317Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19517Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei213 – 23220Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28923Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 10292Solcar 1Add
    BLAST
    Repeati111 – 20191Solcar 2Add
    BLAST
    Repeati210 – 29586Solcar 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni274 – 29623Purine nucleotide bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277477.
    HOGENOMiHOG000165140.
    HOVERGENiHBG009528.
    InParanoidiP25874.
    KOiK08769.
    OMAiCSIVTMP.
    OrthoDBiEOG793B7Z.
    PhylomeDBiP25874.
    TreeFamiTF323211.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00784. MTUNCOUPLING.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25874-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS    50
    SVIRYKGVLG TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ 100
    EFLTAGKETA PSLGSKILAG LTTGGVAVFI GQPTEVVKVR LQAQSHLHGI 150
    KPRYTGTYNA YRIIATTEGL TGLWKGTTPN LMRSVIINCT ELVTYDLMKE 200
    AFVKNNILAD DVPCHLVSAL IAGFCATAMS SPVDVVKTRF INSPPGQYKS 250
    VPNCAMKVFT NEGPTAFFKG LVPSFLRLGS WNVIMFVCFE QLKRELSKSR 300
    QTMDCAT 307
    Length:307
    Mass (Da):33,005
    Last modified:July 19, 2005 - v3
    Checksum:iBCC99AB27171FC67
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211G → P in CAA36214. (PubMed:2380264)Curated

    Polymorphismi

    The Thr-64 polymorphism is associated with an increased waist-to-hip ratio. The Leu-229 polymorphism is associated with susceptibility to type II diabetes mellitus.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti64 – 641A → T.1 Publication
    Corresponds to variant rs45539933 [ dbSNP | Ensembl ].
    VAR_022840
    Natural varianti229 – 2291M → L.1 Publication
    Corresponds to variant rs2270565 [ dbSNP | Ensembl ].
    VAR_022841

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51952
    , X51953, X51954, X51955 Genomic DNA. Translation: CAA36214.1.
    U28480 mRNA. Translation: AAA85271.1.
    AC108019 Genomic DNA. Translation: AAY41026.1.
    BC069556 mRNA. Translation: AAH69556.1.
    BC098168 mRNA. Translation: AAH98168.1.
    BC098258 mRNA. Translation: AAH98258.1.
    CCDSiCCDS3753.1.
    PIRiG01858.
    RefSeqiNP_068605.1. NM_021833.4.
    UniGeneiHs.249211.

    Genome annotation databases

    EnsembliENST00000262999; ENSP00000262999; ENSG00000109424.
    GeneIDi7350.
    KEGGihsa:7350.
    UCSCiuc011chj.2. human.

    Polymorphism databases

    DMDMi71153184.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51952
    , X51953 , X51954 , X51955 Genomic DNA. Translation: CAA36214.1 .
    U28480 mRNA. Translation: AAA85271.1 .
    AC108019 Genomic DNA. Translation: AAY41026.1 .
    BC069556 mRNA. Translation: AAH69556.1 .
    BC098168 mRNA. Translation: AAH98168.1 .
    BC098258 mRNA. Translation: AAH98258.1 .
    CCDSi CCDS3753.1.
    PIRi G01858.
    RefSeqi NP_068605.1. NM_021833.4.
    UniGenei Hs.249211.

    3D structure databases

    ProteinModelPortali P25874.
    SMRi P25874. Positions 13-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113197. 1 interaction.
    STRINGi 9606.ENSP00000262999.

    Protein family/group databases

    TCDBi 2.A.29.3.2. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei P25874.

    Polymorphism databases

    DMDMi 71153184.

    Proteomic databases

    PaxDbi P25874.
    PRIDEi P25874.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262999 ; ENSP00000262999 ; ENSG00000109424 .
    GeneIDi 7350.
    KEGGi hsa:7350.
    UCSCi uc011chj.2. human.

    Organism-specific databases

    CTDi 7350.
    GeneCardsi GC04M141480.
    HGNCi HGNC:12517. UCP1.
    HPAi CAB037199.
    MIMi 113730. gene.
    neXtProti NX_P25874.
    PharmGKBi PA37164.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277477.
    HOGENOMi HOG000165140.
    HOVERGENi HBG009528.
    InParanoidi P25874.
    KOi K08769.
    OMAi CSIVTMP.
    OrthoDBi EOG793B7Z.
    PhylomeDBi P25874.
    TreeFami TF323211.

    Enzyme and pathway databases

    Reactomei REACT_6196. The proton buffering model.
    REACT_6258. The fatty acid cycling model.

    Miscellaneous databases

    GeneWikii Thermogenin.
    GenomeRNAii 7350.
    NextBioi 28774.
    PROi P25874.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25874.
    Bgeei P25874.
    CleanExi HS_UCP1.
    Genevestigatori P25874.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00784. MTUNCOUPLING.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4."
      Cassard A.M., Bouillaud F., Mattei M.-G., Hentz E., Raimbault S., Thomas M., Ricquier D.
      J. Cell. Biochem. 43:255-264(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Bouillaud F.
      Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Sequence of the cDNA coding for the human uncoupling protein UCP."
      Bouillaud F., Ricquier D., Raimbault S.
      Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brown adipose tissue.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe."
      Bouillaud F., Villarroya F., Hentz E., Raimbault S., Cassard A.M., Ricquier D.
      Clin. Sci. 75:21-27(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-196, TISSUE SPECIFICITY.
      Tissue: Brown adipose tissue.
    7. "A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus."
      Mori H., Okazawa H., Iwamoto K., Maeda E., Hashiramoto M., Kasuga M.
      Diabetologia 44:373-376(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-229.
    8. "Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio."
      Herrmann S.M., Wang J.G., Staessen J.A., Kertmen E., Schmidt-Petersen K., Zidek W., Paul M., Brand E.
      J. Mol. Med. 81:327-332(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT THR-64.

    Entry informationi

    Entry nameiUCP1_HUMAN
    AccessioniPrimary (citable) accession number: P25874
    Secondary accession number(s): Q13218, Q4KMZ3, Q68G66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3