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Protein

Ubiquitin-conjugating enzyme E2 2

Gene

UBC2

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Glycyl thioester intermediate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 2 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 2
Ubiquitin carrier protein 2
Ubiquitin-conjugating enzyme E2-16 kDa
Ubiquitin-protein ligase 2
Gene namesi
Name:UBC2
Synonyms:UBC1
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unassembled WGS sequence

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi88C → S: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825731 – 152Ubiquitin-conjugating enzyme E2 2Add BLAST152

Proteomic databases

PRIDEiP25866.

Structurei

3D structure databases

ProteinModelPortaliP25866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPARKRLM RDFKRLQQDP PAGISGAPHD NNITLWNAVI FGPDDTPWDG
60 70 80 90 100
GTFKLTLQFT EDYPNKPPTV RFVSRMFHPN IYADGSICLD ILQNQWSPIY
110 120 130 140 150
DVAAILTSIQ SLLCDPNPNS PANSEAARMY SENKREYNRK VREVVEQSWT

AD
Length:152
Mass (Da):17,301
Last modified:May 1, 1992 - v1
Checksum:iF13AA5439EB4C8AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62720 mRNA. Translation: AAA34310.1.
UniGeneiTa.16377.

Genome annotation databases

EnsemblPlantsiTRIAE_CS42_5AL_TGACv1_374210_AA1193710.1; TRIAE_CS42_5AL_TGACv1_374210_AA1193710.1; TRIAE_CS42_5AL_TGACv1_374210_AA1193710.
TRIAE_CS42_5BL_TGACv1_404210_AA1290280.1; TRIAE_CS42_5BL_TGACv1_404210_AA1290280.1; TRIAE_CS42_5BL_TGACv1_404210_AA1290280.
GrameneiTRIAE_CS42_5AL_TGACv1_374210_AA1193710.1; TRIAE_CS42_5AL_TGACv1_374210_AA1193710.1; TRIAE_CS42_5AL_TGACv1_374210_AA1193710.
TRIAE_CS42_5BL_TGACv1_404210_AA1290280.1; TRIAE_CS42_5BL_TGACv1_404210_AA1290280.1; TRIAE_CS42_5BL_TGACv1_404210_AA1290280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62720 mRNA. Translation: AAA34310.1.
UniGeneiTa.16377.

3D structure databases

ProteinModelPortaliP25866.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP25866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiTRIAE_CS42_5AL_TGACv1_374210_AA1193710.1; TRIAE_CS42_5AL_TGACv1_374210_AA1193710.1; TRIAE_CS42_5AL_TGACv1_374210_AA1193710.
TRIAE_CS42_5BL_TGACv1_404210_AA1290280.1; TRIAE_CS42_5BL_TGACv1_404210_AA1290280.1; TRIAE_CS42_5BL_TGACv1_404210_AA1290280.
GrameneiTRIAE_CS42_5AL_TGACv1_374210_AA1193710.1; TRIAE_CS42_5AL_TGACv1_374210_AA1193710.1; TRIAE_CS42_5AL_TGACv1_374210_AA1193710.
TRIAE_CS42_5BL_TGACv1_404210_AA1290280.1; TRIAE_CS42_5BL_TGACv1_404210_AA1290280.1; TRIAE_CS42_5BL_TGACv1_404210_AA1290280.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBC2_WHEAT
AccessioniPrimary (citable) accession number: P25866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.