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Protein

Metallothionein-like protein 2A

Gene

MT2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of copper (Cu) and zinc (Zn) (PubMed:18287486). Plays a role in Cu homeostasis, specifically in the remobilization of Cu from senescing leaves. The mobilization of Cu from internal sources is important for seed development (PubMed:24635746).Curated2 Publications

GO - Molecular functioni

  • copper ion binding Source: TAIR

GO - Biological processi

  • cellular copper ion homeostasis Source: TAIR

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-like protein 2A
Short name:
MT-2A
Short name:
MT-K
Alternative name(s):
MT-1G
Gene namesi
Name:MT2A
Ordered Locus Names:At3g09390
ORF Names:F3L24.28
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G09390.
TAIRilocus:2083519. AT3G09390.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973861 – 81Metallothionein-like protein 2AAdd BLAST81

Proteomic databases

PaxDbiP25860.

Expressioni

Tissue specificityi

Abundant in leaves, inflorescences and roots of mature plants. Also detected in roots of young plants, and in siliques (PubMed:7565594). Expressed in leaf mesophyll cells, filaments, stigma and tips of elongating lateral roots (Ref. 8).2 Publications

Inductioni

Strongly induced in seedlings by CuSO4.1 Publication

Gene expression databases

ExpressionAtlasiP25860. baseline and differential.
GenevisibleiP25860. AT.

Interactioni

Protein-protein interaction databases

BioGridi5432. 2 interactors.
STRINGi3702.AT3G09390.1.

Structurei

3D structure databases

ProteinModelPortaliP25860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J5R6. Eukaryota.
ENOG410Z616. LUCA.
HOGENOMiHOG000220916.
InParanoidiP25860.
OMAiAGCKCGS.
OrthoDBiEOG0936118M.
PhylomeDBiP25860.

Family and domain databases

InterProiView protein in InterPro
IPR000347. Metalthion_15p.
PfamiView protein in Pfam
PF01439. Metallothio_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P25860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCCGGNCGC GSGCKCGNGC GGCKMYPDLG FSGETTTTET FVLGVAPAMK
60 70 80
NQYEASGESN NAENDACKCG SDCKCDPCTC K
Length:81
Mass (Da):8,163
Last modified:November 1, 1997 - v2
Checksum:iB2639167E56854EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64N → S in BAA01990 (Ref. 1) Curated1
Sequence conflicti64N → S in CAA44630 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11394 Genomic DNA. Translation: BAA01990.1.
X62818 mRNA. Translation: CAA44630.1.
U15108 mRNA. Translation: AAA50250.1.
AC011436 Genomic DNA. Translation: AAF14034.1.
CP002686 Genomic DNA. Translation: AEE74760.1.
CP002686 Genomic DNA. Translation: ANM65194.1.
AY037263 mRNA. Translation: AAK59864.1.
AY077669 mRNA. Translation: AAL76147.1.
Z26416 mRNA. Translation: CAA81248.1.
PIRiS18069. SMMUL.
S57861.
RefSeqiNP_001327181.1. NM_001337815.1.
NP_187550.1. NM_111773.4.
UniGeneiAt.24444.
At.42166.
At.67557.

Genome annotation databases

EnsemblPlantsiAT3G09390.1; AT3G09390.1; AT3G09390.
AT3G09390.2; AT3G09390.2; AT3G09390.
GeneIDi820098.
GrameneiAT3G09390.1; AT3G09390.1; AT3G09390.
AT3G09390.2; AT3G09390.2; AT3G09390.
KEGGiath:AT3G09390.

Similar proteinsi

Entry informationi

Entry nameiMT2A_ARATH
AccessioniPrimary (citable) accession number: P25860
Secondary accession number(s): P43391
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1997
Last modified: June 7, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families