Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional regulatory protein ZraR

Gene

zraR

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 176ATPPROSITE-ProRule annotation8
Nucleotide bindingi232 – 241ATPPROSITE-ProRule annotation10
DNA bindingi421 – 440H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein ZraR
Gene namesi
Name:zraR
Synonyms:hydG
Ordered Locus Names:STM4174
ORF Names:STMF1.27
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000812831 – 441Transcriptional regulatory protein ZraRAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by ZraS.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP25852.
PRIDEiP25852.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4174.

Structurei

Secondary structure

1441
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi146 – 158Combined sources13
Beta strandi165 – 169Combined sources5
Helixi175 – 185Combined sources11
Beta strandi189 – 191Combined sources3
Beta strandi195 – 197Combined sources3
Helixi203 – 210Combined sources8
Helixi228 – 232Combined sources5
Beta strandi235 – 241Combined sources7
Helixi247 – 258Combined sources12
Beta strandi259 – 261Combined sources3
Beta strandi276 – 283Combined sources8
Helixi285 – 291Combined sources7
Helixi296 – 302Combined sources7
Beta strandi303 – 308Combined sources6
Helixi313 – 318Combined sources6
Helixi319 – 333Combined sources15
Helixi343 – 351Combined sources9
Helixi357 – 371Combined sources15
Beta strandi374 – 377Combined sources4
Helixi379 – 381Combined sources3
Helixi384 – 386Combined sources3
Helixi402 – 415Combined sources14
Turni416 – 419Combined sources4
Helixi421 – 428Combined sources8
Helixi432 – 438Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OJLX-ray3.00A/B/C/D/E/F141-441[»]
ProteinModelPortaliP25852.
SMRiP25852.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25852.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST115
Domaini141 – 370Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST230

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation
Contains 1 sigma-54 factor interaction domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C1W. Bacteria.
COG2204. LUCA.
HOGENOMiHOG000058489.
KOiK07713.
OMAiVATDSRW.
PhylomeDBiP25852.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25852-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRGKIDILV VDDDVSHCTI LQALLRGWGY NVALAYSGHD ALAQVREKVF
60 70 80 90 100
DLVLCDVRMA EMDGIATLKE IKALNPAIPI LIMTAFSSVE TAVEALKAGA
110 120 130 140 150
LDYLIKPLDF DRLQETLEKA LAHTRETGAE LPSASAAQFG MIGSSPAMQH
160 170 180 190 200
LLNEIAMVAP SDATVLIHGD SGTGKELVAR ALHACSARSD RPLVTLNCAA
210 220 230 240 250
LNESLLESEL FGHEKGAFTG ADKRREGRFV EADGGTLFLD EIGDISPLMQ
260 270 280 290 300
VRLLRAIQER EVQRVGSNQT ISVDVRLIAA THRDLAEEVS AGRFRQDLYY
310 320 330 340 350
RLNVVAIEMP SLRQRREDIP LLADHFLRRF AERNRKVVKG FTPQAMDLLI
360 370 380 390 400
HYDWPGNIRE LENAIERAVV LLTGEYISER ELPLAIAATP IKTEYSGEIQ
410 420 430 440
PLVDVEKEVI LAALEKTGGN KTEAARQLGI TRKTLLAKLS R
Length:441
Mass (Da):48,590
Last modified:January 23, 2002 - v2
Checksum:i5753C4E54F8C52F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159A → R in AAA27149 (PubMed:1756170).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64988 mRNA. Translation: AAA27149.1.
AF170176 Genomic DNA. Translation: AAF33506.1.
AE006468 Genomic DNA. Translation: AAL23002.1.
PIRiS19606.
RefSeqiNP_463043.1. NC_003197.1.
WP_000617942.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23002; AAL23002; STM4174.
GeneIDi1255700.
KEGGistm:STM4174.
PATRICi32387233. VBISalEnt20916_4388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64988 mRNA. Translation: AAA27149.1.
AF170176 Genomic DNA. Translation: AAF33506.1.
AE006468 Genomic DNA. Translation: AAL23002.1.
PIRiS19606.
RefSeqiNP_463043.1. NC_003197.1.
WP_000617942.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OJLX-ray3.00A/B/C/D/E/F141-441[»]
ProteinModelPortaliP25852.
SMRiP25852.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4174.

Proteomic databases

PaxDbiP25852.
PRIDEiP25852.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL23002; AAL23002; STM4174.
GeneIDi1255700.
KEGGistm:STM4174.
PATRICi32387233. VBISalEnt20916_4388.

Phylogenomic databases

eggNOGiENOG4105C1W. Bacteria.
COG2204. LUCA.
HOGENOMiHOG000058489.
KOiK07713.
OMAiVATDSRW.
PhylomeDBiP25852.

Miscellaneous databases

EvolutionaryTraceiP25852.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZRAR_SALTY
AccessioniPrimary (citable) accession number: P25852
Secondary accession number(s): Q9L9H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2002
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be involved in the regulation of the labile hydrogenase activity.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.