Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Profilin

Gene

chic

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. This profilin is required for intercellular cytoplasm transport during Drosophila oogenesis.

GO - Molecular functioni

  • actin binding Source: FlyBase
  • actin monomer binding Source: GO_Central
  • phosphatidylinositol-4,5-bisphosphate binding Source: FlyBase

GO - Biological processi

  • actin filament organization Source: FlyBase
  • actin filament polymerization Source: FlyBase
  • actin polymerization or depolymerization Source: FlyBase
  • actomyosin contractile ring assembly Source: FlyBase
  • axon guidance Source: FlyBase
  • brain development Source: FlyBase
  • cell morphogenesis Source: FlyBase
  • dorsal closure Source: FlyBase
  • histoblast morphogenesis Source: FlyBase
  • karyosome formation Source: FlyBase
  • larval central nervous system remodeling Source: FlyBase
  • larval salivary gland morphogenesis Source: FlyBase
  • maintenance of protein location in cell Source: FlyBase
  • male germ-line stem cell population maintenance Source: FlyBase
  • mitotic cytokinesis Source: FlyBase
  • neuron remodeling Source: FlyBase
  • ovarian nurse cell to oocyte transport Source: FlyBase
  • pole plasm oskar mRNA localization Source: FlyBase
  • positive regulation of axon extension involved in axon guidance Source: CACAO
  • positive regulation of axon regeneration Source: FlyBase
  • positive regulation of filopodium assembly Source: FlyBase
  • sequestering of actin monomers Source: GO_Central
  • somatic stem cell population maintenance Source: FlyBase
  • spermatogenesis Source: FlyBase
  • wound healing Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin
Alternative name(s):
Protein chickadee
Gene namesi
Name:chic
Synonyms:chi
ORF Names:CG9553
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000308. chic.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: GO_Central
  • cell cortex Source: GO_Central
  • cytoplasm Source: FlyBase
  • neuron projection Source: FlyBase
  • perinuclear region of cytoplasm Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126126ProfilinPRO_0000199597Add
BLAST

Proteomic databases

PaxDbiP25843.
PRIDEiP25843.

Expressioni

Tissue specificityi

Expressed in ovary and head.1 Publication

Gene expression databases

BgeeiFBgn0000308.
ExpressionAtlasiP25843. differential.
GenevisibleiP25843. DM.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Binary interactionsi

WithEntry#Exp.IntActNotes
Diap1Q243062EBI-156199,EBI-456419
enaQ8T4F73EBI-156199,EBI-466810
Rac1P407923EBI-156199,EBI-74845

GO - Molecular functioni

  • actin binding Source: FlyBase
  • actin monomer binding Source: GO_Central

Protein-protein interaction databases

BioGridi59999. 50 interactions.
DIPiDIP-22165N.
IntActiP25843. 6 interactions.
MINTiMINT-873227.
STRINGi7227.FBpp0089196.

Structurei

3D structure databases

ProteinModelPortaliP25843.
SMRiP25843. Positions 2-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
GeneTreeiENSGT00730000112841.
InParanoidiP25843.
KOiK05759.
OMAiQFKPQEI.
OrthoDBiEOG091G104O.
PhylomeDBiP25843.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQDYVDNQ LLASQCVTKA CIAGHDGNIW AQSSGFEVTK EELSKLISGF
60 70 80 90 100
DQQDGLTSNG VTLAGQRYIY LSGTDRVVRA KLGRSGVHCM KTTQAVIVSI
110 120
YEDPVQPQQA ASVVEKLGDY LITCGY
Length:126
Mass (Da):13,723
Last modified:May 1, 1992 - v1
Checksum:i6E2942C12A81ADEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84528 mRNA. Translation: AAA28418.1.
M84529 mRNA. Translation: AAA28419.1.
DQ062770 mRNA. Translation: AAY56643.1.
AE014134 Genomic DNA. Translation: AAF52315.1.
AE014134 Genomic DNA. Translation: AAF52316.1.
AE014134 Genomic DNA. Translation: AAN10565.1.
AE014134 Genomic DNA. Translation: AAS64643.1.
AY069444 mRNA. Translation: AAL39589.1.
AY128443 mRNA. Translation: AAM75036.1.
PIRiA38154.
RefSeqiNP_001245905.1. NM_001258976.2.
NP_001245906.1. NM_001258977.2.
NP_477016.1. NM_057668.6.
NP_599131.1. NM_134304.3.
NP_723136.1. NM_164667.2.
NP_995635.1. NM_205913.3.
UniGeneiDm.4775.

Genome annotation databases

EnsemblMetazoaiFBtr0079233; FBpp0078864; FBgn0000308.
FBtr0079234; FBpp0078865; FBgn0000308.
FBtr0079235; FBpp0078866; FBgn0000308.
FBtr0079236; FBpp0089196; FBgn0000308.
FBtr0309212; FBpp0301151; FBgn0000308.
FBtr0309213; FBpp0301152; FBgn0000308.
GeneIDi33834.
KEGGidme:Dmel_CG9553.
UCSCiCG9553-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84528 mRNA. Translation: AAA28418.1.
M84529 mRNA. Translation: AAA28419.1.
DQ062770 mRNA. Translation: AAY56643.1.
AE014134 Genomic DNA. Translation: AAF52315.1.
AE014134 Genomic DNA. Translation: AAF52316.1.
AE014134 Genomic DNA. Translation: AAN10565.1.
AE014134 Genomic DNA. Translation: AAS64643.1.
AY069444 mRNA. Translation: AAL39589.1.
AY128443 mRNA. Translation: AAM75036.1.
PIRiA38154.
RefSeqiNP_001245905.1. NM_001258976.2.
NP_001245906.1. NM_001258977.2.
NP_477016.1. NM_057668.6.
NP_599131.1. NM_134304.3.
NP_723136.1. NM_164667.2.
NP_995635.1. NM_205913.3.
UniGeneiDm.4775.

3D structure databases

ProteinModelPortaliP25843.
SMRiP25843. Positions 2-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59999. 50 interactions.
DIPiDIP-22165N.
IntActiP25843. 6 interactions.
MINTiMINT-873227.
STRINGi7227.FBpp0089196.

Proteomic databases

PaxDbiP25843.
PRIDEiP25843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079233; FBpp0078864; FBgn0000308.
FBtr0079234; FBpp0078865; FBgn0000308.
FBtr0079235; FBpp0078866; FBgn0000308.
FBtr0079236; FBpp0089196; FBgn0000308.
FBtr0309212; FBpp0301151; FBgn0000308.
FBtr0309213; FBpp0301152; FBgn0000308.
GeneIDi33834.
KEGGidme:Dmel_CG9553.
UCSCiCG9553-RA. d. melanogaster.

Organism-specific databases

CTDi33834.
FlyBaseiFBgn0000308. chic.

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
GeneTreeiENSGT00730000112841.
InParanoidiP25843.
KOiK05759.
OMAiQFKPQEI.
OrthoDBiEOG091G104O.
PhylomeDBiP25843.

Miscellaneous databases

ChiTaRSichic. fly.
GenomeRNAii33834.
PROiP25843.

Gene expression databases

BgeeiFBgn0000308.
ExpressionAtlasiP25843. differential.
GenevisibleiP25843. DM.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPROF_DROME
AccessioniPrimary (citable) accession number: P25843
Secondary accession number(s): Q3YMV6, Q9VMJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.